Streptozocin (CED0003055)

Record Information

Version

1.0

Creation Date

2009-07-21 20:26:53 UTC

Update Date

2026-08-24 16:01:02 UTC

SynCED ID

CED0003055

Secondary Accession Numbers

CHEM002193
T3D2788

Identification

Common Name

Streptozocin

Class

Small Molecule

Description

Streptozocin is a solid compound with the formula C8H15N3O7 and an average molecular weight of 265.22 g/mol. It is exogenous in origin. Streptozocin belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. This compound serves as an antineoplastic agent, an antibiotic, a metabolite, and a toxin (PMC7215452 ). Biologically and chemically, it functions as a DNA synthesis inhibitor (PMC7215452 ). It is recorded as being found in healthcare, pharmaceuticals and veterinary products as an antineoplastic agent, as well as in electrical and electronic equipment such as antennas, magnets, and radio transmission systems. The recorded exposure route for this substance is intravenous. Streptozocin has three recorded protein targets: O-GlcNAcase BT_4395, Protein O-GlcNAcase (OGA), and it acts as an antagonist of Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2). In terms of health effects, the compound is associated with hyperglycemia (PMC5674211 ) and diabetes mellitus (PMC11916920 ).

Contaminant Type

Amine
Antibiotic
Antibiotic, Antineoplastic
Antineoplastic Agent
Drug
Metabolite
Organic Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose	ChEBI
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose	ChEBI
Estreptozocina	ChEBI
N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff	ChEBI
N-D-Glucosyl-(2)-n'-nitrosomethylurea	ChEBI
Streptozocine	ChEBI
Streptozocinium	ChEBI
Streptozocinum	ChEBI
Streptozotocin	ChEBI
Zanosar	ChEBI
Streptozotocine	HMDB
Teva brand OF streptozocin	HMDB
Streptozocin teva brand	HMDB
2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose	HMDB

Chemical Formula

C₈H₁₅N₃O₇

Average Molecular Mass

265.221 g/mol

Monoisotopic Mass

265.091 g/mol

CAS Registry Number

18883-66-4

IUPAC Name

3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

Traditional Name

streptozocin

SMILES

CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

InChI Identifier

InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI Key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Hexoses

Alternative Parents

Substituents

Hexose monosaccharide
N-methylnitrosourea
Nitrosourea
Oxane
Nitrosamide
Semicarbazide
Organic n-nitroso compound
Hemiacetal
Carbonic acid derivative
Secondary alcohol
Organic nitroso compound
Oxacycle
Polyol
Organoheterocyclic compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic nitrogen compound
Carbonyl group
Primary alcohol
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

N-nitrosoureas (CHEBI:9288 )
N-acylglucosamine (CHEBI:9288 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

antibiotic ?
antimicrobial agent (PMC9332406 , PMC10886320 )?
metabolite ?A chemical produced during metabolism process, as an intermediate or end-product
neurotoxin (PMC10800989 , PMC12745963 )?A chemical substance that interferes with the normal functioning of the nervous system
alkylating agent (PMC13393497 , PMC12347654 )?
DNA synthesis inhibitor ?
xenobiotic (PMC2721020 )?
toxin (PMC7215452 , PMC10800989 )?A chemical substance naturally produced by an organism and poisonous to other organisms
antineoplastic agent (PMC11916920 )?

Chemical Roles

DNA synthesis inhibitor ?

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	115°C
Boiling Point	Not Available
Solubility	5070 mg/L

Predicted Properties

Property	Value	Source
Water Solubility	33.5 g/L	ALOGPS
logP	-1.7	ALOGPS
logP	-2.7	ChemAxon
logS	-0.9	ALOGPS
pKa (Strongest Acidic)	11.43	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	151.92 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	55.96 m³·mol⁻¹	ChemAxon
Polarizability	23.74 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-02mj-5940000000-8fb8f1885498bea8bc01	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-000i-5384590000-954f20357dc689aab130	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-066s-1390000000-8a52d6755935e91be345	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-9730000000-8e7df34a65b316df695e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-9800000000-8768229ecc0345cd843a	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-9340000000-9e14b4f8a6d8f44c6ad6	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9220000000-2ac584cea0c0d26bc11f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9200000000-dd74fa78262e5a7d35e0	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-4940000000-29bcfe413e3e5b2dd305	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0536-9100000000-2a734221e4d6f4a10693	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9000000000-722b10d68ba035f6a8c2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000t-1090000000-4646c5accac0f8935a29	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01ox-9000000000-d7d9d98474284352116c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-9300000000-9cad9495adf263c410f9	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
2031.0 Log mg/kg [1100:3600]	Rat	LD50	oral	predicted	Not Available	Not Available
40.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
100.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
40.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas. It is used in medical research to produce an animal model for Type 1 diabetes in large dose as well as Type 2 diabetes with multiple low doses. Streptozotocin is similar enough to glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. This explains its relative toxicity to beta cells, since these cells have relatively high levels of GLUT2. Streptozotocin is a glucosamine-nitrosourea (i.e. alkylating) compound. As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute.

Carcinogenicity (IARC Classification)

2B, possibly carcinogenic to humans. (6)

Minimum Risk Level

Not Available

Symptoms

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
gestational diabetes	Associated With?	Not Available	A disorder, occurring in pregnant women, characterized by hyperglycemia.	PMC4623071
diabetes mellitus	Associated With?	Not Available	A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. (DO)	PMC11916920 , PMC10058777
neuropathic pain	Associated With?	Not Available	Not Available	PMC13334684
hyperglycemia	Associated With?	Not Available	A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance. (NCI CTCAE)	PMC5674211 , PMC13393497
type 1 diabetes mellitus	Not Available	Not Available	Not Available	PMC11687964
type 1 diabetes mellitus	Associated With?	Not Available	Not Available	PMC8880550
Oxidative Stress	Associated With?	increase	Not Available	PMC4090508 , PMC10761490
Weight loss	Associated With?	Not Available	Not Available	PMC13393497
infectious disease	Not Available	Not Available	Not Available	PMC10886320
Ketosis	Associated With?	Not Available	Not Available	PMC13128434
Glycosuria	Associated With?	Not Available	Not Available	PMC4431732
Pancreatitis, Acute Necrotizing	Associated With?	Not Available	Not Available	PMC13393497
Ketonuria	Associated With?	Not Available	Not Available	PMC4431732

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000051	Surface water?Surface water can serve as a significant vector for the introduction of synthetic chemical contaminants into aquatic ecosystems.	Aquatic systems & sediments	PMC10886320
CEDs000358	Antineoplastic agents?Antineoplastic agents are a class of synthetic chemicals used primarily in the treatment of cancer.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000483	WWTP effluent?Wastewater treatment plant (WWTP) effluent can serve as a significant source of synthetic chemical contamination in the environment.	Wastewater, sanitation & biosolids	PMC10886320
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000527	Magnets?Magnets, commonly used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials used in their production.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000630	Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000667	Gaseous Fire Fighting?Gaseous fire fighting systems utilize synthetic chemicals, such as halocarbons and inert gases, to suppress fires through chemical and physical processes.	Fire suppression systems & agents	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000692	Silica Free Oxide Glass?Silica Free Oxide Glass is a type of glass that is produced using alternative materials to traditional silica-based formulations.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000732	Spectacle Cases?Spectacle cases can serve as a source of synthetic chemical contamination due to the materials used in their production, such as polycarbonate, PVC, and various plastics, which may leach harmful substances over time.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs02090	Waste	Waste management, landfill & incineration	PMC10886320
CEDs02265	River Water	Aquatic systems & sediments	PMC10886320
CEDs02456	Msunduzi River	Aquatic systems & sediments	PMC10886320
CEDs03012	Wastewater Effluents	Wastewater, sanitation & biosolids	PMC10886320
CEDs03028	Wastewater Effluent	Wastewater, sanitation & biosolids	PMC10886320

Pathways

2 pathwaysPathway Source: PathBank

Streptozocin Drug Metabolism

Streptozocin Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	CD44 antigen	P16070	Humans	Predicted (SEA)	Prediction Confidence Score 0.344 Applicability Domain 0.344 Statistical Significance 8.00e-05 Supporting Reference Compounds 1 E-value 0.622794
Click to view 3D structure	CD44 antigen	P15379	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.344 Applicability Domain 0.344 Statistical Significance 8.00e-05 Supporting Reference Compounds 1 E-value 0.622794
Click to view 3D structure	N-acetylglucosamine-6-phosphate deacetylase	Q9Y303	Humans	Predicted (SEA)	Prediction Confidence Score 0.327 Applicability Domain 0.327 Statistical Significance 7.00e-05 Supporting Reference Compounds 1 E-value 0.544945
Click to view 3D structure	Lectin	B4EH87	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656/ NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315))	Predicted (SEA)	Prediction Confidence Score 0.318 Applicability Domain 0.405 Statistical Significance 2.90e-04 Supporting Reference Compounds 3 E-value 2.25763
Click to view 3D structure	Killer cell lectin-like receptor subfamily B member 1A	P27471	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.297 Applicability Domain 0.328 Statistical Significance 6.00e-05 Supporting Reference Compounds 2 E-value 0.467095
Click to view 3D structure	Type 1 fimbrin D-mannose specific adhesin	P08191	Escherichia coli K-12	Predicted (SEA)	Prediction Confidence Score 0.297 Applicability Domain 0.405 Statistical Significance 5.10e-04 Supporting Reference Compounds 4 E-value 3.97031
Click to view 3D structure	Oligo-1,6-glucosidase IMA1	P53051	Saccharomyces cerevisiae S288c	Predicted (SEA)	Prediction Confidence Score 0.276 Applicability Domain 0.276 Low confidence Statistical Significance 0.0011 Supporting Reference Compounds 1 E-value 8.64126
Click to view 3D structure	N-acetyllactosaminide alpha-1,3-galactosyltransferase	P50127	Sus scrofa	Predicted (SEA)	Prediction Confidence Score 0.268 Applicability Domain 0.268 Low confidence Statistical Significance 6.70e-04 Supporting Reference Compounds 1 E-value 5.2159
Click to view 3D structure	Galectin-7	P47929	Humans	Predicted (SEA)	Prediction Confidence Score 0.257 Applicability Domain 0.281 Low confidence Statistical Significance 4.50e-04 Supporting Reference Compounds 4 E-value 3.50322
Click to view 3D structure	Galectin-3	P17931	Humans	Predicted (SEA)	Prediction Confidence Score 0.251 Applicability Domain 0.281 Low confidence Statistical Significance 0.002 Supporting Reference Compounds 23 E-value 15.4141
Click to view 3D structure	Peptidoglycan-N-acetylglucosamine deacetylase	Q8DP63	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	Predicted (SEA)	Prediction Confidence Score 0.25 Applicability Domain 0.25 Low confidence Statistical Significance 9.30e-04 Supporting Reference Compounds 1 E-value 7.23998
Click to view 3D structure	Alpha-amylase	Q7M328	Sus scrofa domesticus	Predicted (SEA)	Prediction Confidence Score 0.25 Applicability Domain 0.25 Low confidence Statistical Significance 2.30e-04 Supporting Reference Compounds 1 E-value 1.79053
Click to view 3D structure	Galectin-9	O00182	Humans	Predicted (SEA)	Prediction Confidence Score 0.247 Applicability Domain 0.281 Low confidence Statistical Significance 0.0017 Supporting Reference Compounds 15 E-value 13.5458
Click to view 3D structure	Cytidine deaminase	P32320	Humans	Predicted (SEA)	Prediction Confidence Score 0.245 Applicability Domain 0.255 Low confidence Statistical Significance 0.0021 Supporting Reference Compounds 4 E-value 16.4262
Click to view 3D structure	Beta-1,4-galactosyltransferase 1	P08037	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.244 Applicability Domain 0.333 Statistical Significance 0.0014 Supporting Reference Compounds 2 E-value 10.7432
Click to view 3D structure	1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase	P9WJN3	Mycobacterium tuberculosis	Predicted (SEA)	Prediction Confidence Score 0.241 Applicability Domain 0.241 Low confidence Statistical Significance 8.30e-04 Supporting Reference Compounds 1 E-value 6.46149
Click to view 3D structure	Adenosine receptor A1	P30542	Humans	Predicted (SEA)	Prediction Confidence Score 0.239 Applicability Domain 0.286 Low confidence Statistical Significance 0.1334 Supporting Reference Compounds 302 E-value 1038.2
Click to view 3D structure	Cytidine deaminase	P56389	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.238 Applicability Domain 0.264 Low confidence Statistical Significance 0.0028 Supporting Reference Compounds 5 E-value 22.0313
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	Prediction Confidence Score 0.236 Applicability Domain 0.263 Low confidence Statistical Significance 0.1824 Supporting Reference Compounds 332 E-value 1419.89
Click to view 3D structure	Solute carrier family 28 member 3	Q9HAS3	Humans	Predicted (SEA)	Prediction Confidence Score 0.235 Applicability Domain 0.25 Low confidence Statistical Significance 0.0041 Supporting Reference Compounds 3 E-value 32.0739
Click to view 3D structure	Galectin-7	O54974	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.23 Applicability Domain 0.274 Low confidence Statistical Significance 0.0013 Supporting Reference Compounds 2 E-value 10.5096
Click to view 3D structure	Carbonic anhydrase 7	P43166	Humans	Predicted (SEA)	Prediction Confidence Score 0.229 Applicability Domain 0.263 Low confidence Statistical Significance 0.1735 Supporting Reference Compounds 242 E-value 1351.0
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.229 Applicability Domain 0.263 Low confidence Statistical Significance 0.2551 Supporting Reference Compounds 407 E-value 1985.93
Click to view 3D structure	Asialoglycoprotein receptor 1	P07306	Humans	Predicted (SEA)	Prediction Confidence Score 0.228 Applicability Domain 0.228 Low confidence Statistical Significance 2.30e-04 Supporting Reference Compounds 1 E-value 1.79053
Click to view 3D structure	Beta-hexosaminidase	Q9HZK0	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.226 Low confidence Statistical Significance 3.40e-04 Supporting Reference Compounds 1 E-value 2.64687
Click to view 3D structure	Solute carrier family 2, facilitated glucose transporter member 2	P11168	Humans	Known	Not Available
Click to view 3D structure	Protein O-GlcNAcase	O60502	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DB00428

HMDB ID

HMDB0014572

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Link

General References

Brentjens R, Saltz L: Islet cell tumors of the pancreas: the medical oncologist's perspective. Surg Clin North Am. 2001 Jun;81(3):527-42. [PubMed: 11459269]
Wang Z, Gleichmann H: GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes. 1998 Jan;47(1):50-6. [PubMed: 9421374]
Schnedl WJ, Ferber S, Johnson JH, Newgard CB: STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 1994 Nov;43(11):1326-33. [PubMed: 7926307]
VAVRA JJ, DEBOER C, DIETZ A, HANKA LJ, SOKOLSKI WT: Streptozotocin, a new antibacterial antibiotic. Antibiot Annu. 1959-1960;7:230-5. [PubMed: 13841501]
Mansford KR, Opie L: Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet. 1968 Mar 30;1(7544):670-1. [PubMed: 4170654]
International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. - http://monographs.iarc.fr/index.php
Drugs.com - http://www.drugs.com/cons/Streptozocin.html
BC Breast Cancer Agency (2007). Streptozocin. - http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Streptozocin.htm

Streptozocin (CED0003055)

Structure for CHEM002193: Streptozocin

Structure