Methohexital (CED0005994)

Record Information

Version

1.0

Creation Date

2009-07-21 20:26:59 UTC

Update Date

2026-05-14 16:39:54 UTC

SynCED ID

CED0005994

Secondary Accession Numbers

CHEM002205
T3D2803

Identification

Common Name

Methohexital

Class

Small Molecule

Description

Methohexital belongs to the pyrimidines and pyrimidine derivatives, a subclass of diazines within the organic compounds. This exogenous compound has the formula C14H18N2O3 and an average molecular weight of 262.30 g/mol. At room temperature, it exists as a solid. It is utilized as an intravenous anaesthetic. Recorded exposure routes for the compound include intravenous, intramuscular, and rectal administration. Methohexital is found in several recorded sources, including healthcare, pharmaceuticals, and veterinary products such as hypnotics, sedatives, and anesthetics. It is also associated with electrical and electronic equipment, specifically electrically stimulated smoking devices and conductive bodies characterized by conductive materials, as well as household cleaning and consumer products such as tobacco smoke filters, cigar cigarettes, non-electric simulated smoking devices, and other smoking requisites. The compound targets the gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1). Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Consequently, the post-synaptic inhibitory effect of GABA in the thalamus is prolonged.

Contaminant Type

Amide
Amine
Anesthetic
Anesthetic, Intravenous
Barbiturate
Drug
Human Neurotoxin
Metabolite
Organic Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid	ChEBI
5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione	ChEBI
5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione	ChEBI
5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid	ChEBI
alpha-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid	ChEBI
Methohexitalum	ChEBI
Methohexitone	ChEBI
Metohexital	ChEBI
(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbitate	Generator
(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbitic acid	Generator
5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbitate	Generator
5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbitic acid	Generator
a-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitate	Generator
a-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitic acid	Generator
alpha-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitate	Generator
alpha-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitic acid	Generator
Α-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitate	Generator
Α-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbitic acid	Generator
Methodrexitone	HMDB
Brevital	MeSH, HMDB
Sodium, methohexital	MeSH, HMDB
Brietal	MeSH, HMDB
Lilly brand OF methohexital sodium	MeSH, HMDB
Methohexital sodium	MeSH, HMDB
Brietal-sodium	MeSH, HMDB
Brevimytal natrium	MeSH, HMDB
Jones brand OF methohexital sodium	MeSH, HMDB
Methohexital, monosodium salt	MeSH, HMDB
Monosodium salt methohexital	MeSH, HMDB
Natrium, brevimytal	MeSH, HMDB
Brietal sodium	MeSH, HMDB

Chemical Formula

C₁₄H₁₈N₂O₃

Average Molecular Mass

262.304 g/mol

Monoisotopic Mass

262.132 g/mol

CAS Registry Number

151-83-7

IUPAC Name

5-(hex-3-yn-2-yl)-1-methyl-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione

Traditional Name

methohexital

SMILES

CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O

InChI Identifier

InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19)

InChI Key

NZXKDOXHBHYTKP-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as barbituric acid derivatives. Barbituric acid derivatives are compounds containing a perhydropyrimidine ring substituted at C-2, -4 and -6 by oxo groups.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Diazines

Sub Class

Pyrimidines and pyrimidine derivatives

Direct Parent

Barbituric acid derivatives

Alternative Parents

Substituents

Barbiturate
N-acyl urea
Ureide
1,3-diazinane
Dicarboximide
Urea
Carbonic acid derivative
Carboxylic acid derivative
Azacycle
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Organic oxygen compound
Carbonyl group
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

barbiturates (CHEBI:102216 )
acetylenic compound (CHEBI:102216 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

intravenous anaesthetic

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	5.24e-02 g/L

Predicted Properties

Property	Value	Source
Water Solubility	0.052 g/L	ALOGPS
logP	2.43	ALOGPS
logP	2.29	ChemAxon
logS	-3.7	ALOGPS
pKa (Strongest Acidic)	8.73	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	66.48 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	71.51 m³·mol⁻¹	ChemAxon
Polarizability	27.4 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-001j-4390000000-8c577a429e1b4575b629	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00ya-3900000000-577a972e968dc27cf6a6	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-2090000000-43730b3bde391b731ebe	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00dl-3970000000-fc9a91490da8afc576f0	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0f9x-9000000000-93587b41eae6b9864e81	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-2920000000-ad50a444d0a4a9a5af2c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4l-4910000000-c5dc261173ac7024e26f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-9200000000-7cedeac5d5e1a5954aa4	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0090000000-c3de47045d3b9ea5dd1f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03dl-4890000000-e57232418c552e436a95	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-015c-3910000000-34338787c291ec35bb4c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0190000000-859e807fb540e8aaf091	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-053r-0910000000-70fde9c253e18d448791	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-9300000000-67ceed0497570d0689e3	Not Available	View Spectrum
MS	MS Spectrum	splash10-0fbc-9520000000-5141cdceea7f6d5013b0	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
282.0 Log mg/kg [160:500]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Methohexital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions.

Treatment

Establish an airway and ensure oxygenation and ventilation. Resuscitative measures should be initiated promptly. For hypotension, intravenous fluids should be administered and the patient's legs raised. If desirable increase in blood pressure is not obtained, vasopressor and/or inotropic drugs may be used as dictated by the clinical situation. For convulsions, diazepam intravenously and phenytoin may be required. If the seizures are refractory to diazepam and phenytoin, general anesthesia and paralysis with a neuromuscular blocking agent may be necessary. Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient's vital signs, blood gases, serum electrolytes, etc. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. Safeguard the patient's airway when employing gastric emptying or charcoal. (3)

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000369	Anesthetics?Anesthetics are synthetic chemicals used to induce loss of sensation or consciousness in patients undergoing medical procedures.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000376	Hypnotics and sedatives?Hypnotics and sedatives are synthetic chemicals primarily used to induce sleep, reduce anxiety, and manage various psychiatric disorders.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000651	Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs01077	Medications	Healthcare, pharmaceuticals & veterinary products	PMC272247

Pathways

2 pathwaysPathway Source: PathBank

Methohexital Drug Metabolism Action Pathway

Methohexital Predicted Metabolism Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Adenosine receptor A2b	P29275	Humans	Predicted (SEA)	Prediction Confidence Score 0.177 Applicability Domain 0.203 Low confidence Statistical Significance 0.7389 Supporting Reference Compounds 187 E-value 5752.36
Click to view 3D structure	Adenosine receptor A2a	P46616	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.177 Applicability Domain 0.203 Low confidence Statistical Significance 0.0678 Supporting Reference Compounds 27 E-value 527.584
Click to view 3D structure	Adenosine receptor A1	P25099	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.172 Applicability Domain 0.18 Low confidence Statistical Significance 0.7026 Supporting Reference Compounds 221 E-value 5469.61
Click to view 3D structure	Adenosine receptor A2a	P30543	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.172 Applicability Domain 0.18 Low confidence Statistical Significance 0.6902 Supporting Reference Compounds 174 E-value 5373.23
Click to view 3D structure	Adenosine receptor A1	P47745	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.171 Applicability Domain 0.18 Low confidence Statistical Significance 0.1194 Supporting Reference Compounds 38 E-value 929.675
Click to view 3D structure	Beta-secretase 1	P56817	Humans	Predicted (SEA)	Prediction Confidence Score 0.163 Applicability Domain 0.175 Low confidence Statistical Significance 0.8758 Supporting Reference Compounds 163 E-value 6818.03
Click to view 3D structure	Adenosine receptor A2a	P29274	Humans	Predicted (SEA)	Prediction Confidence Score 0.161 Applicability Domain 0.169 Low confidence Statistical Significance 0.9515 Supporting Reference Compounds 303 E-value 7407.04
Click to view 3D structure	Adenosine receptor A2b	P29276	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.158 Applicability Domain 0.176 Low confidence Statistical Significance 0.5702 Supporting Reference Compounds 36 E-value 4438.88
Click to view 3D structure	Adenosine receptor A1	P28190	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.158 Applicability Domain 0.18 Low confidence Statistical Significance 0.6346 Supporting Reference Compounds 72 E-value 4940.23
Click to view 3D structure	Adenosine receptor A1	P30542	Humans	Predicted (SEA)	Prediction Confidence Score 0.158 Applicability Domain 0.18 Low confidence Statistical Significance 0.9542 Supporting Reference Compounds 302 E-value 7428.76
Click to view 3D structure	Histamine oxidase	Q59118	Arthrobacter globiformis	Predicted (SEA)	Prediction Confidence Score 0.155 Applicability Domain 0.155 Low confidence Statistical Significance 0.0094 Supporting Reference Compounds 1 E-value 73.334
Click to view 3D structure	Adenosine receptor A3	P0DMS8	Humans	Predicted (SEA)	Prediction Confidence Score 0.155 Applicability Domain 0.167 Low confidence Statistical Significance 0.9759 Supporting Reference Compounds 391 E-value 7597.15
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	Humans	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.165 Low confidence Statistical Significance 0.9823 Supporting Reference Compounds 906 E-value 7646.82
Click to view 3D structure	cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	Humans	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.18 Low confidence Statistical Significance 0.9448 Supporting Reference Compounds 183 E-value 7354.96
Click to view 3D structure	Beta-secretase 2	Q9Y5Z0	Humans	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.175 Low confidence Statistical Significance 0.6246 Supporting Reference Compounds 38 E-value 4862.23
Click to view 3D structure	Protein kinase C alpha type	P17252	Humans	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.16 Low confidence Statistical Significance 0.9647 Supporting Reference Compounds 258 E-value 7510.19
Click to view 3D structure	5-hydroxytryptamine receptor 1E	P28566	Humans	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.159 Low confidence Statistical Significance 0.9336 Supporting Reference Compounds 139 E-value 7267.77
Click to view 3D structure	3-oxoacyl-[acyl-carrier-protein] synthase 2	P9WQD7	Mycobacterium tuberculosis	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.153 Low confidence Statistical Significance 0.0017 Supporting Reference Compounds 1 E-value 13.4679
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.159 Low confidence Statistical Significance 0.9911 Supporting Reference Compounds 823 E-value 7715.95
Click to view 3D structure	Amine oxidase [flavin-containing] A	P21397	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.159 Low confidence Statistical Significance 0.9481 Supporting Reference Compounds 241 E-value 7380.65
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.159 Low confidence Statistical Significance 0.9913 Supporting Reference Compounds 686 E-value 7717.12
Click to view 3D structure	Protein kinase C epsilon type	Q02156	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.16 Low confidence Statistical Significance 0.9578 Supporting Reference Compounds 189 E-value 7456.55
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.169 Low confidence Statistical Significance 0.9909 Supporting Reference Compounds 532 E-value 7713.77
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-3	P28472	Humans	Predicted (SEA)	Prediction Confidence Score 0.152 Applicability Domain 0.333 Statistical Significance 5.80e-04 Supporting Reference Compounds 3 E-value 4.51525
Click to view 3D structure	Cathepsin D	P07339	Humans	Predicted (SEA)	Prediction Confidence Score 0.151 Applicability Domain 0.175 Low confidence Statistical Significance 0.8251 Supporting Reference Compounds 81 E-value 6423.03
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-1	P14867	Humans	Known	Methohexital binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Concentrations

Not Available

External Links

DrugBank ID

DB00474

HMDB ID

HMDB0258127

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Methohexital

Chemspider ID

8683

ChEBI ID

102216

PubChem Compound ID

Not Available

Kegg Compound ID

C07844

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Link

General References

Janssen PA, Niemegeers CJ, Marsboom RP: Etomidate, a potent non-barbiturate hypnotic. Intravenous etomidate in mice, rats, guinea-pigs, rabbits and dogs. Arch Int Pharmacodyn Ther. 1975 Mar;214(1):92 -132. [PubMed: 1156027]
Drugs.com - http://www.drugs.com/cons/Methohexital.html
RxList: The Internet Drug Index (2009). - http://www.rxlist.com/

Methohexital (CED0005994)

Structure for CHEM002205: Methohexital

Structure