Oxycodone (CED0002036)

Record Information

Version

1.0

Creation Date

2009-07-21 20:27:02 UTC

Update Date

2026-05-14 16:40:30 UTC

SynCED ID

CED0002036

Secondary Accession Numbers

CHEM002211
T3D2809

Identification

Common Name

Oxycodone

Class

Small Molecule

Description

Oxycodone belongs to the phenanthrenes and derivatives, a class of benzenoids within the organic compounds. This exogenous compound has the formula C18H21NO4 and an average molecular weight of 315.36 g/mol. At room temperature, it exists as a solid. It is used as an opioid analgesic, mu-opioid receptor agonist, analgesic, and antitussive (PMC7941040 ). It is used as a treatment for pain (PMC7012325 ) and chronic pain (PMC6205722 ), though it is associated with lethargy and depression (PMC7012325 ). Oxycodone targets the mu-type opioid receptor (OPRM1), kappa-type opioid receptor (OPRK1), and delta-type opioid receptor (OPRD1), while also acting as an inhibitor of the voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B). Within the central nervous system (CNS), it acts as a weak agonist at the mu, kappa, and delta opioid receptors. It primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators of synaptic transmission via G-proteins that activate effector proteins. Binding stimulates the exchange of GTP for GDP on the G-protein complex. Because the effector system consists of cAMP and adenylate cyclase located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Oxycodone is recorded in several sources, including analgesics, drinking water, the preparation of vinegar, and household cleaning and consumer products such as pipe accessories, other smoking requisites, and non-electric simulated smoking devices. It is also found in electrical and electronic equipment, including antennas, amplifiers, relays, auxiliary devices, and line transmission systems. Recorded exposure routes include oral and rectal administration.

Contaminant Type

Amine
Analgesic, Opioid
Antitussive Agent
Drug
Ether
Human Neurotoxin
Metabolite
Narcotic
Opiate Agonist
Organic Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(-)-14-Hydroxydihydrocodeinone	ChEBI
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one	ChEBI
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one	ChEBI
Dihydro-14-hydroxycodeinone	ChEBI
Dihydrohydroxycodeinone	ChEBI
Dihydroxycodeinone	ChEBI
Oxicodona	ChEBI
Oxycodonum	ChEBI
4,5a-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one	Generator
4,5Α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one	Generator
Dihydrohydroxycondeinone	HMDB
Dihydrone	HMDB
PTI-821	HMDB
Dinarkon	HMDB
Oxiconum	HMDB
Oxycone	HMDB
Oxycontin	HMDB
Theocodin	HMDB
Eucodal	HMDB
Oxycodeinon	HMDB
Oxycodone hydrochloride	HMDB
Pancodine	HMDB
Purdue frederick brand OF oxycodone	HMDB

Chemical Formula

C₁₈H₂₁NO₄

Average Molecular Mass

315.364 g/mol

Monoisotopic Mass

315.147 g/mol

CAS Registry Number

76-42-6

IUPAC Name

(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one

Traditional Name

(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one

SMILES

[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O

InChI Identifier

InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1

InChI Key

BRUQQQPBMZOVGD-XFKAJCMBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenanthrenes and derivatives. These are polycyclic compounds containing a phenanthrene moiety, which is a tricyclic aromatic compound with three non-linearly fused benzene.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Phenanthrenes and derivatives

Sub Class

Not Available

Direct Parent

Phenanthrenes and derivatives

Alternative Parents

Substituents

Phenanthrene
Isoquinolone
Tetralin
Coumaran
Anisole
Alkyl aryl ether
Aralkylamine
Piperidine
Cyclic alcohol
Tertiary alcohol
Tertiary aliphatic amine
Tertiary amine
1,2-aminoalcohol
Ketone
Oxacycle
Azacycle
Organoheterocyclic compound
Ether
Alcohol
Organonitrogen compound
Organopnictogen compound
Organooxygen compound
Organic oxide
Carbonyl group
Organic oxygen compound
Amine
Organic nitrogen compound
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

organic heteropentacyclic compound (CHEBI:7852 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

opioid analgesic (PMC8106324 )?
mu-opioid receptor agonist ?
analgesic (PMC7941040 , PMC6205722 )?
opioid receptor agonist (PMC8494138 , PMC5725546 )?
agonist (PMC12888292 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	219°C
Boiling Point	Not Available
Solubility	100 mg/ml

Predicted Properties

Property	Value	Source
Water Solubility	5.59 g/L	ALOGPS
logP	1.04	ALOGPS
logP	1.03	ChemAxon
logS	-1.8	ALOGPS
pKa (Strongest Acidic)	13.56	ChemAxon
pKa (Strongest Basic)	8.21	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	59 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	84.04 m³·mol⁻¹	ChemAxon
Polarizability	32.79 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0a4i-9061000000-5297e69aa2cc5152068f	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-00fr-9538000000-1b9bf2a9c0682b6738c4	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-014i-0009000000-d55749fa4d1f47ce2244	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00kb-0095000000-83c78e9e15857145cc78	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0090000000-ad908ecfa38c7efce138	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-88d302b8770cb7121937	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03fu-0790000000-4af50b834ee854320001	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-014i-0009000000-60bc25dea256a8ba83bb	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0090000000-fccf9384aae73d4c8009	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03fu-0790000000-7931a551d5483e7067a3	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03fu-0690000000-3d8d447a366cdf1fdb74	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00kb-0096000000-55405b387941a889b750	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-1f6f5ca02d934d0d4537	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0093000000-a61df116baabe44f4c3a	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03fu-0690000000-7dc7939fd86861c02ab4	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-fff1638b31b7719ed170	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-014i-0009000000-377e0e430e1a242d1475	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00kb-0095000000-f6e8b2a3a26565536bcb	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-97492063e89cfb7228d2	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03fu-0690000000-f855a40fc07061c8e49a	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0090000000-e6d1bf0cfddfd668c1e7	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-23ea760da624641941d9	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0090000000-263ed99e8027a31dffea	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0006-0390000000-d74e4902e1858436d186	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0090000000-8ab780e3f382a1cb1520	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00kb-0095000000-187a15135033fe090084	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-1091000000-36b41da08ca2b913a212	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a5c-5090000000-a251627d2dc7a2e0750c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0029000000-9ffd2b473cfe2ec06b32	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01ot-1096000000-a01cf940a0da1fca0ffd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-052g-2090000000-da3286e89dfed1ee6a32	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014i-0009000000-135924c69299cfc5fa80	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014j-0049000000-917515e0916ba20e2965	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-07vr-0092000000-d7bf1aff2cea78cb32c0	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0009000000-a9f6ec6e6fe2a282293c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0009000000-a9f6ec6e6fe2a282293c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03dj-0095000000-9186eea3c2994138ab39	Not Available	View Spectrum
MS	MS Spectrum	splash10-014i-6975000000-ecd49efa58246c903e23	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
421.0 Log mg/kg [240:750]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.

Treatment

To treat Oxycodone overdose, primary attention should be given to the reestablishment of a patent airway and institution of assisted or controlled ventilation. Supportive measures (including oxygen and vasopressors) should be employed in the management of circulatory shock and pulmonary edema accompanying overdose as indicated. Cardiac arrest or arrhythmias may require cardiac massage or defibrillation. The narcotic antagonists, naloxone or nalmefene, are specific antidotes for opioid overdose. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to Oxycodone overdose. If needed the appropriate dose of naloxone hydrochloride or nalmefene should be administered simultaneously with efforts at respiratory resuscitation (see package insert for each drug for the details). Since the duration of action of oxycodone may exceed that of the antagonist, the patient should be kept under continued surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration. Gastric emptying may be useful in removing unabsorbed drug. (4)

Health Effects

Health Effect	Relationship	Direction	Description	Reference
hypertension	Associated With?	decrease	A disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. (NCI CTCAE)	PMC12888292
drowsiness	Associated With?	Not Available	A state of sleepiness or lethargy.	PMC7012325
pain	Not Available	Not Available	A disorder characterized by the sensation of marked discomfort, distress or agony. (NCI CTCAE)	PMC7012325 , PMC4133035
chronic pain	Not Available	Not Available	A state in which pain lasts for several weeks or months and may increase in severity.	PMC6205722 , PMC8675278
depression	Associated With?	Not Available	Not Available	PMC7012325
nausea	Associated With?	Not Available	A disorder characterized by a queasy sensation and/or the urge to vomit. (NCI CTCAE)	PMC12888292
vomiting	Associated With?	Not Available	A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth. (NCI CTCAE)	PMC12888292
lethargy	Associated With?	Not Available	A disorder characterized by a decrease in consciousness characterized by mental and physical inertness. (NCI CTCAE)	PMC7012325
tachycardia	Has Therapeutic Effect On	Not Available	A disorder characterized as a type of heart rhythm disorder in which the heart beats faster than normal while at rest.	PMC12888292
tachycardia	Associated With?	decrease	A disorder characterized as a type of heart rhythm disorder in which the heart beats faster than normal while at rest.	PMC12888292
depressive disorder	Associated With?	Not Available	Not Available	PMC7012325
Opiate Overdose	Associated With?	Not Available	Not Available	PMC7027962
Retching	Has Therapeutic Effect On	Not Available	Not Available	PMC12888292
Breakthrough pain	Not Available	Not Available	Not Available	PMC7914202

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000115	Drinking water?Drinking water can be a medium for synthetic chemical contamination, often originating from various industrial processes and agricultural practices.	Drinking water & water supply	Not Available
CEDs000370	Analgesics?Analgesics are a class of synthetic chemicals designed to alleviate pain.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000505	Amplifiers?Amplifiers, commonly used in various electronic devices to enhance signal strength, can be a source of synthetic chemical contamination due to the materials and processes involved in their production and disposal.	Electrical & Electronic Equipment	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000507	Auxiliary Devices?Auxiliary devices, such as capacitors, transformers, and circuit breakers, are integral components in various electronic systems.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000517	Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000525	Line Transmission Systems?Line Transmission Systems, commonly used for the distribution of electrical energy, can be a source of synthetic chemical contamination through the insulation materials and coatings utilized in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000531	Relays?Relays are electromechanical switches used to control circuits and manage electrical loads.	Electrical & Electronic Equipment	PubChem
CEDs000534	Still Video Cameras?Still video cameras, which capture images in digital format, can be a source of synthetic chemical contamination due to the materials and components used in their production and operation.	Electrical & Electronic Equipment	PubChem
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	PubChem
CEDs000539	Video Games?Video games, through their production and disposal processes, can be a source of synthetic chemical contamination.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000548	Preparation Of Vinegar?Vinegar is produced through the fermentation of ethanol by acetic acid bacteria, resulting in a solution that typically contains 4-8% acetic acid.	Food, food processing & cookware	PubChem
CEDs000555	Bleaching Agents?Bleaching agents are chemical substances used to whiten or lighten materials, often employed in various cleaning products for their stain removal and disinfecting properties.	Household cleaning & consumer products	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000562	Pipe Accessories?Pipe accessories, such as fittings, connectors, and seals, are components used in plumbing systems to facilitate the flow of liquids and gases.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000581	Paper Making Machines?Paper making machines utilize various synthetic chemicals throughout the production process, including additives, coatings, and bleaching agents.	Industrial manufacturing & chemical processing	PubChem
CEDs000583	Anchoring Equipment?Anchoring equipment, commonly used in marine applications, can be a source of synthetic chemical contamination due to the materials and coatings utilized in their manufacturing.	Marine, shipping & aquaculture	PubChem
CEDs000592	Marine Propulsion Or Steering?Marine propulsion and steering systems often rely on various synthetic chemicals, including lubricants, fuels, and hydraulic fluids.	Marine, shipping & aquaculture	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000600	Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000613	Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000616	Face Mask Cosmetics?Face mask cosmetics often contain a variety of synthetic chemicals, including preservatives, emulsifiers, and fragrances, which can contribute to chemical contamination.	Personal care & cosmetics	PubChem
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000630	Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000651	Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.	Textiles, leather & furnishings	PubChem
CEDs000662	Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	PubChem
CEDs000694	Cheese Making?Cheese making involves the fermentation of milk, utilizing bacteria and enzymes to coagulate proteins and develop flavor.	Food, food processing & cookware	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000727	Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.	Paper, pulp & fiber products	PubChem
CEDs000729	Stamps?Stamps, particularly those produced using synthetic inks and adhesives, can contribute to chemical contamination when disposed of improperly.	Paper, pulp & fiber products	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000743	Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.	Wastewater, sanitation & biosolids	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs01081	Tablets	Healthcare, pharmaceuticals & veterinary products	PMC11162896
CEDs03009	Waste Water	Wastewater, sanitation & biosolids	PMC7456777 , PMC7456777

Pathways

4 pathwaysPathway Source: PathBank

Oxycodone Action Pathway

Oxycodone Opioid Agonist Action Pathway

Oxycodone Drug Metabolism Action Pathway

Oxycodone Predicted Metabolism Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Known	Not Available
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Predicted (SEA)	Prediction Confidence Score 0.694 Applicability Domain 1.0 Statistical Significance 6.00e-04 Supporting Reference Compounds 527 E-value 4.67095
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Predicted (SEA)	Prediction Confidence Score 0.694 Applicability Domain 1.0 Statistical Significance 8.50e-04 Supporting Reference Compounds 427 E-value 6.61718
Click to view 3D structure	Mu-type opioid receptor	P33535	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.694 Applicability Domain 1.0 Statistical Significance 8.10e-04 Supporting Reference Compounds 229 E-value 6.30579
Click to view 3D structure	Kappa-type opioid receptor	P41144	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.694 Applicability Domain 1.0 Statistical Significance 5.00e-04 Supporting Reference Compounds 199 E-value 3.89246
Click to view 3D structure	Delta-type opioid receptor	P33533	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.694 Applicability Domain 1.0 Statistical Significance 4.40e-04 Supporting Reference Compounds 164 E-value 3.42537
Click to view 3D structure	Kappa-type opioid receptor	P34975	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.691 Applicability Domain 1.0 Statistical Significance 2.20e-04 Supporting Reference Compounds 66 E-value 1.71268
Click to view 3D structure	Mu-type opioid receptor	P42866	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.691 Applicability Domain 1.0 Statistical Significance 1.80e-04 Supporting Reference Compounds 107 E-value 1.40129
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.598 Applicability Domain 0.768 Statistical Significance 0.0027 Supporting Reference Compounds 532 E-value 21.0971
Click to view 3D structure	Mu-type opioid receptor	P97266	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.598 Applicability Domain 0.768 Statistical Significance 0.0025 Supporting Reference Compounds 186 E-value 19.7737
Click to view 3D structure	Delta-type opioid receptor	P32300	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.598 Applicability Domain 0.768 Statistical Significance 0.0022 Supporting Reference Compounds 166 E-value 17.4382
Click to view 3D structure	Kappa-type opioid receptor	P33534	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.513 Applicability Domain 0.591 Statistical Significance 0.0014 Supporting Reference Compounds 61 E-value 11.1324
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.45 Applicability Domain 1.0 Statistical Significance 0.0131 Supporting Reference Compounds 1498 E-value 101.671
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.418 Applicability Domain 1.0 Statistical Significance 0.0088 Supporting Reference Compounds 562 E-value 68.7409
Click to view 3D structure	Mu-type opioid receptor	P79350	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.418 Applicability Domain 0.591 Statistical Significance 7.60e-04 Supporting Reference Compounds 17 E-value 5.91654
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.377 Applicability Domain 0.591 Statistical Significance 0.0202 Supporting Reference Compounds 1130 E-value 157.567
Click to view 3D structure	Nociceptin receptor	P41146	Humans	Predicted (SEA)	Prediction Confidence Score 0.37 Applicability Domain 0.576 Statistical Significance 0.0113 Supporting Reference Compounds 73 E-value 88.0475
Click to view 3D structure	Acetylcholinesterase	O42275	Electrophorus electricus	Predicted (SEA)	Prediction Confidence Score 0.323 Applicability Domain 0.375 Statistical Significance 0.0154 Supporting Reference Compounds 206 E-value 120.044
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Predicted (SEA)	Prediction Confidence Score 0.318 Applicability Domain 0.375 Statistical Significance 0.0273 Supporting Reference Compounds 406 E-value 212.918
Click to view 3D structure	Orexin/Hypocretin receptor type 1	O43613	Humans	Predicted (SEA)	Prediction Confidence Score 0.317 Applicability Domain 0.4 Statistical Significance 0.0049 Supporting Reference Compounds 70 E-value 38.1461
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q9R0C9	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.316 Applicability Domain 0.591 Statistical Significance 0.0158 Supporting Reference Compounds 207 E-value 123.002
Click to view 3D structure	Acetylcholinesterase	P04058	Torpedo californica	Predicted (SEA)	Prediction Confidence Score 0.305 Applicability Domain 0.375 Statistical Significance 0.0036 Supporting Reference Compounds 30 E-value 27.9479
Click to view 3D structure	Cholinesterase	P81908	Equus caballus	Predicted (SEA)	Prediction Confidence Score 0.292 Applicability Domain 0.375 Statistical Significance 0.0307 Supporting Reference Compounds 201 E-value 238.997
Click to view 3D structure	Acetylcholinesterase	P37136	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.278 Applicability Domain 0.375 Statistical Significance 0.0206 Supporting Reference Compounds 95 E-value 160.525
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Predicted (SEA)	Prediction Confidence Score 0.268 Applicability Domain 0.273 Low confidence Statistical Significance 0.0827 Supporting Reference Compounds 425 E-value 643.735
Click to view 3D structure	Tissue factor	P13726	Humans	Predicted (SEA)	Prediction Confidence Score 0.267 Applicability Domain 0.273 Low confidence Statistical Significance 0.0076 Supporting Reference Compounds 29 E-value 59.1654
Click to view 3D structure	Cytochrome P450 3A7	P24462	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 3A5	P20815	Humans	Known	Not Available
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Known	Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Known	Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Known	Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Concentrations

Not Available

External Links

DrugBank ID

DB00497

HMDB ID

HMDB0014640

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou, “Preparation of oxycodone from codeine.” U.S. Patent US6008355, issued March, 1990.

MSDS

Link

General References

Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed: 17525040]
Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed: 18039433]
Drugs.com - http://www.drugs.com/cons/Oxycodone.html
RxList: The Internet Drug Index (2009). - http://www.rxlist.com/

Oxycodone (CED0002036)

Structure for CHEM002211: Oxycodone

Structure