Thioridazine (CED0003936)

Record Information
Version1.0
Creation Date2009-07-21 20:27:24 UTC
Update Date2026-05-14 16:45:52 UTC
SynCED IDCED0003936
Secondary Accession Numbers
  • CHEM002246
  • T3D2858
Identification
Common NameThioridazine
ClassSmall Molecule
Description
Thioridazine belongs to the phenothiazines, a subclass of benzothiazines within the organic compounds. This exogenous solid has the chemical formula C21H26N2S2 and an average molecular weight of 370.57 g/mol. It is classified as a first generation antipsychotic. In biological and chemical applications, it acts as a dopaminergic, serotonergic, H1-receptor, and alpha-adrenergic antagonist. Additionally, it functions as an inhibitor of EC 3.4.21.26 (prolyl oligopeptidase) and EC 1.8.1.12 (trypanothione-disulfide reductase). The compound targets 15 recorded proteins, including the Alpha-1A adrenergic receptor (ADRA1A), D(2) dopamine receptor (DRD2), 5-hydroxytryptamine receptor 2A (HTR2A), Alpha-1B adrenergic receptor (ADRA1B), Voltage-gated inwardly rectifying potassium channel KCNH2, Muscarinic acetylcholine receptor M2 (CHRM2), and Muscarinic acetylcholine receptor M4 (CHRM4). Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain, blocks alpha-adrenergic effect, and depresses the release of hypothalamic and hypophyseal hormones; it is believed to depress the reticular activating system, thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Thioridazine is found in 14 recorded sources, including antipsychotics within healthcare, pharmaceuticals and veterinary products, as well as food preservation in food, food processing and cookware. It is also associated with household cleaning and consumer products such as tobacco smoke filters, perfumes within detergents and soaps, and non electric simulated smoking devices, as well as electrical and electronic equipment including electrodes, antennas, and electrically stimulated smoking devices. The recorded exposure route for this compound is oral.
Contaminant Type
  • Amine
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Ether
  • Human Neurotoxin
  • Metabolite
  • Organic Compound
  • Phenothiazine
  • Synthetic Compound
Chemical Structure
Synonyms
ValueSource
10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazineChEBI
2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazineChEBI
3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazineChEBI
MallorolChEBI
MallorylChEBI
MelerilChEBI
MellarilChEBI
Mellaril-SChEBI
MelleretsChEBI
MelleretteChEBI
MellerilChEBI
OrsanilChEBI
SonapaxChEBI
ThioridazinChEBI
ThioridazinumChEBI
TioridazinaChEBI
10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulphanyl-phenothiazineGenerator
Thioridazine chlorideHMDB
ApoThioridazineHMDB
MellerylHMDB
Pinewood brand OF thioridazine hydrochlorideHMDB
Thioridazine hydrochlorideHMDB
Neurazpharm brand OF thioridazine hydrochlorideHMDB
AWD.pharma brand OF thioridazine hydrochlorideHMDB
AldazineHMDB
Arzneimittelwerk dresden brand OF thioridazineHMDB
DDSA brand OF thioridazine hydrochlorideHMDB
RiderilHMDB
ThiozineHMDB
Alphapharm brand OF thioridazine hydrochlorideHMDB
Apo thioridazineHMDB
Clonmel brand OF thioridazine hydrochlorideHMDB
MellerettenHMDB
Thioridazine HCLHMDB
Thioridazine novartis brandHMDB
Thioridazine neurazpharmHMDB
Apo-thioridazineHMDB
Apotex brand OF thioridazine hydrochlorideHMDB
MelzineHMDB
Novartis brand OF thioridazineHMDB
Roxane brand OF thioridazine hydrochlorideHMDB
Thioridazine-neurazpharmHMDB
ThioridazineneurazpharmHMDB
Chemical FormulaC21H26N2S2
Average Molecular Mass370.575 g/mol
Monoisotopic Mass370.154 g/mol
CAS Registry Number50-52-2
IUPAC Name10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
Traditional Namethioridazine
SMILESCSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1
InChI IdentifierInChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
InChI KeyKLBQZWRITKRQQV-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazines
Sub ClassPhenothiazines
Direct ParentPhenothiazines
Alternative Parents
Substituents
  • Phenothiazine
  • Alkyldiarylamine
  • Diarylthioether
  • Aryl thioether
  • Tertiary aliphatic/aromatic amine
  • Thiophenol ether
  • Alkylarylthioether
  • Piperidine
  • Para-thiazine
  • Benzenoid
  • Tertiary amine
  • Tertiary aliphatic amine
  • Thioether
  • Azacycle
  • Sulfenyl compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Organosulfur compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Membrane
Biofluid LocationsNot Available
Tissue LocationsNot Available
Applications
Biological Roles
Chemical Roles
Organoleptic EffectsNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point73°C
Boiling Point230°C at 2.00E-02 mm Hg
Solubility0.0336 mg/L
Predicted Properties
PropertyValueSource
Water Solubility0.00086 g/LALOGPS
logP5.93ALOGPS
logP5.47ChemAxon
logS-5.6ALOGPS
pKa (Strongest Basic)8.93ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity113.52 m³·mol⁻¹ChemAxon
Polarizability43.26 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
GC-MSGC-MS Spectrumsplash10-0002-9110000000-042dbd4f525abce007c0Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0002-9112000000-03a53f455eb75bee12b1Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-4539000000-9b298eff08d8aae4d50cNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0002-9110000000-042dbd4f525abce007c0Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0002-9112000000-03a53f455eb75bee12b1Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-00di-4539000000-9b298eff08d8aae4d50cNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-052b-9133000000-5c5d51f787da054d1cd8Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-72ae3160baada68a101cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-1409000000-ca7f19c9476403b237f6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004j-8920000000-1ac0f55aa083ad77c72bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-002b-9320000000-494b15b3b671ebe76be9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9220000000-e3e4ef2154cbee0f6852Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0109000000-0729d6c8c352282a1d00Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9300000000-7b3f963cdcb2b42af246Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00ba-4904000000-3d19a92d11da4536561aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9220000000-e3e4ef2154cbee0f6852Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-bff15ad076402d6c8d67Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-1409000000-ca7f19c9476403b237f6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-72ae3160baada68a101cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-004j-8920000000-1ac0f55aa083ad77c72bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-002b-9320000000-494b15b3b671ebe76be9Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0109000000-598e54239d6d13ff6dd4Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00fr-3529000000-18e24c0e0b54472d7826Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4m-9521000000-43949f1e3ce6dea95cbdNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00xs-3009000000-6a6f8dcd7ed070a5e1e3Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-02mj-2297000000-57d37082170bc3391ec8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-9100000000-8657369f1e7405e6943bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009000000-b5f90a911ff7bb6a25eeNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0092-9616000000-cb1233f7b165a2d465ffNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-9010000000-d79d5f56e64b7d0e6a41Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-0009000000-e1981bf8caf13296fc86Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-0059000000-ba6507d64713944a5b65Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0006-0291000000-e2ab9d33b69ca372721aNot AvailableView Spectrum
MSMS Spectrumsplash10-006t-9552000000-ea4c5c56ee4333d0815aNot AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
1031.0 Log mg/kg [580:1800]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. LD50=956-1034 mg/kg (Orally in rats).
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Minimum Risk LevelNot Available
SymptomsLD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
TreatmentAn airway must be established and maintained. Adequate oxygenation and ventilation must be ensured. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. Treatment may include one or more of the following therapeutic interventions: correction of electrolyte abnormalities and acid-base balance, lidocaine, phenytoin, isoproterenol, ventricular pacing, and defibrillation. Disopyramide, procainamide, and quinidine may produce additive QT-prolonging effects when administered to patients with acute overdosage of Mellaril and should be avoided. Caution must be exercised when administering lidocaine, as it may increase the risk of developing seizures. Treatment of hypotension may require intravenous fluids and vasopressors. Phenylephrine, levarterenol, or metaraminol are the appropriate pressor agents for use in the management of refractory hypotension. Gastric lavage and repeated doses of activated charcoal should be considered. Induction of emesis is less preferable to gastric lavage because of the risk of dystonia and the potential for aspiration of vomitus. Acute extrapyramidal symptoms may be treated with diphenhydramine hydrochloride or benztropine mesylate. Forced diuresis, hemoperfusion, hemodialysis and manipulation of urine pH are of unlikely benefit in the treatment of phenothiazine overdose due to their large volume of distribution and extensive plasma protein binding. (2)
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementNot Available
CEDs000374Antipsychotics?Antipsychotics are a class of synthetic chemicals used primarily for the treatment of psychiatric disorders, including schizophrenia and bipolar disorder.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000506Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.Electrical & Electronic EquipmentNot Available
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentNot Available
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentNot Available
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentNot Available
CEDs000520Emergency Protective Devices?Emergency protective devices, such as circuit breakers and surge protectors, are essential components in electrical systems designed to prevent damage from overcurrent and surges.Electrical & Electronic EquipmentNot Available
CEDs000530Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.Electrical & Electronic EquipmentNot Available
CEDs000534Still Video Cameras?Still video cameras, which capture images in digital format, can be a source of synthetic chemical contamination due to the materials and components used in their production and operation.Electrical & Electronic EquipmentNot Available
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwareNot Available
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsNot Available
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsNot Available
CEDs000560Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.Household cleaning & consumer productsNot Available
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsNot Available
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsNot Available
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingNot Available
CEDs000596Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.Agriculture & land managementNot Available
CEDs000602Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementNot Available
CEDs000609Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.Personal care & cosmeticsNot Available
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsNot Available
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsNot Available
CEDs000613Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.Personal care & cosmeticsNot Available
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsNot Available
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsNot Available
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsNot Available
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsNot Available
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsNot Available
CEDs000642Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.Textiles, leather & furnishingsNot Available
CEDs000650Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.Textiles, leather & furnishingsNot Available
CEDs000657Surface Finishing Of Leather?Surface finishing of leather often involves the use of various synthetic chemicals, including dyes, resins, and finishing agents.Textiles, leather & furnishingsNot Available
CEDs000678Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.Agriculture & land managementNot Available
CEDs000679Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.Agriculture & land managementNot Available
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionNot Available
CEDs000688Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.Building & ConstructionNot Available
CEDs000693Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.Building & ConstructionNot Available
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingNot Available
CEDs000727Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.Paper, pulp & fiber productsNot Available
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructureNot Available
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsNot Available
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsNot Available
CEDs000741Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.Paper, pulp & fiber productsNot Available
CEDs000742Leather Tanning?Leather tanning is a process that transforms raw animal hides into durable leather through the application of various chemicals, including chromium salts, aldehydes, and vegetable tannins.Textiles, leather & furnishingsNot Available
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsNot Available
Pathways
3 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansPredicted (SEA)
Prediction Confidence Score
0.573
Applicability Domain
1.0
Statistical Significance
0.0022
Supporting Reference Compounds
861
E-value
17.4382
Serine/threonine-protein kinase pim-1 structureClick to view 3D structureSerine/threonine-protein kinase pim-1P11309HumansPredicted (SEA)
Prediction Confidence Score
0.569
Applicability Domain
1.0
Statistical Significance
0.0011
Supporting Reference Compounds
967
E-value
8.32987
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansPredicted (SEA)
Prediction Confidence Score
0.565
Applicability Domain
1.0
Statistical Significance
0.0038
Supporting Reference Compounds
1103
E-value
29.972
D(1A) dopamine receptor structureClick to view 3D structureD(1A) dopamine receptorP21728HumansPredicted (SEA)
Prediction Confidence Score
0.565
Applicability Domain
1.0
Statistical Significance
0.0012
Supporting Reference Compounds
425
E-value
9.41976
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansPredicted (SEA)
Prediction Confidence Score
0.52
Applicability Domain
1.0
Statistical Significance
0.0025
Supporting Reference Compounds
823
E-value
19.8516
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)
Prediction Confidence Score
0.52
Applicability Domain
1.0
Statistical Significance
0.0037
Supporting Reference Compounds
955
E-value
28.9599
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansPredicted (SEA)
Prediction Confidence Score
0.52
Applicability Domain
1.0
Statistical Significance
0.0014
Supporting Reference Compounds
536
E-value
11.2103
5-hydroxytryptamine receptor 7 structureClick to view 3D structure5-hydroxytryptamine receptor 7P34969HumansPredicted (SEA)
Prediction Confidence Score
0.516
Applicability Domain
1.0
Statistical Significance
0.0024
Supporting Reference Compounds
565
E-value
18.5281
Click to view 3D structure5-hydroxytryptamine receptor 1AP19327Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.513
Applicability Domain
1.0
Statistical Significance
0.0039
Supporting Reference Compounds
541
E-value
30.7504
Sigma non-opioid intracellular receptor 1 structureClick to view 3D structureSigma non-opioid intracellular receptor 1Q99720HumansPredicted (SEA)
Prediction Confidence Score
0.512
Applicability Domain
1.0
Statistical Significance
0.0018
Supporting Reference Compounds
562
E-value
14.4021
Histamine H1 receptor structureClick to view 3D structureHistamine H1 receptorP35367HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
0.0017
Supporting Reference Compounds
507
E-value
13.4679
Alpha-2B adrenergic receptor structureClick to view 3D structureAlpha-2B adrenergic receptorP18089HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
6.50e-04
Supporting Reference Compounds
340
E-value
5.0602
Alpha-2A adrenergic receptor structureClick to view 3D structureAlpha-2A adrenergic receptorP08913HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
0.0013
Supporting Reference Compounds
487
E-value
10.0426
Muscarinic acetylcholine receptor M5 structureClick to view 3D structureMuscarinic acetylcholine receptor M5P08912HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
3.30e-04
Supporting Reference Compounds
266
E-value
2.56902
Sodium-dependent noradrenaline transporter structureClick to view 3D structureSodium-dependent noradrenaline transporterP23975HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
9.10e-04
Supporting Reference Compounds
451
E-value
7.08428
5-hydroxytryptamine receptor 2B structureClick to view 3D structure5-hydroxytryptamine receptor 2BP41595HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
0.0019
Supporting Reference Compounds
686
E-value
15.0249
Click to view 3D structureAlpha-1A adrenergic receptorP43140Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
9.10e-04
Supporting Reference Compounds
208
E-value
7.08428
Click to view 3D structureAlpha-1D adrenergic receptorP25100HumansPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
7.90e-04
Supporting Reference Compounds
258
E-value
6.15009
Click to view 3D structureAlpha-1B adrenergic receptorP15823Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.511
Applicability Domain
1.0
Statistical Significance
2.80e-04
Supporting Reference Compounds
130
E-value
2.17978
Muscarinic acetylcholine receptor M1 structureClick to view 3D structureMuscarinic acetylcholine receptor M1P11229HumansPredicted (SEA)
Prediction Confidence Score
0.508
Applicability Domain
1.0
Statistical Significance
1.00e-03
Supporting Reference Compounds
385
E-value
7.78492
Muscarinic acetylcholine receptor M2 structureClick to view 3D structureMuscarinic acetylcholine receptor M2P08172HumansPredicted (SEA)
Prediction Confidence Score
0.508
Applicability Domain
1.0
Statistical Significance
5.20e-04
Supporting Reference Compounds
373
E-value
4.04816
Muscarinic acetylcholine receptor M3 structureClick to view 3D structureMuscarinic acetylcholine receptor M3P20309HumansPredicted (SEA)
Prediction Confidence Score
0.508
Applicability Domain
1.0
Statistical Significance
6.50e-04
Supporting Reference Compounds
310
E-value
5.0602
Muscarinic acetylcholine receptor M4 structureClick to view 3D structureMuscarinic acetylcholine receptor M4P08173HumansPredicted (SEA)
Prediction Confidence Score
0.508
Applicability Domain
1.0
Statistical Significance
5.40e-04
Supporting Reference Compounds
297
E-value
4.20386
Click to view 3D structureD(2) dopamine receptorP61169RatPredicted (SEA)
Prediction Confidence Score
0.507
Applicability Domain
1.0
Statistical Significance
0.0048
Supporting Reference Compounds
528
E-value
37.679
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)
Prediction Confidence Score
0.503
Applicability Domain
1.0
Statistical Significance
0.0058
Supporting Reference Compounds
1498
E-value
45.3861
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansKnownNot Available
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansKnownThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansKnownThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Muscarinic acetylcholine receptor M2 structureClick to view 3D structureMuscarinic acetylcholine receptor M2P08172HumansKnownNot Available
D(1A) dopamine receptor structureClick to view 3D structureD(1A) dopamine receptorP21728HumansKnownThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Muscarinic acetylcholine receptor M1 structureClick to view 3D structureMuscarinic acetylcholine receptor M1P11229HumansKnownNot Available
Muscarinic acetylcholine receptor M3 structureClick to view 3D structureMuscarinic acetylcholine receptor M3P20309HumansKnownNot Available
Muscarinic acetylcholine receptor M4 structureClick to view 3D structureMuscarinic acetylcholine receptor M4P08173HumansKnownNot Available
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansKnownNot Available
5-hydroxytryptamine receptor 7 structureClick to view 3D structure5-hydroxytryptamine receptor 7P34969HumansKnownNot Available
Alpha-1A adrenergic receptor structureClick to view 3D structureAlpha-1A adrenergic receptorP35348HumansKnownThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Click to view 3D structureAlpha-1B adrenergic receptorP35368HumansKnownNot Available
Alpha-2A adrenergic receptor structureClick to view 3D structureAlpha-2A adrenergic receptorP08913HumansKnownNot Available
D(1B) dopamine receptor structureClick to view 3D structureD(1B) dopamine receptorP21918HumansKnownNot Available
Histamine H1 receptor structureClick to view 3D structureHistamine H1 receptorP35367HumansKnownNot Available
Concentrations
Not Available
External Links
DrugBank IDDB00679
HMDB IDHMDB0014817
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkThioridazine
Chemspider ID5253
ChEBI ID9566
PubChem Compound ID5452
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSLink
General References
  1. Drugs.com http://www.drugs.com/cons/Thioridazine.html
  2. RxList: The Internet Drug Index (2009). http://www.rxlist.com/