Esomeprazole (CED0003125)

Esomeprazole is an exogenous organic compound with the formula C17H19N3O3S and an average molecular weight of 345.42 g/mol. It exists as a solid at room temperature. Esomeprazole belongs to the sulfinylbenzimidazoles, a subclass of benzimidazoles within the organic compounds. As a proton pump inhibitor, esomeprazole suppresses gastric acid secretion through the specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, it blocks the final step in acid production, which reduces gastric acidity. The compound has seven recorded protein targets, including the potassium-transporting ATPase alpha chain 1 (ATP4A), the sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), the potassium-transporting ATPase subunit beta (ATP4B), the ATP-dependent translocase ABCB1, cytochrome P450 3A4 (CYP3A4), cytochrome P450 2C9 (CYP2C9), and one other protein. Esomeprazole is found in or released from 13 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as antiinflammatory and antirheumatic products and drugs for acid related disorders. It is also associated with drinking water and water supply, household cleaning and consumer products including pipe accessories and other smoking requisites, building and construction materials such as ladders, floors, tents or canopies, and electrical and electronic equipment including amplifiers, antennas, magnets, relays, and video games. Recorded exposure routes for the compound include oral, intravenous, and topical administration.