Scopolamine (CED0001890)

Record Information

Version

1.0

Creation Date

2009-07-21 20:27:33 UTC

Update Date

2026-05-14 16:47:46 UTC

Accession Number

CHEM002264

Identification

Common Name

Scopolamine

Class

Small Molecule

Description

Scopolamine is an exogenous solid compound with the formula C17H21NO4 and an average molecular weight of 303.35 g/mol. Scopolamine belongs to the beta hydroxy acids and derivatives, a subclass of hydroxy acids and derivatives within the organic compounds. It functions as a metabolite and a muscarinic antagonist, interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system, specifically the vomiting center. Its recorded protein targets include the Muscarinic acetylcholine receptor M1 (CHRM1), which it inhibits, the Muscarinic acetylcholine receptor M2 (CHRM2), Muscarinic acetylcholine receptor M3 (CHRM3), Muscarinic acetylcholine receptor M4 (CHRM4), and the intestinal sucrase-isomaltase (SI), which it induces, among three other proteins. The compound is used as an antiemetic, antispasmodic drug, mydriatic agent, antidepressant, adjuvant, and anaesthesia adjuvant. It has been detected in the brain, nerve cells, neuron, adipose tissue, and stratum corneum. Exposure routes include oral, buccal, sublingual, inhalation, intravenous, intramuscular, subcutaneous, transdermal, transmucosal, topical, touch, and ophthalmic administration. Scopolamine is found in 40 recorded sources across various sectors. These include healthcare, pharmaceuticals and veterinary products (such as hypnotics and sedatives, mydriatics and cycloplegics, antiemetics and antinauseants, and medical devices); food, food processing and cookware (including food preservation, food packaging, and the preparation of vinegar, wine, or sparkling wine, as well as fermentation processes for beer); household cleaning and consumer products (including perfumes within detergents and soaps, cigar cigarettes, pipe accessories, and non-electric simulated smoking devices); electrical and electronic equipment (such as batteries, capacitors, cell phones, printed circuit boards, and wires and cables); textiles, leather and furnishings (including synthetic textiles, carpets and rugs); and drinking water and water supply.

Contaminant Type

Adjuvant
Adjuvant, Anesthesia
Amine
Antimuscarinic
Antispasmodic
Cholinergic Antagonist
Drug
Ester
Ether
Food Toxin
Metabolite
Muscarinic Antagonist
Mydriatic
Natural Compound
Organic Compound
PFAS
Phytotoxin
Plant Toxin

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(-)-Hyoscine	ChEBI
(-)-Scopolamine	ChEBI
(1S,3S,5R,6R,7S)-6,7-Epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate	ChEBI
6,7-Epoxytropine tropate	ChEBI
6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate	ChEBI
alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	ChEBI
Hyoscine	ChEBI
Scopine (-)-tropate	ChEBI
Transderm-scop	ChEBI
(1S,3S,5R,6R,7S)-6,7-Epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoic acid	Generator
6,7-Epoxytropine tropic acid	Generator
6-b,7-b-Epoxy-3-a-tropanyl S-(-)-tropate	Generator
6-b,7-b-Epoxy-3-a-tropanyl S-(-)-tropic acid	Generator
6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropic acid	Generator
6-Β,7-β-epoxy-3-α-tropanyl S-(-)-tropate	Generator
6-Β,7-β-epoxy-3-α-tropanyl S-(-)-tropic acid	Generator
a-(Hydroxymethyl)benzeneacetate 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	Generator
a-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	Generator
alpha-(Hydroxymethyl)benzeneacetate 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	Generator
Α-(hydroxymethyl)benzeneacetate 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	Generator
Α-(hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester	Generator
Scopine (-)-tropic acid	Generator
(+)-Hyoscine	HMDB
(+)-Scopolamine	HMDB
(-)-Hyoscine hydrobromide	HMDB
(-)-Scopolamine bromide	HMDB
(-)-Scopolamine hydrobromide	HMDB
Atrochin	HMDB
Atroquin	HMDB
Beldavrin	HMDB
Buscopan	HMDB
Epoxytropine tropate	HMDB
Euscopol	HMDB
Hydroscine hydrobromide	HMDB
Hyosceine	HMDB
Hyoscine bromide	HMDB
Hyoscine hydrobromide	HMDB
Hyoscyine hydrobromide	HMDB
Hyosol	HMDB
Hysco	HMDB
Isopto hyoscine	HMDB
Isoscopil	HMDB
Kwells	HMDB
L-Hyoscine hydrobromide	HMDB
L-Scopolamine-hydrobromide	HMDB
Methscopolamine bromide	HMDB
Oscine	HMDB
Pamine	HMDB
S-(-)-Tropate	HMDB
Scop	HMDB
Scopamin	HMDB
Scopine tropate	HMDB
Scopolamine bromide	HMDB
Scopolamine hydrobromide	HMDB
Scopolaminium bromide	HMDB
Scopolammonium bromide	HMDB
SEE	HMDB
Tranaxine	HMDB
Norhyoscine	HMDB
6beta,7beta-Epoxy-3alpha-tropanyl S-(-)-tropate	PhytoBank
6β,7β-Epoxy-3α-tropanyl S-(-)-tropate	PhytoBank
9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-tropate	PhytoBank
l-Scopolamine	PhytoBank
(-)-Atropine	PhytoBank
(-)-Hyoscyamine	PhytoBank
(S)-(-)-Hyoscyamine	PhytoBank
(S)-Atropine	PhytoBank
1alphaH,5alphaH-Tropan-3alpha-yl (-)-tropate	PhytoBank
1αH,5αH-Tropan-3α-yl (-)-tropate	PhytoBank
Cystospaz	PhytoBank
Daturine	PhytoBank
Duboisine	PhytoBank
Hyoscyamine	PhytoBank
L-Hyoscyamin	PhytoBank
l-Hyoscyamine	PhytoBank
l-Atropine	PhytoBank
l-Tropine tropate	PhytoBank
(±)-Atropine	PhytoBank
(±)-Hyoscyamine	PhytoBank
Atropin	PhytoBank
Atropine	PhytoBank
Atropinum sulfuricum	PhytoBank
Atropinum sulphuricum	PhytoBank
dl-Hyoscyamine	PhytoBank
Tropine (±)-tropate	PhytoBank
Tropine tropate	PhytoBank
dl-Tropyl tropate	PhytoBank

Chemical Formula

C₁₇H₂₁NO₄

Average Molecular Mass

303.353 g/mol

Monoisotopic Mass

303.147 g/mol

CAS Registry Number

51-34-3

IUPAC Name

(1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate

Traditional Name

(1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate

SMILES

CN1[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1

InChI Identifier

InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1

InChI Key

STECJAGHUSJQJN-FWXGHANASA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as beta hydroxy acids and derivatives. Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Hydroxy acids and derivatives

Sub Class

Beta hydroxy acids and derivatives

Direct Parent

Beta hydroxy acids and derivatives

Alternative Parents

Substituents

Beta-hydroxy acid
Monocyclic benzene moiety
Morpholine
Oxazinane
Piperidine
N-alkylpyrrolidine
Benzenoid
Pyrrolidine
Amino acid or derivatives
Carboxylic acid ester
Tertiary amine
Tertiary aliphatic amine
Oxacycle
Organoheterocyclic compound
Azacycle
Carboxylic acid derivative
Dialkyl ether
Oxirane
Ether
Monocarboxylic acid or derivatives
Primary alcohol
Organopnictogen compound
Organonitrogen compound
Organooxygen compound
Amine
Organic oxide
Carbonyl group
Organic oxygen compound
Organic nitrogen compound
Alcohol
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

tertiary amino compound (CHEBI:16794 )
epoxide (CHEBI:16794 )
propanoate ester (CHEBI:16794 )
tropane alkaloid (CHEBI:16794 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biofluid Locations

Not Available

Tissue Locations

Adipose Tissue
Brain
Nerve Cells
Neuron
Stratum Corneum

Applications

Biological Roles

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	59°C
Boiling Point	Not Available
Solubility	1E+005 mg/L

Predicted Properties

Property	Value	Source
Water Solubility	6.61 g/L	ALOGPS
logP	1.4	ALOGPS
logP	0.89	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	15.15	ChemAxon
pKa (Strongest Basic)	6.95	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	62.3 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	79.72 m³·mol⁻¹	ChemAxon
Polarizability	31.24 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum	splash10-0f7c-7900000000-28f924e821203772c1ad	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-00di-4910000000-24c90e50ab88ad57e82c	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0006-4900000000-596180a39c76ec0fe1ae	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-0009000000-9733effdc3262b114ed6	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-0809000000-a686e4c768aedb57cf8e	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-1901000000-f66f538c7db471e86fd5	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-3900000000-5eedeba4bedea55de9ad	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udr-7900000000-1309364bbca3810a6afa	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-0900000000-1c1d2f52fb7a5d745e1e	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-9700000000-80887cb9e3f0d05c8bf5	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-9800000000-80887cb9e3f0d05c8bf5	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-6900000000-010e6e0ca9f0d9f3618b	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0f79-4900000000-a0695c5add6db92de8b2	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-2900000000-887570e409db5eca481c	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0f79-4900000000-5e1feadfe643a530d956	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-2900000000-9556767e32b410cf8d73	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0udi-0309000000-fda2d2422fa0a3b4172e	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0k9i-0903000000-cc938997b1c67e020c14	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0f79-0955000000-64498c50c4e2afb15c32	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-1930000000-5d768d7bc9f10614fd97	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0lxt-4900000000-f39cfd7374383b7b1aaf	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0549000000-2102ba2525a572e05e74	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0uk9-1952000000-23caf7102d633b0031b2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0hr0-4900000000-854ad2f78678cc2d4db3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0f6t-0904000000-0366209ad3f767f88736	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0f79-1900000000-bd791764fd2502fdc39d	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0gb9-2910000000-c7c4ffc22c1425ab3dbd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0019000000-cc4ab81a673ee149c93e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0429000000-48f2a2d6a6bb3fbcd837	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-6910000000-719e539fec930d736ea5	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
1284.0	Log mg/kg	[720:2300]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
7	Pesticides	Agriculture & land management	Not Available
10	Insecticides	Agriculture & land management	Not Available
115	Drinking water	Drinking water & water supply	Not Available
120	Wires and cables	Electrical & Electronic Equipment	Not Available
121	Printed circuit boards	Electrical & Electronic Equipment	Not Available
125	Batteries	Electrical & Electronic Equipment	Not Available
130	Semiconductors	Electrical & Electronic Equipment	Not Available
138	Lubricants	Energy, oil & gas	Not Available
147	Food packaging	Food, food processing & cookware	Not Available
174	Lubricants	Industrial manufacturing & chemical processing	Not Available
234	Medical devices	Healthcare, pharmaceuticals & veterinary products	Not Available
249	Antiemetics and antinauseants	Healthcare, pharmaceuticals & veterinary products	Not Available
376	Hypnotics and sedatives	Healthcare, pharmaceuticals & veterinary products	Not Available
399	Mydriatics and cycloplegics	Healthcare, pharmaceuticals & veterinary products	Not Available
451	Carpets and Rugs	Textiles, leather & furnishings	Not Available
454	Synthetic textiles	Textiles, leather & furnishings	Not Available
490		Personal care & cosmetics	Not Available
492	Cell phones	Electrical & Electronic Equipment	Not Available
493	Capacitors	Electrical & Electronic Equipment	Not Available
500	Stairs And Ramps	Building & Construction	Not Available
505	Amplifiers	Electrical & Electronic Equipment	Not Available
506	Antennas	Electrical & Electronic Equipment	Not Available
511	Conductors Or Conductive Bodies Characterised By The Conductive Materials	Electrical & Electronic Equipment	Not Available
516	Electric Hearing Aids	Electrical & Electronic Equipment	Not Available
518	Electrically Stimulated Smoking Devices	Electrical & Electronic Equipment	Not Available
519	Electrodes	Electrical & Electronic Equipment	Not Available
524	Hybrid Capacitors	Electrical & Electronic Equipment	Not Available
527	Magnets	Electrical & Electronic Equipment	Not Available
537	Television Systems	Electrical & Electronic Equipment	Not Available
539	Video Games	Electrical & Electronic Equipment	Not Available
544	Fermentation Processes For Beer	Food, food processing & cookware	Not Available
545	Food Preservation	Food, food processing & cookware	Not Available
548	Preparation Of Vinegar	Food, food processing & cookware	Not Available
549	Preparation Of Wine Or Sparkling Wine	Food, food processing & cookware	Not Available
556	Cigar Cigarettes	Household cleaning & consumer products	Not Available
559	Non Electric Simulated Smoking Devices	Household cleaning & consumer products	Not Available
560	Other Smoking Requisites	Household cleaning & consumer products	Not Available
561	Perfumes Within Detergents And Soaps	Household cleaning & consumer products	Not Available
562	Pipe Accessories	Household cleaning & consumer products	Not Available
563	Soap Detergents	Household cleaning & consumer products	Not Available
564	Soap Dispensers	Household cleaning & consumer products	Not Available
569	Tobacco Smoke Filters	Household cleaning & consumer products	Not Available
578	Making Cigars	Industrial manufacturing & chemical processing	Not Available
580	Manufacture Preparation Of Tobacco Products	Industrial manufacturing & chemical processing	Not Available
596	Acaricides	Agriculture & land management	Not Available
600	Herbicides And Algicides	Agriculture & land management	Not Available
602	Molluscicides	Agriculture & land management	Not Available
603	Nematocides	Agriculture & land management	Not Available
605	Pest Repellants	Agriculture & land management	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available
607	Rodenticides(1)	Agriculture & land management	Not Available
608	Rodenticides	Agriculture & land management	Not Available
609	Aftershave	Personal care & cosmetics	Not Available
610	Aftersun Products	Personal care & cosmetics	Not Available
611	Anti Perspirants Or Body Deoderants	Personal care & cosmetics	Not Available
612	Body Washing Or Cleaning Implements	Personal care & cosmetics	Not Available
613	Depilatories	Personal care & cosmetics	Not Available
614	Essential Oils Or Perfumes	Personal care & cosmetics	Not Available
615	Eye Makeup Products	Personal care & cosmetics	Not Available
616	Face Mask Cosmetics	Personal care & cosmetics	Not Available
617	Lip Care Products	Personal care & cosmetics	Not Available
618	Lip Makeup Products	Personal care & cosmetics	Not Available
632	Apparel	Textiles, leather & furnishings	Not Available
642	Footwear	Textiles, leather & furnishings	Not Available
643	Headwear	Textiles, leather & furnishings	Not Available
650	Purses Luggage Hand Bags	Textiles, leather & furnishings	Not Available
662	Yarns Or Threads	Textiles, leather & furnishings	Not Available
663	Sanitary Equipment	Wastewater, sanitation & biosolids	Not Available

Pathways

2 pathways

Scopolamine Drug Metabolism Action Pathway

Scopolamine Predicted Metabolism Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	0.622794
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Predicted (SEA)	0.155698
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	0.233548
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Predicted (SEA)	0.311397
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P08483	Rattus norvegicus	Predicted (SEA)	0.0778492
Click to view 3D structure	Muscarinic receptor 4	Q8VH25	Cavia porcellus	Predicted (SEA)	0.155698
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Predicted (SEA)	0.700643
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P08482	Rattus norvegicus	Predicted (SEA)	0.778492
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P10980	Rattus norvegicus	Predicted (SEA)	1.32344
Click to view 3D structure	Muscarinic acetylcholine receptor M3	Q8VH26	Cavia porcellus	Predicted (SEA)	1.32344
Click to view 3D structure	Muscarinic acetylcholine receptor M1	Q8WMX0	Bos taurus	Predicted (SEA)	0.467095
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08485	Rattus norvegicus	Predicted (SEA)	1.08989
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08911	Rattus norvegicus	Predicted (SEA)	1.01204
Click to view 3D structure	Muscarinic acetylcholine receptor DM1	P16395	Drosophila melanogaster	Predicted (SEA)	0.233548
Click to view 3D structure	Muscarinic receptor 2	Q8VH27	Cavia porcellus	Predicted (SEA)	1.01204
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	170.801
Click to view 3D structure	Alpha-1D adrenergic receptor	P25100	Humans	Predicted (SEA)	60.6445
Click to view 3D structure	Sodium-dependent dopamine transporter	P23977	Rattus norvegicus	Predicted (SEA)	94.6646
Click to view 3D structure	Acetylcholine-binding protein	P58154	Lymnaea stagnalis	Predicted (SEA)	5.52729
Click to view 3D structure	Glutathione S-transferase theta-1	Q01579	Rattus norvegicus	Predicted (SEA)	1.63483
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	220.235
Click to view 3D structure	Norepinephrine transporter	Q9WTR4	Rattus norvegicus	Predicted (SEA)	85.8677
Click to view 3D structure	Acetylcholinesterase	P21836	Mus musculus	Predicted (SEA)	75.1245
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	351.801
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	360.675
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Known	Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Known	Not Available
Click to view 3D structure	Sucrase-isomaltase, intestinal	P14410	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DB00747

HMDB ID

HMDB0003573

FooDB ID

FDB023199

Phenol Explorer ID

Not Available

KNApSAcK ID

C00002292

BiGG ID

Not Available

BioCyc ID

SCOPOLAMINE

METLIN ID

3433

PDB ID

Not Available

Wikipedia Link

Scopolamine

Chemspider ID

10194106

ChEBI ID

16794

PubChem Compound ID

Not Available

Kegg Compound ID

C01851

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Yang Guodong, “Preparation and application of scopolamine and chlorpromazine as a drug-withdrawal agent.” U.S. Patent US5543407, issued February, 1993.

MSDS

Link

General References

1. https://www.ncbi.nlm.nih.gov/pubmed/?term=11718188

2. https://www.ncbi.nlm.nih.gov/pubmed/?term=23334071

3. Chemnitius, F. Method for the technical preparation of scopolamine. Journal fuer Praktische Chemie (Leipzig) (1928), 120 221-4.

4. Lee HW, Park WS, Kim YW, Cho SH, Kim SS, Seo JH, Lee KT: A rapid and sensitive liquid chromatography/positive ion tandem mass spectrometry method for the determination of cimetropium in human plasma by liquid-liquid extraction. J Mass Spectrom. 2006 Jul;41(7):855-60.

5. Blin J, Piercey MF, Giuffra ME, Mouradian MM, Chase TN: Metabolic effects of scopolamine and physostigmine in human brain measured by positron emission tomography. J Neurol Sci. 1994 May;123(1-2):44-51.

6. Frey KA, Koeppe RA, Mulholland GK, Jewett D, Hichwa R, Ehrenkaufer RL, Carey JE, Wieland DM, Kuhl DE, Agranoff BW: In vivo muscarinic cholinergic receptor imaging in human brain with [11C]scopolamine and positron emission tomography. J Cereb Blood Flow Metab. 1992 Jan;12(1):147-54.

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