Diflunisal (CED0005867)

Diflunisal is an exogenous organic compound with the formula C13H8F2O3 and an average molecular weight of 250.20 g/mol. It exists as a solid at room temperature. Diflunisal belongs to the biphenyls and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. This compound is used as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is found in 18 recorded sources, including analgesics within healthcare, pharmaceuticals, and veterinary products; food preservation within food, food processing, and cookware; and various household cleaning and consumer products such as perfumes within detergents and soaps, ash trays, and non-electric simulated smoking devices. It is also associated with electrical and electronic equipment, including antennas, coils, conductors or conductive bodies characterized by the conductive materials, electrodes, and electrically stimulated smoking devices. The recorded exposure route is oral. Diflunisal has seven recorded protein targets: Prostaglandin G/H synthase 1 (PTGS1), Prostaglandin G/H synthase 2 (PTGS2), Transthyretin (TTR), Albumin (ALB), Carbonic anhydrase 1 (CA1), Carbonic anhydrase 2 (CA2), and Solute carrier family 22 member 6 (SLC22A6). While the precise mechanism of its analgesic and anti-inflammatory actions is not known, diflunisal is a prostaglandin synthetase inhibitor. Because prostaglandins are known to be among the mediators of inflammation and pain—and because they sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animals—the mode of action for diflunisal may be due to a decrease of prostaglandins in peripheral tissues.