Methoxyflurane (CED0005451)

Record Information

Version

1.0

Creation Date

2009-07-21 20:28:12 UTC

Update Date

2026-05-14 16:56:12 UTC

SynCED ID

CED0005451

Secondary Accession Numbers

CHEM002325
T3D2962

Identification

Common Name

Methoxyflurane

Class

Small Molecule

Description

Methoxyflurane belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. This exogenous liquid has the formula C3H4Cl2F2O and an average molecular weight of 164.97 g/mol. It is utilized as an inhalation anaesthetic and a non-narcotic analgesic. Biologically, the compound acts as a hepatotoxic agent and a nephrotoxic agent. Recorded exposure occurs via the respiratory route, with the compound found in analgesics, electrically stimulated smoking devices, conductors or conductive bodies characterised by the conductive materials, tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, and cigar cigarettes. The compound interacts with 24 recorded protein targets, including Gamma-aminobutyric acid receptor subunits alpha-1 (GABRA1), pi (GABRP), delta (GABRD), and beta-1 (GABRB1), as well as Calcium-transporting ATPase type 2C member 1 (ATP2C1). It acts as a positive allosteric modulator of Transient receptor potential cation channel subfamily A member 1 (TRPA1). Methoxyflurane binds to the GABA receptor, the glutamate receptor, and the large conductance Ca2+ activated potassium channel. It also appears to bind the D subunit of ATP synthase (ATP5F1D) and NADH dehydogenase (MT-ND1). Furthermore, methoxyflurane activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It induces a reduction in junctional conductance by increasing gap junction channel closing times and decreasing gap junction channel opening times.

Contaminant Type

Anesthetic, Inhalation
Drug
Ether
Human Neurotoxin
Lachrymator
Metabolite
Organic Compound
Organochloride
Organofluoride
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Methoflurane	ChEBI
Methoxyfluoran	ChEBI
Methoxyfluran	ChEBI
Methoxyfluranum	ChEBI
Methyl 1,1-difluoro-2,2-dichloroethyl ether	ChEBI
Metoxiflurano	ChEBI
Penthrane	ChEBI
Methoxiflurane	HMDB
Methoxifluranum	HMDB
Methoxyfluorane	HMDB
Metossiflurano	HMDB
Metoxfluran	HMDB
Metoxifluran	HMDB
Methofluranum	HMDB
Anecotan	HMDB
Pentrane	HMDB

Chemical Formula

C₃H₄Cl₂F₂O

Average Molecular Mass

164.966 g/mol

Monoisotopic Mass

163.961 g/mol

CAS Registry Number

76-38-0

IUPAC Name

2,2-dichloro-1,1-difluoro-1-methoxyethane

Traditional Name

methoxyflurane

SMILES

COC(F)(F)C(Cl)Cl

InChI Identifier

InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3

InChI Key

RFKMCNOHBTXSMU-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dialkyl ethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are alkyl groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Ethers

Direct Parent

Dialkyl ethers

Alternative Parents

Substituents

Dialkyl ether
Hydrocarbon derivative
Organofluoride
Organochloride
Organohalogen compound
Alkyl halide
Alkyl fluoride
Alkyl chloride
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

organofluorine compound (CHEBI:6843 )
organochlorine compound (CHEBI:6843 )
ether (CHEBI:6843 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

non-narcotic analgesic ?
hepatotoxic agent ?A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
nephrotoxic agent ?A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals.
anaesthetic (PMC12919125 )?
inhalation anaesthetic (PMC3329710 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Liquid

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	-35°C
Boiling Point	105°C
Solubility	2.83E+004 mg/L (at 37°C)

Predicted Properties

Property	Value	Source
Water Solubility	6.46 g/L	ALOGPS
logP	2.01	ALOGPS
logP	2.31	ChemAxon
logS	-1.4	ALOGPS
pKa (Strongest Basic)	-4.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	9.23 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	27.98 m³·mol⁻¹	ChemAxon
Polarizability	11.46 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-001i-9300000000-2b014e075c584d7d00e8	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03e9-0900000000-31aa3948ca3dc3167617	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0900000000-286e18d415df7a2ecce2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-1900000000-a0e34ecec1f1427e9b36	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0900000000-5826e7c4a8fc419eecaa	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03dl-0900000000-38434e069c688783ff1c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03ec-0900000000-f972b01b9fa825e56f30	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0900000000-c2759436c4d32d8702ce	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0900000000-f4a5c266171cbb5ab6fb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-8900000000-fbf5bd1b60bed06b6fa7	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-9100000000-f375f8e7cda89aed201f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01q9-9500000000-8e6af6b8d5c2905c7078	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0900000000-d7dee0ac770c9b80f6d9	Not Available	View Spectrum
MS	MS Spectrum	splash10-001i-9100000000-e9387eb71a01da84865e	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
3600.0 mg/kg	Rat	LD50	Oral	experimental	Not Available	1
2102.0 Log mg/kg [1200:3700]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Symptoms of overexposure include eye irritation, CNS depression, analgesia, anesthesia, seizures, respiratory depression, and liver and kidney damage.

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
Anesthesia	Associated With?	Not Available	Not Available	PMC12919125
acute kidney injury	Associated With?	Not Available	Not Available	PMC1858334

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000370	Analgesics?Analgesics are a class of synthetic chemicals designed to alleviate pain.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000651	Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000699	Mining Or Quarrying?Mining and quarrying operations can lead to synthetic chemical contamination through the release of various pollutants associated with the extraction and processing of minerals.	Mining & metal processing	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000743	Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.	Wastewater, sanitation & biosolids	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs01920	Silicon Rubber	Industrial manufacturing & chemical processing	PMC9026426

Pathways

2 pathwaysPathway Source: PathBank

Methoxyflurane Drug Metabolism

Methoxyflurane Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Albumin	P02768	Humans	Known	Not Available
Click to view 3D structure	Inward rectifier potassium channel 2	P35561	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.154 Applicability Domain 0.154 Low confidence Statistical Significance 0.2501 Supporting Reference Compounds 1 E-value 1947.32
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.139 Applicability Domain 0.158 Low confidence Statistical Significance 0.9968 Supporting Reference Compounds 823 E-value 7759.7
Click to view 3D structure	ACCase	H9BT73	Alopecurus japonicus	Predicted (SEA)	Prediction Confidence Score 0.137 Applicability Domain 0.137 Low confidence Statistical Significance 0.3565 Supporting Reference Compounds 1 E-value 2775.01
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.137 Applicability Domain 0.158 Low confidence Statistical Significance 0.9978 Supporting Reference Compounds 955 E-value 7767.64
Click to view 3D structure	Liver carboxylesterase	Q29550	Sus scrofa	Predicted (SEA)	Prediction Confidence Score 0.135 Applicability Domain 0.154 Low confidence Statistical Significance 0.4338 Supporting Reference Compounds 20 E-value 3377.25
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	Prediction Confidence Score 0.131 Applicability Domain 0.143 Low confidence Statistical Significance 0.9965 Supporting Reference Compounds 536 E-value 7757.75
Click to view 3D structure	Cholesteryl ester transfer protein	P22687	Oryctolagus cuniculus	Predicted (SEA)	Prediction Confidence Score 0.128 Applicability Domain 0.129 Low confidence Statistical Significance 0.186 Supporting Reference Compounds 2 E-value 1448.38
Click to view 3D structure	Cocaine esterase	O00748	Humans	Predicted (SEA)	Prediction Confidence Score 0.128 Applicability Domain 0.143 Low confidence Statistical Significance 0.8356 Supporting Reference Compounds 40 E-value 6505.16
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.126 Applicability Domain 0.143 Low confidence Statistical Significance 0.999 Supporting Reference Compounds 686 E-value 7776.98
Click to view 3D structure	Acylcarnitine hydrolase	Q91WG0	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.125 Applicability Domain 0.143 Low confidence Statistical Significance 0.0351 Supporting Reference Compounds 2 E-value 273.562
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.125 Applicability Domain 0.133 Low confidence Statistical Significance 0.9986 Supporting Reference Compounds 593 E-value 7774.02
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.124 Applicability Domain 0.133 Low confidence Statistical Significance 0.9994 Supporting Reference Compounds 1498 E-value 7780.41
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Predicted (SEA)	Prediction Confidence Score 0.123 Applicability Domain 0.154 Low confidence Statistical Significance 0.9983 Supporting Reference Compounds 406 E-value 7772.0
Click to view 3D structure	Liver carboxylesterase 1	P23141	Humans	Predicted (SEA)	Prediction Confidence Score 0.122 Applicability Domain 0.14 Low confidence Statistical Significance 0.8724 Supporting Reference Compounds 55 E-value 6791.64
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.122 Applicability Domain 0.143 Low confidence Statistical Significance 0.9993 Supporting Reference Compounds 1245 E-value 7779.55
Click to view 3D structure	5-hydroxytryptamine receptor 7	P34969	Humans	Predicted (SEA)	Prediction Confidence Score 0.122 Applicability Domain 0.143 Low confidence Statistical Significance 0.9984 Supporting Reference Compounds 565 E-value 7772.23
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	Prediction Confidence Score 0.121 Applicability Domain 0.143 Low confidence Statistical Significance 0.999 Supporting Reference Compounds 953 E-value 7777.29
Click to view 3D structure	CG8425-PA [Drosophila melanogaster]	A1ZA98	Drosophila melanogaster	Predicted (SEA)	Prediction Confidence Score 0.121 Applicability Domain 0.143 Low confidence Statistical Significance 0.0417 Supporting Reference Compounds 4 E-value 324.709
Click to view 3D structure	Metabotropic glutamate receptor 7	P35400	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.121 Applicability Domain 0.13 Low confidence Statistical Significance 0.9369 Supporting Reference Compounds 27 E-value 7294.0
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.12 Applicability Domain 0.133 Low confidence Statistical Significance 0.9949 Supporting Reference Compounds 297 E-value 7745.37
Click to view 3D structure	Metabotropic glutamate receptor 8	P70579	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.12 Applicability Domain 0.13 Low confidence Statistical Significance 0.8592 Supporting Reference Compounds 28 E-value 6688.81
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.12 Applicability Domain 0.133 Low confidence Statistical Significance 0.9995 Supporting Reference Compounds 1130 E-value 7780.8
Click to view 3D structure	Fatty-acid amide hydrolase 1	O08914	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.119 Applicability Domain 0.128 Low confidence Statistical Significance 0.9472 Supporting Reference Compounds 46 E-value 7373.64
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	Prediction Confidence Score 0.118 Applicability Domain 0.133 Low confidence Statistical Significance 0.9996 Supporting Reference Compounds 1538 E-value 7781.96
Click to view 3D structure	Cytochrome P450 1A2	P05177	Humans	Predicted (SEA)	Prediction Confidence Score 0.118 Applicability Domain 0.122 Low confidence Statistical Significance 0.9992 Supporting Reference Compounds 793 E-value 7778.93
Click to view 3D structure	Cytochrome b5	P00167	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	ATP synthase F(1) complex subunit delta, mitochondrial	P30049	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Calcium-transporting ATPase type 2C member 1	P98194	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-1	P14867	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Glutamate receptor 1	P42261	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Glycine receptor subunit alpha-1	P23415	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 1	P03886	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Potassium voltage-gated channel subfamily A member 1	Q09470	Humans	Known	Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.
Click to view 3D structure	Transient receptor potential cation channel subfamily A member 1	O75762	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DB01028

HMDB ID

HMDB0015162

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Link

General References

Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M: DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. [PubMed: 18048412]
Drugs.com - http://www.drugs.com/cons/Methoxyflurane.html

Methoxyflurane (CED0005451)

Structure for CHEM002325: Methoxyflurane

Structure