Pimozide (CED0004241)

Record Information
Version1.0
Creation Date2009-07-21 20:28:22 UTC
Update Date2026-05-14 16:57:49 UTC
SynCED IDCED0004241
Secondary Accession Numbers
  • CHEM002345
  • T3D2984
Identification
Common NamePimozide
ClassSmall Molecule
Description
Pimozide is an exogenous organic compound with the formula C28H29F2N3O and an average molecular weight of 461.55 g/mol. It exists as a solid at room temperature. Pimozide belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. This first generation antipsychotic functions as a dopaminergic antagonist, serotonergic antagonist, and H1-receptor antagonist. It is used as an antipsychotic agent and as an antidyskinesia agent. Its ability to suppress phonic and motor tics in Tourette's Disorder is believed to be primarily a function of its dopaminergic blocking activity. Pimozide targets 20 proteins, including the D(2) dopamine receptor (DRD2) in the CNS and the D(3) dopamine receptor (DRD3), which it inhibits. Additionally, it acts as an antagonist at opiate receptors (OPRD1) and appears to block voltage-operated calcium channels, such as the voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G). Other recorded protein targets include the voltage-gated inwardly rectifying potassium channel KCNH2, solute carrier family 22 member 2 (SLC22A2), ATP-dependent translocase ABCB1, and cytochrome P450 3A4 (CYP3A4). Pimozide is found in healthcare, pharmaceuticals, and veterinary products as an antipsychotic. It has also been recorded in electrical and electronic equipment—including antennas, amplifiers, radio transmission systems, television systems, and electrically stimulated smoking devices—as well as household cleaning and consumer products such as tobacco smoke filters, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. The recorded exposure route for this compound is oral.
Contaminant Type
  • Amine
  • Anti-Dyskinesia Agent
  • Antidyskinetic
  • Antipsychotic Agent
  • Dopamine Antagonist
  • Drug
  • Human Neurotoxin
  • Metabolite
  • Organic Compound
  • Organofluoride
  • Synthetic Compound
Chemical Structure
Synonyms
ValueSource
HalomonthChEBI
NeoperidoleChEBI
OpiranChEBI
OrapChEBI
PimozidaChEBI
PimozidumChEBI
Janssen brand OF pimozideHMDB
Pharmascience brand OF pimozideHMDB
Orap forteHMDB
ASTA medica brand OF pimozideHMDB
AntalonHMDB
Chemical FormulaC28H29F2N3O
Average Molecular Mass461.546 g/mol
Monoisotopic Mass461.228 g/mol
CAS Registry Number2062-78-4
IUPAC Name1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Traditional Namepimozide
SMILESFC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1
InChI IdentifierInChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI KeyYVUQSNJEYSNKRX-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Phenylbutylamine
  • Benzimidazole
  • Aralkylamine
  • Fluorobenzene
  • Halobenzene
  • Aryl fluoride
  • Aryl halide
  • Piperidine
  • N-substituted imidazole
  • Azole
  • Heteroaromatic compound
  • Imidazole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Organooxygen compound
  • Amine
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Membrane
Biofluid LocationsNot Available
Tissue LocationsNot Available
Applications
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point214-218°C
Boiling PointNot Available
Solubility10 mg/L (at 25°C)
Predicted Properties
PropertyValueSource
Water Solubility0.0017 g/LALOGPS
logP6.36ALOGPS
logP5.83ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)12.9ChemAxon
pKa (Strongest Basic)8.38ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area35.58 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity132.21 m³·mol⁻¹ChemAxon
Polarizability50.04 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0ugi-1391000000-81a5491e04c0772aa266Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03fr-3945500000-63d831a19fe77286e9e1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-2900000000-c5c24c6004ad63c44b7bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-2900000000-4ec6383bd789926aace8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-001i-0900000000-f7e5bc8b3118f019d29aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-001i-0900000000-15ed37cc4150d726424fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4j-2900000000-4cb696b16013c21eaeccNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-054k-3922000000-3dece675311cfc7dcecbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0000900000-a6c11637d319ae7e0d4bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0001900000-e11e7746c656531d49c3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-001i-0900000000-a10c36c7b309fd6a144aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0010900000-930a125974bd00e0c2ebNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03dj-0292700000-2985b790e5501b39bbd6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00ks-2981100000-75644e2a4fa99f98d3bcNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0000900000-d214f454d376b4403eddNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03e9-0410900000-0d1a6255c713f6209ad8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-2920000000-0b02fc753cd5d50662e6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0000900000-1007eb55b47c59016fd5Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0001900000-6016ca53ea77d615c57cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03yj-2790700000-5ee4d094cbf2edb564c4Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-0000900000-d24101b35641ce78a840Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03xr-1000900000-a8261095a6ae4bd8e429Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-3911100000-2bfbcbf4417742b7624dNot AvailableView Spectrum
MSMS Spectrumsplash10-001i-4890100000-ff909df45204eac82c46Not AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
1100.0 mg/kg RatLD50OralexperimentalNot Available1
228.0 mg/kg MouseLD50OralexperimentalNot Available1
767.0 Log mg/kg [430:1400]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityThe ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds and inhibits the dopamine D2 receptor in the CNS. It also appears to block voltage-operated calcium channels and acts as an antagonist at opiate receptors (OP2).
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentIn the event of overdosage, gastric lavage, establishment of a patent airway and, if necessary, mechanically-assisted respiration are advised. Electrocardiographic monitoring should commence immediately and continue until the ECG parameters are within the normal range. Hypotension and circulatory collapse may be counteracted by use of intravenous fluids, plasma, or concentrated albumin, and vasopressor agents such as metaraminol, phenylephrine and norepinephrine. Epinephrine should not be used. In case of severe extrapyramidal reactions, antiparkinson medication should be administered. Because of the long half-life of pimozide, patients who take an overdose should be observed for at least 4 days. (3)
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000374Antipsychotics?Antipsychotics are a class of synthetic chemicals used primarily for the treatment of psychiatric disorders, including schizophrenia and bipolar disorder.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000505Amplifiers?Amplifiers, commonly used in various electronic devices to enhance signal strength, can be a source of synthetic chemical contamination due to the materials and processes involved in their production and disposal.Electrical & Electronic EquipmentPubChem
CEDs000506Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.Electrical & Electronic EquipmentPubChem
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentPubChem
CEDs000530Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.Electrical & Electronic EquipmentPubChem
CEDs000537Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.Electrical & Electronic EquipmentPubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsPubChem
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsPubChem
CEDs000560Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsPubChem
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingPubChem
CEDs000596Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.Agriculture & land managementPubChem
CEDs000600Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.Agriculture & land managementPubChem
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementPubChem
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsPubChem
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsPubChem
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsPubChem
CEDs000631Anthraquinone Dyes?Anthraquinone dyes are a class of synthetic organic compounds characterized by their vibrant colors and stability, making them widely used in various applications, particularly in coloring textiles and leather.Textiles, leather & furnishingsPubChem
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsPubChem
CEDs000642Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.Textiles, leather & furnishingsPubChem
CEDs000671Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.Aviation & AerospacePubChem
CEDs000682Traction Harness?Traction harnesses, commonly used in agricultural practices for animals and machinery, can be a source of synthetic chemical contamination through the materials used in their production.Agriculture & land managementPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructurePubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsPubChem
CEDs000741Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.Paper, pulp & fiber productsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
2 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansPredicted (SEA)
Prediction Confidence Score
0.659
Applicability Domain
1.0
Statistical Significance
0.0012
Supporting Reference Compounds
1103
E-value
9.03051
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)
Prediction Confidence Score
0.65
Applicability Domain
1.0
Statistical Significance
5.90e-04
Supporting Reference Compounds
1498
E-value
4.5931
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansPredicted (SEA)
Prediction Confidence Score
0.643
Applicability Domain
1.0
Statistical Significance
0.0011
Supporting Reference Compounds
861
E-value
8.79696
Kappa-type opioid receptor structureClick to view 3D structureKappa-type opioid receptorP41145HumansPredicted (SEA)
Prediction Confidence Score
0.564
Applicability Domain
1.0
Statistical Significance
0.0047
Supporting Reference Compounds
532
E-value
36.5891
Mu-type opioid receptor structureClick to view 3D structureMu-type opioid receptorP35372HumansPredicted (SEA)
Prediction Confidence Score
0.564
Applicability Domain
1.0
Statistical Significance
0.0043
Supporting Reference Compounds
527
E-value
33.553
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansPredicted (SEA)
Prediction Confidence Score
0.548
Applicability Domain
1.0
Statistical Significance
9.60e-04
Supporting Reference Compounds
536
E-value
7.47353
Muscarinic acetylcholine receptor M1 structureClick to view 3D structureMuscarinic acetylcholine receptor M1P11229HumansPredicted (SEA)
Prediction Confidence Score
0.537
Applicability Domain
0.702
Statistical Significance
7.00e-04
Supporting Reference Compounds
385
E-value
5.44945
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)
Prediction Confidence Score
0.527
Applicability Domain
0.702
Statistical Significance
0.0034
Supporting Reference Compounds
955
E-value
26.4687
Delta-type opioid receptor structureClick to view 3D structureDelta-type opioid receptorP41143HumansPredicted (SEA)
Prediction Confidence Score
0.527
Applicability Domain
1.0
Statistical Significance
0.0081
Supporting Reference Compounds
427
E-value
62.7465
D(1A) dopamine receptor structureClick to view 3D structureD(1A) dopamine receptorP21728HumansPredicted (SEA)
Prediction Confidence Score
0.52
Applicability Domain
1.0
Statistical Significance
0.002
Supporting Reference Compounds
425
E-value
15.2584
Muscarinic acetylcholine receptor M5 structureClick to view 3D structureMuscarinic acetylcholine receptor M5P08912HumansPredicted (SEA)
Prediction Confidence Score
0.508
Applicability Domain
0.702
Statistical Significance
3.30e-04
Supporting Reference Compounds
266
E-value
2.56902
5-hydroxytryptamine receptor 1A structureClick to view 3D structure5-hydroxytryptamine receptor 1AP08908HumansPredicted (SEA)
Prediction Confidence Score
0.498
Applicability Domain
0.702
Statistical Significance
0.0064
Supporting Reference Compounds
953
E-value
49.8235
Voltage-dependent T-type calcium channel subunit alpha-1H structureClick to view 3D structureVoltage-dependent T-type calcium channel subunit alpha-1HO95180HumansPredicted (SEA)
Prediction Confidence Score
0.478
Applicability Domain
1.0
Statistical Significance
3.00e-05
Supporting Reference Compounds
90
E-value
0.233548
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)
Prediction Confidence Score
0.473
Applicability Domain
1.0
Statistical Significance
0.007
Supporting Reference Compounds
1538
E-value
54.8837
Click to view 3D structurePhospholipase D1P70496Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.472
Applicability Domain
0.478
Statistical Significance
9.00e-05
Supporting Reference Compounds
2
E-value
0.700643
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansPredicted (SEA)
Prediction Confidence Score
0.456
Applicability Domain
0.547
Statistical Significance
0.0061
Supporting Reference Compounds
823
E-value
47.488
Bile salt export pump structureClick to view 3D structureBile salt export pumpO95342HumansPredicted (SEA)
Prediction Confidence Score
0.45
Applicability Domain
1.0
Statistical Significance
3.40e-04
Supporting Reference Compounds
104
E-value
2.64687
Histamine H1 receptor structureClick to view 3D structureHistamine H1 receptorP35367HumansPredicted (SEA)
Prediction Confidence Score
0.444
Applicability Domain
0.547
Statistical Significance
0.0046
Supporting Reference Compounds
507
E-value
35.5771
Sodium channel protein type 2 subunit alpha structureClick to view 3D structureSodium channel protein type 2 subunit alphaP04775Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.443
Applicability Domain
1.0
Statistical Significance
0.0015
Supporting Reference Compounds
21
E-value
11.9109
Click to view 3D structureVoltage-dependent T-type calcium channel subunit alpha-1GO43497HumansPredicted (SEA)
Prediction Confidence Score
0.441
Applicability Domain
1.0
Statistical Significance
4.00e-05
Supporting Reference Compounds
27
E-value
0.311397
Click to view 3D structureDNA damage-inducible transcript 3 proteinP35639Mus musculusPredicted (SEA)
Prediction Confidence Score
0.438
Applicability Domain
1.0
Statistical Significance
1.20e-04
Supporting Reference Compounds
226
E-value
0.934191
X-box-binding protein 1 structureClick to view 3D structureX-box-binding protein 1P17861HumansPredicted (SEA)
Prediction Confidence Score
0.438
Applicability Domain
1.0
Statistical Significance
1.20e-04
Supporting Reference Compounds
227
E-value
0.934191
5-hydroxytryptamine receptor 2B structureClick to view 3D structure5-hydroxytryptamine receptor 2BP41595HumansPredicted (SEA)
Prediction Confidence Score
0.434
Applicability Domain
0.547
Statistical Significance
0.0053
Supporting Reference Compounds
686
E-value
41.0265
Click to view 3D structure5-hydroxytryptamine receptor 7P32305Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.431
Applicability Domain
1.0
Statistical Significance
0.0032
Supporting Reference Compounds
115
E-value
24.6782
Phospholipase D1 structureClick to view 3D structurePhospholipase D1Q13393HumansPredicted (SEA)
Prediction Confidence Score
0.43
Applicability Domain
0.478
Statistical Significance
1.40e-04
Supporting Reference Compounds
10
E-value
1.08989
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansKnownThe ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds to the dopamine D2 receptor in the CNS. It also appears to block voltage-operated calcium channels and acts as an antagonist at opiate receptors (OP2).
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansKnownThe ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds to the dopamine D2 receptor in the CNS. It also appears to block voltage-operated calcium channels and acts as an antagonist at opiate receptors (OP2).
Delta-type opioid receptor structureClick to view 3D structureDelta-type opioid receptorP41143HumansKnownThe ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds to the dopamine D2 receptor in the CNS. It also appears to block voltage-operated calcium channels and acts as an antagonist at opiate receptors (OP2).
Click to view 3D structureVoltage-dependent T-type calcium channel subunit alpha-1GO43497HumansKnownThe ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds to the dopamine D2 receptor in the CNS. It also appears to block voltage-operated calcium channels and acts as an antagonist at opiate receptors (OP2).
5-hydroxytryptamine receptor 1A structureClick to view 3D structure5-hydroxytryptamine receptor 1AP08908HumansKnownNot Available
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansKnownNot Available
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansKnownNot Available
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansKnownNot Available
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansKnownNot Available
D(1A) dopamine receptor structureClick to view 3D structureD(1A) dopamine receptorP21728HumansKnownNot Available
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansKnownNot Available
Kappa-type opioid receptor structureClick to view 3D structureKappa-type opioid receptorP41145HumansKnownNot Available
Mu-type opioid receptor structureClick to view 3D structureMu-type opioid receptorP35372HumansKnownNot Available
Click to view 3D structureMultidrug and toxin extrusion protein 1Q96FL8HumansKnownNot Available
Click to view 3D structureMultidrug and toxin extrusion protein 2Q86VL8HumansKnownNot Available
ATP-dependent translocase ABCB1 structureClick to view 3D structureATP-dependent translocase ABCB1P08183HumansKnownNot Available
Solute carrier family 22 member 2 structureClick to view 3D structureSolute carrier family 22 member 2O15244HumansKnownNot Available
Concentrations
Not Available
External Links
DrugBank IDDB01100
HMDB IDHMDB0015232
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkPimozide
Chemspider ID15520
ChEBI ID8212
PubChem Compound ID16362
Kegg Compound IDC07566
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSLink
General References
  1. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M: DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. [PubMed: 18048412]
  2. Drugs.com - http://www.drugs.com/cons/Pimozide.html
  3. RxList: The Internet Drug Index (2009). - http://www.rxlist.com/