Fluoroacetic acid (CED0009200)

Fluoroacetic acid (C2H3FO2) is an exogenous organic compound with an average molecular weight of 78.04 g/mol. At room temperature, it exists as a solid. Fluoroacetic acid belongs to the alpha-halocarboxylic acids and derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. This compound acts as a biological and chemical inhibitor of EC 4.2.1.3 (aconitate hydratase). It has two recorded protein targets: hepatocyte nuclear factor 4-alpha (HNF4A) and cytoplasmic aconitate hydratase (ACO1). In the case of the latter, fluoroacetate is metabolized into fluorocitrate, which binds to the aconitase. Fluoroacetic acid is found in or released from 32 recorded sources. These include food, food processing, and cookware, such as the preparation of vinegar, preparation of wine or sparkling wine, food preservation, cellar tools, and fermentation processes for beer. It is also associated with household cleaning and consumer products, including bleaching agents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Additionally, it is found in electrical and electronic equipment, including antennas, conductors or conductive bodies characterised by the conductive materials, contacts, discharge lamps, and electric switches.