Promethazine (CED0003417)

Record Information

Version

1.0

Creation Date

2014-08-30 21:04:24 UTC

Update Date

2026-08-19 20:38:34 UTC

SynCED ID

CED0003417

Secondary Accession Numbers

CHEM003520
T3D4560

Identification

Common Name

Promethazine

Class

Small Molecule

Description

Promethazine belongs to the phenothiazines, a subclass of benzothiazines within the organic compounds. This exogenous compound has the formula C17H20N2S and an average molecular weight of 284.42 g/mol. At room temperature, it exists as a solid. It is classified within the superclass of organoheterocyclic compounds. The compound functions as an H1-receptor antagonist and is used as a sedative, antiemetic, local anaesthetic, antipruritic drug, and anti-allergic agent. It acts as an antagonist, inhibitor, or modulator of 100 recorded protein targets, including the Histamine H1 receptor (HRH1), the D(2) dopamine receptor (DRD2), Muscarinic acetylcholine receptor M1 (CHRM1), and Muscarinic acetylcholine receptor M4 (CHRM4). Promethazine is found in 26 recorded sources. These include healthcare, pharmaceuticals, and veterinary products such as antihistamines, antipruritics, and unclassified therapeutic products. It is also associated with household cleaning and consumer products, including perfumes within detergents and soaps, bleaching agents, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Other sources include food, food processing and cookware—specifically the preparation of wort, fermentation processes for beer, food preservation, and the preparation of wine or sparkling wine—as well as fencing in building and construction. Additionally, it is found in electrical and electronic equipment, such as discharge lamps, electric hearing aids, antennas, conductors or conductive bodies characterised by the conductive materials, and electric switches. Recorded exposure routes for the compound include oral, intravenous, intramuscular, rectal, and topical administration.

Contaminant Type

Amine
Anti-Allergic Agent
Antipruritic
Drug
Ether
Histamine H1 Antagonist
Organic Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine	ChEBI
10-(2-Dimethylaminopropyl)phenothiazine	ChEBI
10-[2-(Dimethylamino)propyl]phenothiazine	ChEBI
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine	ChEBI
N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine	ChEBI
Proazamine	ChEBI
Prometazina	ChEBI
Promethazinum	ChEBI
N,N,a-Trimethyl-10H-phenothiazine-10-ethanamine	Generator
N,N,Α-trimethyl-10H-phenothiazine-10-ethanamine	Generator
Isopromethazine	HMDB
Lilly 1516	HMDB
Proazaimine	HMDB
Promazinamide	HMDB
Prometazine	HMDB
Promethazin	HMDB
Promethiazine	HMDB
Promezathine	HMDB
Prothazin	HMDB
Prothazine	HMDB
Diprazin	HMDB
Rumergan	HMDB
Phenargan	HMDB
Phensedyl	HMDB
Promet	HMDB
Promethazine hydrochloride	HMDB
Remsed	HMDB
Prometazin	HMDB
Pyrethia	HMDB
Atosil	HMDB
Diphergan	HMDB
Hydrochloride, promethazine	HMDB
Phenergan	HMDB
Pipolfen	HMDB
Pipolphen	HMDB

Chemical Formula

C₁₇H₂₀N₂S

Average Molecular Mass

284.419 g/mol

Monoisotopic Mass

284.135 g/mol

CAS Registry Number

60-87-7

IUPAC Name

dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine

Traditional Name

promethazine

SMILES

CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C

InChI Identifier

InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

InChI Key

PWWVAXIEGOYWEE-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzothiazines

Sub Class

Phenothiazines

Direct Parent

Phenothiazines

Alternative Parents

Substituents

Phenothiazine
Alkyldiarylamine
Diarylthioether
Aryl thioether
Tertiary aliphatic/aromatic amine
Para-thiazine
Benzenoid
Tertiary amine
Tertiary aliphatic amine
Thioether
Azacycle
Organic nitrogen compound
Hydrocarbon derivative
Organopnictogen compound
Organonitrogen compound
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

phenothiazines (CHEBI:8461 )
tertiary amine (CHEBI:8461 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

H1-receptor antagonist ?
histamine antagonist (PMC10976893 , PMC10976893 )?
antioxidant (PMC5852693 )?
antipsychotic agent (PMC10053029 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	60 °C
Boiling Point	190-192 °C at 3.00E+00 mm Hg
Solubility	15.6 mg/L (at 24 °C)

Predicted Properties

Property	Value	Source
Water Solubility	0.024 g/L	ALOGPS
logP	4.52	ALOGPS
logP	4.29	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Basic)	9.05	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	6.48 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	88.5 m³·mol⁻¹	ChemAxon
Polarizability	32.38 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum	splash10-000i-0090000000-f1fe9756bed13819bbb4	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-00di-9000000000-abbdf5514dccef4821b2	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-00di-9100000000-9bef9a6b83d662fc7e2c	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-0079-8290000000-fe5d6b4e9f62b7270798	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-0090000000-f1fe9756bed13819bbb4	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-00di-9000000000-abbdf5514dccef4821b2	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-00di-9100000000-9bef9a6b83d662fc7e2c	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-0079-8290000000-fe5d6b4e9f62b7270798	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0229-9150000000-19753aa755aa19143e9b	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000j-0690000000-0b4dfbac9712d2e36046	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-9220000000-9d761be1437f10dcc94b	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-9120000000-53ae2d83de014d922ec7	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0920000000-c051699dc72e950f2e98	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0910000000-e92aacd8ca86df8a0e18	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0910000000-0ce89af1c9b2c4633eda	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0950000000-70d959c63d9e713a865a	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000i-0090000000-842e411dfa4c9fad1f7f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-2090000000-76a910470a52a47a6757	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000f-8090000000-d597b4b7604e8276f449	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00dr-9110000000-cbed4a551fc77cf0e5b9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0090000000-e24a248a31f0e31f1ec5	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-009t-0940000000-afb556a81c40edffb9a1	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-3910000000-3daef27d94a5cac7d4a7	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-9070000000-e74135a63711b2ca001f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-9020000000-25ad7e0e10410cbe88c3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000j-9610000000-32a1e6113f4291e6a186	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0090000000-a26692bb509bb9fc8701	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000t-0590000000-3a84419d780b185fa21a	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01ot-0940000000-7c01990eb3e291008595	Not Available	View Spectrum
MS	MS Spectrum	splash10-00di-9210000000-7167670dff3395a6ade2	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
230.0 Log mg/kg [130:410]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. IV, Mouse: LD₅₀=55mg/kg

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex).

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000233	Brushes?Brushes used in personal care and cosmetics can be a source of synthetic chemical contamination due to the materials and coatings used in their manufacturing.	Personal care & cosmetics	PubChem
CEDs000304	Antipruritics?Antipruritics are synthetic chemicals used to alleviate itching associated with various dermatological conditions.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000393	Antihistamines?Antihistamines are a class of synthetic chemicals primarily used to alleviate allergic reactions by blocking the action of histamine in the body.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000409	Unclassified therapeutic products?Unclassified therapeutic products encompass a range of substances used in medical and veterinary contexts that have not undergone formal classification processes.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000496	Fencing?Fencing materials, particularly those used in construction and landscaping, can be a source of synthetic chemical contamination due to the treatments and coatings applied for durability and weather resistance.	Building & Construction	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000514	Discharge Lamps?Discharge lamps, including fluorescent and high-intensity discharge (HID) lamps, are commonly used for lighting applications due to their energy efficiency and brightness.	Electrical & Electronic Equipment	PubChem
CEDs000516	Electric Hearing Aids?Electric hearing aids are small electronic devices designed to amplify sound for individuals with hearing loss.	Electrical & Electronic Equipment	PubChem
CEDs000517	Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000524	Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.	Electrical & Electronic Equipment	PubChem
CEDs000525	Line Transmission Systems?Line Transmission Systems, commonly used for the distribution of electrical energy, can be a source of synthetic chemical contamination through the insulation materials and coatings utilized in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	PubChem
CEDs000544	Fermentation Processes For Beer?Fermentation processes for beer involve the conversion of sugars into alcohol and carbon dioxide by yeast.	Food, food processing & cookware	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000549	Preparation Of Wine Or Sparkling Wine?The preparation of wine or sparkling wine involves various stages, including fermentation, aging, and bottling, which can introduce potential sources of synthetic chemical contamination.	Food, food processing & cookware	PubChem
CEDs000550	Preparation Of Wort?The preparation of wort involves the extraction of sugars from malted grains, a crucial step in the brewing process.	Food, food processing & cookware	PubChem
CEDs000555	Bleaching Agents?Bleaching agents are chemical substances used to whiten or lighten materials, often employed in various cleaning products for their stain removal and disinfecting properties.	Household cleaning & consumer products	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000581	Paper Making Machines?Paper making machines utilize various synthetic chemicals throughout the production process, including additives, coatings, and bleaching agents.	Industrial manufacturing & chemical processing	PubChem
CEDs000584	Buoys?Buoys, often used for navigation and marine monitoring, can be sources of synthetic chemical contamination due to the materials and coatings employed in their construction.	Marine, shipping & aquaculture	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000597	Chemosterilants?Chemosterilants are synthetic chemicals designed to induce sterility in target pest populations, thereby controlling their reproduction and mitigating damage to crops.	Agriculture & land management	PubChem
CEDs000600	Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.	Agriculture & land management	PubChem
CEDs000602	Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.	Agriculture & land management	PubChem
CEDs000603	Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000609	Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.	Personal care & cosmetics	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000612	Body Washing Or Cleaning Implements?Body washing or cleaning implements, such as synthetic sponges, loofahs, and washcloths, can be sources of synthetic chemical contamination due to the materials used in their production.	Personal care & cosmetics	PubChem
CEDs000613	Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000616	Face Mask Cosmetics?Face mask cosmetics often contain a variety of synthetic chemicals, including preservatives, emulsifiers, and fragrances, which can contribute to chemical contamination.	Personal care & cosmetics	PubChem
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000643	Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000651	Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.	Textiles, leather & furnishings	PubChem
CEDs000657	Surface Finishing Of Leather?Surface finishing of leather often involves the use of various synthetic chemicals, including dyes, resins, and finishing agents.	Textiles, leather & furnishings	PubChem
CEDs000661	Umbrellas?Umbrellas are commonly manufactured using synthetic materials such as polyester, nylon, and polyvinyl chloride (PVC), which can contribute to synthetic chemical contamination.	Textiles, leather & furnishings	PubChem
CEDs000662	Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000678	Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.	Agriculture & land management	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000689	Glass Fibres?Glass fibres are composed of fine strands of glass, commonly utilized for their tensile strength and lightweight properties.	Building & Construction	PubChem
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000699	Mining Or Quarrying?Mining and quarrying operations can lead to synthetic chemical contamination through the release of various pollutants associated with the extraction and processing of minerals.	Mining & metal processing	PubChem
CEDs000717	Fountain Pens?Fountain pens utilize a liquid ink that often contains synthetic chemicals, including dyes, pigments, and solvents, which can contribute to environmental contamination.	Paper, pulp & fiber products	PubChem
CEDs000720	Ink Reservoir Pens2?Ink reservoir pens are writing instruments that utilize a reservoir to store ink, which is often composed of synthetic dyes, solvents, and additives.	Paper, pulp & fiber products	PubChem
CEDs000730	Contact Lens Cases?Contact lens cases are small containers designed to store contact lenses in a sterile environment, typically made from various synthetic materials including plastics such as polypropylene or polycarbonate.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000734	Coating Compositions?Coating compositions, which include paints, sealants, and varnishes, are formulated with a variety of synthetic chemicals such as solvents, resins, pigments, and additives.	Building & Construction	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000738	Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.	Industrial manufacturing & chemical processing	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000741	Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.	Paper, pulp & fiber products	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem

Pathways

6 pathwaysPathway Source: PathBank

Promethazine H1-Antihistamine Action

Promethazine Drug Metabolism Action Pathway

Promethazine H1 Antihistamine Neurological Sleep Action Pathway

Promethazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway

Promethazine H1-Antihistamine Blood Vessel Constriction Action Pathway

Promethazine H1-Antihistamine Immune Response Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.548 Applicability Domain 1.0 Statistical Significance 0.0019 Supporting Reference Compounds 823 E-value 14.6357
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.548 Applicability Domain 1.0 Statistical Significance 0.003 Supporting Reference Compounds 861 E-value 23.1212
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.548 Applicability Domain 1.0 Statistical Significance 0.0025 Supporting Reference Compounds 955 E-value 19.8516
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	Prediction Confidence Score 0.548 Applicability Domain 1.0 Statistical Significance 9.60e-04 Supporting Reference Compounds 536 E-value 7.47353
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.548 Applicability Domain 1.0 Statistical Significance 0.0011 Supporting Reference Compounds 686 E-value 8.32987
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 0.0012 Supporting Reference Compounds 562 E-value 9.6533
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 4.80e-04 Supporting Reference Compounds 340 E-value 3.73676
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 8.90e-04 Supporting Reference Compounds 487 E-value 6.92858
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 2.50e-04 Supporting Reference Compounds 266 E-value 1.94623
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 6.70e-04 Supporting Reference Compounds 451 E-value 5.2159
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 5.20e-04 Supporting Reference Compounds 310 E-value 4.04816
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Predicted (SEA)	Prediction Confidence Score 0.54 Applicability Domain 1.0 Statistical Significance 4.10e-04 Supporting Reference Compounds 297 E-value 3.19182
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 0.0013 Supporting Reference Compounds 507 E-value 9.9647
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 7.00e-04 Supporting Reference Compounds 385 E-value 5.44945
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 3.40e-04 Supporting Reference Compounds 373 E-value 2.64687
Click to view 3D structure	Alpha-1A adrenergic receptor	P43140	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 7.20e-04 Supporting Reference Compounds 208 E-value 5.60514
Click to view 3D structure	Alpha-1D adrenergic receptor	P25100	Humans	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 6.20e-04 Supporting Reference Compounds 258 E-value 4.82665
Click to view 3D structure	Alpha-1B adrenergic receptor	P15823	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 1.0 Statistical Significance 2.20e-04 Supporting Reference Compounds 130 E-value 1.71268
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.531 Applicability Domain 1.0 Statistical Significance 0.0017 Supporting Reference Compounds 593 E-value 13.3122
Click to view 3D structure	Alpha-2C adrenergic receptor	P18825	Humans	Predicted (SEA)	Prediction Confidence Score 0.531 Applicability Domain 1.0 Statistical Significance 6.40e-04 Supporting Reference Compounds 386 E-value 4.98235
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P19327	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.525 Applicability Domain 1.0 Statistical Significance 0.0034 Supporting Reference Compounds 541 E-value 26.7023
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	Prediction Confidence Score 0.523 Applicability Domain 1.0 Statistical Significance 0.006 Supporting Reference Compounds 1103 E-value 47.0988
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.523 Applicability Domain 1.0 Statistical Significance 0.0023 Supporting Reference Compounds 1130 E-value 17.6718
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Predicted (SEA)	Prediction Confidence Score 0.522 Applicability Domain 1.0 Statistical Significance 0.0019 Supporting Reference Compounds 425 E-value 15.0249
Click to view 3D structure	Histamine H2 receptor	P25021	Humans	Predicted (SEA)	Prediction Confidence Score 0.521 Applicability Domain 1.0 Statistical Significance 3.70e-04 Supporting Reference Compounds 256 E-value 2.88042
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Known	Not Available
Click to view 3D structure	Alpha-1A adrenergic receptor	P35348	Humans	Known	Not Available
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Known	Not Available
Click to view 3D structure	Histamine H2 receptor	P25021	Humans	Known	Not Available
Click to view 3D structure	Histamine H4 receptor	Q9H3N8	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Known	Not Available
Click to view 3D structure	Solute carrier family 22 member 1	O15245	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DB01069

HMDB ID

HMDB0015202

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

DrugSyn.org

MSDS

Not Available

General References

Peters RJ Jr, Kelder SH, Markham CM, Yacoubian GS Jr, Peters LA, Ellis A: Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) onset and perceived addiction among urban Houstonian adolescents: an addiction trend in the city of lean. J Drug Educ. 2003;33(4):415-25. [PubMed: 15237866]

Promethazine (CED0003417)

Structure for CHEM003520: Promethazine

Structure