Diclofenac (CED0001514)

Diclofenac belongs to the halobenzenes, a subclass of benzene and substituted derivatives within the organic compounds. This exogenous compound has the formula C14H11Cl2NO2 and an average molecular weight of 296.15 g/mol. At room temperature, it exists as a solid. It functions as a drug (PMC8125292, PMC9888349), anti-inflammatory drug (PMC10390773), analgesic (PMC11124379, PMC12531790, PMC13074443, PMC5371579), and antioxidant (PMC9022185). Its recorded protein targets include Prostaglandin G/H synthase 1 (PTGS1), Prostaglandin G/H synthase 2 (PTGS2), Polyunsaturated fatty acid 5-lipoxygenase (ALOX5), Sodium channel protein type 4 subunit alpha (SCN4A), and four other proteins. Diclofenac is used for the treatment of pain (PMC10297473, PMC11859530, PMC12085248, PMC12841708, PMC7033978, PMC7470770, PMC8204944, PMC8956874, PMC9022185), inflammation (PMC10297473, PMC12085248, PMC12344651, PMC12841708, PMC13074443, PMC7033978, PMC8204944, PMC8956874, PMC9888349), fever (PMC13074443, PMC7470770, PMC8956874), arthritis (PMC7033978), gout (PMC7033978), rheumatoid arthritis (PMC10698095, PMC9899055), and osteoarthritis (PMC10698095). It has therapeutic effects on inflammation (PMC6539241), pain (PMC12684957), and neuropathic pain (PMC7609673), though it is associated with renal failure (PMC13089115) and stroke (PMC9392978). The compound is found in 38 recorded sources, including healthcare, pharmaceuticals, and veterinary products such as antiinflammatory agents and dermatological preparations; aquatic systems and sediments like seawater, groundwater, and freshwater; wastewater, sanitation, and biosolids; drinking water and water supply; household cleaning and consumer products; and electrical and electronic equipment. Recorded exposure routes include oral, intravenous, rectal, sublingual, transdermal, topical, cutaneous, inhalation, touch, and ophthalmic.