Fludarabine (CED0001965)

Record Information

Version

1.0

Creation Date

2014-09-11 05:14:03 UTC

Update Date

2026-08-18 00:11:58 UTC

SynCED ID

CED0001965

Secondary Accession Numbers

CHEM003693
T3D4736

Identification

Common Name

Fludarabine

Class

Small Molecule

Description

Fludarabine is an exogenous compound with the chemical formula C10H13FN5O7P and an average molecular weight of 365.21 g/mol. At room temperature, this substance exists as a solid. Fludarabine belongs to the purine ribonucleotides, a subclass of purine nucleotides within the organic compounds. It is a chemotherapy drug utilized in the treatment of hematological malignancies. The compound is found in or released from two recorded sources: antennas within electrical and electronic equipment and antineoplastic agents within healthcare, pharmaceuticals, and veterinary products. Recorded routes of exposure include oral and intravenous administration. Fludarabine acts upon four recorded protein targets, serving as an inhibitor of the DNA polymerase alpha catalytic subunit (POLA1), the ribonucleoside-diphosphate reductase large subunit (RRM1), deoxycytidine kinase (DCK), and adenosine deaminase (ADA).

Contaminant Type

Amine
Antineoplastic Agent
Drug
Ether
Human Neurotoxin
Organic Compound
Organofluoride
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Fluoro-ara AMP	ChEBI
2-Fluoroadenine arabinoside 5'-monophosphate	ChEBI
2F-Ara-AMP	ChEBI
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate	ChEBI
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)	ChEBI
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate	ChEBI
FAMP	ChEBI
Fludara	ChEBI
Fludarabine 5'-monophosphate	ChEBI
Fludarabine monophosphate	ChEBI
2-Fluoroadenine arabinoside 5'-monophosphoric acid	Generator
9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphate	Generator
9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid	Generator
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid	Generator
9-Β-arabinofuranosyl-2-fluoroadenine-5'-phosphate	Generator
9-Β-arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid	Generator
9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)	Generator
9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)	Generator
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)	Generator
9-Β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)	Generator
9-Β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)	Generator
9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate	Generator
9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid	Generator
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid	Generator
9-Β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate	Generator
9-Β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid	Generator
Fludarabine 5'-monophosphoric acid	Generator
Fludarabine monophosphoric acid	Generator
Fludarabine phosphate	HMDB
FaraAMP	HMDB
Beneflur	HMDB
9 beta-D-Arabinofuranosyl-2-fluoroadenine monophosphate	HMDB
F-Ara-AMP	HMDB
Fluoro-ara-AMP	HMDB
Fludarabine phosphoric acid	Generator

Chemical Formula

C₁₀H₁₃FN₅O₇P

Average Molecular Mass

365.212 g/mol

Monoisotopic Mass

365.054 g/mol

CAS Registry Number

75607-67-9

IUPAC Name

{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Traditional Name

fludarabine

SMILES

NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]3O)C2=NC(F)=N1

InChI Identifier

InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

InChI Key

GIUYCYHIANZCFB-FJFJXFQQSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside monophosphates

Alternative Parents

Substituents

Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Halopyrimidine
2-halopyrimidine
Monoalkyl phosphate
Imidolactam
Alkyl phosphate
Aryl fluoride
Aryl halide
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Phosphoric acid ester
Pyrimidine
Azole
Tetrahydrofuran
Heteroaromatic compound
Imidazole
Secondary alcohol
1,2-diol
Organoheterocyclic compound
Azacycle
Oxacycle
Organooxygen compound
Alcohol
Organic nitrogen compound
Organopnictogen compound
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Organohalogen compound
Primary amine
Amine
Organofluoride
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

organofluorine compound (CHEBI:63599 )
nucleoside analogue (CHEBI:63599 )
purine arabinonucleoside monophosphate (CHEBI:63599 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	260°C
Boiling Point	Not Available
Solubility	3.53 mg/ml

Predicted Properties

Property	Value	Source
Water Solubility	2.97 g/L	ALOGPS
logP	-2.5	ALOGPS
logP	-3.6	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	1.34	ChemAxon
pKa (Strongest Basic)	0.6	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	186.07 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	74.93 m³·mol⁻¹	ChemAxon
Polarizability	28.88 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0002-9623000000-df7fef014b7ed6f138ca	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-01vk-9412300000-a8e2be4c7ab19ccd3280	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0913000000-80f61b17aa4ad7d3fce9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0900000000-e0aa5e8a08f61ff3d3b7	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ue9-0900000000-0bba10c09fa50579ea86	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0i29-4409000000-1d1175238eed452b53c2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0fb9-8900000000-b0d8f9f14834a2ff1f97	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-9200000000-b33283ba6688bd6f3e24	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0gb9-0946000000-3a07161a0ba92c58de3b	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0900000000-aa1b46adc5cdd97f9294	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ue9-0900000000-19d5fbe69fb7f606a97a	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-2009000000-acf04284a548ec80568e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-9102000000-d93a2baa104d5742de76	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-9300000000-c74fcde8d9f9eae4249b	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
3796.0 Log mg/kg [2100:6700]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000358	Antineoplastic agents?Antineoplastic agents are a class of synthetic chemicals used primarily in the treatment of cancer.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	Not Available
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	Not Available
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	Not Available
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	Not Available
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	Not Available
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	Not Available
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	Not Available
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	Not Available
CEDs000667	Gaseous Fire Fighting?Gaseous fire fighting systems utilize synthetic chemicals, such as halocarbons and inert gases, to suppress fires through chemical and physical processes.	Fire suppression systems & agents	Not Available
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	Not Available
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	Not Available
CEDs000692	Silica Free Oxide Glass?Silica Free Oxide Glass is a type of glass that is produced using alternative materials to traditional silica-based formulations.	Building & Construction	Not Available
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	Not Available
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	Not Available
CEDs000732	Spectacle Cases?Spectacle cases can serve as a source of synthetic chemical contamination due to the materials used in their production, such as polycarbonate, PVC, and various plastics, which may leach harmful substances over time.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	Not Available
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	Not Available

Pathways

3 pathwaysPathway Source: PathBank

Fludarabine Action Pathway

Fludarabine Drug Metabolism

Fludarabine Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	P2Y purinoceptor 1	P47900	Humans	Predicted (SEA)	Prediction Confidence Score 0.661 Applicability Domain 0.732 Statistical Significance 1.10e-04 Supporting Reference Compounds 42 E-value 0.856341
Click to view 3D structure	P2Y purinoceptor 1	P49652	Meleagris gallopavo	Predicted (SEA)	Prediction Confidence Score 0.66 Applicability Domain 0.732 Statistical Significance 1.10e-04 Supporting Reference Compounds 19 E-value 0.856341
Click to view 3D structure	P2Y purinoceptor 2	P41231	Humans	Predicted (SEA)	Prediction Confidence Score 0.636 Applicability Domain 0.732 Statistical Significance 4.00e-04 Supporting Reference Compounds 44 E-value 3.11397
Click to view 3D structure	P2Y purinoceptor 1	P49651	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.632 Applicability Domain 0.646 Statistical Significance 5.00e-05 Supporting Reference Compounds 9 E-value 0.389246
Click to view 3D structure	Heat shock cognate 71 kDa protein	P19120	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.629 Applicability Domain 0.629 Statistical Significance 1.20e-04 Supporting Reference Compounds 1 E-value 0.934191
Click to view 3D structure	Sensor protein kinase WalK	Q9RDT3	Staphylococcus aureus	Predicted (SEA)	Prediction Confidence Score 0.629 Applicability Domain 0.629 Statistical Significance 1.20e-04 Supporting Reference Compounds 1 E-value 0.934191
Click to view 3D structure	P2X purinoceptor 3	P56373	Humans	Predicted (SEA)	Prediction Confidence Score 0.627 Applicability Domain 0.657 Statistical Significance 1.20e-04 Supporting Reference Compounds 51 E-value 0.934191
Click to view 3D structure	P2X purinoceptor 1	P51575	Humans	Predicted (SEA)	Prediction Confidence Score 0.621 Applicability Domain 0.636 Statistical Significance 1.30e-04 Supporting Reference Compounds 35 E-value 1.01204
Click to view 3D structure	P2Y purinoceptor 12	Q9EPX4	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.613 Applicability Domain 0.636 Statistical Significance 1.10e-04 Supporting Reference Compounds 11 E-value 0.856341
Click to view 3D structure	ADP-ribose glycohydrolase MACROD1	Q9BQ69	Humans	Predicted (SEA)	Prediction Confidence Score 0.609 Applicability Domain 0.609 Statistical Significance 1.10e-04 Supporting Reference Compounds 1 E-value 0.856341
Click to view 3D structure	ADP-ribose glycohydrolase MACROD2	A1Z1Q3	Humans	Predicted (SEA)	Prediction Confidence Score 0.609 Applicability Domain 0.609 Statistical Significance 1.10e-04 Supporting Reference Compounds 1 E-value 0.856341
Click to view 3D structure	P2Y purinoceptor 11	Q96G91	Humans	Predicted (SEA)	Prediction Confidence Score 0.608 Applicability Domain 0.656 Statistical Significance 1.20e-04 Supporting Reference Compounds 13 E-value 0.934191
Click to view 3D structure	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	P22413	Humans	Predicted (SEA)	Prediction Confidence Score 0.607 Applicability Domain 0.646 Statistical Significance 4.00e-05 Supporting Reference Compounds 29 E-value 0.311397
Click to view 3D structure	5-hydroxymethyl-dUMP N-hydrolase	O35820	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.569 Applicability Domain 0.569 Statistical Significance 2.00e-05 Supporting Reference Compounds 1 E-value 0.155698
Click to view 3D structure	GTP:AMP phosphotransferase AK3, mitochondrial	P29411	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.568 Applicability Domain 0.623 Statistical Significance 1.40e-04 Supporting Reference Compounds 2 E-value 1.08989
Click to view 3D structure	5'-nucleotidase	P21589	Humans	Predicted (SEA)	Prediction Confidence Score 0.563 Applicability Domain 0.683 Statistical Significance 4.00e-05 Supporting Reference Compounds 26 E-value 0.311397
Click to view 3D structure	S-adenosylmethionine synthase isoform type-2	P18298	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.559 Applicability Domain 0.559 Statistical Significance 1.40e-04 Supporting Reference Compounds 1 E-value 1.08989
Click to view 3D structure	P2X purinoceptor 4	Q99571	Humans	Predicted (SEA)	Prediction Confidence Score 0.556 Applicability Domain 0.636 Statistical Significance 1.20e-04 Supporting Reference Compounds 32 E-value 0.934191
Click to view 3D structure	P2X purinoceptor 2	P49653	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.555 Applicability Domain 0.636 Statistical Significance 1.70e-04 Supporting Reference Compounds 38 E-value 1.32344
Click to view 3D structure	2-5A-dependent ribonuclease	Q05921	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.552 Applicability Domain 0.631 Statistical Significance 9.00e-05 Supporting Reference Compounds 2 E-value 0.700643
Click to view 3D structure	Adenosine receptor A3	P0DMS8	Humans	Predicted (SEA)	Prediction Confidence Score 0.534 Applicability Domain 0.704 Statistical Significance 0.0028 Supporting Reference Compounds 391 E-value 21.4864
Click to view 3D structure	5'-nucleotidase	P21588	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.529 Applicability Domain 0.683 Statistical Significance 1.50e-04 Supporting Reference Compounds 21 E-value 1.16774
Click to view 3D structure	Adenosine receptor A1	P30542	Humans	Predicted (SEA)	Prediction Confidence Score 0.528 Applicability Domain 0.732 Statistical Significance 0.0023 Supporting Reference Compounds 302 E-value 18.1389
Click to view 3D structure	Adenylate kinase 2, mitochondrial	P29410	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.521 Applicability Domain 0.623 Statistical Significance 1.70e-04 Supporting Reference Compounds 3 E-value 1.32344
Click to view 3D structure	P2X purinoceptor 6	P51579	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.519 Applicability Domain 0.636 Statistical Significance 8.00e-05 Supporting Reference Compounds 5 E-value 0.622794
Click to view 3D structure	DNA polymerase alpha catalytic subunit	P09884	Humans	Known	Not Available
Click to view 3D structure	Ribonucleoside-diphosphate reductase large subunit	P23921	Humans	Known	Not Available
Click to view 3D structure	Deoxycytidine kinase	P27707	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DBSALT000425

HMDB ID

HMDB0015206

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

John G. Bauman, Randolph C. Wirsching, “Process for the preparation of fludarabine or fludarabine phosphate from guanosine.” U.S. Patent US5602246, issued January, 1992.

MSDS

Not Available

General References

Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, Hines J, Threatte GA, Larson RA, Cheson BD, Schiffer CA: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000 Dec 14;343(24):1750-7. [PubMed: 11114313]
Gonzalez H, Leblond V, Azar N, Sutton L, Gabarre J, Binet JL, Vernant JP, Dighiero G: Severe autoimmune hemolytic anemia in eight patients treated with fludarabine. Hematol Cell Ther. 1998 Jun;40(3):113-8. [PubMed: 9698219]
Tournilhac O, Cazin B, Lepretre S, Divine M, Maloum K, Delmer A, Grosbois B, Feugier P, Maloisel F, Villard F, Villemagne B, Bastit D, Belhadj K, Azar N, Michallet M, Manhes G, Travade P: Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1;103(1):363-5. Epub 2003 Sep 11. [PubMed: 12969985]

Fludarabine (CED0001965)

Structure for CHEM003693: Fludarabine

Structure