Amiodarone (CED0001622)

Amiodarone belongs to the carbonyl compounds, a subclass of organooxygen compounds within the organic compounds. With an average molecular weight of 645.31 g/mol, Amiodarone is a heavy molecule. This exogenous compound has the formula C25H29I2NO3 and exists as a solid at room temperature. It is used as a biological drug (PMC10042770). Recorded exposure routes for the compound include oral and intravenous administration. Amiodarone is found in 13 recorded sources, including food preservation, household cleaning and consumer products such as tobacco smoke filters and cigar cigarettes, and electrical and electronic equipment including antennas, electrodes, hybrid capacitors, and electric switches. It is also found in healthcare, pharmaceuticals, and veterinary products specifically within class i and iii antiarrhythmics. The compound acts as a downregulator for the Beta-1 adrenergic receptor (ADRB1), the Voltage-gated inwardly rectifying potassium channel KCNH2, the Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H), the Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2), and 18 other proteins, functioning as an agonist/antagonist and binder/inhibitor/inhibitor. In terms of health effects, Amiodarone is used as a treatment for ventricular tachycardia (PMC12396106) and atrial fibrillation (PMC5358124). However, it is associated with pulmonary fibrosis (PMC10042770) as well as hypothyroidism and hyperthyroidism (PMC9571437).