Testosterone Propionate (CED0003845)

Record Information

Version

1.0

Creation Date

2014-09-11 05:14:58 UTC

Update Date

2026-08-21 23:02:33 UTC

SynCED ID

CED0003845

Secondary Accession Numbers

CHEM003711
T3D4754

Identification

Common Name

Testosterone Propionate

Class

Small Molecule

Description

Testosterone Propionate (C22H32O3) is an exogenous organic compound with an average molecular weight of 344.49 g/mol. It exists as a solid at room temperature. Testosterone Propionate belongs to the steroid esters, a subclass of steroids and steroid derivatives within the organic compounds. This compound targets six recorded proteins, including the Androgen receptor (AR), Estrogen receptor (ESR1), Glucocorticoid receptor (NR3C1), and Muscarinic acetylcholine receptor M4 (CHRM4). It is associated with several health effects, including obesity (PMC12063626 , PMC4591525 ) and prostate cancer (PMC2072856 , PMC6523118 ). It is also linked to testicular cancer (PMC10965717 ) and an increase in polycystic ovary syndrome (PMC4591525 , PMC8281489 ). Conversely, it is associated with a decrease in hypospadias (PMC8530230 ) and cryptorchidism (PMC8530230 ). Blood levels of the compound are elevated in cases of obesity (increase) (PMC1332690 ) and polycystic ovary syndrome (increase) (PMC10893032 ). Testosterone Propionate is found in or released from 11 recorded sources. These include household cleaning and consumer products, such as soap detergents, perfumes within detergents and soaps, and non electric simulated smoking devices. It is also found in food, food processing and cookware, specifically in the preparation of wine or sparkling wine, the preparation of vinegar, and food preservation. Additionally, it is released from electrical and electronic equipment, including power cables, line transmission systems, electrodes, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials.

Contaminant Type

Drug
Ester
Ether
Metabolite
Organic Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Testex	Kegg
Testosterone propionic acid	Generator
Eifelfango brand OF testosterone propionate	HMDB
Virormone	HMDB
Agovirin	HMDB
Testosteron propionat eifelfango	HMDB
Ferring brand OF testosterone propionate	HMDB
Propionat eifelfango, testosteron	HMDB
Eifelfango, testosteron propionat	HMDB

Chemical Formula

C₂₂H₃₂O₃

Average Molecular Mass

344.488 g/mol

Monoisotopic Mass

344.235 g/mol

CAS Registry Number

57-85-2

IUPAC Name

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate

Traditional Name

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate

SMILES

[H][C@@]12CC[C@H](OC(=O)CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

InChI Identifier

InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

InChI Key

PDMMFKSKQVNJMI-BLQWBTBKSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroid esters. Steroid esters are compounds containing a steroid moiety which bears a carboxylic acid ester group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroid esters

Direct Parent

Steroid esters

Alternative Parents

Substituents

Steroid ester
Androgen-skeleton
Androstane-skeleton
3-oxosteroid
3-oxo-delta-4-steroid
Oxosteroid
Delta-4-steroid
Cyclohexenone
Ketone
Carboxylic acid ester
Cyclic ketone
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organooxygen compound
Carbonyl group
Organic oxide
Organic oxygen compound
Hydrocarbon derivative
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

steroid ester (CHEBI:9466 )
C19 steroids (androgens) and derivatives (C08158 )
C19 steroids (androgens) and derivatives (LMST02020076 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

carcinogenic agent (PMC9079236 )?A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
antagonist (PMC11217908 )?Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
androgen (PMC12024979 , PMC6610071 )?
steroid hormone (PMC7472741 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	120°C
Boiling Point	Not Available
Solubility	1.48 mg/L (at 25°C)

Predicted Properties

Property	Value	Source
Water Solubility	0.005 g/L	ALOGPS
logP	3.65	ALOGPS
logP	4.51	ChemAxon
logS	-4.8	ALOGPS
pKa (Strongest Acidic)	19.09	ChemAxon
pKa (Strongest Basic)	-4.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	43.37 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	98.21 m³·mol⁻¹	ChemAxon
Polarizability	40.45 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-00or-4395000000-e888bc1b6c2a4c99d301	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0a4j-9700000000-764405bfcba7c5fe17d4	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-052b-8900000000-4b2c3ab6d4ce48b53a23	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0002-0009000000-0b70d9f4dfe7d2b1882f	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-052b-8941000000-71e897f7bddbd3065fb6	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0a6s-9300000000-ae3c374d8e9e15f95613	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0a4j-9500000000-8e8b74c239d0be2293ab	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-052b-8900000000-3b051eb836dd8f828e7e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-052b-4069000000-515cef716c1456ad0ff1	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-6392000000-9fad427c5fd42708c35b	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4r-3590000000-8e5391da57f43fc2f8d0	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-1049000000-96980216f4e665c10566	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-4094000000-3757f1e13b7d134d9d32	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ab9-4090000000-94160172dab6424eaf2d	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00ds-0094000000-8c969c8df525e9804ec3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-044s-0962000000-2061e148bffa88e3c96e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-2910000000-d364cf854d78cc7d4e9f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00dl-9008000000-fde8ba8c4ed57693204c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00di-9001000000-02ee41375158c3c608c9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ab9-9061000000-82ba060dba23b610bd79	Not Available	View Spectrum
MS	MS Spectrum	splash10-0a4i-9800000000-8aff9c2cbe0b5c20d85a	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
2395.0 Log mg/kg [1300:4300]	Rat	LD50	oral	predicted	Not Available	Not Available
2.0 mg/day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.25 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.06 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.5 mg	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.5 mg	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.5 mg/kg-day	Mouse	LOEC	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.5 mg/kg-day	Mouse	NOEC	injection	experimental	Not Available	ECOTOX - EPA ORD
0.5 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.5 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.25 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
inflammation	Associated With?	Not Available	Not Available	PMC12036885
cancer	Associated With?	Not Available	Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. There are over 100 types of cancers affect humans. The risk of developing certain cancers can be reduced by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat and avoiding too much sunlight exposure. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy and targeted therapy. The majority of cancers, some 90–95% of cases, are due to genetic mutations from environmental and lifestyle factors. The remaining 5–10% are due to inherited genetics.	PMC4500939 , PMC12036885
Alzheimer's disease	Associated With?	Not Available	A neurodegenerative disease which causes neural atrophy, leading to dementia and memory loss.	PMC3090512
type 2 diabetes mellitus	Associated With?	Not Available	Not Available	PMC10871592
type 2 diabetes mellitus	Elevated in Blood In	Not Available	Not Available	PMC12016791
type 2 diabetes mellitus	Associated With?	increase	Not Available	PMC4591525 , PMC3527168
osteoporosis	Associated With?	Not Available	A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. (NCI CTCAE)	PMC7716604
polycystic ovary syndrome	Elevated in Blood In	increase	A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. (DO)	PMC10893032
polycystic ovary syndrome	Associated With?	increase	A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. (DO)	PMC4591525 , PMC8281489
polycystic ovary syndrome	Associated With?	Not Available	A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. (DO)	PMC4591525 , PMC5295269
polycystic ovary syndrome	Elevated in Blood In	Not Available	A syndrome characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. (DO)	PMC12841019 , PMC12185472
asthma	Associated With?	increase	A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has symptom recurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (DO)	PMC11418887
Prostate cancer	Associated With?	Not Available	A male reproductive organ cancer that is located in the prostate. (DO)	PMC2072856 , PMC6523118
Prostate cancer	Associated With?	increase	A male reproductive organ cancer that is located in the prostate. (DO)	PMC11481604 , PMC11418887
Prostate cancer	Elevated in Blood In	increase	A male reproductive organ cancer that is located in the prostate. (DO)	PMC7716604 , PMC10214012
chronic pain	Associated With?	inverse	A state in which pain lasts for several weeks or months and may increase in severity.	PMC9904225
obesity	Elevated in Blood In	increase	A disorder characterized by having a high amount of body fat. (NCI CTCAE)	PMC1332690
obesity	Associated With?	Not Available	A disorder characterized by having a high amount of body fat. (NCI CTCAE)	PMC12063626 , PMC4591525
obesity	Associated With?	increase	A disorder characterized by having a high amount of body fat. (NCI CTCAE)	PMC4591525
atherosclerosis	Associated With?	Not Available	A disorder involving build-up of fatty material and calcium deposition in the arterial wall. It results in partial or complete occlusion of the arterial lumen.	PMC12652398
male infertility	Associated With?	Not Available	Not Available	PMC6984740 , PMC7912982
testicular cancer	Associated With?	Not Available	A male reproductive system cancer that is located in the testicles. (DO)	PMC10965717
hypogonadism	Associated With?	decrease	A gonadal disease that is characterized by diminished functional activity of the gonads. (DO)	PMC12678750
neurodegenerative disease	Has Therapeutic Effect On	Not Available	A central nervous system disease that results in the progressive deterioration of function or structure of neurons. (DO)	PMC12038863
hyperandrogenism	Associated With?	Not Available	Not Available	PMC13113401 , PMC9071071
cryptorchidism	Associated With?	decrease	Not Available	PMC8530230
cryptorchidism	Associated With?	Not Available	Not Available	PMC5783658
periodontal disease	Associated With?	Not Available	A disorder in the gingival tissue around the teeth. (NCI CTCAE)	PMC5111072
hypospadias	Associated With?	decrease	Not Available	PMC8530230
hypospadias	Associated With?	Not Available	Not Available	PMC5783658 , PMC5928321
pre-eclampsia	Elevated in Blood In	increase	Not Available	PMC6144938
anovulation	Associated With?	increase	Not Available	PMC12656294
congenital adrenal hyperplasia	Associated With?	increase	Congenital Adrenal Hyperplasia (CAH) is a inherited metabolic disorder of steroid metabolism that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency. The most common cause of CAH is the absence of the enzyme 21-hydroxylase (coded by the CYP21A2 gene). Many individuals with CAH present with abnormally enlarged adrenal glands (hyperplastic adrenomegaly) that produce excessive amounts of androgens leading to abnormal sexual development in females affected with the disease. Females with severe or classic virilizing CAH due to 21-hydroxylase deficiency will most likely have ambiguous or atypical external genitalia. The most common form of CAH, 21 hydroxylase deficiency, affects approximately 1:10,000 to 1:15,000 people in the United States and Europe.	PMC1332676
congenital adrenal hyperplasia	Associated With?	Not Available	Congenital Adrenal Hyperplasia (CAH) is a inherited metabolic disorder of steroid metabolism that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency. The most common cause of CAH is the absence of the enzyme 21-hydroxylase (coded by the CYP21A2 gene). Many individuals with CAH present with abnormally enlarged adrenal glands (hyperplastic adrenomegaly) that produce excessive amounts of androgens leading to abnormal sexual development in females affected with the disease. Females with severe or classic virilizing CAH due to 21-hydroxylase deficiency will most likely have ambiguous or atypical external genitalia. The most common form of CAH, 21 hydroxylase deficiency, affects approximately 1:10,000 to 1:15,000 people in the United States and Europe.	PMC5303542
mood disorder	Associated With?	increase	Not Available	PMC12710442
Spermiation failure	Associated With?	Not Available	Not Available	PMC4252707
abdominal obesity-metabolic syndrome	Associated With?	increase	Not Available	PMC3005328
Oxidative Stress	Associated With?	Not Available	Not Available	PMC6854986
cardiovascular disorder	Associated With?	increase	Not Available	PMC4591525
Pregnancy Complications	Associated With?	Not Available	Not Available	PMC10384739
Carcinogenesis	Associated With?	increase	Not Available	PMC12949270
hyperinsulinism	Associated With?	increase	Not Available	PMC3527168
Neoplasm Metastasis	Associated With?	Not Available	Not Available	PMC12036885 , PMC11284039
testicular dysgenesis syndrome	Associated With?	Not Available	Not Available	PMC11054796
Immunosuppression Therapy	Associated With?	increase	Not Available	PMC13397028
testicular germ cell tumor	Associated With?	decrease	Not Available	PMC8530230
Premature pubarche	Associated With?	Not Available	Not Available	PMC4591525
Pelvic pain	Associated With?	inverse	Not Available	PMC9904225
Myocardial fibrosis	Associated With?	Not Available	Not Available	PMC12652398

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000525	Line Transmission Systems?Line Transmission Systems, commonly used for the distribution of electrical energy, can be a source of synthetic chemical contamination through the insulation materials and coatings utilized in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000529	Power Cables?Power cables are used to transmit electrical energy and are typically composed of conductive materials, insulation, and protective coatings.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000548	Preparation Of Vinegar?Vinegar is produced through the fermentation of ethanol by acetic acid bacteria, resulting in a solution that typically contains 4-8% acetic acid.	Food, food processing & cookware	PubChem
CEDs000549	Preparation Of Wine Or Sparkling Wine?The preparation of wine or sparkling wine involves various stages, including fermentation, aging, and bottling, which can introduce potential sources of synthetic chemical contamination.	Food, food processing & cookware	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000601	Lawn Mowers?Lawn mowers, particularly those powered by gasoline, can be a source of synthetic chemical contamination due to the combustion of fossil fuels and the use of engine oils.	Agriculture & land management	PubChem
CEDs000604	Pest Attractants?Pest attractants are synthetic chemicals designed to lure specific pests for monitoring or control purposes.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000643	Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000658	Touch Fasteners?Touch fasteners, commonly known as hook-and-loop fasteners, are composed of synthetic materials such as nylon or polyester.	Textiles, leather & furnishings	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000727	Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.	Paper, pulp & fiber products	PubChem
CEDs000732	Spectacle Cases?Spectacle cases can serve as a source of synthetic chemical contamination due to the materials used in their production, such as polycarbonate, PVC, and various plastics, which may leach harmful substances over time.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000741	Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.	Paper, pulp & fiber products	PubChem
CEDs000743	Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.	Wastewater, sanitation & biosolids	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs00745	Corn Oil	Agriculture & land management	PMC9945469
CEDs02845	Cosmetics	Personal care & cosmetics	PMC8399500
CEDs03009	Waste Water	Wastewater, sanitation & biosolids	PMC9343308
CEDs03030	Sewage Effluent	Wastewater, sanitation & biosolids	PMC3807508

Pathways

1 pathwayPathway Source: PathBank

Testosterone propionate Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Aldehyde dehydrogenase 1A1	P00352	Humans	Known	Not Available
Click to view 3D structure	Androgen receptor	P10275	Humans	Known	Not Available
Click to view 3D structure	Androgen receptor	P15207	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.693 Applicability Domain 1.0 Statistical Significance 4.00e-05 Supporting Reference Compounds 73 E-value 0.311397
Click to view 3D structure	Androgen receptor	P10275	Humans	Predicted (SEA)	Prediction Confidence Score 0.652 Applicability Domain 1.0 Statistical Significance 8.00e-05 Supporting Reference Compounds 146 E-value 0.622794
Click to view 3D structure	Sex hormone-binding globulin	P04278	Humans	Predicted (SEA)	Prediction Confidence Score 0.598 Applicability Domain 0.642 Statistical Significance 4.00e-05 Supporting Reference Compounds 33 E-value 0.311397
Click to view 3D structure	Corticosteroid-binding globulin	P08185	Humans	Predicted (SEA)	Prediction Confidence Score 0.596 Applicability Domain 0.642 Statistical Significance 5.00e-05 Supporting Reference Compounds 21 E-value 0.389246
Click to view 3D structure	Androgen receptor	P19091	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.589 Applicability Domain 1.0 Statistical Significance 1.00e-05 Supporting Reference Compounds 19 E-value 0.0778492
Click to view 3D structure	Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	Humans	Predicted (SEA)	Prediction Confidence Score 0.572 Applicability Domain 1.0 Statistical Significance 8.00e-05 Supporting Reference Compounds 69 E-value 0.622794
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Predicted (SEA)	Prediction Confidence Score 0.566 Applicability Domain 0.642 Statistical Significance 3.60e-04 Supporting Reference Compounds 154 E-value 2.80257
Click to view 3D structure	Progesterone receptor	Q690N0	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.566 Applicability Domain 0.642 Statistical Significance 5.00e-05 Supporting Reference Compounds 40 E-value 0.389246
Click to view 3D structure	Mineralocorticoid receptor	P08235	Humans	Predicted (SEA)	Prediction Confidence Score 0.512 Applicability Domain 0.636 Statistical Significance 2.30e-04 Supporting Reference Compounds 74 E-value 1.79053
Click to view 3D structure	Progesterone receptor	P06401	Humans	Predicted (SEA)	Prediction Confidence Score 0.461 Applicability Domain 0.636 Statistical Significance 8.90e-04 Supporting Reference Compounds 119 E-value 6.92858
Click to view 3D structure	Actin, cytoplasmic 1	P60709	Humans	Known	Not Available
Click to view 3D structure	3-oxo-5-alpha-steroid 4-dehydrogenase 2	P31213	Humans	Predicted (SEA)	Prediction Confidence Score 0.457 Applicability Domain 0.586 Statistical Significance 2.30e-04 Supporting Reference Compounds 19 E-value 1.79053
Click to view 3D structure	Solute carrier family 22 member 3	O88446	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.454 Applicability Domain 0.632 Statistical Significance 4.00e-05 Supporting Reference Compounds 3 E-value 0.311397
Click to view 3D structure	3-oxo-5-alpha-steroid 4-dehydrogenase 1	P18405	Humans	Predicted (SEA)	Prediction Confidence Score 0.452 Applicability Domain 0.586 Statistical Significance 2.00e-04 Supporting Reference Compounds 14 E-value 1.55698
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	Prediction Confidence Score 0.45 Applicability Domain 0.642 Statistical Significance 0.0013 Supporting Reference Compounds 201 E-value 10.2761
Click to view 3D structure	Solute carrier organic anion transporter family member 1A1	P46720	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.446 Applicability Domain 0.642 Statistical Significance 1.00e-04 Supporting Reference Compounds 10 E-value 0.778492
Click to view 3D structure	Aromatase	P11511	Humans	Predicted (SEA)	Prediction Confidence Score 0.426 Applicability Domain 0.642 Statistical Significance 0.0011 Supporting Reference Compounds 127 E-value 8.64126
Click to view 3D structure	Solute carrier family 22 member 2	Q9R0W2	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.395 Applicability Domain 0.636 Statistical Significance 2.00e-05 Supporting Reference Compounds 14 E-value 0.155698
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.393 Applicability Domain 0.642 Statistical Significance 0.0132 Supporting Reference Compounds 562 E-value 102.45
Click to view 3D structure	G-protein coupled bile acid receptor 1	Q8TDU6	Humans	Predicted (SEA)	Prediction Confidence Score 0.388 Applicability Domain 0.636 Statistical Significance 0.0024 Supporting Reference Compounds 54 E-value 19.0731
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Predicted (SEA)	Prediction Confidence Score 0.37 Applicability Domain 0.642 Statistical Significance 0.0028 Supporting Reference Compounds 174 E-value 21.4864
Click to view 3D structure	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	P9WQP7	Mycobacterium tuberculosis	Predicted (SEA)	Prediction Confidence Score 0.37 Applicability Domain 0.37 Statistical Significance 2.70e-04 Supporting Reference Compounds 1 E-value 2.10193
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase type 2	P80365	Humans	Predicted (SEA)	Prediction Confidence Score 0.37 Applicability Domain 0.469 Statistical Significance 4.10e-04 Supporting Reference Compounds 32 E-value 3.19182
Click to view 3D structure	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	P14060	Humans	Predicted (SEA)	Prediction Confidence Score 0.367 Applicability Domain 0.387 Statistical Significance 2.20e-04 Supporting Reference Compounds 3 E-value 1.71268
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 3	O35627	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.366 Applicability Domain 0.5 Statistical Significance 3.00e-05 Supporting Reference Compounds 2 E-value 0.233548
Click to view 3D structure	C-8 sterol isomerase ERG2	P32352	Baker's yeast	Predicted (SEA)	Prediction Confidence Score 0.364 Applicability Domain 0.642 Statistical Significance 1.00e-04 Supporting Reference Compounds 20 E-value 0.778492
Click to view 3D structure	17-beta-hydroxysteroid dehydrogenase type 2	P37059	Humans	Known	Not Available
Click to view 3D structure	Peroxisomal multifunctional enzyme type 2	P51659	Humans	Known	Not Available
Click to view 3D structure	Aromatase	P11511	Humans	Known	Not Available
Click to view 3D structure	Androgen receptor	P10275	Humans	Known	Not Available
Click to view 3D structure	Estrogen receptor	P03372	Humans	Known	Not Available
Click to view 3D structure	Progesterone receptor	P06401	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Known	Not Available
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Known	Not Available
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Known	Not Available