Finasteride (CED0003253)

Record Information
Version1.0
Creation Date2014-09-11 05:18:00 UTC
Update Date2026-08-22 02:05:20 UTC
SynCED IDCED0003253
Secondary Accession Numbers
  • CHEM003777
  • T3D4820
Identification
Common NameFinasteride
ClassSmall Molecule
Description
Finasteride (C23H36N2O2) is an exogenous organic compound with an average molecular weight of 372.54 g/mol. It exists as a solid at room temperature. Finasteride belongs to the androstane steroids, a subclass of steroids and steroid derivatives within the organic compounds. It is recorded as being found in or released from 12 sources, including healthcare, pharmaceuticals and veterinary products such as drugs used in benign prostatic hypertrophy and dermatological preparations; household cleaning and consumer products including cigar cigarettes, non electric simulated smoking devices, and other smoking requisites; and electrical and electronic equipment such as amplifiers, antennas, auxiliary devices, line transmission systems, and electrically stimulated smoking devices. Exposure routes include topical and oral administration. The compound acts as an inhibitor of nine protein targets, including the androgen receptor (AR), peroxisome proliferator-activated receptor delta (PPARD), estrogen-related receptor gamma (ESRRG), and nuclear receptor ROR-beta (RORB). Finasteride is used as a treatment for alopecia (PMC11432267 ) and as a surgical alternative for the treatment of benign prostatic hyperplasia. Regarding oncology, it has a therapeutic effect on prostate cancer (PMC2935905 ) and is associated with a decrease in prostate cancer (PMC6497009 ). Additionally, the compound is associated with health effects including stroke (PMC11093553 ), myocardial infarction (PMC11093553 ), and thrombosis (PMC11093553 ).
Contaminant Type
  • 5-alpha Reductase Inhibitor
  • Amide
  • Amine
  • Drug
  • Ester
  • Food Toxin
  • Human Neurotoxin
  • Metabolite
  • Organic Compound
  • Skin and Mucous Membrane Agent
  • Synthetic Compound
Chemical Structure
Synonyms
ValueSource
(5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamideChEBI
FinasteridaChEBI
FinasteridumChEBI
PropeciaKegg
ProscarKegg
(5a,17b)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamideGenerator
(5Α,17β)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamideGenerator
Chibro-proscarHMDB
FinastidHMDB
FinpeciaHMDB
ProstideHMDB
Chibro proscarHMDB
EucoprostHMDB
Merck brand 1 OF finasterideHMDB
Merck brand 2 OF finasterideHMDB
Cahill may roberts brand OF finasterideHMDB
Lipha brand OF finasterideHMDB
Merck frosst brand 1 OF finasterideHMDB
Frosst iberica brand OF finasterideHMDB
MSD Chibropharm brand OF finasterideHMDB
Merck sharp and dohme brand 1 OF finasterideHMDB
PropeshiaHMDB
MSD Brand OF finasterideHMDB
Merck frosst brand 2 OF finasterideHMDB
Merck sharp and dhome brand 2 OF finasterideHMDB
Chemical FormulaC23H36N2O2
Average Molecular Mass372.544 g/mol
Monoisotopic Mass372.278 g/mol
CAS Registry Number98319-26-7
IUPAC Name(1S,2R,7R,10S,11S,14S,15S)-N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
Traditional Name(1S,2R,7R,10S,11S,14S,15S)-N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
SMILES[H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C
InChI IdentifierInChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
InChI KeyDBEPLOCGEIEOCV-WSBQPABSSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • 20-hydroxysteroid
  • Androgen-skeleton
  • 3-hydroxysteroid
  • Hydroxysteroid
  • 4-azasteroid
  • Azasteroid
  • Cyclic carboximidic acid
  • Carboximidic acid
  • Carboximidic acid derivative
  • Azacycle
  • Organoheterocyclic compound
  • Propargyl-type 1,3-dipolar organic compound
  • Organic 1,3-dipolar compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Extracellular
  • Membrane
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point252-254°C
Boiling PointNot Available
Solubility11.7 mg/L
Predicted Properties
PropertyValueSource
Water Solubility0.002 g/LALOGPS
logP3.53ALOGPS
logP3.07ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)14.53ChemAxon
pKa (Strongest Basic)0.33ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area58.2 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity108.2 m³·mol⁻¹ChemAxon
Polarizability43.96 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0a4i-1579000000-3a73a92e1d34b87c3e4cNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-5910000000-7dd7b7fbb29b6ae08f4cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0ab9-1319000000-9f18f09bea4e9168f1dfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-5900000000-3ad6a0d10c51f9892144Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0119000000-f683db304300c01e907aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0129000000-a097bfd2187d4d4c97c6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00xr-0119000000-43c6646bf19d62255966Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-01b9-2539000000-c47506144391db372c4bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-0900000000-a55cf309ee5a976c5e45Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aou-9400000000-e2d92afbb0c688a7c65fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0936000000-473b441c435f8a167da5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fr-0109000000-a6753fafb9b44a98b5eaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aor-9500000000-2323be14f82809784cbbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-5429921102770ed801ecNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-42255449abab8a1efb5bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-5f84c9991fe026c30104Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-832f340612f54390180cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-acfb1d6450dbdd3c37ceNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00di-0009000000-47e745329afb05408179Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0ab9-0219000000-040ec285d4c909fdf035Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0019000000-ef517ef831d75ea5a8d6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aor-9500000000-37e99d4fd1c40df1d5ccNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-0900000000-8f6e5a1b596a8bc1b9abNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0019000000-31f477b04660038200d9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-9712000000-fff84a210500c7b13651Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fr-2109000000-fac227e7925084bce47fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-5900000000-3ad6a0d10c51f9892144Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009000000-a6be7718311b4f11aad5Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0zmi-0439000000-e0a2fad4c18c6da72e1cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0uej-3790000000-df2f90aa3664e0df8776Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009000000-be3980c97e5b8f8767a6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-3029000000-5489b391a47dec8eb0f1Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00dl-9131000000-a1b8897126899f67f5fbNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0009000000-64191ce56bc0a12a6731Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0029000000-c3a45a5af2ba75c8d0daNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00dl-4092000000-b28fbb15865477750ec3Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-0029000000-e908d5239203640a66b4Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-4698000000-23a3432f63a0ed02934fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-06ry-0930000000-437bd94123d3ae75b6e1Not AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
276.0 Log mg/kg [160:490]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityThe mechanism of action of Finasteride is based on its preferential inhibition of Type II 5a-reductase through the formation of a stable complex with the enzyme. Inhibition of Type II 5a-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT concentrations, minimal to moderate increase in serum testosterone concentrations, and substantial increases in prostatic testosterone concetrations. As DHT appears to be the principal androgen responsible for stimulation of prostatic growth, a decrease in DHT concentrations will result in a decrease in prostatic volume (approximately 20-30% after 6-24 months of continued therapy). In men with androgenic alopecia, the mechanism of action has not been fully determined, but finasteride has shown to decrease scalp DHT concentration to the levels found in hairy scalp, reduce serum DHT, increase hair regrowth, and slow hair loss.
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
strokeAssociated With?Not AvailableNot AvailablePMC11093553
Prostate cancerHas Therapeutic Effect OnNot AvailableA male reproductive organ cancer that is located in the prostate. (DO)PMC2935905
Prostate cancerAssociated With?decreaseA male reproductive organ cancer that is located in the prostate. (DO)PMC6497009 , PMC12369773
Prostate cancerNot AvailableNot AvailableA male reproductive organ cancer that is located in the prostate. (DO)PMC12369773 , PMC12369773
myocardial infarctionAssociated With?Not AvailableA disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area. (NCI CTCAE)PMC11093553
AcneNot AvailableNot AvailableA disorder of the skin in which oil glands and hair glands become inflamed.PMC13254629
thrombosisAssociated With?Not AvailableA formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.PMC11093553 , PMC11093553
alopeciaNot AvailableNot AvailableA disorder characterized by the partial or complete lack of hair growth.PMC11432267 , PMC12502033
impotenceAssociated With?decreaseA disorder characterized by the inability in a man to achieve an erection or orgasm.PMC4876981
benign prostatic hyperplasiaNot AvailableNot AvailableNot AvailablePMC11093553 , PMC7502313
androgenic alopeciaNot AvailableNot AvailableNot AvailablePMC11093553 , PMC6559788
HirsutismNot AvailableNot AvailableNot AvailablePMC13254629
Exposure Sources
Source IDSourceSectorReference
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementPubChem
CEDs000233Brushes?Brushes used in personal care and cosmetics can be a source of synthetic chemical contamination due to the materials and coatings used in their manufacturing.Personal care & cosmeticsPubChem
CEDs000315Dermatological preparations?Dermatological preparations encompass a wide range of topical products, including creams, ointments, gels, and lotions, designed for the treatment of skin conditions.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000327Drugs used in benign prostatic hypertrophy?Drugs used in the treatment of benign prostatic hypertrophy (BPH) primarily include alpha-1 adrenergic antagonists and 5-alpha reductase inhibitors.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000505Amplifiers?Amplifiers, commonly used in various electronic devices to enhance signal strength, can be a source of synthetic chemical contamination due to the materials and processes involved in their production and disposal.Electrical & Electronic EquipmentPubChem
CEDs000506Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.Electrical & Electronic EquipmentPubChem
CEDs000507Auxiliary Devices?Auxiliary devices, such as capacitors, transformers, and circuit breakers, are integral components in various electronic systems.Electrical & Electronic EquipmentPubChem
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentPubChem
CEDs000518Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.Electrical & Electronic EquipmentPubChem
CEDs000525Line Transmission Systems?Line Transmission Systems, commonly used for the distribution of electrical energy, can be a source of synthetic chemical contamination through the insulation materials and coatings utilized in their construction.Electrical & Electronic EquipmentPubChem
CEDs000537Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.Electrical & Electronic EquipmentPubChem
CEDs000539Video Games?Video games, through their production and disposal processes, can be a source of synthetic chemical contamination.Electrical & Electronic EquipmentPubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000556Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.Household cleaning & consumer productsPubChem
CEDs000559Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.Household cleaning & consumer productsPubChem
CEDs000560Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsPubChem
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsPubChem
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingPubChem
CEDs000596Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.Agriculture & land managementPubChem
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementPubChem
CEDs000605Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.Agriculture & land managementPubChem
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementPubChem
CEDs000609Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.Personal care & cosmeticsPubChem
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsPubChem
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000612Body Washing Or Cleaning Implements?Body washing or cleaning implements, such as synthetic sponges, loofahs, and washcloths, can be sources of synthetic chemical contamination due to the materials used in their production.Personal care & cosmeticsPubChem
CEDs000613Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.Personal care & cosmeticsPubChem
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsPubChem
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsPubChem
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsPubChem
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsPubChem
CEDs000643Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.Textiles, leather & furnishingsPubChem
CEDs000650Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.Textiles, leather & furnishingsPubChem
CEDs000662Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.Textiles, leather & furnishingsPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000688Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.Building & ConstructionPubChem
CEDs000693Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.Building & ConstructionPubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000727Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.Paper, pulp & fiber productsPubChem
CEDs000732Spectacle Cases?Spectacle cases can serve as a source of synthetic chemical contamination due to the materials used in their production, such as polycarbonate, PVC, and various plastics, which may leach harmful substances over time.Healthcare, pharmaceuticals & veterinary productsPubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000741Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.Paper, pulp & fiber productsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
2 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
3-oxo-5-alpha-steroid 4-dehydrogenase 2 structureClick to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 2P31213HumansPredicted (SEA)
Prediction Confidence Score
0.71
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
19
E-value
0.0778492
Click to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 1P18405HumansPredicted (SEA)
Prediction Confidence Score
0.71
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
14
E-value
0.0778492
Click to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 1P24008Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.537
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
9
E-value
0.0778492
Click to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 2P31214Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.457
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
7
E-value
0.0778492
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)
Prediction Confidence Score
0.399
Applicability Domain
1.0
Statistical Significance
0.018
Supporting Reference Compounds
1245
E-value
140.44
Click to view 3D structure3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1P14060HumansPredicted (SEA)
Prediction Confidence Score
0.369
Applicability Domain
0.413
Statistical Significance
2.20e-04
Supporting Reference Compounds
3
E-value
1.71268
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)
Prediction Confidence Score
0.363
Applicability Domain
1.0
Statistical Significance
0.0163
Supporting Reference Compounds
825
E-value
127.128
Gamma-aminobutyric acid type B receptor subunit 1 structureClick to view 3D structureGamma-aminobutyric acid type B receptor subunit 1Q9Z0U4Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.321
Applicability Domain
0.321
Statistical Significance
3.20e-04
Supporting Reference Compounds
1
E-value
2.49118
Sex hormone-binding globulin structureClick to view 3D structureSex hormone-binding globulinP04278HumansPredicted (SEA)
Prediction Confidence Score
0.32
Applicability Domain
0.353
Statistical Significance
0.0023
Supporting Reference Compounds
33
E-value
17.5939
Corticosteroid-binding globulin structureClick to view 3D structureCorticosteroid-binding globulinP08185HumansPredicted (SEA)
Prediction Confidence Score
0.32
Applicability Domain
0.353
Statistical Significance
0.002
Supporting Reference Compounds
21
E-value
15.5698
Androgen receptor structureClick to view 3D structureAndrogen receptorP15207Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.317
Applicability Domain
0.353
Statistical Significance
0.0032
Supporting Reference Compounds
73
E-value
25.1453
G-protein coupled bile acid receptor 1 structureClick to view 3D structureG-protein coupled bile acid receptor 1Q8TDU6HumansPredicted (SEA)
Prediction Confidence Score
0.317
Applicability Domain
0.369
Statistical Significance
0.0048
Supporting Reference Compounds
54
E-value
37.679
Androgen receptor structureClick to view 3D structureAndrogen receptorP19091Mus musculusPredicted (SEA)
Prediction Confidence Score
0.317
Applicability Domain
0.353
Statistical Significance
9.60e-04
Supporting Reference Compounds
19
E-value
7.47353
Androgen receptor structureClick to view 3D structureAndrogen receptorP10275HumansPredicted (SEA)
Prediction Confidence Score
0.308
Applicability Domain
0.353
Statistical Significance
0.0077
Supporting Reference Compounds
146
E-value
60.0218
Click to view 3D structureCytochrome P450 7B1O75881HumansPredicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.3
Statistical Significance
1.60e-04
Supporting Reference Compounds
1
E-value
1.24559
Glucocorticoid receptor structureClick to view 3D structureGlucocorticoid receptorP04150HumansPredicted (SEA)
Prediction Confidence Score
0.296
Applicability Domain
0.353
Statistical Significance
0.0067
Supporting Reference Compounds
154
E-value
52.3147
Mineralocorticoid receptor structureClick to view 3D structureMineralocorticoid receptorP08235HumansPredicted (SEA)
Prediction Confidence Score
0.293
Applicability Domain
0.353
Statistical Significance
0.0048
Supporting Reference Compounds
74
E-value
37.4455
Aldo-keto reductase family 1 member B10 structureClick to view 3D structureAldo-keto reductase family 1 member B10O60218HumansPredicted (SEA)
Prediction Confidence Score
0.292
Applicability Domain
0.369
Statistical Significance
0.0054
Supporting Reference Compounds
49
E-value
41.9607
Click to view 3D structureProgesterone receptorQ690N0Bos taurusPredicted (SEA)
Prediction Confidence Score
0.29
Applicability Domain
0.353
Statistical Significance
0.0024
Supporting Reference Compounds
40
E-value
18.5281
Estrogen receptor structureClick to view 3D structureEstrogen receptorP03372HumansPredicted (SEA)
Prediction Confidence Score
0.286
Applicability Domain
0.353
Statistical Significance
0.0174
Supporting Reference Compounds
201
E-value
135.302
Progesterone receptor structureClick to view 3D structureProgesterone receptorP06401HumansPredicted (SEA)
Prediction Confidence Score
0.278
Applicability Domain
0.353
Statistical Significance
0.0092
Supporting Reference Compounds
119
E-value
71.8548
Steroid 17-alpha-hydroxylase/17,20 lyase structureClick to view 3D structureSteroid 17-alpha-hydroxylase/17,20 lyaseP05093HumansPredicted (SEA)
Prediction Confidence Score
0.271
Applicability Domain
0.324
Statistical Significance
0.0045
Supporting Reference Compounds
69
E-value
34.9543
Click to view 3D structureSolute carrier family 22 member 3O88446Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.27
Applicability Domain
0.338
Statistical Significance
0.0013
Supporting Reference Compounds
3
E-value
10.1982
Click to view 3D structureSex hormone-binding globulinP08689Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.265
Applicability Domain
0.303
Statistical Significance
4.60e-04
Supporting Reference Compounds
2
E-value
3.58106
Click to view 3D structureCycloartenol-C-24-methyltransferaseQ9LM02Arabidopsis thalianaPredicted (SEA)
Prediction Confidence Score
0.26
Applicability Domain
0.26 Low confidence
Statistical Significance
4.00e-04
Supporting Reference Compounds
1
E-value
3.11397
3-oxo-5-alpha-steroid 4-dehydrogenase 2 structureClick to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 2P31213HumansKnownNot Available
Click to view 3D structure3-oxo-5-alpha-steroid 4-dehydrogenase 1P18405HumansKnownNot Available
Aldo-keto reductase family 1 member D1 structureClick to view 3D structureAldo-keto reductase family 1 member D1P51857HumansKnownNot Available
Estrogen-related receptor gamma structureClick to view 3D structureEstrogen-related receptor gammaP62508HumansKnownNot Available
Click to view 3D structureNuclear receptor ROR-betaQ92753HumansKnownNot Available
Androgen receptor structureClick to view 3D structureAndrogen receptorP10275HumansKnownNot Available
Peroxisome proliferator-activated receptor delta structureClick to view 3D structurePeroxisome proliferator-activated receptor deltaQ03181HumansKnownNot Available
Bile acid receptor structureClick to view 3D structureBile acid receptorQ96RI1HumansKnownNot Available
Concentrations
Not Available
External Links
DrugBank IDDB01216
HMDB IDHMDB0001984
FooDB IDFDB022782
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkFinasteride
Chemspider ID51714
ChEBI ID5062
PubChem Compound ID57363
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis Reference

Roman Davis, Alan Millar, “Method for preparing finasteride.” U.S. Patent US5670643, issued October, 1992.

MSDSLink
General References
  1. Suzuki R, Satoh H, Ohtani H, Hori S, Sawada Y: Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics. Drug Metab Pharmacokinet. 2010;25(2):208-13. [PubMed: 20460827]
  2. Smith AB, Carson CC: Finasteride in the treatment of patients with benign prostatic hyperplasia: a review. Ther Clin Risk Manag. 2009 Jun;5(3):535-45. Epub 2009 Jul 12. [PubMed: 19707263]
  3. Trueb RM: Pharmacologic interventions in aging hair. Clin Interv Aging. 2006;1(2):121-9. [PubMed: 18044109]
  4. Otberg N, Finner AM, Shapiro J: Androgenetic alopecia. Endocrinol Metab Clin North Am. 2007 Jun;36(2):379-98. [PubMed: 17543725]
  5. Lin AM, Small EJ: Prostate cancer update: 2006. Curr Opin Oncol. 2007 May;19(3):229-33. [PubMed: 17414641]
  6. Dunn BK, Ford LG: Hormonal interventions to prevent hormonal cancers: breast and prostate cancers. Eur J Cancer Prev. 2007 Jun;16(3):232-42. [PubMed: 17415094]
  7. Thorpe JF, Jain S, Marczylo TH, Gescher AJ, Steward WP, Mellon JK: A review of phase III clinical trials of prostate cancer chemoprevention. Ann R Coll Surg Engl. 2007 Apr;89(3):207-11. [PubMed: 17394699]