Hydrazine, 1,2-dimethyl- (CHEM004254)

Record Information
Version1.0
Creation Date2016-05-19 01:38:59 UTC
Update Date2026-08-22 09:59:42 UTC
Accession NumberCHEM004254
Identification
Common NameHydrazine, 1,2-dimethyl-
ClassSmall Molecule
Description
A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Contaminant Sources
  • Clean Air Act Chemicals
  • IARC Carcinogens Group 2A
Contaminant Type
  • Human Neurotoxin
Chemical Structure
MOLSDF3D SDFPDBSMILESInChI View 3D Structure
Synonyms
ValueSource
(CH3NH)2ChEBI
(MeNH)2ChEBI
1,2-DimethylhydrazinChEBI
1,2-DMHChEBI
DMHChEBI
HydrazomethaneChEBI
MeNHNHMeChEBI
N,N'-dimethylhydrazineChEBI
SDMHChEBI
Sym-dimethylhydrazineChEBI
Symmetrical-dimethylhydrazineChEBI
1,2 DimethylhydrazineHMDB
1,2-Dimethyl-hydrazineHMDB
N,N' dimethylhydrazineHMDB
1,2 Dimethyl hydrazineHMDB
Sym dimethylhydrazineHMDB
Chemical FormulaC2H8N2
Average Molecular Mass60.100 g/mol
Monoisotopic Mass60.069 g/mol
CAS Registry Number540-73-8
IUPAC Name1,2-dimethylhydrazine
Traditional Name1,2-dimethylhydrazine
SMILESCNNC
InChI IdentifierInChI=1S/C2H8N2/c1-3-4-2/h3-4H,1-2H3
InChI KeyDIIIISSCIXVANO-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alkylhydrazines. These are organonitrogen compounds that containing a hydrazine group to which an alkyl group is attached.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassHydrazines and derivatives
Direct ParentAlkylhydrazines
Alternative Parents
Substituents
  • Alkylhydrazine
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility422 g/LALOGPS
logP-1.1ALOGPS
logP-0.59ChemAxon
logS0.85ALOGPS
pKa (Strongest Basic)6.08ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area24.06 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity39.22 m³·mol⁻¹ChemAxon
Polarizability7.14 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDHMDB0244081
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia Link1,2-dimethylhydrazine
Chemspider ID1282
ChEBI ID73755
PubChem Compound ID1322
Kegg Compound IDC19176
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=21193881
2. Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26.