ETHYLENE GLYCOL MONOBUTYL ETHER (CED0014314)

Record Information
Version1.0
Creation Date2016-05-19 02:04:06 UTC
Update Date2026-08-23 07:26:13 UTC
Accession NumberCHEM005588
Identification
Common NameETHYLENE GLYCOL MONOBUTYL ETHER
ClassSmall Molecule
Description
ETHYLENE GLYCOL MONOBUTYL ETHER (C6H14O2) is a compound with an average molecular weight of 118.17 g/mol. ETHYLENE GLYCOL MONOBUTYL ETHER belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. In industrial applications, this compound serves as a solvent (PMC10568719, PMC7299911), cleaning agent, and solubility enhancer. It is further utilized as a surfactant (surface active agent), viscosity modifier, and dispersing agent. Other industrial roles include use as a deodorizer, dye, pharmaceutical, UV stabilizer, plasticizer, film former, fragrance, flow promoter, and chemical reaction regulator. It is also employed as a flavouring and nutrient, a degradant/impurity, and as processing aids not otherwise specified. The compound is found in or released from 42 recorded sources. These include electrical and electronic equipment such as antennas, coils, adjustable resistors, auxiliary devices, and communication cables or conductors, among 19 others. Within household cleaning and consumer products, it appears in bleaching agents, soap detergents, perfumes within detergents and soaps, cigar cigarettes, and pipe accessories. In the realm of food, food processing, and cookware, it is associated with food preservation, food contact materials, processing meats, fermentation processes for beer, and the treatment of hops. Additional sources include household items like watch chains, drinking water and water supply, and building and construction materials such as floors, ceilings, ladders, fencing, and tents or canopies. Recorded exposure routes for the compound include touch, oral, and inhalation. Regarding health effects, ETHYLENE GLYCOL MONOBUTYL ETHER is associated with liver cancer (PMC5036686).
Contaminant TypeNot Available
Chemical Structure
Synonyms
ValueSource
2-Hydroxyethyl N-butyl etherChEBI
3-Oxa-1-heptanolChEBI
BuOCH2ch2ohChEBI
ButoxyethanolChEBI
Butyl cellosolveChEBI
Butyl glycolChEBI
Butyl oxitolChEBI
Ethylene glycol butyl etherChEBI
Ethylene glycol mono-N-butyl etherChEBI
Ethylene glycol monobutyl etherChEBI
Glycol butyl etherChEBI
N-ButoxyethanolChEBI
O-Butyl ethylene glycolChEBI
2-Butossi-etanoloHMDB
2-Butoxy ethanolHMDB
2-BUTOXY ethanol (ethylene glycol monobutyl ether)HMDB
2-Butoxy-1-ethanolHMDB
2-Butoxy-aethanolHMDB
2-Butoxy-ethanolHMDB
2-Butoxyethan-1-olHMDB
2-Butoxyethanol (butyl cellosolve)HMDB
2-Butoxyethanol (ethylene glycol monobutyl ether)HMDB
2-N-Butoxy-1-ethanolHMDB
2-N-ButoxyethanolHMDB
beta-ButoxyethanolHMDB
BUCSHMDB
Butoksyetylowy alkoholHMDB
ButyglycolHMDB
Butyl 2-hydroxyethyl etherHMDB
Butyl cellu-solHMDB
Butyl icinolHMDB
Butyl monoether glycolHMDB
ButylcellosolveHMDB
ButylcelosolvHMDB
ButylglycolHMDB
ButyloxitolHMDB
Chimec NRHMDB
Dowanol ebHMDB
Eb solventHMDB
EGBEHMDB
EgmbeHMDB
Ek tasolve eb solventHMDB
Ektasolve ebHMDB
Ektasolve eb solventHMDB
Eter monobutilico del etilenglicolHMDB
Ether alcoholHMDB
Ether monobutylique de l'ethyleneglycolHMDB
Ethylene glycol mono butyl etherHMDB
Ethylene glycol monobutyl ether (egbe)(2-butoxyet)HMDB
Ethylene glycol N-butyl etherHMDB
Ethylene glycol, monobutyl etherHMDB
Ethyleneglycol monobutyl etherHMDB
g Lycol ether ebHMDB
Gafcol ebHMDB
Glycol ether ebHMDB
Glycol ether eb acetateHMDB
Glycol monobutyl etherHMDB
Jeffersol ebHMDB
Minex BDHHMDB
Monobutyl ether OF ethylene glycolHMDB
Monobutyl ethylene glycol etherHMDB
Monobutyl glycol etherHMDB
N-Butoxyethanol sodium saltHMDB
N-Butyl cellosolveHMDB
Poly-solv ebHMDB
Chemical FormulaC6H14O2
Average Molecular Mass118.174 g/mol
Monoisotopic Mass118.099 g/mol
CAS Registry Number111-76-2
IUPAC Name2-butoxyethan-1-ol
Traditional Namebutoxyethanol
SMILESCCCCOCCO
InChI IdentifierInChI=1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3
InChI KeyPOAOYUHQDCAZBD-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dialkyl ethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are alkyl groups.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassEthers
Direct ParentDialkyl ethers
Alternative Parents
Substituents
  • Dialkyl ether
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility76.5 g/LALOGPS
logP0.78ALOGPS
logP0.76ChemAxon
logS-0.19ALOGPS
pKa (Strongest Acidic)15.12ChemAxon
pKa (Strongest Basic)-2.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity33.18 m³·mol⁻¹ChemAxon
Polarizability14.37 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
GC-MSGC-MS Spectrumsplash10-0a4i-9000000000-b90ed32396f13e81b974Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-014i-0900000000-cce152f1d2586d1d2b15Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0a4i-9000000000-5b26a54363815eed68aaNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0a4i-9000000000-b90ed32396f13e81b974Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-014i-0900000000-cce152f1d2586d1d2b15Not AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0a4i-9000000000-5b26a54363815eed68aaNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-055e-9000000000-4bc4c78979feb7a936fdNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0g70-9400000000-b1cfb4a2c8a4a3cd0444Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06r2-9100000000-9ca55ec0519f43dd019dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-06r2-9000000000-857dde35ae681bda3d78Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052b-9000000000-acfb670e155b8a68b222Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052b-9000000000-0df2eaac5c037254ca71Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9000000000-ae23aebac426b1197643Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9000000000-b330ce860102fa3dad94Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9000000000-96294c5d422b9ed294d9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9000000000-8f85841d89776b712641Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0005-9000000000-27894f73f5639e7aca3cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-9000000000-519af6bd841092769c10Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0005-9000000000-e9b3c41bd7491284a99bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0005-9000000000-f9118f238deda1ca2d0dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0005-9000000000-0a0d39e0f11d58fcdd39Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000e-9000000000-01750c846375d7a2fd9fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000m-9000000000-8882e145f0e838ca056eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-3900000000-7e5510dd6a2109cef737Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-9300000000-243c5694676c56febadaNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-9000000000-599a38b76a51e584e4feNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-4900000000-6ab24f579d778a4b37eeNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-9400000000-546a6675ceaed44aa642Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0006-9000000000-178f016dcc4e654a65c5Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-9200000000-89ce4eae9d67a431b7cfNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0600-9200000000-b5f9f7dbea4d41cbd8ddNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4l-9000000000-7fefeb01f6629d79f190Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-9000000000-ef6d91db183f65996c39Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-9000000000-519c2e8e3e8728833c21Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-052f-9000000000-4fe5e419426db994313aNot AvailableView Spectrum
1D NMR1H NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
1D NMR13C NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
2558.0Log mg/kg[1400:4500]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
liver cancerassociated_withNot AvailablePMC5036686
Exposure Sources
Source IDSourceSectorReference
10InsecticidesAgriculture & land managementNot Available
115Drinking waterDrinking water & water supplyNot Available
233BrushesPersonal care & cosmeticsNot Available
490Personal care & cosmeticsNot Available
494Food contact materialsFood, food processing & cookwareNot Available
495CeilingsBuilding & ConstructionNot Available
496FencingBuilding & ConstructionNot Available
497FloorsBuilding & ConstructionNot Available
498LaddersBuilding & ConstructionNot Available
503Tents Or CanopiesBuilding & ConstructionNot Available
504Adjustable ResistorsElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
507Auxiliary DevicesElectrical & Electronic EquipmentNot Available
508CoilsElectrical & Electronic EquipmentNot Available
510Communication Cables Or ConductorsElectrical & Electronic EquipmentNot Available
511Conductors Or Conductive Bodies Characterised By The Conductive MaterialsElectrical & Electronic EquipmentNot Available
513Cores Yokes Or ArmaturesElectrical & Electronic EquipmentNot Available
514Discharge LampsElectrical & Electronic EquipmentNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
517Electric SwitchesElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
519ElectrodesElectrical & Electronic EquipmentNot Available
520Emergency Protective DevicesElectrical & Electronic EquipmentNot Available
521Fixed Capacitors And Their ManufactureElectrical & Electronic EquipmentNot Available
523Gas Filled Discharge Tubes With Solid CathodeElectrical & Electronic EquipmentNot Available
524Hybrid CapacitorsElectrical & Electronic EquipmentNot Available
527MagnetsElectrical & Electronic EquipmentNot Available
529Power CablesElectrical & Electronic EquipmentNot Available
530Radio Transmission SystemsElectrical & Electronic EquipmentNot Available
531RelaysElectrical & Electronic EquipmentNot Available
535Superconducting Magnets And Superconducting CoilsElectrical & Electronic EquipmentNot Available
536Superconductive Or Hyperconductive Conductors Cables Or Transmission LinesElectrical & Electronic EquipmentNot Available
538Thin Magnetic FilmsElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
544Fermentation Processes For BeerFood, food processing & cookwareNot Available
545Food PreservationFood, food processing & cookwareNot Available
552Processing MeatsFood, food processing & cookwareNot Available
553Treatment Of HopsFood, food processing & cookwareNot Available
555Bleaching AgentsHousehold cleaning & consumer productsNot Available
556Cigar CigarettesHousehold cleaning & consumer productsNot Available
561Perfumes Within Detergents And SoapsHousehold cleaning & consumer productsNot Available
562Pipe AccessoriesHousehold cleaning & consumer productsNot Available
563Soap DetergentsHousehold cleaning & consumer productsNot Available
569Tobacco Smoke FiltersHousehold cleaning & consumer productsNot Available
577Watch ChainsHousehold itemsNot Available
579Manufacture Of Iron Or SteelIndustrial manufacturing & chemical processingNot Available
580Manufacture Preparation Of Tobacco ProductsIndustrial manufacturing & chemical processingNot Available
581Paper Making MachinesIndustrial manufacturing & chemical processingNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
596AcaricidesAgriculture & land managementNot Available
600Herbicides And AlgicidesAgriculture & land managementNot Available
603NematocidesAgriculture & land managementNot Available
604Pest AttractantsAgriculture & land managementNot Available
605Pest RepellantsAgriculture & land managementNot Available
606Plant Growth RegulatorsAgriculture & land managementNot Available
607Rodenticides(1)Agriculture & land managementNot Available
608RodenticidesAgriculture & land managementNot Available
609AftershavePersonal care & cosmeticsNot Available
610Aftersun ProductsPersonal care & cosmeticsNot Available
611Anti Perspirants Or Body DeoderantsPersonal care & cosmeticsNot Available
612Body Washing Or Cleaning ImplementsPersonal care & cosmeticsNot Available
613DepilatoriesPersonal care & cosmeticsNot Available
614Essential Oils Or PerfumesPersonal care & cosmeticsNot Available
615Eye Makeup ProductsPersonal care & cosmeticsNot Available
617Lip Care ProductsPersonal care & cosmeticsNot Available
618Lip Makeup ProductsPersonal care & cosmeticsNot Available
619Manicure PedicurePersonal care & cosmeticsNot Available
630ToysRecreation & sports surfacesNot Available
631Anthraquinone DyesTextiles, leather & furnishingsNot Available
632ApparelTextiles, leather & furnishingsNot Available
633Azo DyesTextiles, leather & furnishingsNot Available
635ButtonsTextiles, leather & furnishingsNot Available
638Decorating TextilesTextiles, leather & furnishingsNot Available
639Degreasing LeatherTextiles, leather & furnishingsNot Available
641Foam DyeingTextiles, leather & furnishingsNot Available
642FootwearTextiles, leather & furnishingsNot Available
643HeadwearTextiles, leather & furnishingsNot Available
645Inorganic FibresTextiles, leather & furnishingsNot Available
648Nitro DyesTextiles, leather & furnishingsNot Available
652RopesTextiles, leather & furnishingsNot Available
655Slide FastenersTextiles, leather & furnishingsNot Available
657Surface Finishing Of LeatherTextiles, leather & furnishingsNot Available
659Transfer PrintingTextiles, leather & furnishingsNot Available
661UmbrellasTextiles, leather & furnishingsNot Available
662Yarns Or ThreadsTextiles, leather & furnishingsNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureCeramide glucosyltransferaseO88693Mus musculusPredicted (SEA)1.55698
Click to view 3D structureSodium- and chloride-dependent creatine transporter 1P28570Rattus norvegicusPredicted (SEA)0.389246
Click to view 3D structureNon-lysosomal glucosylceramidaseQ9HCG7HumansPredicted (SEA)2.88042
Click to view 3D structureSucrase-isomaltaseB5THE3Mus musculusPredicted (SEA)1.86838
Click to view 3D structureAcylcarnitine hydrolaseQ91WG0Mus musculusPredicted (SEA)2.10193
UDP-3-O-acyl-N-acetylglucosamine deacetylase structureClick to view 3D structureUDP-3-O-acyl-N-acetylglucosamine deacetylaseO67648Aquifex aeolicus (strain VF5)Predicted (SEA)50.7577
Click to view 3D structureLysosomal alpha-glucosidaseP70699Mus musculusPredicted (SEA)2.95827
Lysosomal acid glucosylceramidase structureClick to view 3D structureLysosomal acid glucosylceramidaseP04062HumansPredicted (SEA)6.22794
Click to view 3D structureCocaine esteraseO00748HumansPredicted (SEA)17.4382
Click to view 3D structurePutative inactive group IIC secretory phospholipase A2Q5R387HumansPredicted (SEA)7.62922
Click to view 3D structureLiver carboxylesteraseQ29550Sus scrofaPredicted (SEA)8.56341
Click to view 3D structureTransient receptor potential cation channel subfamily V member 2Q9WUD2Rattus norvegicusPredicted (SEA)30.5947
Click to view 3D structureFatty-acid amide hydrolase 1P97612Rattus norvegicusPredicted (SEA)238.374
Click to view 3D structureCG8425-PA [Drosophila melanogaster]A1ZA98Drosophila melanogasterPredicted (SEA)4.35956
Click to view 3D structureCannabinoid receptor 1P20272Rattus norvegicusPredicted (SEA)163.717
Click to view 3D structureNon-lysosomal glucosylceramidaseQ69ZF3Mus musculusPredicted (SEA)3.34752
Lysophosphatidic acid receptor 2 structureClick to view 3D structureLysophosphatidic acid receptor 2Q9HBW0HumansPredicted (SEA)22.4206
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)3025.38
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)2913.82
Click to view 3D structureLysophosphatidic acid receptor 3Q9UBY5HumansPredicted (SEA)40.0145
Click to view 3D structureJuvenile hormone esteraseQ9GPG0Manduca sextaPredicted (SEA)8.71911
Peroxisome proliferator-activated receptor alpha structureClick to view 3D structurePeroxisome proliferator-activated receptor alphaQ07869HumansPredicted (SEA)653.155
Click to view 3D structure1-deoxy-D-xylulose-5-phosphate synthaseB7UJP3Escherichia coli O127:H6 (strain E2348/69 / EPEC)Predicted (SEA)2.17978
Liver carboxylesterase 1 structureClick to view 3D structureLiver carboxylesterase 1P23141HumansPredicted (SEA)111.714
Click to view 3D structureFatty-acid amide hydrolase 1O00519HumansPredicted (SEA)714.111
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDHMDB0031327
FooDB IDFDB003389
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia Link2-Butoxyethanol
Chemspider ID13836399
ChEBI ID63921
PubChem Compound ID8133
Kegg Compound IDC19355
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=15371241
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=15705494
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=22330932
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=9372852
5. Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.