sodium hexafluorosilicate (CED0013302)

Record Information

Version

1.0

Creation Date

2016-05-19 03:24:23 UTC

Update Date

2026-04-17 15:41:54 UTC

SynCED ID

CED0013302

Secondary Accession Numbers

CHEM010562

Identification

Common Name

sodium hexafluorosilicate

Class

Small Molecule

Description

Sodium hexafluorosilicate is an inorganic compound with the chemical formula F6Na2Si and an average molecular weight of 188.06 g/mol. It is classified as a mixed metal/non-metal compound. Sodium hexafluorosilicate belongs to the alkali metal fluorides, a subclass of alkali metal salts within the inorganic compounds. In industrial contexts, the compound serves several roles and uses. It is employed as an abrasive and as an anti-scaling agent. Additionally, it is used for pharmaceutical purposes and is identified as a degradant or impurity.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Hexafluorosilicate, ammonium salt	MeSH
Hexafluorosilicate, sodium salt	MeSH
Hexafluorosilicate	MeSH
Hexafluorosilicate, magnesium salt	MeSH
Sodium hexafluorosilicate	MeSH
Hexafluorosilicate (2-)	MeSH
Hexafluorosilicate, barium salt	MeSH
Hexafluorosilicate, magnesium salt, hydrate	MeSH
Sodium fluorosilicate	MeSH
Ammonium hexafluorosilicate	MeSH
Cesium hexafluosilicate	MeSH
Hexafluorosilicate, potassium salt	MeSH
Hexafluorosilicate, calcium salt	MeSH
Magnesium hexafluorosilicate	MeSH
Magnesium fluorosilicate	MeSH
Sodium hexafluorosilicic acid	Generator
Sodium fluosilicate	MeSH
Na(2)sif(6)	MeSH

Chemical Formula

F₆Na₂Si

Average Molecular Mass

188.055 g/mol

Monoisotopic Mass

187.947 g/mol

CAS Registry Number

16893-85-9

IUPAC Name

disodium hexafluorosilanediuide

Traditional Name

disodium hexafluorosilanediuide

SMILES

[Na+].[Na+].F[Si--](F)(F)(F)(F)F

InChI Identifier

InChI=1S/F6Si.2Na/c1-7(2,3,4,5)6;;/q-2;2*+1

InChI Key

TWGUZEUZLCYTCG-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as alkali metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is an alkali metal.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Alkali metal salts

Sub Class

Alkali metal fluorides

Direct Parent

Alkali metal fluorides

Alternative Parents

Substituents

Alkali metal fluoride
Inorganic sodium salt
Inorganic salt
Inorganic metalloid salt

Molecular Framework

Not Available

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	9.01 m³·mol⁻¹	ChemAxon
Polarizability	5.9 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs02756	Phosphogypsum	Building & Construction	PMC11279332 , PMC10456710

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Carbonic anhydrase 9	Q16790	Humans	Predicted (SEA)	Prediction Confidence Score 0.067 Applicability Domain 0.111 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 372 E-value 7784.84
Click to view 3D structure	Carbonic anhydrase 2	P00918	Humans	Predicted (SEA)	Prediction Confidence Score 0.066 Applicability Domain 0.083 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 472 E-value 7784.77
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.066 Applicability Domain 0.111 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 407 E-value 7784.84
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.083 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 332 E-value 7784.69
Click to view 3D structure	Carbonic anhydrase 3	P07451	Humans	Predicted (SEA)	Prediction Confidence Score 0.062 Applicability Domain 0.083 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 64 E-value 7784.46
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	Prediction Confidence Score 0.058 Applicability Domain 0.095 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 201 E-value 7784.61
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Predicted (SEA)	Prediction Confidence Score 0.058 Applicability Domain 0.095 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 174 E-value 7784.61
Click to view 3D structure	Alanine--glyoxylate aminotransferase	P21549	Humans	Predicted (SEA)	Prediction Confidence Score 0.055 Applicability Domain 0.074 Low confidence Statistical Significance 0.9396 Supporting Reference Compounds 2 E-value 7314.4
Click to view 3D structure	Amine oxidase [flavin-containing] B	P27338	Humans	Predicted (SEA)	Prediction Confidence Score 0.055 Applicability Domain 0.061 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 315 E-value 7784.69
Click to view 3D structure	Carbonic anhydrase 7	P43166	Humans	Predicted (SEA)	Prediction Confidence Score 0.054 Applicability Domain 0.067 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 242 E-value 7784.61
Click to view 3D structure	Nuclear receptor ROR-gamma	P51449	Humans	Predicted (SEA)	Prediction Confidence Score 0.053 Applicability Domain 0.095 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 102 E-value 7784.46
Click to view 3D structure	Carbonic anhydrase 4	P22748	Humans	Predicted (SEA)	Prediction Confidence Score 0.053 Applicability Domain 0.067 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 193 E-value 7784.69
Click to view 3D structure	Carbonic anhydrase 5A, mitochondrial	P35218	Humans	Predicted (SEA)	Prediction Confidence Score 0.052 Applicability Domain 0.063 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 165 E-value 7784.69
Click to view 3D structure	Fatty-acid amide hydrolase 1	P97612	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.052 Applicability Domain 0.067 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 102 E-value 7784.53
Click to view 3D structure	Receptor-type tyrosine-protein phosphatase zeta	P23471	Humans	Predicted (SEA)	Prediction Confidence Score 0.051 Applicability Domain 0.065 Low confidence Statistical Significance 0.9391 Supporting Reference Compounds 2 E-value 7310.51
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.05 Applicability Domain 0.063 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 1245 E-value 7784.69
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P11507	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.05 Applicability Domain 0.05 Low confidence Statistical Significance 0.9241 Supporting Reference Compounds 1 E-value 7193.81
Click to view 3D structure	Carbonic anhydrase	Q2PCB5	Dicentrarchus labrax	Predicted (SEA)	Prediction Confidence Score 0.049 Applicability Domain 0.083 Low confidence Statistical Significance 0.9905 Supporting Reference Compounds 9 E-value 7710.81
Click to view 3D structure	Ribosomal protein S6 kinase alpha-3	P51812	Humans	Predicted (SEA)	Prediction Confidence Score 0.049 Applicability Domain 0.059 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 733 E-value 7784.69
Click to view 3D structure	Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	Humans	Predicted (SEA)	Prediction Confidence Score 0.049 Applicability Domain 0.061 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 52 E-value 7784.38
Click to view 3D structure	Carbonic anhydrase 5B, mitochondrial	Q9Y2D0	Humans	Predicted (SEA)	Prediction Confidence Score 0.048 Applicability Domain 0.063 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 157 E-value 7784.69
Click to view 3D structure	Amine oxidase [flavin-containing] A	P21397	Humans	Predicted (SEA)	Prediction Confidence Score 0.048 Applicability Domain 0.051 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 241 E-value 7784.61
Click to view 3D structure	Glycogen synthase kinase-3 beta	P49841	Humans	Predicted (SEA)	Prediction Confidence Score 0.048 Applicability Domain 0.053 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 1157 E-value 7784.69
Click to view 3D structure	Mitogen-activated protein kinase 14	Q16539	Humans	Predicted (SEA)	Prediction Confidence Score 0.048 Applicability Domain 0.054 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 668 E-value 7784.69
Click to view 3D structure	Serum paraoxonase/arylesterase 2	Q15165	Humans	Predicted (SEA)	Prediction Confidence Score 0.048 Applicability Domain 0.054 Low confidence Statistical Significance 0.9904 Supporting Reference Compounds 2 E-value 7710.19