Sulfamethoxazole (CED0001184)

Record Information
Version1.0
Creation Date2016-05-20 16:14:00 UTC
Update Date2026-08-17 22:34:40 UTC
Accession NumberCHEM016087
Identification
Common NameSulfamethoxazole
ClassSmall Molecule
Description
Sulfamethoxazole (C10H11N3O3S) is a compound with an average molecular weight of 253.28 g/mol. Sulfamethoxazole belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. It functions as an antagonist of the protein target dihydropteroate synthase (folP). In medical applications, it is used as a treatment for pneumonia (PMC10922816). The compound is found in or released from 30 recorded sources. These include healthcare, pharmaceuticals and veterinary products such as antibiotics, sulfonamides and trimethoprim, and drugs for the treatment of tuberculosis and gynecologicals. It is also associated with food, food processing and cookware, specifically the preparation of vinegar, food preservation, processing meats, and fermentation processes for beer. Other sources include household cleaning and consumer products like soap detergents, perfumes within detergents and soaps, tobacco smoke filters, and non-electric simulated smoking devices. Additionally, it is found in drinking water and water supply, roofs within building and construction, and electrical and electronic equipment, including antennas, amplifiers, auxiliary devices, discharge lamps, and conductors or conductive bodies characterised by the conductive materials. Recorded exposure routes for the compound include oral, intravenous, and inhalation.
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
3-(p-Aminophenylsulfonamido)-5-methylisoxazoleChEBI
3-Sulfanilamido-5-methylisoxazoleChEBI
4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamideChEBI
GantanolChEBI
SMXChEBI
SulphamethoxazoleChEBI
3-(p-Aminophenylsulphonamido)-5-methylisoxazoleGenerator
3-Sulphanilamido-5-methylisoxazoleGenerator
4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulphonamideGenerator
3-(p-Aminobenzenesulfonamido)-5-methylisoxazoleHMDB
3-(Para-aminophenylsulphonamido)-5-methylisoxazoleHMDB
4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamideHMDB
4-Amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamideHMDB
5-Methyl-3-sulfanilamidoisoxazoleHMDB
5-Methyl-3-sulfanylamidoisoxazoleHMDB
5-Methyl-3-sulfonylamidoisoxazoleHMDB
5-Methyl-3-sulphanil-amidoisoxazoleHMDB
Azo-gantanolHMDB
BactrimHMDB
MetoxalHMDB
N'-(5-methyl-3-isoxazole)sulfanilamideHMDB
N'-(5-methyl-3-isoxazolyl)-sulfanilamideHMDB
N'-(5-methyl-3-isoxazolyl)sulfanilamideHMDB
N'-(5-methylisoxazol-3-yl)sulphanilamideHMDB
N1-(5-Methyl-3-isoxazolyl)-sulfanilamideHMDB
N1-(5-Methyl-3-isoxazolyl)sulfanilamideHMDB
N1-(5-Methyl-3-isoxazolyl)sulphanilamideHMDB
Ndimethyl1-(5-methyl-3-isoxazolyl)-sulfanilamideHMDB
N^1-(5-methyl-3-isoxazolyl)-sulfanilamideHMDB
RadonilHMDB
SimsinominHMDB
SinominHMDB
SulfamethalazoleHMDB
SulfamethoxazolHMDB
Sulfamethoxazole(usan)HMDB
SulfamethylisoxazoleHMDB
SulfisomezoleHMDB
Sulpha-methoxizoleHMDB
SulphamethoxazolHMDB
SulphamethylisoxazoleHMDB
SulphisomezoleHMDB
Chemical FormulaC10H11N3O3S
Average Molecular Mass253.278 g/mol
Monoisotopic Mass253.052 g/mol
CAS Registry Number723-46-6
IUPAC Name4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
Traditional Namesulfamethoxazole
SMILESCC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
InChI IdentifierInChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
InChI KeyJLKIGFTWXXRPMT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Aminobenzenesulfonamide
  • Benzenesulfonyl group
  • Aniline or substituted anilines
  • Organosulfonic acid amide
  • Imidolactam
  • Azole
  • Isoxazole
  • Organic sulfonic acid or derivatives
  • Organosulfonic acid or derivatives
  • Sulfonyl
  • Aminosulfonyl compound
  • Heteroaromatic compound
  • Organoheterocyclic compound
  • Azacycle
  • Oxacycle
  • Organonitrogen compound
  • Organic nitrogen compound
  • Organic oxygen compound
  • Amine
  • Primary amine
  • Organosulfur compound
  • Organopnictogen compound
  • Organic oxide
  • Organooxygen compound
  • Hydrocarbon derivative
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.46 g/LALOGPS
logP0.79ALOGPS
logP0.79ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)6.16ChemAxon
pKa (Strongest Basic)1.97ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area98.22 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity64.5 m³·mol⁻¹ChemAxon
Polarizability24.99 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
GC-MSGC-MS Spectrumsplash10-05mo-8900000000-8a6ba1e89f89f5cb1e3cNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-05mo-8900000000-8a6ba1e89f89f5cb1e3cNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0005-9120000000-73aebd463dbf4176fb01Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2960000000-9e8c6c452dea7906eac4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4901000000-b25f2b64f82210ccef6fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0940000000-88c5b1ef2f503737ca9aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-b1b1b8e70ec8043bb89bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-f9d7f50685c7e96eefcdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-465bcb56920d86311f93Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0390000000-5dac2c73d05262cd10c0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-754d521e9fa8d49057e7Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-5dea192ddf68e39f5c6cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-5900000000-f376319dc72913e8db61Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-08fu-9300000000-275ed92901e4719e8eb0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-b02c397c2d2954785c81Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-c61eade368561111e908Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-c85d502fd299d3c8942cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-c8c24b18f27b59f6e693Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-c61eade368561111e908Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0910000000-64449078c4fdd8bf4614Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3900000000-58869a5ce23e7feeeedfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-9000000000-c388b00730b45caa4648Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3910000000-a82697559a690c6121eaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0910000000-44dbcbdfb3ce5df0ba57Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-181bb6cd1b54b2b6495cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052b-0900000000-ef143045595a430e870dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0900000000-c3682226c90f2e2715a0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0190000000-24d764d31dded89ff00fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052v-0900000000-2bfa4615b96e29115a6bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-64a7ff77c37052fd7340Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-2940000000-0ca0de185b8cef9d025bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-7fa1e7f1e8a16439e36bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-7900000000-8584244d965e9da53c66Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9500000000-00c6bdb3c2f34a8492b6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9400000000-914135419173af598f05Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-cf49e6fbc7d210f2db82Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-2940000000-cf1c49b6edd74e0db359Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-be7ef446a6f0292a0c15Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-7900000000-96c9b596ad5235d5e8fdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9600000000-c5bd253f35dc1f56f173Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9400000000-68dc3bc1422a652b6c43Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4v-0900000000-e147c7f66af9a39125b4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2970000000-6fea429d8717a3a0e019Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-6900000000-b134f68352446228a2deNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-9200000000-f766fcb18caedb6dc7b8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-6900000000-55bf55718dd534098430Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9500000000-6adbdcc86fd0c4aac92aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0900000000-e69bb2beedb2b53adcdaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0900000000-c7d050466aea7503baafNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1970000000-cbfc43ff8e81c2553da0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2960000000-9e8c6c452dea7906eac4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4901000000-b25f2b64f82210ccef6fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-4930000000-0673f294c7ef0fcc9fc5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2970000000-a5d25021f3fe2a2aaa29Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9300000000-b77ecf0e4ebc12e1258cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9820000000-3d8d121f72903597fa68Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9800000000-3015e99e2efadba25adeNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-9300000000-ee435d06936a7b2aa021Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-9200000000-67a51c01f03fcd5da052Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-2920000000-2c408b74a832f662b4a8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0390000000-5dac2c73d05262cd10c0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-c85d502fd299d3c8942cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-6900000000-b134f68352446228a2deNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00kf-9200000000-a2aab9e90cbad227f54dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-c8c24b18f27b59f6e693Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-754d521e9fa8d49057e7Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9800000000-39de965985344c6a228aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-cb5f68cc93f9c5fbfd9cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pbc-8950000000-2faaf22f437db50e5027Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-edae1e1e2ba8943cd0eaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2970000000-2458513774290876b051Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0190000000-963df5f00d61af7a36d1Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-c61eade368561111e908Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-9000000000-d0994901e1a7f0fd049aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-f9d7f50685c7e96eefcdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9300000000-4e9a372c0303a4592b19Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-9100000000-19ec2e3170150cbb2f72Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-b64fe0d201c9dfb7efe6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-4940000000-e81ade8e579359effff3Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0910000000-2a407f225837be56886dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-befa75f1261f9677cbbcNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3910000000-3ccd4483e7ba9b121982Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-2940000000-364ce1242252a0230ce6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1960000000-745bfb01a075a25009caNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9300000000-80a8934aa860252a64edNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-1950000000-48fbf15c366a328d38a4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-181bb6cd1b54b2b6495cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0900000000-c3682226c90f2e2715a0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052b-0900000000-ef143045595a430e870dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0910000000-b904b45340f3131f2ff4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1960000000-61d749781d96ba9517afNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9400000000-847ca60ba6952c8495b4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9300000000-b0a17d83daae7264b2b8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9300000000-c72c780b0a8a258e71d2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9400000000-05bd2d9b0f8085fa7c43Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9600000000-8bba21e4d09dfdf5a196Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9500000000-b72c7ad2f48524ddf307Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9400000000-39d0f4bc78b1f3f88a0cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9500000000-2bd62c81c2c718be048cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9820000000-a5ca00b8dc3d3c0a906bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9700000000-48e8d79f987f6154d621Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-2920000000-72dba8ecfc2f61d17f13Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-fbe8a8e2dd4f6ac0056aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-15661d73aca6f5d6e7e9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-7900000000-2218ff5fddbb88daf769Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-8900000000-d782b517577f1a78f8cfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3900000000-5817613da6b14d51a46fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9600000000-8beaf3b4b3b30c2c0338Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9600000000-f9589a9a58ee258253ceNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014l-9100000000-396ffb76152c394cbbbaNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-5900000000-0533a86e5f08463b41c5Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-b02c397c2d2954785c81Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-5900000000-f376319dc72913e8db61Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052v-0900000000-08fa7e3f865ed3f5a8d8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-b1b1b8e70ec8043bb89bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0940000000-88c5b1ef2f503737ca9aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4v-0900000000-c699718decdea6874b8cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-5dea192ddf68e39f5c6cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-ea7b5a6df5194b83692fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9200000000-7bff8b525c2668160955Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-7900000000-a8bdfaad7fb2a44c962cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014l-9100000000-b16d8200d61409da50e2Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-c1b6c321b29abd8b41f4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-08fu-9300000000-275ed92901e4719e8eb0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pb9-2940000000-5ca04ce7e4316880dadbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-9000000000-9876028d1ca3d056bc24Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9800000000-319975207e1e7bb49aafNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1790000000-9420cf370927a046e871Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-3900000000-58869a5ce23e7feeeedfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-9000000000-ea85c4bcf6c83a085441Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-9000000000-c388b00730b45caa4648Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-9400000000-40c4ba72e5fb8ca74d32Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0940000000-085c730b971fa07d92e9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-7900000000-f67175196d03deb72888Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-052f-9400000000-e5ef6a2c8052a154b5ccNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-2920000000-edc45dad7bd4e772d58cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-d08e106e2d4892e4dd0eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-2970000000-c82a27f9a62b820f9423Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0910000000-64449078c4fdd8bf4614Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-03a04a0d677c71c5715dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-9300000000-e8cf95db81013343d487Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014l-9100000000-de0135dd1758e6d3f39fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9400000000-b183a4502dce7d9d3b96Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-6e81b080f143e2c3f583Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1980000000-72a831170e4084e7213fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-0510cc055e86199cca20Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4l-9600000000-4bb127fb886fae5770bbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-1960000000-de9926b1b3b1641f8018Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05mo-9200000000-086fa82bc3f0e970a636Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-4900000000-ac6d5ea59c5138b07516Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-0900000000-4e1c42b1884f39472561Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-dbdcf73b4694c21ee7fdNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0900000000-e5741aa08a45dc3415ccNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0290000000-24e25399c01747629ea6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-4930000000-faeffbb5af050ec8fd66Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-9000000000-73da60b4f8b357b7ee7aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0090000000-3f8c543fcb38edca6c1cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-3190000000-364d0e40dde4501d780aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0006-9310000000-34cc478537d6f9ae2901Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0490000000-180b218861b0ab122ba8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4l-8910000000-0600ba2bb874c85f18c9Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014l-9000000000-697dbbb3ba125c83d937Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0090000000-d69a7e58754016213974Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-2190000000-54463baf69c0e793d244Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0aor-9400000000-9673414e025c58a9db1eNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
6148.0Log mg/kg[3500:11000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
pneumoniais_treatment_forNot AvailablePMC10922816
toxoplasmosisis_treatment_forNot AvailablePMC5600344
sinusitisis_treatment_forNot AvailablePMC5600344
Exposure Sources
Source IDSourceSectorReference
10InsecticidesAgriculture & land managementNot Available
115Drinking waterDrinking water & water supplyNot Available
233BrushesPersonal care & cosmeticsNot Available
306AntibioticsHealthcare, pharmaceuticals & veterinary productsNot Available
316GynecologicalsHealthcare, pharmaceuticals & veterinary productsNot Available
342Sulfonamides and trimethoprimHealthcare, pharmaceuticals & veterinary productsNot Available
349Drugs for treatment of tuberculosisHealthcare, pharmaceuticals & veterinary productsNot Available
499RoofsBuilding & ConstructionNot Available
505AmplifiersElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
507Auxiliary DevicesElectrical & Electronic EquipmentNot Available
511Conductors Or Conductive Bodies Characterised By The Conductive MaterialsElectrical & Electronic EquipmentNot Available
514Discharge LampsElectrical & Electronic EquipmentNot Available
517Electric SwitchesElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
519ElectrodesElectrical & Electronic EquipmentNot Available
521Fixed Capacitors And Their ManufactureElectrical & Electronic EquipmentNot Available
523Gas Filled Discharge Tubes With Solid CathodeElectrical & Electronic EquipmentNot Available
524Hybrid CapacitorsElectrical & Electronic EquipmentNot Available
525Line Transmission SystemsElectrical & Electronic EquipmentNot Available
530Radio Transmission SystemsElectrical & Electronic EquipmentNot Available
533Sparking PlugsElectrical & Electronic EquipmentNot Available
537Television SystemsElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
544Fermentation Processes For BeerFood, food processing & cookwareNot Available
545Food PreservationFood, food processing & cookwareNot Available
548Preparation Of VinegarFood, food processing & cookwareNot Available
552Processing MeatsFood, food processing & cookwareNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
561Perfumes Within Detergents And SoapsHousehold cleaning & consumer productsNot Available
563Soap DetergentsHousehold cleaning & consumer productsNot Available
569Tobacco Smoke FiltersHousehold cleaning & consumer productsNot Available
580Manufacture Preparation Of Tobacco ProductsIndustrial manufacturing & chemical processingNot Available
581Paper Making MachinesIndustrial manufacturing & chemical processingNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
596AcaricidesAgriculture & land managementNot Available
598Fertiliser DistributorsAgriculture & land managementNot Available
600Herbicides And AlgicidesAgriculture & land managementNot Available
602MolluscicidesAgriculture & land managementNot Available
603NematocidesAgriculture & land managementNot Available
605Pest RepellantsAgriculture & land managementNot Available
606Plant Growth RegulatorsAgriculture & land managementNot Available
609AftershavePersonal care & cosmeticsNot Available
610Aftersun ProductsPersonal care & cosmeticsNot Available
611Anti Perspirants Or Body DeoderantsPersonal care & cosmeticsNot Available
614Essential Oils Or PerfumesPersonal care & cosmeticsNot Available
615Eye Makeup ProductsPersonal care & cosmeticsNot Available
617Lip Care ProductsPersonal care & cosmeticsNot Available
618Lip Makeup ProductsPersonal care & cosmeticsNot Available
621Chutes And SlidesRecreation & sports surfacesNot Available
630ToysRecreation & sports surfacesNot Available
632ApparelTextiles, leather & furnishingsNot Available
642FootwearTextiles, leather & furnishingsNot Available
643HeadwearTextiles, leather & furnishingsNot Available
650Purses Luggage Hand BagsTextiles, leather & furnishingsNot Available
652RopesTextiles, leather & furnishingsNot Available
653SewingTextiles, leather & furnishingsNot Available
662Yarns Or ThreadsTextiles, leather & furnishingsNot Available
Pathways
2 pathways
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureATP-dependent 6-phosphofructokinaseQ4E657Trypanosoma cruziPredicted (SEA)0.155698
Carbonic anhydrase 9 structureClick to view 3D structureCarbonic anhydrase 9Q16790HumansPredicted (SEA)53.7938
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)72.0884
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)63.3693
Click to view 3D structureCarbonic anhydrase 4Q95323Bos taurusPredicted (SEA)18.9952
Click to view 3D structureAGAP002992-PAQ5TU56Anopheles gambiaePredicted (SEA)4.28171
Click to view 3D structureCarbonic anhydrase 13Q9D6N1Mus musculusPredicted (SEA)9.03051
Click to view 3D structureEndothelin-1 receptorP26684Rattus norvegicusPredicted (SEA)10.6653
Dihydrofolate reductase structureClick to view 3D structureDihydrofolate reductaseP16184Pneumocystis cariniiPredicted (SEA)13.5458
Carbonic anhydrase 12 structureClick to view 3D structureCarbonic anhydrase 12O43570HumansPredicted (SEA)74.5796
Dihydropteroate synthase structureClick to view 3D structureDihydropteroate synthaseP0AC13Escherichia coli (strain K12)Predicted (SEA)0.155698
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansPredicted (SEA)111.869
Click to view 3D structureDelta carbonic anhydraseQ5U9J1Conticribra weissflogiiPredicted (SEA)9.49761
Carbonic anhydrase 6 structureClick to view 3D structureCarbonic anhydrase 6P23280HumansPredicted (SEA)30.5169
Click to view 3D structureCarbonic anhydraseO24855Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)Predicted (SEA)14.2464
Click to view 3D structureCarbonate dehydrataseB2V8E3Sulfurihydrogenibium sp. (strain YO3AOP1)Predicted (SEA)13.935
Click to view 3D structureAstrosclerin-3A6YCJ1Astrosclera willeyanaPredicted (SEA)15.3363
Click to view 3D structureCarbonic anhydraseQ6FTL6Candida glabrata CBS 138Predicted (SEA)21.7978
Click to view 3D structureAlpha carbonic anhydraseB5SU02Stylophora pistillataPredicted (SEA)13.0787
Click to view 3D structureCarbonic anhydrase 2Q3I4V7Cryptococcus neoformansPredicted (SEA)16.6597
Click to view 3D structureCarbonic anhydrase, alpha familyQ31FD6Thiomicrospira crunogenaPredicted (SEA)13.935
Click to view 3D structureCarbonic anhydraseQ5AJ71Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Predicted (SEA)19.2288
Click to view 3D structureCarbonic anhydraseC0IX24Stylophora pistillataPredicted (SEA)13.0787
Click to view 3D structureCarbonic anhydrase 5B, mitochondrialQ9Y2D0HumansPredicted (SEA)40.0924
Click to view 3D structureBeta-carbonic anhydrase 1P9WPJ7Mycobacterium tuberculosisPredicted (SEA)21.6421
Concentrations
StatusValueUnitSample LocationReference
Detected and Quantified240ng/LBioggio,Lugano
Detected and Quantified77ng/LBussigny-prés-Lausanne
Detected and Quantified190ng/LHallau,Klettgau
Detected and Quantified110ng/LThal,Altenrhein
Detected and Quantified250ng/LUetendorf,Thun
Detected and Quantified380ng/LVernier,Aïre
Detected and Quantified300ng/LWinterthur
Detected and Quantified560ng/LWerdhölzli,Zürich
Detected and Quantified390ng/LSchönau,Zug
Detected and Quantified180ng/LAffoltern,Zwillikon
External Links
DrugBank IDDB01015
HMDB IDHMDB0015150
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB ID08D
Wikipedia LinkSulfamethoxazole
Chemspider ID5138
ChEBI ID9332
PubChem Compound ID5329
Kegg Compound IDC07315
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=10843725
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=10891117
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=10969989
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=11350866
5. https://www.ncbi.nlm.nih.gov/pubmed/?term=11431418
6. https://www.ncbi.nlm.nih.gov/pubmed/?term=12019187
7. https://www.ncbi.nlm.nih.gov/pubmed/?term=15497867
8. https://www.ncbi.nlm.nih.gov/pubmed/?term=15588915
9. https://www.ncbi.nlm.nih.gov/pubmed/?term=15967282
10. https://www.ncbi.nlm.nih.gov/pubmed/?term=15984773
11. https://www.ncbi.nlm.nih.gov/pubmed/?term=17095123
12. https://www.ncbi.nlm.nih.gov/pubmed/?term=17110110
13. https://www.ncbi.nlm.nih.gov/pubmed/?term=17158933
14. https://www.ncbi.nlm.nih.gov/pubmed/?term=17311370
15. https://www.ncbi.nlm.nih.gov/pubmed/?term=17442935
16. https://www.ncbi.nlm.nih.gov/pubmed/?term=17573190
17. https://www.ncbi.nlm.nih.gov/pubmed/?term=18334600
18. https://www.ncbi.nlm.nih.gov/pubmed/?term=18958736
19. https://www.ncbi.nlm.nih.gov/pubmed/?term=19436870
20. https://www.ncbi.nlm.nih.gov/pubmed/?term=20564608
21. https://www.ncbi.nlm.nih.gov/pubmed/?term=22534821
22. https://www.ncbi.nlm.nih.gov/pubmed/?term=226453
23. https://www.ncbi.nlm.nih.gov/pubmed/?term=23611245
24. https://www.ncbi.nlm.nih.gov/pubmed/?term=23649399
25. https://www.ncbi.nlm.nih.gov/pubmed/?term=23742687
26. https://www.ncbi.nlm.nih.gov/pubmed/?term=25851465
27. https://www.ncbi.nlm.nih.gov/pubmed/?term=313909
28. https://www.ncbi.nlm.nih.gov/pubmed/?term=3906132
29. https://www.ncbi.nlm.nih.gov/pubmed/?term=6864729
30. https://www.ncbi.nlm.nih.gov/pubmed/?term=7486915
31. https://www.ncbi.nlm.nih.gov/pubmed/?term=7490723
32. https://www.ncbi.nlm.nih.gov/pubmed/?term=7534104
33. https://www.ncbi.nlm.nih.gov/pubmed/?term=7602118
34. https://www.ncbi.nlm.nih.gov/pubmed/?term=7731020
35. https://www.ncbi.nlm.nih.gov/pubmed/?term=7798534
36. https://www.ncbi.nlm.nih.gov/pubmed/?term=8208693
37. https://www.ncbi.nlm.nih.gov/pubmed/?term=8632413
38. Hobday JD: The prophylactic treatment of recurrent urinary tract infection with sulphamethoxizole-trimethoprim. Aust Paediatr J. 1971 Dec;7(4):199-202.
39. Arora VK, Tumbanatham A, Kumar SV, Ratnakar C: Pneumocystis carinii pneumonia simulating as pulmonary tuberculosis in AIDS. Indian J Chest Dis Allied Sci. 1996 Oct-Dec;38(4):253-7.