Chenodeoxycholic acid (CED0002895)

Chenodeoxycholic acid (C24H40O4) is a compound with an average molecular weight of 392.57 g/mol. Chenodeoxycholic acid belongs to the bile acids, alcohols and derivatives, a subclass of steroids and steroid derivatives within the organic compounds. It serves as a biological ligand (PMC3676171). The compound is found in or released from 25 recorded sources, including drinking water and water supply. Within healthcare, pharmaceuticals and veterinary products, it is used in bile therapy. Other recorded sources include food, food processing and cookware—specifically the processing of meats, food preservation, and fermentation processes for beer and the preparation of wine or sparkling wine—as well as household cleaning and consumer products such as soap detergents, perfumes within detergents and soaps, tobacco smoke filters, tobacco product cases, and cigar cigarettes. Additionally, it is associated with electrical and electronic equipment, including antennas, amplifiers, electric switches, auxiliary devices, and conductors or conductive bodies characterised by the conductive materials. The recorded exposure route for this compound is oral. Chenodeoxycholic acid interacts with four recorded protein targets, acting as an agonist, antagonist, or substrate of the bile acid receptor (NR1H4), the G-protein coupled bile acid receptor 1 (GPBAR1), the nuclear receptor subfamily 1 group I member 2 (NR1I2), and the aldo-keto reductase family 1 member C2 (AKR1C2). Regarding health effects, the compound is associated with cholestasis (PMC9488005) and has been observed to decrease in the blood in cases of pancreatic cancer (PMC7399932).