Tolbutamide (CED0003593)

Tolbutamide is an organic compound with the formula C12H18N2O3S and an average molecular weight of 270.35 g/mol. Tolbutamide belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. The compound is associated with 21 recorded sources across several categories. Within healthcare, pharmaceuticals, and veterinary products, it is found in blood glucose lowering drugs (excluding insulins), gynecologicals, and unclassified diagnostic agents. Other sources include food, food processing, and cookware, specifically in the preparation of wort, the preparation of wine or sparkling wine, the preparation of vinegar, and food preservation. It is also released from household cleaning and consumer products, such as tobacco smoke filters, perfumes within detergents and soaps, non electric simulated smoking devices, other smoking requisites, and cigar cigarettes. Additionally, it is found in electrical and electronic equipment, including electrodes, antennas, colour television systems, electrically stimulated smoking devices, and conductors or conductive bodies characterised by the conductive materials, among four other sources. The recorded exposure route for this compound is oral. At the molecular level, tolbutamide interacts with three recorded protein targets. It acts as a blocker or inhibitor of the ATP-sensitive inward rectifier potassium channel 1 (KCNJ1) and targets the ATP-binding cassette sub-family C member 8 (ABCC8) and the ATP-binding cassette sub-family C member 9 (ABCC9).