Aminohippuric acid (CED0007280)

Aminohippuric acid (C9H10N2O3) is a compound with an average molecular weight of 194.19 g/mol. Aminohippuric acid belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It functions biologically as an endocrine disruptor (PMC11994996) and acts as an inhibitor of the protein target Organic anion transporter 3 (SLC22A8). The compound is found in or released from nine recorded sources, including electrical and electronic equipment such as hybrid capacitors, electrodes, television systems, conductive bodies characterized by conductive materials, and electrically stimulated smoking devices. Other sources include food preservation, unclassified diagnostic agents in healthcare, pharmaceuticals and veterinary products, and household cleaning and consumer products such as tobacco smoke filters and non-electric simulated smoking devices. Recorded exposure routes include intravenous administration, as well as inhalation (PMC3114816, PMC4492867) and smoking (PMC4543297, PMC9969860). Aminohippuric acid is associated with several health effects. It is linked to atherosclerosis (PMC11083012), arthritis (PMC11382499), heart disease (PMC11382499), hypertension (PMC11382499), obesity (PMC9977221), lung disease (PMC6521202), cataract (PMC12316782), and melanoma (PMC8458058). It is associated with an increase in inflammation (PMC11946043, PMC6054606), stroke (PMC10946040), breast cancer (PMC5581466), pancreatic cancer (PMC9600415), skin cancer (PMC12316782), and lung cancer (PMC12316782, PMC3017938, PMC3384073). It is further associated with depression (PMC11382499, PMC13224428) and anxiety (PMC13224428), while a decrease in cancer is noted (PMC11298429, PMC13215396, PMC3114816, PMC5509823). Additionally, it is elevated in the urine of those with male infertility (PMC11946043).