Bumetanide (CED0003712)

Bumetanide is an organic compound with the formula C17H20N2O5S and an average molecular weight of 364.42 g/mol. Bumetanide belongs to the diphenylethers, a subclass of benzene and substituted derivatives within the organic compounds. It functions biologically as a diuretic (PMC8766311). The compound is recorded as being found in or released from 15 sources, including healthcare, pharmaceuticals & veterinary products such as gynecologicals and diuretics; food, food processing & cookware specifically for food preservation; household cleaning & consumer products including soap detergents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices; and electrical & electronic equipment including antennas, conductors or conductive bodies characterised by the conductive materials, electrodes, electric hearing aids, and electrically stimulated smoking devices. Recorded exposure routes include oral, nasal, intravenous, and intramuscular administration. Bumetanide acts on five recorded protein targets, serving as an antagonist/inhibitor of the solute carrier family 12 member 1 (SLC12A1), solute carrier family 12 member 2 (SLC12A2), solute carrier family 12 member 4 (SLC12A4), and the cystic fibrosis transmembrane conductance regulator (CFTR), along with one other protein. Regarding health effects, the compound is associated with loss of appetite (PMC8766311) and has a therapeutic effect on epilepsy (PMC8766311).