Cefazolin (CED0001757)

Record Information
Version1.0
Creation Date2016-05-22 03:38:30 UTC
Update Date2026-08-19 05:26:48 UTC
SynCED IDCED0001757
Secondary Accession Numbers
  • CHEM016613
Identification
Common NameCefazolin
ClassSmall Molecule
Description
Cefazolin is an organic compound with the chemical formula C14H14N8O4S3 and an average molecular weight of 454.51 g/mol. Cefazolin belongs to the beta lactams, a subclass of lactams within the organic compounds. It is further categorized under the superclass of organoheterocyclic compounds. The compound is found in or released from four recorded sources: antennas within electrical and electronic equipment, drinking water and water supply, and healthcare, pharmaceuticals and veterinary products, specifically antibiotics and beta-lactam antibacterials. Recorded exposure routes for this substance include intramuscular, intravenous, oral, parenteral, and inhalation. In terms of biological activity, there are eight recorded protein targets for cefazolin. It acts as an inhibitor of serum paraoxonase/arylesterase 1 (PON1), as well as penicillin-binding protein 1A (mrcA), penicillin-binding protein 1B (mrcB), peptidoglycan D,D-transpeptidase MrdA (mrdA), and four other proteins.
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidChEBI
CefamezinChEBI
CefazolinaChEBI
CefazolineChEBI
CefazolinumChEBI
CephamezineChEBI
CephazolidinChEBI
CephazolinChEBI
CephazolineChEBI
CEZChEBI
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateGenerator
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateGenerator
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidGenerator
CefamedinHMDB
CefamezineHMDB
Sodium cephazolinHMDB
Sodium, cefazolinHMDB
Sodium, cephazolinHMDB
GramaxinHMDB
AncefHMDB
Cefazolin sodiumHMDB
Cephazolin sodiumHMDB
Cephazolin, sodiumHMDB
KefzolHMDB
TotacefHMDB
Chemical FormulaC14H14N8O4S3
Average Molecular Mass454.507 g/mol
Monoisotopic Mass454.030 g/mol
CAS Registry Number25953-19-9
IUPAC Name(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[2-(1H-1,2,3,4-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional Namecefazolin
SMILES[H][C@]12SCC(CSC3=NN=C(C)S3)=C(N1C(=O)[C@H]2NC(=O)CN1C=NN=N1)C(O)=O
InChI IdentifierInChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1
InChI KeyMLYYVTUWGNIJIB-BXKDBHETSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as cephalosporins. Cephalosporins are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]Oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactams
Sub ClassBeta lactams
Direct ParentCephalosporins
Alternative Parents
Substituents
  • Cephalosporin
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid or derivatives
  • Aryl thioether
  • Alkylarylthioether
  • Meta-thiazine
  • Azole
  • Heteroaromatic compound
  • Tertiary carboxylic acid amide
  • Tetrazole
  • Thiadiazole
  • Azetidine
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Carboxylic acid derivative
  • Carboxylic acid
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Dialkylthioether
  • Sulfenyl compound
  • Hemithioaminal
  • Thioether
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.49 g/LALOGPS
logP-0.4ALOGPS
logP-1.5ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)3.03ChemAxon
pKa (Strongest Basic)0.26ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area156.09 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity119.86 m³·mol⁻¹ChemAxon
Polarizability41.44 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-05ai-9331300000-a190d4fa6f7addfc7f8cNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-00e9-9310500000-949cf3462e4c45379627Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fr-0109500000-d35195620e6ac4356773Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aba-0943000000-da64d40a841f7fe440feNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-0910000000-f074c2d1d56b5f3da552Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0q2i-0900000000-bbd7d226d641cfe51521Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0l1r-0900000000-18addd569fa36108660eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pvi-0900000000-287aa1c6700ef519dedbNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0q2i-0900000000-9e7cde1888a3978aed23Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fr-0109500000-d35195620e6ac4356773Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aba-0953000000-486d054de7bf3c3c59f8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0q2i-0900000000-854b2bd437ac40b2e4b9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-0910000000-c1f36584835748883d05Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fs-0943000000-663a761fef5117d13f02Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-0920000000-30e9df76adf5b0ab0e2eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05fr-0109500000-a3dc371ba38a25191014Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0l1r-0900000000-ec13af7a17d51561e88aNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0q39-0900000000-7fdfdaaae2066b530d9eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pvi-0900000000-32fabc5e15ec2390ad50Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0q2i-0900000000-bbd7d226d641cfe51521Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0zfr-0910000000-f074c2d1d56b5f3da552Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aba-0943000000-da64d40a841f7fe440feNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aba-0953000000-b91c41e30ce101731626Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0l1r-0900000000-18addd569fa36108660eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ap0-2749700000-4a77f2bfb0a94e40248aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-9442000000-ae982fa3122bc6aa8c09Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a6r-9328000000-5482d1c278b4443581ceNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00xu-9311000000-fc7869714720e58c02c6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-4920000000-c40df0bab8447e63198dNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-066r-9143000000-9ff6c941993091c7a3f9Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4i-0001900000-891651204946fd50a7b0Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0690-2901600000-ea04782cfec528ec2005Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00di-9652400000-9440668abcfbf77fd819Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0000900000-91bb802c4957f217ae06Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-057s-9311200000-832a9acb24d6fa1ef4b6Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0561-9300100000-69019e41e6b0fdab76d9Not AvailableView Spectrum
1D NMR13C NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
1D NMR1H NMR Spectrum (1D, D2O, predicted)Not AvailableNot AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
6311.0 Log mg/kg [3500:11000]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000010Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.Agriculture & land managementNot Available
CEDs000070Stormwater runoff?Stormwater runoff refers to the flow of rainwater or melted snow that does not soak into the ground and instead collects pollutants as it travels over impervious surfaces such as roads and parking lots.Automotive & urban infrastructureNot Available
CEDs000115Drinking water?Drinking water can be a medium for synthetic chemical contamination, often originating from various industrial processes and agricultural practices.Drinking water & water supplyNot Available
CEDs000306Antibiotics?Antibiotics are synthetic or semi-synthetic compounds used to treat bacterial infections in humans and animals.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000341Beta-lactam antibacterials?Beta-lactam antibacterials are a class of synthetic antibiotics characterized by their β-lactam ring structure, which is essential for their antibacterial activity.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000506Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.Electrical & Electronic EquipmentNot Available
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentNot Available
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentNot Available
CEDs000524Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.Electrical & Electronic EquipmentNot Available
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwareNot Available
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsNot Available
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsNot Available
CEDs000569Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.Household cleaning & consumer productsNot Available
CEDs000580Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.Industrial manufacturing & chemical processingNot Available
CEDs000596Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.Agriculture & land managementNot Available
CEDs000600Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.Agriculture & land managementNot Available
CEDs000603Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.Agriculture & land managementNot Available
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementNot Available
CEDs000610Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.Personal care & cosmeticsNot Available
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsNot Available
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsNot Available
CEDs000615Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.Personal care & cosmeticsNot Available
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsNot Available
CEDs000632Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.Textiles, leather & furnishingsNot Available
CEDs000642Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.Textiles, leather & furnishingsNot Available
CEDs000671Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.Aviation & AerospaceNot Available
CEDs000673Unmanned Aerial Vehicles?Unmanned Aerial Vehicles (UAVs), commonly known as drones, utilize various synthetic chemicals in their manufacturing, operation, and maintenance processes.Aviation & AerospaceNot Available
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionNot Available
CEDs000688Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.Building & ConstructionNot Available
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingNot Available
CEDs000698Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.Mining & metal processingNot Available
CEDs000727Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.Paper, pulp & fiber productsNot Available
CEDs000729Stamps?Stamps, particularly those produced using synthetic inks and adhesives, can contribute to chemical contamination when disposed of improperly.Paper, pulp & fiber productsNot Available
CEDs000730Contact Lens Cases?Contact lens cases are small containers designed to store contact lenses in a sterile environment, typically made from various synthetic materials including plastics such as polypropylene or polycarbonate.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000733Walking Sticks?Walking sticks, while primarily designed for mobility assistance, can be sources of synthetic chemical contamination if not properly manufactured or maintained.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000734Coating Compositions?Coating compositions, which include paints, sealants, and varnishes, are formulated with a variety of synthetic chemicals such as solvents, resins, pigments, and additives.Building & ConstructionNot Available
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructureNot Available
CEDs000738Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.Industrial manufacturing & chemical processingNot Available
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsNot Available
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsNot Available
CEDs000741Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.Paper, pulp & fiber productsNot Available
CEDs000743Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.Wastewater, sanitation & biosolidsNot Available
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsNot Available
Pathways
2 pathwaysPathway Source: PathBank
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureSolute carrier family 22 member 6Q4U2R8HumansPredicted (SEA)
Prediction Confidence Score
0.404
Applicability Domain
0.494
Statistical Significance
7.00e-05
Supporting Reference Compounds
26
E-value
0.544945
Click to view 3D structureOrganic anion transporter 3Q8TCC7HumansPredicted (SEA)
Prediction Confidence Score
0.404
Applicability Domain
0.494
Statistical Significance
6.00e-05
Supporting Reference Compounds
20
E-value
0.467095
Solute carrier family 22 member 11 structureClick to view 3D structureSolute carrier family 22 member 11Q9NSA0HumansPredicted (SEA)
Prediction Confidence Score
0.404
Applicability Domain
0.494
Statistical Significance
3.00e-05
Supporting Reference Compounds
9
E-value
0.233548
Click to view 3D structureStreptokinase AP10520Streptococcus pyogenes serotype M1Predicted (SEA)
Prediction Confidence Score
0.311
Applicability Domain
0.37
Statistical Significance
0.0148
Supporting Reference Compounds
425
E-value
115.606
Speckle-type POZ protein structureClick to view 3D structureSpeckle-type POZ proteinO43791HumansPredicted (SEA)
Prediction Confidence Score
0.295
Applicability Domain
0.295 Low confidence
Statistical Significance
8.00e-05
Supporting Reference Compounds
1
E-value
0.622794
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 structureClick to view 3D structureCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1Q9GZU7HumansPredicted (SEA)
Prediction Confidence Score
0.293
Applicability Domain
0.417
Statistical Significance
0.0088
Supporting Reference Compounds
128
E-value
68.663
Click to view 3D structureBeta-lactamaseB2ZTR6Acinetobacter baumanniiPredicted (SEA)
Prediction Confidence Score
0.258
Applicability Domain
0.358
Statistical Significance
1.00e-04
Supporting Reference Compounds
3
E-value
0.778492
Click to view 3D structureADC-11D6NSM8Acinetobacter baumanniiPredicted (SEA)
Prediction Confidence Score
0.258
Applicability Domain
0.358
Statistical Significance
1.00e-04
Supporting Reference Compounds
3
E-value
0.778492
DNA (cytosine-5)-methyltransferase 1 structureClick to view 3D structureDNA (cytosine-5)-methyltransferase 1P26358HumansPredicted (SEA)
Prediction Confidence Score
0.243
Applicability Domain
0.417
Statistical Significance
0.0476
Supporting Reference Compounds
116
E-value
370.484
26S proteasome non-ATPase regulatory subunit 14 structureClick to view 3D structure26S proteasome non-ATPase regulatory subunit 14O00487HumansPredicted (SEA)
Prediction Confidence Score
0.224
Applicability Domain
0.303
Statistical Significance
0.0176
Supporting Reference Compounds
39
E-value
137.326
Tyrosine-protein phosphatase non-receptor type 11 structureClick to view 3D structureTyrosine-protein phosphatase non-receptor type 11Q06124HumansPredicted (SEA)
Prediction Confidence Score
0.223
Applicability Domain
0.37
Statistical Significance
0.1144
Supporting Reference Compounds
109
E-value
890.829
Dual specificity protein phosphatase 3 structureClick to view 3D structureDual specificity protein phosphatase 3P51452HumansPredicted (SEA)
Prediction Confidence Score
0.216
Applicability Domain
0.37
Statistical Significance
0.1776
Supporting Reference Compounds
147
E-value
1382.91
Apoptotic protease-activating factor 1 structureClick to view 3D structureApoptotic protease-activating factor 1O14727HumansPredicted (SEA)
Prediction Confidence Score
0.211
Applicability Domain
0.306
Statistical Significance
0.1485
Supporting Reference Compounds
112
E-value
1156.37
72 kDa type IV collagenase structureClick to view 3D structure72 kDa type IV collagenaseP08253HumansPredicted (SEA)
Prediction Confidence Score
0.209
Applicability Domain
0.303
Statistical Significance
0.4968
Supporting Reference Compounds
400
E-value
3867.39
Induced myeloid leukemia cell differentiation protein Mcl-1 structureClick to view 3D structureInduced myeloid leukemia cell differentiation protein Mcl-1Q07820HumansPredicted (SEA)
Prediction Confidence Score
0.207
Applicability Domain
0.223 Low confidence
Statistical Significance
0.4013
Supporting Reference Compounds
343
E-value
3124.17
Prothrombin structureClick to view 3D structureProthrombinP00734HumansPredicted (SEA)
Prediction Confidence Score
0.203
Applicability Domain
0.223 Low confidence
Statistical Significance
0.5357
Supporting Reference Compounds
331
E-value
4170.54
PER-2 beta-lactamase structureClick to view 3D structurePER-2 beta-lactamaseA2RP81Citrobacter freundiiPredicted (SEA)
Prediction Confidence Score
0.203
Applicability Domain
0.25 Low confidence
Statistical Significance
2.10e-04
Supporting Reference Compounds
6
E-value
1.63483
Small ubiquitin-related modifier 1 structureClick to view 3D structureSmall ubiquitin-related modifier 1P63165HumansPredicted (SEA)
Prediction Confidence Score
0.203
Applicability Domain
0.306
Statistical Significance
0.2358
Supporting Reference Compounds
95
E-value
1835.61
Peroxisomal acyl-coenzyme A oxidase 1 structureClick to view 3D structurePeroxisomal acyl-coenzyme A oxidase 1P07872Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.201
Applicability Domain
0.208 Low confidence
Statistical Significance
0.0753
Supporting Reference Compounds
3
E-value
586.205
Solute carrier family 15 member 2 structureClick to view 3D structureSolute carrier family 15 member 2Q63424Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.201
Applicability Domain
0.348
Statistical Significance
0.0183
Supporting Reference Compounds
6
E-value
142.62
Transcription factor NF-E2 45 kDa subunit structureClick to view 3D structureTranscription factor NF-E2 45 kDa subunitQ16621HumansPredicted (SEA)
Prediction Confidence Score
0.2
Applicability Domain
0.2 Low confidence
Statistical Significance
0.0207
Supporting Reference Compounds
1
E-value
160.836
High affinity nerve growth factor receptor structureClick to view 3D structureHigh affinity nerve growth factor receptorP04629HumansPredicted (SEA)
Prediction Confidence Score
0.199
Applicability Domain
0.22 Low confidence
Statistical Significance
0.8459
Supporting Reference Compounds
869
E-value
6585.03
BDNF/NT-3 growth factors receptor structureClick to view 3D structureBDNF/NT-3 growth factors receptorQ16620HumansPredicted (SEA)
Prediction Confidence Score
0.199
Applicability Domain
0.22 Low confidence
Statistical Significance
0.8232
Supporting Reference Compounds
721
E-value
6408.31
Probable flavin-dependent thymidylate synthase structureClick to view 3D structureProbable flavin-dependent thymidylate synthaseO41156Paramecium bursaria Chlorella virus 1Predicted (SEA)
Prediction Confidence Score
0.196
Applicability Domain
0.196 Low confidence
Statistical Significance
0.0114
Supporting Reference Compounds
1
E-value
88.5924
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)
Prediction Confidence Score
0.194
Applicability Domain
0.214 Low confidence
Statistical Significance
0.9627
Supporting Reference Compounds
1538
E-value
7494.31
Concentrations
Not Available
External Links
DrugBank IDDB01327
HMDB IDHMDB0015422
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkCefazolin
Chemspider ID30723
ChEBI ID474053
PubChem Compound ID33255
Kegg Compound IDC06880
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available