Lansoprazole (CED0003061)

Record Information
Version1.0
Creation Date2016-05-22 03:42:42 UTC
Update Date2026-08-19 14:39:29 UTC
Accession NumberCHEM016753
Identification
Common NameLansoprazole
ClassSmall Molecule
Description
Lansoprazole is an organic compound with the chemical formula C16H14F3N3O2S and an average molecular weight of 369.36 g/mol. Lansoprazole belongs to the sulfinylbenzimidazoles, a subclass of benzimidazoles within the organic compounds. It is classified as an organoheterocyclic compound. The compound is utilized in healthcare, pharmaceuticals, and veterinary products as a drug for acid related disorders. It has been identified in 30 recorded sources. These include drinking water and water supply systems, as well as food and food processing applications such as food preservation and the processing of fish. It is found in building and construction materials including roofs, floors, ceilings, ladders, and fencing. Additionally, it is present in household cleaning and consumer products, such as soap dispensers, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Electrical and electronic equipment sources include antennas, amplifiers, electric switches, electric hearing aids, and electrically stimulated smoking devices, among nine other sources. Exposure to lansoprazole occurs via oral and intravenous routes. The compound interacts with two recorded protein targets, acting as a binder or inhibitor of the potassium-transporting ATPase alpha chain 1 (ATP4A) and the microtubule-associated protein tau (MAPT).
Contaminant Type
  • Human Neurotoxin
Chemical Structure
Synonyms
ValueSource
AG 1749ChEBI
BamaliteChEBI
LansoprazolChEBI
LansoprazolumChEBI
LanzolChEBI
LanzopralChEBI
LanzulChEBI
LimpidexChEBI
MonolitumChEBI
OgastroChEBI
OpirenChEBI
PrevacidChEBI
PrezalMeSH
UlpaxMeSH
LansolMeSH
Lansoprazole sodiumMeSH
Pro ulcoMeSH
PromecoMeSH
ZotonMeSH
AgoptonMeSH
OgastMeSH
TakepronMeSH
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazoleMeSH
LansoprazolesMeSH
LanzorMeSH
Sodium, lansoprazoleMeSH
AmarinHMDB
AprazolHMDB
BlasonHMDB
KetianHMDB
LancidHMDB
LanfastHMDB
LanprotonHMDB
LansopepHMDB
LansophedHMDB
LansoxHMDB
LanstonHMDB
LanzHMDB
LanzoHMDB
LaprazHMDB
LasoprolHMDB
LinamarinHMDB
MesactolHMDB
Lansoprazole hormona brandMeSH, HMDB
Lansoprazole tecnobio brandMeSH, HMDB
Lansoprazole wyeth brandMeSH, HMDB
Vinas brand OF lansoprazoleMeSH, HMDB
Wyeth brand OF lansoprazoleMeSH, HMDB
Almirall brand OF lansoprazoleMeSH, HMDB
Lansoprazole abbot brandMeSH, HMDB
Lansoprazole hoechst brandMeSH, HMDB
Lansoprazole takeda brandMeSH, HMDB
Salvar brand OF lansoprazoleMeSH, HMDB
Takeda brand OF lansoprazoleMeSH, HMDB
tecnobio Brand OF lansoprazoleMeSH, HMDB
Abbot brand OF lansoprazoleMeSH, HMDB
Hoechst brand OF lansoprazoleMeSH, HMDB
Lansoprazole lederle brandMeSH, HMDB
Lansoprazole promeco brandMeSH, HMDB
Lansoprazole vinas brandMeSH, HMDB
Lederle brand OF lansoprazoleMeSH, HMDB
Hormona brand OF lansoprazoleMeSH, HMDB
Lansoprazole almirall brandMeSH, HMDB
Lansoprazole salvar brandMeSH, HMDB
Lansoprazole tap brandMeSH, HMDB
promeco Brand OF lansoprazoleMeSH, HMDB
TAP brand OF lansoprazoleMeSH, HMDB
Chemical FormulaC16H14F3N3O2S
Average Molecular Mass369.361 g/mol
Monoisotopic Mass369.076 g/mol
CAS Registry Number103577-45-3
IUPAC Name2-{[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazole
Traditional Namelansoprazole
SMILESCC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1
InChI IdentifierInChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI KeyMJIHNNLFOKEZEW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sulfinylbenzimidazoles. These are polycyclic aromatic compounds containing a sulfinyl group attached at the position 2 of a benzimidazole moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzimidazoles
Sub ClassSulfinylbenzimidazoles
Direct ParentSulfinylbenzimidazoles
Alternative Parents
Substituents
  • Sulfinylbenzimidazole
  • Alkyl aryl ether
  • Methylpyridine
  • Pyridine
  • Benzenoid
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Sulfoxide
  • Azacycle
  • Sulfinyl compound
  • Ether
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Alkyl fluoride
  • Organopnictogen compound
  • Organic nitrogen compound
  • Organic oxide
  • Alkyl halide
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.25 g/LALOGPS
logP2.84ALOGPS
logP3.03ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)9.35ChemAxon
pKa (Strongest Basic)4.16ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area67.87 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity87.61 m³·mol⁻¹ChemAxon
Polarizability34.59 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0udi-3692000000-7bae74d48caf51b77e10Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0090000000-502b719a981f262577baNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0uxr-0890000000-2734547f6dc584ba4877Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-053i-0930000000-94e6e179919ee803d567Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-0339000000-30ca3e1162573d0632ebNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-1676d647709a023eb1d8Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-95a3126e9d69aa2812d6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-0bb1e54ec8c7d6bb5746Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-52d969183040eb21720cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-bba914a2bd85fb3b0823Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-02u0-0900000000-10a04626464fa2bcd6f9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-014i-2900000000-14157d06ad23e343435eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-02t9-8900000000-025e7246e314127a8422Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03xr-9300000000-6a804721218ef90d3f61Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-a108432755e4f5916f6eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0390000000-b8a59093f6b667fae5e4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fs9-0790000000-a2f5e86f6faaab508112Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00li-0940000000-cc60a0c246e3fc1399d6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pvr-0910000000-3c73fbb04b031d6b077dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-1900000000-731f4b8d7ac3ecfe924eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4i-6900000000-9474d5b5b8646c57c023Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0aor-9400000000-1533765e29fdaabcfcfeNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-066s-9200000000-1a1318476ca6543b3482Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0006-0339000000-30ca3e1162573d0632ebNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-2590000000-3562d6bdd29198e5bf3eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-a0cf04fa4d0e4de4b30fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0390000000-dd1b8d2df6815fa1179cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-1e4f9c95576433305a45Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-267e02d00f1bf471b3dfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0290000000-45e04ec6f327ca0afef9Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0390000000-c20bf2ef5170ff8bb1beNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-ae1f3f824a037450dc8fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-05nr-0940000000-0ed0617034395bebaedfNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-34c1beedb096399b4e51Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00li-0940000000-bfab77e885c343739783Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fs9-0790000000-ee7abfb70f45991d7309Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-8364ce030614d86ac9a6Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-1c69f3c14c3024df650cNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-8a8baf981a5a650baa17Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0pvr-0910000000-8609460aea21f3ae9798Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-03di-0900000000-0fff014fb57bc4c0fb13Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0fk9-0179000000-5cfcc8f944fb98b8de94Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0392000000-337f7fc96032201fb855Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0pi0-3910000000-4c5108c4c3adf0b5f96dNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-0719000000-5e77bdceea9908f5d4ecNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-0900000000-3ed397c90e44d64dd400Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-3901000000-0a4de90a6a2e2069b266Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-0209000000-6c4cfb2e3f981c688c9cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014r-3953000000-27584165f4f3410f7487Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-02t9-0940000000-4d71afc408680428a49fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0092000000-b149b23524b3dab98742Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0291000000-0a66886897e315833245Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0019-0930000000-7755dbd5a7deb0e944b5Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
233.0Log mg/kg[130:410]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
gastric ulceris_treatment_forNot AvailablePMC3371421
Exposure Sources
Source IDSourceSectorReference
115Drinking waterDrinking water & water supplyNot Available
242Drugs for acid related disordersHealthcare, pharmaceuticals & veterinary productsNot Available
495CeilingsBuilding & ConstructionNot Available
496FencingBuilding & ConstructionNot Available
497FloorsBuilding & ConstructionNot Available
498LaddersBuilding & ConstructionNot Available
499RoofsBuilding & ConstructionNot Available
505AmplifiersElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
517Electric SwitchesElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
519ElectrodesElectrical & Electronic EquipmentNot Available
520Emergency Protective DevicesElectrical & Electronic EquipmentNot Available
523Gas Filled Discharge Tubes With Solid CathodeElectrical & Electronic EquipmentNot Available
527MagnetsElectrical & Electronic EquipmentNot Available
530Radio Transmission SystemsElectrical & Electronic EquipmentNot Available
531RelaysElectrical & Electronic EquipmentNot Available
534Still Video CamerasElectrical & Electronic EquipmentNot Available
535Superconducting Magnets And Superconducting CoilsElectrical & Electronic EquipmentNot Available
537Television SystemsElectrical & Electronic EquipmentNot Available
545Food PreservationFood, food processing & cookwareNot Available
551Processing FishFood, food processing & cookwareNot Available
556Cigar CigarettesHousehold cleaning & consumer productsNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
560Other Smoking RequisitesHousehold cleaning & consumer productsNot Available
561Perfumes Within Detergents And SoapsHousehold cleaning & consumer productsNot Available
564Soap DispensersHousehold cleaning & consumer productsNot Available
566Tobacco PipesHousehold cleaning & consumer productsNot Available
569Tobacco Smoke FiltersHousehold cleaning & consumer productsNot Available
578Making CigarsIndustrial manufacturing & chemical processingNot Available
579Manufacture Of Iron Or SteelIndustrial manufacturing & chemical processingNot Available
580Manufacture Preparation Of Tobacco ProductsIndustrial manufacturing & chemical processingNot Available
581Paper Making MachinesIndustrial manufacturing & chemical processingNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
596AcaricidesAgriculture & land managementNot Available
606Plant Growth RegulatorsAgriculture & land managementNot Available
607Rodenticides(1)Agriculture & land managementNot Available
608RodenticidesAgriculture & land managementNot Available
611Anti Perspirants Or Body DeoderantsPersonal care & cosmeticsNot Available
614Essential Oils Or PerfumesPersonal care & cosmeticsNot Available
615Eye Makeup ProductsPersonal care & cosmeticsNot Available
618Lip Makeup ProductsPersonal care & cosmeticsNot Available
630ToysRecreation & sports surfacesNot Available
632ApparelTextiles, leather & furnishingsNot Available
634BucklesTextiles, leather & furnishingsNot Available
640Embroidering And TuftingTextiles, leather & furnishingsNot Available
642FootwearTextiles, leather & furnishingsNot Available
647Multicolour DyeingTextiles, leather & furnishingsNot Available
650Purses Luggage Hand BagsTextiles, leather & furnishingsNot Available
653SewingTextiles, leather & furnishingsNot Available
655Slide FastenersTextiles, leather & furnishingsNot Available
657Surface Finishing Of LeatherTextiles, leather & furnishingsNot Available
659Transfer PrintingTextiles, leather & furnishingsNot Available
Pathways
4 pathways
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Cytochrome P450 2C8 structureClick to view 3D structureCytochrome P450 2C8P10632HumansPredicted (SEA)142.698
Replicase polyprotein 1ab structureClick to view 3D structureReplicase polyprotein 1abP0DTD1SARS-CoV-2Predicted (SEA)243.59
D(3) dopamine receptor structureClick to view 3D structureD(3) dopamine receptorP35462HumansPredicted (SEA)1244.42
Click to view 3D structureLuciferin 4-monooxygenaseP08659Photinus pyralisPredicted (SEA)309.217
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)3576.94
Voltage-dependent T-type calcium channel subunit alpha-1H structureClick to view 3D structureVoltage-dependent T-type calcium channel subunit alpha-1HO95180HumansPredicted (SEA)289.755
Methionine aminopeptidase structureClick to view 3D structureMethionine aminopeptidaseP0AE18Escherichia coli (strain K12)Predicted (SEA)18.9952
Broad substrate specificity ATP-binding cassette transporter ABCG2 structureClick to view 3D structureBroad substrate specificity ATP-binding cassette transporter ABCG2Q9UNQ0HumansPredicted (SEA)515.751
Click to view 3D structureFerroportinQ9JHI9Mus musculusPredicted (SEA)11.5217
Photoreceptor-specific nuclear receptor structureClick to view 3D structurePhotoreceptor-specific nuclear receptorQ9Y5X4HumansPredicted (SEA)255.89
Vascular endothelial growth factor receptor 2 structureClick to view 3D structureVascular endothelial growth factor receptor 2P35968HumansPredicted (SEA)3651.13
Replicase polyprotein 1ab structureClick to view 3D structureReplicase polyprotein 1abK9N7C7Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)Predicted (SEA)26.0795
Microtubule-associated protein tau structureClick to view 3D structureMicrotubule-associated protein tauP10636HumansPredicted (SEA)74.5017
5-hydroxytryptamine receptor 1A structureClick to view 3D structure5-hydroxytryptamine receptor 1AP08908HumansPredicted (SEA)2711.96
Click to view 3D structureIndoleamine 2,3-dioxygenase 2Q8R0V5Mus musculusPredicted (SEA)1.24559
D(2) dopamine receptor structureClick to view 3D structureD(2) dopamine receptorP14416HumansPredicted (SEA)3073.95
Click to view 3D structureStreptokinase AP10520Streptococcus pyogenes serotype M1Predicted (SEA)1558.07
Peptidyl-prolyl cis-trans isomerase A structureClick to view 3D structurePeptidyl-prolyl cis-trans isomerase AP62937HumansPredicted (SEA)15.5698
Adenosine receptor A3 structureClick to view 3D structureAdenosine receptor A3P0DMS8HumansPredicted (SEA)1461.7
Aurora kinase B structureClick to view 3D structureAurora kinase BQ96GD4HumansPredicted (SEA)3832.36
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)5445.63
Fatty acid synthase structureClick to view 3D structureFatty acid synthaseP49327HumansPredicted (SEA)7.86277
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)346.04
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)397.81
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)757.706
Concentrations
Not Available
External Links
DrugBank IDDB00448
HMDB IDHMDB0005008
FooDB IDFDB023581
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkLansoprazole
Chemspider ID3746
ChEBI ID6375
PubChem Compound ID3883
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. Nohara, Akira; Maki, Yoshitaka. (Pyridylmethylthio)benzimidazoles and their sulfoxides. Eur. Pat. Appl. (1986), 23 pp. CODEN: EPXXDW EP 174726 A1 19860319 CAN 105:133883 AN 1986:533883
2. Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M: High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes. J Chromatogr B Biomed Sci Appl. 2001 Jun 5;757(1):127-33.
3. Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M: Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes. Eur J Clin Pharmacol. 2001 Dec;57(10):709-15.