Nicardipine (CED0003615)

Nicardipine is an organic compound with the formula C26H29N3O6 and an average molecular weight of 479.52 g/mol. Nicardipine belongs to the hydropyridines, a subclass of pyridines and derivatives within the organic compounds. It is classified as an organoheterocyclic compound. This substance is recorded as being released from or found in 12 sources. These include healthcare, pharmaceuticals and veterinary products as calcium channel blockers, as well as food, food processing and cookware involving food preservation and the preparation of wine or sparkling wine. Other sources include household cleaning and consumer products such as perfumes within detergents and soaps, tobacco smoke filters, cigar cigarettes, and other smoking requisites. It is also associated with electrical and electronic equipment, specifically electrodes, hybrid capacitors, antennas, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. Exposure routes for the compound include oral and intravenous administration. Nicardipine acts on 31 recorded protein targets, serving as an antagonist, inhibitor, or other unknown regulator. These targets include the alpha-1A adrenergic receptor (ADRA1A), dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A), dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B), and voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), among 27 other proteins. Regarding health effects, nicardipine is used as a treatment for hypertension (PMC5698911), as well as dementia (PMC12454544) and memory loss (PMC12454544).