Pentoxifylline (CED0002703)

Pentoxifylline is an organic compound with the formula C13H18N4O3 and an average molecular weight of 278.31 g/mol. Pentoxifylline belongs to the purines and purine derivatives, a subclass of imidazopyrimidines within the organic compounds. This compound acts as a biological antioxidant (PMC8614781). Its recorded protein targets include 5'-nucleotidase (NT5E), Tumor necrosis factor (TNF), Adenosine receptor A1 (ADORA1), and Adenosine receptor A2a (ADORA2A), where it may function as an agonist, antagonist, inhibitor, or other. Pentoxifylline is utilized in healthcare, pharmaceuticals, and veterinary products as peripheral vasodilators and drugs for obstructive airway diseases. It is also used in food preservation. The compound is found in 14 recorded sources, including household cleaning and consumer products such as perfumes within detergents and soaps, tobacco smoke filters, cigar cigarettes, non electric simulated smoking devices, and other smoking requisites. It is also associated with electrical and electronic equipment, including antennas, conductors or conductive bodies characterised by the conductive materials, electrodes, hybrid capacitors, and electrically stimulated smoking devices. Recorded exposure routes include topical and oral administration. Regarding health effects, pentoxifylline is used as a treatment for pain (PMC9022185), peripheral vascular disease (PMC10855613), and rheumatoid arthritis (PMC1010320). Additionally, it has a therapeutic effect on proteinuria (PMC8614781).