Raloxifene (CED0002655)

Raloxifene is an organic compound with the formula C28H27NO4S and an average molecular weight of 473.58 g/mol. Raloxifene belongs to the carbonyl compounds, a subclass of organooxygen compounds within the organic compounds. This compound is found in or released from 20 recorded sources, including household cleaning and consumer products such as bleaching agents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Other sources include electrical and electronic equipment—specifically electrodes, antennas, adjustable resistors, line transmission systems, and electrically stimulated smoking devices—as well as building and construction materials like tents or canopies and ladders. Additionally, it is associated with food preservation, the preparation of vinegar, and healthcare products involving sex hormones and modulators of the genital system. The recorded exposure route is oral. At the molecular level, raloxifene interacts with four recorded protein targets, acting as an agonist or binder of estrogen receptor (ESR1), estrogen receptor beta (ESR2), trefoil factor 1 (TFF1), and serpin B9 (SERPINB9). In clinical applications, it is used as a treatment for osteoporosis (PMC12068388, PMC3074486, PMC3126968, PMC3825671, PMC4092345, PMC7064359) and breast cancer (PMC12722357, PMC3702660), and it has a therapeutic effect on breast cancer (PMC2686344). However, the compound is also associated with an increase in stroke (PMC4906542, PMC7589419, PMC8395200).