Naproxen (CED0002039)

Naproxen belongs to the naphthalenes, a class of benzenoids within the organic compounds. This compound has the formula C14H14O3 and an average molecular weight of 230.26 g/mol. It is used industrially as a softener and conditioner, and biologically as an analgesic (PMC11061303) and an anti-inflammatory drug (PMC7178346, PMC9053168). Its biological activity involves four recorded protein targets: pancreatic triacylglycerol lipase (PNLIP), peptostreptococcal albumin-binding protein (pab), prostaglandin G/H synthase 1 (PTGS1), and prostaglandin G/H synthase 2 (PTGS2), for which it acts as a binder or inhibitor. Naproxen is recorded in 14 sources, including drinking water and water supply; building and construction (tents or canopies); electrical and electronic equipment (radio transmission systems, television systems, magnets, and electric hearing aids); household cleaning and consumer products (tobacco product cases, pipe accessories, other smoking requisites, and non electric simulated smoking devices); and healthcare, pharmaceuticals and veterinary products (analgesics, gynecologicals, antiinflammatory and antirheumatic products, and topical products for joint and muscular pain). Exposure routes include topical, rectal, and oral. Regarding health effects, naproxen is associated with an increase in edema (PMC11859530). It has a therapeutic effect on inflammation (PMC9899055) and is used as a treatment for pain (PMC6415270), headache (PMC11459094), Crohn's disease (PMC11061303), osteoarthritis (PMC13074443), rheumatoid arthritis (PMC13074443), fever (PMC13074443, PMC8332605), and inflammation (PMC13074443, PMC8332605).