Flumethasone (CED0012986)

Flumethasone is an organic compound with the chemical formula C22H28F2O5 and an average molecular weight of 410.46 g/mol. Flumethasone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. The compound is found in or released from nine recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it appears in corticosteroids, combinations of corticosteroids with antibiotics, combinations of corticosteroids with antiseptics, antibiotics, and otologicals. In the category of household cleaning and consumer products, it is associated with tobacco smoke filters and non-electric simulated smoking devices. Additionally, it has been recorded in drinking water and water supply, as well as in electrically stimulated smoking devices categorized under electrical and electronic equipment. Recorded exposure routes for the compound include topical, oral, inhalation, and auricular paths. At the molecular level, flumethasone interacts with four recorded protein targets. It acts as an agonist or modulator of the glucocorticoid receptor (NR3C1) and interacts with three steroid hormone receptors: estrogen-related receptor gamma (ESRRG), steroid hormone receptor ERR1 (ESRRA), and steroid hormone receptor ERR2 (ESRRB).