Amineptine (CHEM020051)

Record Information
Version1.0
Creation Date2016-05-22 06:44:22 UTC
Update Date2026-05-14 18:10:48 UTC
Accession NumberCHEM020051
Identification
Common NameAmineptine
ClassSmall Molecule
Description
A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
Contaminant Sources
  • ToxCast & Tox21 Chemicals
Contaminant TypeNot Available
Chemical Structure
MOLSDF3D SDFPDBSMILESInChI View 3D Structure
Synonyms
ValueSource
AmineptinChEBI
AmineptinoChEBI
AmineptinumChEBI
SurvectorChEBI
7-(6,11-Dihydro-5H-dibenzo[1,2-a:1',2'-e][7]annulen-11-ylamino)heptanoateHMDB
Amineptin sodium saltHMDB
Amineptin hydrochlorideHMDB
10,11-Dihydrodibenzo(a,D)cyclohept-5-enyl-7-aminoheptanoic acidHMDB
AmineptineMeSH
Chemical FormulaC22H27NO2
Average Molecular Mass337.463 g/mol
Monoisotopic Mass337.204 g/mol
CAS Registry Number57574-09-1
IUPAC Name7-({tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}amino)heptanoic acid
Traditional Nameamineptine
SMILESOC(=O)CCCCCCNC1C2=CC=CC=C2CCC2=CC=CC=C12
InChI IdentifierInChI=1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)
InChI KeyONNOFKFOZAJDHT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dibenzocycloheptenes. Dibenzocycloheptenes are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassDibenzocycloheptenes
Sub ClassNot Available
Direct ParentDibenzocycloheptenes
Alternative Parents
Substituents
  • Dibenzocycloheptene
  • Medium-chain fatty acid
  • Amino fatty acid
  • Aralkylamine
  • Fatty acyl
  • Fatty acid
  • Amino acid or derivatives
  • Amino acid
  • Carboxylic acid derivative
  • Carboxylic acid
  • Secondary aliphatic amine
  • Monocarboxylic acid or derivatives
  • Secondary amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Amine
  • Organonitrogen compound
  • Organooxygen compound
  • Carbonyl group
  • Organic oxide
  • Hydrocarbon derivative
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0003 g/LALOGPS
logP1.99ALOGPS
logP2.74ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)4.41ChemAxon
pKa (Strongest Basic)9.17ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.33 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity101.21 m³·mol⁻¹ChemAxon
Polarizability39.72 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDHMDB0248303
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkAmineptine
Chemspider ID32091
ChEBI ID32499
PubChem Compound ID34870
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=2131927
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=2141246
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=2698268
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=7609861
5. https://www.ncbi.nlm.nih.gov/pubmed/?term=9347390
6. Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26.