Morin (CED0001883)

Record Information
Version1.0
Creation Date2016-05-25 21:56:42 UTC
Update Date2026-05-14 19:59:24 UTC
Accession NumberCHEM024813
Identification
Common NameMorin
ClassSmall Molecule
Description
Morin is an organic compound with the formula C15H10O7 and an average molecular weight of 302.24 g/mol. Morin belongs to the flavones, a subclass of flavonoids within the organic compounds. It is further classified under the superclass of phenylpropanoids and polyketides. The compound has been found in or released from 20 recorded sources. Within the category of electrical and electronic equipment, it is associated with antennas, adjustable resistors, auxiliary devices, electric hearing aids, and communication cables or conductors, among four others. In building and construction, it is linked to roofs, tents or canopies, ladders, fencing, and stairs and ramps. Its presence is also recorded in food, food processing and cookware, specifically regarding the processing of fish and the preparation of wine, sparkling wine, or vinegar. Additionally, morin is found in household cleaning and consumer products such as soap dispensers and ash trays, as well as in household items including coins. At a molecular level, morin interacts with four recorded protein targets. It acts as an inhibitor of the estrogen receptor beta (ESR2) and the induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1). It also targets fatty acid synthase (FASN) and solute carrier family 22 member 12 (SLC22A12).
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
2',3,4',5,7-PentahydroxyflavoneChEBI
2',4',3,5,7-PentahydroxyflavoneChEBI
2',4',5,7-Tetrahydroxyflavan-3-olChEBI
2',4',5,7-TetrahydroxyflavonolChEBI
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-oneChEBI
3,5,7,2',4'-PentahydroxyflavoneChEBI
C.I.Natural yellow 8ChEBI
2',3,4',5,7-Pentahydroxy-flavoneHMDB
2',4',5, 7-Tetrahydroxyflavan-3-olHMDB
2'-Hydroxypelargidenolon 1522HMDB
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 9ciHMDB
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-oneHMDB
3,5 7 2 4-PentahydroxyflavoneHMDB
3,5,7,2',4'-PentahydroxyflavonolHMDB
Al-morinHMDB
AuranticaHMDB
Bois D,arcHMDB
C.I. 75660HMDB
C.I. natural yellow 11HMDB
C.I. natural yellow 8HMDB
calico YellowHMDB
Morin hydrateHMDB, MeSH
Morin, reagHMDB
Osage orangeHMDB
Osage orange crystalsHMDB
Osage orange extractHMDB
Toxylon pomiferumHMDB
3,2',4',5,7-PentahydroxyflavoneMeSH
Chemical FormulaC15H10O7
Average Molecular Mass302.236 g/mol
Monoisotopic Mass302.043 g/mol
CAS Registry Number480-16-0
IUPAC Name2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Traditional Namebois d,arc
SMILESOC1=CC(O)=C(C=C1)C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1
InChI IdentifierInChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
InChI KeyYXOLAZRVSSWPPT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as flavonols. Flavonols are compounds that contain a flavone (2-phenyl-1-benzopyran-4-one) backbone carrying a hydroxyl group at the 3-position.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassFlavones
Direct ParentFlavonols
Alternative Parents
Substituents
  • 3-hydroxyflavone
  • 3-hydroxyflavonoid
  • 4'-hydroxyflavonoid
  • 5-hydroxyflavonoid
  • 7-hydroxyflavonoid
  • Hydroxyflavonoid
  • Chromone
  • Benzopyran
  • 1-benzopyran
  • Resorcinol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Pyranone
  • Monocyclic benzene moiety
  • Pyran
  • Benzenoid
  • Heteroaromatic compound
  • Vinylogous acid
  • Polyol
  • Organoheterocyclic compound
  • Oxacycle
  • Organic oxygen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.3 g/LALOGPS
logP2.23ALOGPS
logP2.16ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)6.43ChemAxon
pKa (Strongest Basic)-4.1ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area127.45 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity76.86 m³·mol⁻¹ChemAxon
Polarizability28.38 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
GC-MSGC-MS Spectrumsplash10-0560-3953230000-e5cc9aec411435ccf00eNot AvailableView Spectrum
GC-MSGC-MS Spectrumsplash10-0560-3953230000-e5cc9aec411435ccf00eNot AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-0079-0490000000-3a567ae73e283a90d7b8Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS Spectrumsplash10-00l2-2083079000-0968a32b41727ab72dd4Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-0193000000-da94b75048715f96e77fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0910000000-f4855d0bab3b1b8fa113Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udj-0159000000-3b5e183acbd84887fe16Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-0193000000-da94b75048715f96e77fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0910000000-f4855d0bab3b1b8fa113Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udj-0159000000-3b5e183acbd84887fe16Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0921000000-ff2132edb15ca1469eefNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0984000000-e2028244f5bef38ea281Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fmi-0690000000-469ad7488f8e897e6b2dNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0229000000-a8199e25b519a14a7898Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0349000000-af5335d9f71bb7b4900bNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-0193000000-da94b75048715f96e77fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0910000000-f4855d0bab3b1b8fa113Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-08g0-0190000000-32079ac53e69b8956692Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-000b-0090000000-7d9c05a11578bc5a5791Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0290000000-4f5d8d64c096e355566fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0957000000-45912935a7fbe94f54b0Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0190000000-b3e349d09acc7ec37ac4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0a4r-0290000000-3ee674d38fa696ed6b1eNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-00l2-8900000000-2a3d26f1bc77101663daNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0ufr-0911000000-9c34e044907180f40c93Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0002-0910000000-f4855d0bab3b1b8fa113Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0fk9-0193000000-da94b75048715f96e77fNot AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0209000000-5faeaa4a89658c7f5131Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0349000000-1bf9607ca6ed614a1644Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0gb9-3930000000-e549de2e33a7202ba9b4Not AvailableView Spectrum
LC-MS/MSLC-MS/MS Spectrumsplash10-0udi-0009000000-755618501473dece9586Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0029000000-f3c546f2f72d95625bd8Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0069000000-59d6756b632a0911dd84Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-4590000000-74b52db35534b4faccd7Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0009000000-8f8cf654c4d87d51c34aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0139000000-baaa885f7a846d9e7e5aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001r-5970000000-bcf1a1d494fa93b47574Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0009000000-83a0d85bdd6b793b4e43Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0009000000-b2f55ae4e63b415a0950Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-1912000000-e9d3cb901e6e40959d88Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0009000000-ee351f9e9fc725a3bf83Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0619000000-0d41d7cd737e1851677eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0uki-1920000000-d5375dfcda659558c09aNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
8849.0Log mg/kg[5000:16000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
496FencingBuilding & ConstructionNot Available
498LaddersBuilding & ConstructionNot Available
499RoofsBuilding & ConstructionNot Available
500Stairs And RampsBuilding & ConstructionNot Available
503Tents Or CanopiesBuilding & ConstructionNot Available
504Adjustable ResistorsElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
507Auxiliary DevicesElectrical & Electronic EquipmentNot Available
510Communication Cables Or ConductorsElectrical & Electronic EquipmentNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
529Power CablesElectrical & Electronic EquipmentNot Available
536Superconductive Or Hyperconductive Conductors Cables Or Transmission LinesElectrical & Electronic EquipmentNot Available
538Thin Magnetic FilmsElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
548Preparation Of VinegarFood, food processing & cookwareNot Available
549Preparation Of Wine Or Sparkling WineFood, food processing & cookwareNot Available
551Processing FishFood, food processing & cookwareNot Available
554Ash TraysHousehold cleaning & consumer productsNot Available
564Soap DispensersHousehold cleaning & consumer productsNot Available
571CoinsHousehold itemsNot Available
578Making CigarsIndustrial manufacturing & chemical processingNot Available
583Anchoring EquipmentMarine, shipping & aquacultureNot Available
584BuoysMarine, shipping & aquacultureNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
612Body Washing Or Cleaning ImplementsPersonal care & cosmeticsNot Available
616Face Mask CosmeticsPersonal care & cosmeticsNot Available
620Card GamesRecreation & sports surfacesNot Available
622Game AccessoriesRecreation & sports surfacesNot Available
635ButtonsTextiles, leather & furnishingsNot Available
638Decorating TextilesTextiles, leather & furnishingsNot Available
640Embroidering And TuftingTextiles, leather & furnishingsNot Available
644Hook Or Eye FastenersTextiles, leather & furnishingsNot Available
647Multicolour DyeingTextiles, leather & furnishingsNot Available
649Pins ClothesTextiles, leather & furnishingsNot Available
653SewingTextiles, leather & furnishingsNot Available
655Slide FastenersTextiles, leather & furnishingsNot Available
656Snap FastenersTextiles, leather & furnishingsNot Available
658Touch FastenersTextiles, leather & furnishingsNot Available
663Sanitary EquipmentWastewater, sanitation & biosolidsNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
ATP-dependent translocase ABCB1 structureClick to view 3D structureATP-dependent translocase ABCB1P08183HumansPredicted (SEA)1.79053
Xanthine dehydrogenase/oxidase structureClick to view 3D structureXanthine dehydrogenase/oxidaseP47989HumansPredicted (SEA)0.155698
Click to view 3D structureD-alanine--D-alanine ligaseQ1CTD3Helicobacter pylori (strain HPAG1)Predicted (SEA)0.155698
Click to view 3D structureAldo-keto reductase family 1 member C21Q91WR5Mus musculusPredicted (SEA)0.155698
Click to view 3D structureFatty acid synthaseQ965D7Plasmodium falciparumPredicted (SEA)0.233548
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)1.55698
Alpha-ketoglutarate-dependent dioxygenase FTO structureClick to view 3D structureAlpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1HumansPredicted (SEA)0.155698
Amyloid-beta precursor protein structureClick to view 3D structureAmyloid-beta precursor proteinP05067HumansPredicted (SEA)0.311397
Receptor-type tyrosine-protein kinase FLT3 structureClick to view 3D structureReceptor-type tyrosine-protein kinase FLT3P36888HumansPredicted (SEA)11.5995
Short transient receptor potential channel 5 structureClick to view 3D structureShort transient receptor potential channel 5Q9UL62HumansPredicted (SEA)0.155698
Click to view 3D structureInositol hexakisphosphate kinase 2Q9UHH9HumansPredicted (SEA)0.155698
Tyrosine-protein kinase Yes structureClick to view 3D structureTyrosine-protein kinase YesP07947HumansPredicted (SEA)2.25763
Amine oxidase [flavin-containing] A structureClick to view 3D structureAmine oxidase [flavin-containing] AP21397HumansPredicted (SEA)1.32344
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)1.47914
Carbonic anhydrase 7 structureClick to view 3D structureCarbonic anhydrase 7P43166HumansPredicted (SEA)0.544945
Carbonic anhydrase 12 structureClick to view 3D structureCarbonic anhydrase 12O43570HumansPredicted (SEA)0.700643
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)1.24559
Carbonic anhydrase 4 structureClick to view 3D structureCarbonic anhydrase 4P22748HumansPredicted (SEA)0.233548
Protein E6 structureClick to view 3D structureProtein E6P03126Human papillomavirus type 16Predicted (SEA)0.0778492
Protein deacetylase HDAC6 structureClick to view 3D structureProtein deacetylase HDAC6Q9UBN7HumansPredicted (SEA)0.544945
Click to view 3D structure3-oxoacyl-acyl-carrier protein reductaseQ965D6Plasmodium falciparumPredicted (SEA)0.155698
Click to view 3D structureEnoyl-acyl-carrier protein reductaseQ965D5Plasmodium falciparumPredicted (SEA)0.233548
Cytochrome P450 1B1 structureClick to view 3D structureCytochrome P450 1B1Q16678HumansPredicted (SEA)0.389246
Cytochrome P450 1A1 structureClick to view 3D structureCytochrome P450 1A1P04798HumansPredicted (SEA)0.311397
Click to view 3D structureTyrosine-protein kinase transforming protein FpsP00530Fujinami sarcoma virusPredicted (SEA)0.155698
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDHMDB0030796
FooDB IDFDB002736
Phenol Explorer ID310
KNApSAcK IDC00004624
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkMorin_(flavonol)
Chemspider ID4444989
ChEBI ID75092
PubChem Compound ID5281670
Kegg Compound IDC10105
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=15516722
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=16806951
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=18629640
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=19539802
5. https://www.ncbi.nlm.nih.gov/pubmed/?term=19774509
6. https://www.ncbi.nlm.nih.gov/pubmed/?term=22740350
7. https://www.ncbi.nlm.nih.gov/pubmed/?term=23030699
8. https://www.ncbi.nlm.nih.gov/pubmed/?term=23254912
9. https://www.ncbi.nlm.nih.gov/pubmed/?term=23279849
10. https://www.ncbi.nlm.nih.gov/pubmed/?term=23352912
11. https://www.ncbi.nlm.nih.gov/pubmed/?term=23384060
12. https://www.ncbi.nlm.nih.gov/pubmed/?term=23432089
13. https://www.ncbi.nlm.nih.gov/pubmed/?term=23590821
14. https://www.ncbi.nlm.nih.gov/pubmed/?term=23757948
15. https://www.ncbi.nlm.nih.gov/pubmed/?term=23952478
16. Kang DG, Moon MK, Sohn EJ, Lee DH, Lee HS: Effects of morin on blood pressure and metabolic changes in fructose-induced hypertensive rats. Biol Pharm Bull. 2004 Nov;27(11):1779-83.
17. Jung HJ, Kim SJ, Song YS, Park EH, Lim CJ: Evaluation of the antiangiogenic, anti-inflammatory, and antinociceptive activities of morin. Planta Med. 2010 Feb;76(3):273-5. doi: 10.1055/s-0029-1186079. Epub 2009 Sep 11.
18. Lee HS, Jung KH, Park IS, Kwon SW, Lee DH, Hong SS: Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats. Dig Dis Sci. 2009 Apr;54(4):782-8. doi: 10.1007/s10620-008-0404-x. Epub 2008 Jul 17.
19. Gottlieb M, Leal-Campanario R, Campos-Esparza MR, Sanchez-Gomez MV, Alberdi E, Arranz A, Delgado-Garcia JM, Gruart A, Matute C: Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. Neurobiol Dis. 2006 Aug;23(2):374-86. Epub 2006 Jun 27.
20. Sivaramakrishnan V, Niranjali Devaraj S: Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem Biol Interact. 2009 Aug 14;180(3):353-9. doi: 10.1016/j.cbi.2009.02.004. Epub 2009 Feb 21.
21. Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.