Bradykinin (CED0001490)

Record Information

Version

1.0

Creation Date

2016-05-26 05:58:11 UTC

Update Date

2026-08-22 19:28:02 UTC

SynCED ID

CED0001490

Secondary Accession Numbers

CHEM035663

Identification

Common Name

Bradykinin

Class

Small Molecule

Description

Bradykinin (C50H73N15O11) is a chemical compound with an average molecular weight of 1,060 g/mol. With an average molecular weight of 1,060 g/mol, Bradykinin is a heavy molecule. Bradykinin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. This compound is found in or released from four recorded sources, including food, food processing and cookware, specifically the preparation of wort, as well as electrical and electronic equipment such as antennas, gas filled discharge tubes with gaseous cathodes, and discharge tubes with liquid pool cathodes. Regarding its biological activity, Bradykinin acts as an inhibitor of the B2 bradykinin receptor (BDKRB2). In terms of health effects, the compound is associated with inflammation (PMC9784116 ) and cancer (PMC9784116 ).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Arg-pro-pro-gly-phe-ser-pro-phe-arg	ChEBI
BK	ChEBI
L-Arg-L-pro-L-pro-gly-L-phe-L-ser-L-pro-L-phe-L-arg	ChEBI
L-Bradykinin	ChEBI
RPPGFSPFR	ChEBI
Callidin I	HMDB
Kallidin 9	HMDB
Kallidin I	HMDB
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine	HMDB
Bradykinin acetate, (9-D-arg)-isomer	HMDB
Bradykinin hydrochloride	HMDB
Bradykinin triacetate	HMDB
Bradykinin, (2-D-pro-7-D-pro)-isomer	HMDB
Bradykinin, (8-D-phe)-isomer	HMDB
Arg pro pro gly phe ser pro phe arg	HMDB
Bradykinin, (1-D-arg)-isomer	HMDB
Bradykinin, (2-D-pro-3-D-pro-7-D-pro)-isomer	HMDB
Bradykinin, (3-D-pro-7-D-pro)-isomer	HMDB
Bradykinin, (5-D-phe)-isomer	HMDB
Bradykinin, (5-D-phe-8-D-phe)-isomer	HMDB
Bradykinin, (6-D-ser)-isomer	HMDB
Bradykinin, (7-D-pro)-isomer	HMDB
Bradykinin, (9-D-arg)-isomer	HMDB
Bradykinin diacetate	HMDB
Bradykinin, (2-D-pro)-isomer	HMDB
Bradykinin, (3-D-pro)-isomer	HMDB

Chemical Formula

C₅₀H₇₃N₁₅O₁₁

Average Molecular Mass

1060.209 g/mol

Monoisotopic Mass

1059.561 g/mol

CAS Registry Number

58-82-2

IUPAC Name

(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acid

Traditional Name

L-bradykinin

SMILES

N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI Identifier

InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI Key

QXZGBUJJYSLZLT-FDISYFBBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Oligopeptides

Alternative Parents

Substituents

Alpha-oligopeptide
Phenylalanine or derivatives
Proline or derivatives
N-acyl-alpha amino acid or derivatives
N-acyl-l-alpha-amino acid
N-acyl-alpha-amino acid
Alpha-amino acid amide
N-substituted-alpha-amino acid
Alpha-amino acid or derivatives
Amphetamine or derivatives
N-acylpyrrolidine
Pyrrolidine carboxylic acid or derivatives
Pyrrolidine-2-carboxamide
Monocyclic benzene moiety
Fatty acyl
Benzenoid
Fatty amide
Tertiary carboxylic acid amide
Pyrrolidine
Secondary carboxylic acid amide
Carboxamide group
Amino acid or derivatives
Guanidine
Amino acid
Azacycle
Organoheterocyclic compound
Carboxylic acid
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Monocarboxylic acid or derivatives
Carboximidamide
Amine
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Alcohol
Primary aliphatic amine
Organic oxide
Hydrocarbon derivative
Primary amine
Primary alcohol
Organonitrogen compound
Organooxygen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

oligopeptide (CHEBI:3165 )
Bradykinin [KO:K03898] (C00306 )

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

neurotransmitter (PMC7185389 )?A chemical that allows the transmission of signals from one neuron to the next across synapses
agonist (PMC12584831 )?
vasodilator agent (PMC6151556 , PMC4302234 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.057 g/L	ALOGPS
logP	-2.1	ALOGPS
logP	-6.4	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	3.39	ChemAxon
pKa (Strongest Basic)	12.44	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	18	ChemAxon
Hydrogen Donor Count	14	ChemAxon
Polar Surface Area	413.78 Å²	ChemAxon
Rotatable Bond Count	27	ChemAxon
Refractivity	295.08 m³·mol⁻¹	ChemAxon
Polarizability	109.98 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00di-9605021310-963d37a5c0a6a8c3b581	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00fr-4914021100-da28e55acbc5e55e7615	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00di-9824010200-b5b2c55602c29375ed1a	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ard-9000000008-70e85b5126294f4866f8	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4m-8001001009-d8431ee82b28629bac33	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9001111000-9de36ae5c0196bc1ca98	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-9000000000-eb21ccd98d434e431a1e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03dl-9000210241-b63ee10d53ba3efc65cb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-022l-9780340000-45c697c4a631655e2811	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9000000000-6f7d24ea48539f7cd9fb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-052f-9000100016-0338af4c69622fd514d8	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-052g-9003871073-646bd5ef5605a552ce67	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
hypertension	Associated With?	Not Available	A disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg. (NCI CTCAE)	PMC12584831
inflammation	Associated With?	Not Available	Not Available	PMC9784116 , PMC7400062
inflammation	Associated With?	increase	Not Available	PMC13347398
cancer	Associated With?	Not Available	Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. There are over 100 types of cancers affect humans. The risk of developing certain cancers can be reduced by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat and avoiding too much sunlight exposure. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy and targeted therapy. The majority of cancers, some 90–95% of cases, are due to genetic mutations from environmental and lifestyle factors. The remaining 5–10% are due to inherited genetics.	PMC9784116
type 2 diabetes mellitus	Associated With?	decrease	Not Available	PMC5552834
stroke	Associated With?	Not Available	Not Available	PMC12584831
rheumatoid arthritis	Elevated in Blood In	increase	An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint. (DO)	PMC12584831
pain	Associated With?	Not Available	A disorder characterized by the sensation of marked discomfort, distress or agony. (NCI CTCAE)	PMC12584831 , PMC12584831
cough	Associated With?	increase	A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. (NCI CTCAE)	PMC3537328
cough	Associated With?	Not Available	A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound. (NCI CTCAE)	PMC6405328
osteoarthritis	Elevated in Blood In	increase	An arthritis that has material basis in worn out cartilage located in joint. (DO)	PMC12584831
interstitial cystitis	Associated With?	increase	Not Available	PMC13103315
angioedema	Associated With?	Not Available	Not Available	PMC6405328
migraine with aura	Associated With?	Not Available	Not Available	PMC6220531
bacterial infectious disease	Associated With?	Not Available	Not Available	PMC9784116
Lung Injury	Associated With?	Not Available	Not Available	PMC10069302
Death	Associated With?	Not Available	Not Available	PMC5832253
septic shock	Associated With?	Not Available	Not Available	PMC12584831
Arthralgia	Associated With?	increase	Not Available	PMC12584831
adult respiratory distress syndrome	Associated With?	Not Available	Not Available	PMC10069302
Cancer Pain	Associated With?	Not Available	Not Available	PMC6302803
Pelvic pain	Associated With?	Not Available	Not Available	PMC7076794

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000515	Discharge Tubes With Liquid Pool Cathodes?Discharge tubes with liquid pool cathodes are devices that utilize a liquid metal as the cathode in gas discharge applications.	Electrical & Electronic Equipment	PubChem
CEDs000522	Gas Filled Discharge Tubes With Gaseous Cathodes?Gas Filled Discharge Tubes with Gaseous Cathodes are electrical devices that facilitate the conduction of electricity through a gas medium.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000550	Preparation Of Wort?The preparation of wort involves the extraction of sugars from malted grains, a crucial step in the brewing process.	Food, food processing & cookware	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000603	Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000609	Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.	Personal care & cosmetics	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000612	Body Washing Or Cleaning Implements?Body washing or cleaning implements, such as synthetic sponges, loofahs, and washcloths, can be sources of synthetic chemical contamination due to the materials used in their production.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000620	Card Games?Card games often utilize synthetic materials for playing cards and associated gaming equipment, which may contain various chemicals such as polyvinyl chloride (PVC), plastics, and dyes.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000643	Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000678	Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.	Agriculture & land management	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000732	Spectacle Cases?Spectacle cases can serve as a source of synthetic chemical contamination due to the materials used in their production, such as polycarbonate, PVC, and various plastics, which may leach harmful substances over time.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem

Pathways

1 pathwayPathway Source: PathBank

ACE

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Kappa-type opioid receptor	P34975	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.509 Applicability Domain 0.58 Statistical Significance 0.003 Supporting Reference Compounds 66 E-value 23.0434
Click to view 3D structure	Substance-P receptor	P14600	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.505 Applicability Domain 0.541 Statistical Significance 0.002 Supporting Reference Compounds 34 E-value 15.6477
Click to view 3D structure	Neurotensin receptor type 2	O95665	Humans	Predicted (SEA)	Prediction Confidence Score 0.502 Applicability Domain 0.559 Statistical Significance 9.60e-04 Supporting Reference Compounds 9 E-value 7.47353
Click to view 3D structure	Apical membrane antigen 1	Q7KQK5	Plasmodium falciparum (isolate 3D7)	Predicted (SEA)	Prediction Confidence Score 0.5 Applicability Domain 0.5 Statistical Significance 0.0034 Supporting Reference Compounds 1 E-value 26.7023
Click to view 3D structure	Plasminogen	P00747	Humans	Predicted (SEA)	Prediction Confidence Score 0.497 Applicability Domain 0.69 Statistical Significance 0.0018 Supporting Reference Compounds 195 E-value 13.7793
Click to view 3D structure	Neuromedin-U receptor 1	O55040	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.497 Applicability Domain 0.52 Statistical Significance 0.0011 Supporting Reference Compounds 3 E-value 8.25202
Click to view 3D structure	Mu-type opioid receptor	P42866	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.49 Applicability Domain 0.541 Statistical Significance 0.003 Supporting Reference Compounds 107 E-value 23.0434
Click to view 3D structure	Plasma kallikrein	P03952	Humans	Known	Not Available
Click to view 3D structure	Piezo-type mechanosensitive ion channel component 2	Q9H5I5	Humans	Known	Not Available
Click to view 3D structure	Angiotensin-converting enzyme	P12821	Humans	Known	Not Available
Click to view 3D structure	B2 bradykinin receptor	P25023	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.68 Applicability Domain 1.0 Statistical Significance 4.00e-05 Supporting Reference Compounds 10 E-value 0.311397
Click to view 3D structure	B2 bradykinin receptor	P30411	Humans	Predicted (SEA)	Prediction Confidence Score 0.634 Applicability Domain 1.0 Statistical Significance 1.00e-05 Supporting Reference Compounds 18 E-value 0.0778492
Click to view 3D structure	Adapter molecule crk	P46108	Humans	Predicted (SEA)	Prediction Confidence Score 0.602 Applicability Domain 0.602 Statistical Significance 2.30e-04 Supporting Reference Compounds 1 E-value 1.79053
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.582 Applicability Domain 0.611 Statistical Significance 0.0034 Supporting Reference Compounds 532 E-value 26.1573
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Predicted (SEA)	Prediction Confidence Score 0.581 Applicability Domain 0.602 Statistical Significance 0.0036 Supporting Reference Compounds 427 E-value 27.9479
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Predicted (SEA)	Prediction Confidence Score 0.576 Applicability Domain 0.602 Statistical Significance 0.0035 Supporting Reference Compounds 527 E-value 27.4029
Click to view 3D structure	Neuropeptide FF receptor 2	Q9Y5X5	Humans	Predicted (SEA)	Prediction Confidence Score 0.572 Applicability Domain 0.611 Statistical Significance 5.10e-04 Supporting Reference Compounds 25 E-value 3.97031
Click to view 3D structure	Neuropilin-1	Q9QWJ9	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.566 Applicability Domain 0.582 Statistical Significance 6.00e-05 Supporting Reference Compounds 2 E-value 0.467095
Click to view 3D structure	C5a anaphylatoxin chemotactic receptor 1	P30993	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.563 Applicability Domain 0.563 Statistical Significance 5.70e-04 Supporting Reference Compounds 1 E-value 4.43741
Click to view 3D structure	Mu-type opioid receptor	P33535	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.562 Applicability Domain 0.595 Statistical Significance 0.0043 Supporting Reference Compounds 229 E-value 33.6309
Click to view 3D structure	Mu-type opioid receptor	P97266	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.558 Applicability Domain 0.641 Statistical Significance 0.0045 Supporting Reference Compounds 186 E-value 34.8764
Click to view 3D structure	Kappa-type opioid receptor	P41144	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.538 Applicability Domain 0.58 Statistical Significance 0.0051 Supporting Reference Compounds 199 E-value 39.4696
Click to view 3D structure	Delta-type opioid receptor	P32300	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.533 Applicability Domain 0.58 Statistical Significance 0.0051 Supporting Reference Compounds 166 E-value 39.3917
Click to view 3D structure	Neuropeptide FF receptor 1	Q9GZQ6	Humans	Predicted (SEA)	Prediction Confidence Score 0.531 Applicability Domain 0.611 Statistical Significance 8.40e-04 Supporting Reference Compounds 21 E-value 6.53933
Click to view 3D structure	Delta-type opioid receptor	P33533	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.524 Applicability Domain 0.543 Statistical Significance 0.0049 Supporting Reference Compounds 164 E-value 38.5354
Click to view 3D structure	Neurotensin receptor type 1	P30989	Humans	Predicted (SEA)	Prediction Confidence Score 0.515 Applicability Domain 0.559 Statistical Significance 9.60e-04 Supporting Reference Compounds 44 E-value 7.47353
Click to view 3D structure	Neuromedin-U receptor 2	Q8BZ39	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.514 Applicability Domain 0.514 Statistical Significance 0.0011 Supporting Reference Compounds 1 E-value 8.25202
Click to view 3D structure	Uncharacterized protein	F1N083	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.511 Applicability Domain 0.511 Statistical Significance 7.60e-04 Supporting Reference Compounds 1 E-value 5.91654