Binimetinib (CED0004336)

Record Information

Version

1.0

Creation Date

2026-04-05 13:24:55 UTC

Update Date

2026-08-19 18:45:16 UTC

Accession Number

CHEM102768

Identification

Common Name

Binimetinib

Class

Small Molecule

Description

Binimetinib is an organic compound with the formula C17H15BrF2N4O3 and an average molecular weight of 441.23 g/mol. Binimetinib belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It is recorded as being found in or released from two sources: electrical and electronic equipment, specifically electric hearing aids, and healthcare, pharmaceuticals & veterinary products, where it is categorized as an antineoplastic agent. The recorded exposure route for this compound is oral. At the molecular level, binimetinib acts on two recorded protein targets. It functions as an inhibitor of dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) and dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₇H₁₅BrF₂N₄O₃

Average Molecular Mass

441.233 g/mol

Monoisotopic Mass

440.030 g/mol

CAS Registry Number

606143-89-9

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CN1C=NC2=C1C=C(C(=O)NOCCO)C(NC1=C(F)C=C(Br)C=C1)=C2F

InChI Identifier

InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI Key

ACWZRVQXLIRSDF-UHFFFAOYSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-5004900000-b5fe782069d673930504	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-2009000000-6a5322fdd46ce27f8e4e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-9006000000-7d5a18a713ef987e49f4	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-1104900000-e122a617640e3b9b77e6	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-4109300000-1fde364fb97f0ad73b54	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-029l-3309000000-6e5c49dd9f11f550bd06	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004r-0009500000-cb8f3fe297b2156eac06	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-2009100000-60170205a9d6837dc9b9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-5009000000-7f771875c640ba994159	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-0001900000-22b137df0195f4d6b3c1	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-0005900000-86287f3d21a325c0415e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00dr-0159000000-ae88743e32b2cca577fd	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
2608.0	Log mg/kg	[1500:4600]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
358	Antineoplastic agents	Healthcare, pharmaceuticals & veterinary products	Not Available
516	Electric Hearing Aids	Electrical & Electronic Equipment	Not Available

Pathways

2 pathways

Binimetinib Drug Metabolism

Binimetinib Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	Humans	Predicted (SEA)	7.62922
Click to view 3D structure	Dual specificity mitogen-activated protein kinase kinase 2	P36507	Humans	Predicted (SEA)	10.5875
Click to view 3D structure	Serine/threonine-protein kinase B-raf	P15056	Humans	Predicted (SEA)	36.5891
Click to view 3D structure	Dual specificity mitogen-activated protein kinase kinase 5	Q13163	Humans	Predicted (SEA)	15.8034
Click to view 3D structure	Mitogen-activated protein kinase 1	P28482	Humans	Predicted (SEA)	66.8725
Click to view 3D structure	Vascular endothelial growth factor receptor 2	P35968	Humans	Predicted (SEA)	236.272
Click to view 3D structure	Epidermal growth factor receptor	P00533	Humans	Predicted (SEA)	206.067
Click to view 3D structure	Platelet-derived growth factor receptor beta	P09619	Humans	Predicted (SEA)	128.918
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	P42336	Humans	Predicted (SEA)	93.7305
Click to view 3D structure	Serine/threonine-protein kinase pim-1	P11309	Humans	Predicted (SEA)	141.53
Click to view 3D structure	Vascular endothelial growth factor receptor 1	P17948	Humans	Predicted (SEA)	150.95
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	Humans	Predicted (SEA)	87.9696
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	Humans	Predicted (SEA)	75.7473
Click to view 3D structure	Eukaryotic translation initiation factor 2-alpha kinase 1	Q9BQI3	Humans	Predicted (SEA)	18.7617
Click to view 3D structure	Calcium/calmodulin-dependent protein kinase type II subunit beta	Q13554	Humans	Predicted (SEA)	84.155
Click to view 3D structure	Tyrosine-protein kinase Lck	P06239	Humans	Predicted (SEA)	287.497
Click to view 3D structure	Fibroblast growth factor receptor 1	P11362	Humans	Predicted (SEA)	243.746
Click to view 3D structure	Aurora kinase A	O14965	Humans	Predicted (SEA)	237.518
Click to view 3D structure	Structural maintenance of chromosomes protein 1A	Q14683	Humans	Predicted (SEA)	0.0778492
Click to view 3D structure	Proto-oncogene tyrosine-protein kinase Src	P12931	Humans	Predicted (SEA)	300.264
Click to view 3D structure	Cyclin-dependent kinase 2	P24941	Humans	Predicted (SEA)	217.355
Click to view 3D structure	Receptor-type tyrosine-protein kinase FLT3	P36888	Humans	Predicted (SEA)	324.865
Click to view 3D structure	Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	Humans	Predicted (SEA)	232.224
Click to view 3D structure	Angiopoietin-1 receptor	Q02763	Humans	Predicted (SEA)	102.527
Click to view 3D structure	Mitogen-activated protein kinase kinase kinase 9	P80192	Humans	Predicted (SEA)	38.3018