Fostamatinib (CED0006308)

Record Information
Version1.0
Creation Date2026-04-05 13:37:23 UTC
Update Date2026-08-22 00:47:15 UTC
Accession NumberCHEM102956
Identification
Common NameFostamatinib
ClassSmall Molecule
Description
Fostamatinib is a chemical compound with the molecular formula C23H26FN6O9P. Fostamatinib belongs to the aniline and substituted anilines, a subclass of benzene and substituted derivatives within the organic compounds. With an average molecular weight of 580.46 g/mol, Fostamatinib is a heavy molecule. This compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically vitamin k and other hemostatics. The recorded exposure route for this substance is oral. Fostamatinib is associated with 302 recorded protein targets. It acts as an antagonist or inhibitor of several proteins, including the adenosine receptor A3 (ADORA3), the synaptic vesicular amine transporter (SLC18A2), fatty-acid amide hydrolase 1 (FAAH), and the equilibrative nucleoside transporter 1 (SLC29A1), along with 298 other proteins.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC23H26FN6O9P
Average Molecular Mass580.460 g/mol
Monoisotopic Mass580.148 g/mol
CAS Registry Number901119-35-5
IUPAC NameNot Available
Traditional NameNot Available
SMILESCOC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC
InChI IdentifierInChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)
InChI KeyGKDRMWXFWHEQQT-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0000090000-23ebd85a5d96bfbc3b52Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-1000090000-3b740a34def25351a64cNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ff9-0629000000-0c74cf7aa27895793331Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-2000090000-a3ba42e7f8da38830e4bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9100030000-9288838ff51180fdbe94Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9202000000-6539073d24303037811eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0000390000-8740c8917271dd768c56Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0000960000-a31a696e8e64e70fc4a0Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014i-1002900000-bcd930f0b928b30d9de5Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-0000090000-28edb9aed79aae34d26aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9000000000-ca30e71e114ea6673088Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-004i-9000100000-39c315332c306234c887Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
6786.0Log mg/kg[3800:12000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
275Vitamin k and other hemostaticsHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
2 pathways
Fostamatinib Drug Metabolism Action Pathway
Fostamatinib Drug Metabolism Action Pathway
Fostamatinib Predicted Metabolism Pathway
Fostamatinib Predicted Metabolism Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Aurora kinase A structureClick to view 3D structureAurora kinase AO14965HumansPredicted (SEA)22.8877
Focal adhesion kinase 1 structureClick to view 3D structureFocal adhesion kinase 1Q05397HumansPredicted (SEA)14.1686
Mitogen-activated protein kinase 8 structureClick to view 3D structureMitogen-activated protein kinase 8P45983HumansPredicted (SEA)15.2584
Mitogen-activated protein kinase 9 structureClick to view 3D structureMitogen-activated protein kinase 9P45984HumansPredicted (SEA)12.6894
Proto-oncogene tyrosine-protein kinase receptor Ret structureClick to view 3D structureProto-oncogene tyrosine-protein kinase receptor RetP07949HumansPredicted (SEA)19.1509
Receptor-type tyrosine-protein kinase FLT3 structureClick to view 3D structureReceptor-type tyrosine-protein kinase FLT3P36888HumansPredicted (SEA)48.3444
Aurora kinase B structureClick to view 3D structureAurora kinase BQ96GD4HumansPredicted (SEA)24.1333
Serine/threonine-protein kinase PLK4 structureClick to view 3D structureSerine/threonine-protein kinase PLK4O00444HumansPredicted (SEA)14.7135
Click to view 3D structureInhibitor of nuclear factor kappa-B kinase subunit epsilonQ14164HumansPredicted (SEA)10.1204
Macrophage-stimulating protein receptor structureClick to view 3D structureMacrophage-stimulating protein receptorQ04912HumansPredicted (SEA)10.1204
Tyrosine-protein kinase SYK structureClick to view 3D structureTyrosine-protein kinase SYKP43405HumansPredicted (SEA)30.5947
Non-receptor tyrosine-protein kinase TNK1 structureClick to view 3D structureNon-receptor tyrosine-protein kinase TNK1Q13470HumansPredicted (SEA)8.17417
Serine/threonine-protein kinase Nek9 structureClick to view 3D structureSerine/threonine-protein kinase Nek9Q8TD19HumansPredicted (SEA)4.5931
Mitogen-activated protein kinase kinase kinase 11 structureClick to view 3D structureMitogen-activated protein kinase kinase kinase 11Q16584HumansPredicted (SEA)8.01847
Interleukin-1 receptor-associated kinase 3 structureClick to view 3D structureInterleukin-1 receptor-associated kinase 3Q9Y616HumansPredicted (SEA)5.3716
Serine/threonine-protein kinase 16 structureClick to view 3D structureSerine/threonine-protein kinase 16O75716HumansPredicted (SEA)5.52729
Serine/threonine-protein kinase LATS1 structureClick to view 3D structureSerine/threonine-protein kinase LATS1O95835HumansPredicted (SEA)6.46149
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma structureClick to view 3D structurePhosphatidylinositol 5-phosphate 4-kinase type-2 gammaQ8TBX8HumansPredicted (SEA)4.04816
Click to view 3D structureAarF domain-containing protein kinase 1Q86TW2HumansPredicted (SEA)0.0778492
Tyrosine-protein kinase receptor TYRO3 structureClick to view 3D structureTyrosine-protein kinase receptor TYRO3Q06418HumansPredicted (SEA)62.6686
Epidermal growth factor receptor structureClick to view 3D structureEpidermal growth factor receptorP00533HumansPredicted (SEA)212.061
Hepatocyte growth factor receptor structureClick to view 3D structureHepatocyte growth factor receptorP08581HumansPredicted (SEA)129.152
Vascular endothelial growth factor receptor 2 structureClick to view 3D structureVascular endothelial growth factor receptor 2P35968HumansPredicted (SEA)246.86
Insulin-like growth factor 1 receptor structureClick to view 3D structureInsulin-like growth factor 1 receptorP08069HumansPredicted (SEA)132.11
Tyrosine-protein kinase Lck structureClick to view 3D structureTyrosine-protein kinase LckP06239HumansPredicted (SEA)192.132
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available