Ribociclib succinate (CED0016113)

Record Information
Version1.0
Creation Date2026-04-05 13:49:50 UTC
Update Date2026-08-22 01:30:01 UTC
Accession NumberCHEM103273
Identification
Common NameRibociclib succinate
ClassSmall Molecule
Description
Ribociclib succinate is an organic compound with the formula C23H30N8O and an average molecular weight of 434.55 g/mol. Ribociclib succinate belongs to the piperazines, a subclass of diazinanes within the organic compounds. It functions as an antagonist and inhibitor of the protein targets Cyclin-dependent kinase 4 (CDK4) and Cyclin-dependent kinase 6 (CDK6). The compound is found in or released from three recorded sources, including healthcare, pharmaceuticals, and veterinary products as antineoplastic agents, as well as electrical and electronic equipment such as antennas and electric hearing aids. The recorded exposure route for this substance is oral.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC23H30N8O
Average Molecular Mass434.548 g/mol
Monoisotopic Mass434.254 g/mol
CAS Registry Number1211441-98-3
IUPAC NameNot Available
Traditional NameNot Available
SMILESCN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1
InChI IdentifierInChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChI KeyRHXHGRAEPCAFML-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-014l-5198400000-05147fd0421bf0ce99e1Not AvailableView Spectrum
Predicted GC-MSPredicted GC-MS SpectrumNot AvailableNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0134900000-19b75d4d2f1302535362Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03ka-2396000000-20a47b700b3c92544738Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a6s-4960000000-aded5512d57e7004e372Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-001i-0111900000-1af9a7b18e2253421e44Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00gr-1289400000-77f6701252b94d31984aNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0f6x-9475100000-becc0f6259eb8aaffc1cNot AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
239.0Log mg/kg[130:420]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
358Antineoplastic agentsHealthcare, pharmaceuticals & veterinary productsNot Available
506AntennasElectrical & Electronic EquipmentNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
620Card GamesRecreation & sports surfacesNot Available
631Anthraquinone DyesTextiles, leather & furnishingsNot Available
Pathways
1 pathway
Ribociclib Drug Metabolism Action Pathway
Ribociclib Drug Metabolism Action Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Cyclin-dependent kinase 4 structureClick to view 3D structureCyclin-dependent kinase 4P11802HumansPredicted (SEA)1.40129
Cyclin-dependent kinase 6 structureClick to view 3D structureCyclin-dependent kinase 6Q00534HumansPredicted (SEA)1.24559
Cyclin-dependent kinase 9 structureClick to view 3D structureCyclin-dependent kinase 9P50750HumansPredicted (SEA)3.03612
Receptor-type tyrosine-protein kinase FLT3 structureClick to view 3D structureReceptor-type tyrosine-protein kinase FLT3P36888HumansPredicted (SEA)37.2898
Calcium/calmodulin-dependent protein kinase type II subunit delta structureClick to view 3D structureCalcium/calmodulin-dependent protein kinase type II subunit deltaQ13557HumansPredicted (SEA)20.0851
Calcium/calmodulin-dependent protein kinase type II subunit gamma structureClick to view 3D structureCalcium/calmodulin-dependent protein kinase type II subunit gammaQ13555HumansPredicted (SEA)18.3724
Cyclin-dependent kinase 16 structureClick to view 3D structureCyclin-dependent kinase 16Q00536HumansPredicted (SEA)4.04816
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)62.6686
Cyclin-dependent kinase 2 structureClick to view 3D structureCyclin-dependent kinase 2P24941HumansPredicted (SEA)56.5964
Cyclin-dependent kinase 1 structureClick to view 3D structureCyclin-dependent kinase 1P06493HumansPredicted (SEA)31.8403
Aurora kinase A structureClick to view 3D structureAurora kinase AO14965HumansPredicted (SEA)100.425
MAP/microtubule affinity-regulating kinase 3 structureClick to view 3D structureMAP/microtubule affinity-regulating kinase 3P27448HumansPredicted (SEA)58.3869
Click to view 3D structureNUAK family SNF1-like kinase 1O60285HumansPredicted (SEA)14.1686
Cyclin-G-associated kinase structureClick to view 3D structureCyclin-G-associated kinaseO14976HumansPredicted (SEA)35.5771
Click to view 3D structureSerine/threonine-protein kinase SIK2Q9H0K1HumansPredicted (SEA)21.0971
Glycogen synthase kinase-3 beta structureClick to view 3D structureGlycogen synthase kinase-3 betaP49841HumansPredicted (SEA)127.206
MAP kinase-activated protein kinase 2 structureClick to view 3D structureMAP kinase-activated protein kinase 2P49137HumansPredicted (SEA)66.3275
Mitogen-activated protein kinase 1 structureClick to view 3D structureMitogen-activated protein kinase 1P28482HumansPredicted (SEA)83.4544
High affinity nerve growth factor receptor structureClick to view 3D structureHigh affinity nerve growth factor receptorP04629HumansPredicted (SEA)119.732
Mitogen-activated protein kinase 14 structureClick to view 3D structureMitogen-activated protein kinase 14Q16539HumansPredicted (SEA)99.647
Click to view 3D structureUncharacterized protein FLJ45252Q6ZSR9HumansPredicted (SEA)2.02408
Poly [ADP-ribose] polymerase 1 structureClick to view 3D structurePoly [ADP-ribose] polymerase 1P09874HumansPredicted (SEA)20.0851
LIM domain kinase 1 structureClick to view 3D structureLIM domain kinase 1P53667HumansPredicted (SEA)71.6213
Mitogen-activated protein kinase 12 structureClick to view 3D structureMitogen-activated protein kinase 12P53778HumansPredicted (SEA)79.4062
Macrophage colony-stimulating factor 1 receptor structureClick to view 3D structureMacrophage colony-stimulating factor 1 receptorP07333HumansPredicted (SEA)175.861
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available