Azilsartan medoxomil (CED0012408)

Record Information
Version1.0
Creation Date2026-04-06 04:14:49 UTC
Update Date2026-08-22 10:06:17 UTC
Accession NumberCHEM117431
Identification
Common NameAzilsartan medoxomil
ClassSmall Molecule
Description
Azilsartan medoxomil (C30H24N4O8) is an organic compound that acts as an antagonist of the Type-1 angiotensin II receptor (AGTR1). Azilsartan medoxomil belongs to the biphenyls and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. With an average molecular weight of 568.54 g/mol, Azilsartan medoxomil is a heavy molecule. It is utilized in healthcare, pharmaceuticals, and veterinary products as an angiotensin II receptor blocker (ARB) and is administered via the oral exposure route.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC30H24N4O8
Average Molecular Mass568.542 g/mol
Monoisotopic Mass568.159 g/mol
CAS Registry Number863031-21-4
IUPAC NameNot Available
Traditional NameNot Available
SMILESCCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NC(=O)ON1
InChI IdentifierInChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
InChI KeyQJFSABGVXDWMIW-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0wmi-0200290000-dd7d3ecb1bbc0e066616Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03di-1901660000-a06fd917af594a222ba1Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03xr-0519600000-ba42cf49a4852e899e17Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0829-1000890000-ba2719f1cbbe2ad45256Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-08fr-0200910000-3a396b812de267381c63Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0006-3209300000-a3ca8c482db2df432f5eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-014r-0000390000-0aaa59a3dbdc1bcbafe3Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-000i-0021960000-f2ab467be2700ff9e086Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0uxr-2494010000-474417c85a307440ab2fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-02t9-2202790000-6fb88e3c2d7aa2532cdfNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0odi-2001970000-cb35e28d6191185d1cbcNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0f6x-5022910000-fdb6bb186fe75548c2f9Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
6104.0Log mg/kg[3400:11000]RatLD50oralpredictedNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
296Angiotensin ii receptor blockers (arbs)Healthcare, pharmaceuticals & veterinary productsNot Available
Pathways
2 pathways
Azilsartan medoxomil Action Pathway
Azilsartan medoxomil Action Pathway
Azilsartan medoxomil Drug Metabolism Action Pathway
Azilsartan medoxomil Drug Metabolism Action Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureType-1 angiotensin II receptorP34976Oryctolagus cuniculusPredicted (SEA)16.504
Click to view 3D structureType-1 angiotensin II receptorP25104Bos taurusPredicted (SEA)13.6236
Click to view 3D structureComplement component 3a receptor 1, isoform CRA_aA8K2H7Homo sapiensPredicted (SEA)8.56341
Type-1 angiotensin II receptor structureClick to view 3D structureType-1 angiotensin II receptorP30556HumansPredicted (SEA)75.8251
Click to view 3D structureType-1 angiotensin II receptor AP25095Rattus norvegicusPredicted (SEA)43.5177
Type-2 angiotensin II receptor structureClick to view 3D structureType-2 angiotensin II receptorP50052HumansPredicted (SEA)52.0811
Peroxisome proliferator-activated receptor gamma structureClick to view 3D structurePeroxisome proliferator-activated receptor gammaP37231HumansPredicted (SEA)70.9985
Solute carrier organic anion transporter family member 1B1 structureClick to view 3D structureSolute carrier organic anion transporter family member 1B1Q9Y6L6HumansPredicted (SEA)10.5096
Solute carrier organic anion transporter family member 1B3 structureClick to view 3D structureSolute carrier organic anion transporter family member 1B3Q9NPD5HumansPredicted (SEA)8.40772
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)661.485
Click to view 3D structureType-1 angiotensin II receptor BP29089Rattus norvegicusPredicted (SEA)51.0691
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)1537.76
Epidermal growth factor receptor structureClick to view 3D structureEpidermal growth factor receptorP00533HumansPredicted (SEA)1187.51
Bile salt export pump structureClick to view 3D structureBile salt export pumpO95342HumansPredicted (SEA)44.1405
Receptor tyrosine-protein kinase erbB-2 structureClick to view 3D structureReceptor tyrosine-protein kinase erbB-2P04626HumansPredicted (SEA)854.317
Click to view 3D structureType-2 angiotensin II receptorP35351Rattus norvegicusPredicted (SEA)31.0618
Adenosine receptor A3 structureClick to view 3D structureAdenosine receptor A3P0DMS8HumansPredicted (SEA)341.135
Alpha-2B adrenergic receptor structureClick to view 3D structureAlpha-2B adrenergic receptorP18089HumansPredicted (SEA)449.112
Beta-3 adrenergic receptor structureClick to view 3D structureBeta-3 adrenergic receptorP13945HumansPredicted (SEA)121.834
Click to view 3D structureAngiotensinogenP01015Rattus norvegicusPredicted (SEA)17.2825
Sodium-dependent noradrenaline transporter structureClick to view 3D structureSodium-dependent noradrenaline transporterP23975HumansPredicted (SEA)677.6
Angiotensinogen structureClick to view 3D structureAngiotensinogenP01019HumansPredicted (SEA)10.5096
Click to view 3D structureThromboxane-A synthaseP24557HumansPredicted (SEA)89.6823
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)3637.43
Peroxisome proliferator-activated receptor alpha structureClick to view 3D structurePeroxisome proliferator-activated receptor alphaQ07869HumansPredicted (SEA)456.274
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available