Krytox 143 (CED0029810)

Record Information

Version

1.0

Creation Date

2026-04-06 06:46:53 UTC

Update Date

2026-05-21 06:58:12 UTC

SynCED ID

CED0029810

Secondary Accession Numbers

CHEM119325

Identification

Common Name

Krytox 143

Class

Small Molecule

Description

Krytox 143 is a compound identified in or released from 13 recorded sources across several sectors. Within the electrical and electronic equipment sector, it is found in cell phones, capacitors, batteries, printed circuit boards, wires and cables, and one additional source. It is also associated with the textiles, leather and furnishings sector, specifically in carpets, rugs, and synthetic textiles. The compound is present in the food, food processing and cookware sector through food packaging, and in the healthcare, pharmaceuticals and veterinary products sector via medical devices. In the energy, oil and gas sector as well as the industrial manufacturing and chemical processing sector, it is utilized as a lubricant. It has been recorded in one additional sector. Human exposure to Krytox 143 occurs through the routes of inhalation, oral ingestion, and touch.

Contaminant Type

PFAS

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

Not Available

Average Molecular Mass

Not Available

Monoisotopic Mass

Not Available

CAS Registry Number

Not Available

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

F*.FC(F)C(F)OC(F)(F)C(F)(F)F.FC(F)(F)* |lp:0:3,2:3,4:3,6:3,7:2,9:3,10:3,12:3,13:3,14:3,15:3,17:3,18:3,m:1:3.5,19:3.5,Sg:n:18,17,15,16,0,2,6,3,5,7::ht|

InChI Identifier

Not Available

InChI Key

Not Available

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000007	Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.	Agriculture & land management	Not Available
CEDs000120	Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.	Electrical & Electronic Equipment	Not Available
CEDs000121	Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.	Electrical & Electronic Equipment	Not Available
CEDs000125	Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.	Electrical & Electronic Equipment	Not Available
CEDs000130	Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.	Electrical & Electronic Equipment	Not Available
CEDs000138	Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.	Energy, oil & gas	Not Available
CEDs000147	Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.	Food, food processing & cookware	Not Available
CEDs000174	Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.	Industrial manufacturing & chemical processing	Not Available
CEDs000234	Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000451	Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.	Textiles, leather & furnishings	Not Available
CEDs000454	Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.	Textiles, leather & furnishings	Not Available
CEDs000490		Personal care & cosmetics	Not Available
CEDs000492	Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.	Electrical & Electronic Equipment	Not Available
CEDs000493	Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.	Electrical & Electronic Equipment	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Inward rectifier potassium channel 2	P35561	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.111 Applicability Domain 0.111 Low confidence Statistical Significance 0.6374 Supporting Reference Compounds 1 E-value 4962.27
Click to view 3D structure	Voltage-gated potassium channel KCNC1	P25122	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.104 Applicability Domain 0.104 Low confidence Statistical Significance 0.3159 Supporting Reference Compounds 1 E-value 2459.49
Click to view 3D structure	Ryanodien receptor	H9CNL0	Spodoptera exigua	Predicted (SEA)	Prediction Confidence Score 0.098 Applicability Domain 0.098 Low confidence Statistical Significance 0.7235 Supporting Reference Compounds 1 E-value 5632.16
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.098 Applicability Domain 0.117 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 823 E-value 7784.22
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.097 Applicability Domain 0.117 Low confidence Statistical Significance 0.9998 Supporting Reference Compounds 593 E-value 7783.68
Click to view 3D structure	Receptor-type tyrosine-protein phosphatase zeta	P23471	Humans	Predicted (SEA)	Prediction Confidence Score 0.097 Applicability Domain 0.103 Low confidence Statistical Significance 0.2947 Supporting Reference Compounds 2 E-value 2293.98
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	Prediction Confidence Score 0.094 Applicability Domain 0.117 Low confidence Statistical Significance 0.9998 Supporting Reference Compounds 536 E-value 7783.37
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.104 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 1498 E-value 7784.3
Click to view 3D structure	Macrophage metalloelastase	P39900	Humans	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.095 Low confidence Statistical Significance 0.9994 Supporting Reference Compounds 136 E-value 7780.41
Click to view 3D structure	A disintegrin and metalloproteinase with thrombospondin motifs 5	Q9UNA0	Humans	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.095 Low confidence Statistical Significance 0.9988 Supporting Reference Compounds 79 E-value 7775.89
Click to view 3D structure	A disintegrin and metalloproteinase with thrombospondin motifs 4	O75173	Humans	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.095 Low confidence Statistical Significance 0.9988 Supporting Reference Compounds 79 E-value 7775.42
Click to view 3D structure	ADAM metallopeptidase with thrombospondin type 1 motif 4	A0A8C0SKI4	Canis lupus familiaris	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.095 Low confidence Statistical Significance 0.789 Supporting Reference Compounds 3 E-value 6141.99
Click to view 3D structure	Neutrophil collagenase	P22894	Humans	Predicted (SEA)	Prediction Confidence Score 0.091 Applicability Domain 0.095 Low confidence Statistical Significance 0.9996 Supporting Reference Compounds 176 E-value 7781.5
Click to view 3D structure	Liver carboxylesterase	Q29550	Sus scrofa	Predicted (SEA)	Prediction Confidence Score 0.09 Applicability Domain 0.098 Low confidence Statistical Significance 0.9197 Supporting Reference Compounds 20 E-value 7160.18
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	Prediction Confidence Score 0.09 Applicability Domain 0.098 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 451 E-value 7784.14
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.089 Applicability Domain 0.104 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 1245 E-value 7784.14
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.089 Applicability Domain 0.098 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 955 E-value 7784.3
Click to view 3D structure	72 kDa type IV collagenase	P08253	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.095 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 400 E-value 7784.07
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.098 Low confidence Statistical Significance 0.9998 Supporting Reference Compounds 297 E-value 7783.21
Click to view 3D structure	Monoglyceride lipase	Q99685	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.1 Low confidence Statistical Significance 0.9994 Supporting Reference Compounds 76 E-value 7780.17
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.117 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 686 E-value 7784.38
Click to view 3D structure	Monoacylglycerol lipase ABHD6	Q9BV23	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.1 Low confidence Statistical Significance 0.9962 Supporting Reference Compounds 25 E-value 7755.11
Click to view 3D structure	Cytochrome P450 2C19	P33261	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.098 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 825 E-value 7784.38
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	Prediction Confidence Score 0.088 Applicability Domain 0.098 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 1538 E-value 7784.46
Click to view 3D structure	Nuclear receptor ROR-gamma	P51449	Humans	Predicted (SEA)	Prediction Confidence Score 0.087 Applicability Domain 0.118 Low confidence Statistical Significance 0.9993 Supporting Reference Compounds 102 E-value 7779.24