3-Hydroxy-4p-methoxyflavone (CED0184774)

Record Information
Version1.0
Creation Date2026-04-06 09:03:46 UTC
Update Date2026-05-21 09:07:13 UTC
SynCED IDCED0184774
Secondary Accession Numbers
  • CHEM121060
Identification
Common Name3-Hydroxy-4p-methoxyflavone
ClassSmall Molecule
Description
3-Hydroxy-4p-methoxyflavone belongs to the flavones, a subclass of flavonoids within the organic compounds. This compound is categorized under the superclass of phenylpropanoids and polyketides. It has been identified in or released from 13 recorded sources across several sectors. Within electrical and electronic equipment, it is found in capacitors, batteries, printed circuit boards, wires and cables, cell phones, and one additional source. In the textiles, leather and furnishings sector, it is associated with carpets, rugs, and synthetic textiles. Its presence is also noted in food packaging within the food, food processing and cookware sector, and in medical devices within the healthcare, pharmaceuticals and veterinary products sector. Additionally, the compound is found in lubricants used in both industrial manufacturing and chemical processing as well as in the energy, oil and gas sector, along with one further sector. Recorded routes of exposure for this substance include oral, inhalation, and touch.
Contaminant Type
  • PFAS
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaNot Available
Average Molecular MassNot Available
Monoisotopic MassNot Available
CAS Registry Number6889-78-7
IUPAC NameNot Available
Traditional NameNot Available
SMILESNot Available
InChI IdentifierInChI=1S/C16H12O4/c1-19-11-8-6-10(7-9-11)16-15(18)14(17)12-4-2-3-5-13(12)20-16/h2-9,18H,1H3
InChI KeyIIBBFGMVMNZMGA-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological Roles
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
3700.0 Log mg/kg [2100:6600]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000007Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000120Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.Electrical & Electronic EquipmentNot Available
CEDs000121Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.Electrical & Electronic EquipmentNot Available
CEDs000125Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.Electrical & Electronic EquipmentNot Available
CEDs000130Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.Electrical & Electronic EquipmentNot Available
CEDs000138Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.Energy, oil & gasNot Available
CEDs000147Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.Food, food processing & cookwareNot Available
CEDs000174Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.Industrial manufacturing & chemical processingNot Available
CEDs000234Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000451Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.Textiles, leather & furnishingsNot Available
CEDs000454Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.Textiles, leather & furnishingsNot Available
CEDs000490Personal care & cosmeticsNot Available
CEDs000492Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.Electrical & Electronic EquipmentNot Available
CEDs000493Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.Electrical & Electronic EquipmentNot Available
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Cytochrome P450 1B1 structureClick to view 3D structureCytochrome P450 1B1Q16678HumansPredicted (SEA)
Prediction Confidence Score
0.512
Applicability Domain
0.703
Statistical Significance
5.40e-04
Supporting Reference Compounds
88
E-value
4.20386
ATP-dependent translocase ABCB1 structureClick to view 3D structureATP-dependent translocase ABCB1P08183HumansPredicted (SEA)
Prediction Confidence Score
0.495
Applicability Domain
0.703
Statistical Significance
5.40e-04
Supporting Reference Compounds
139
E-value
4.20386
Poly [ADP-ribose] polymerase tankyrase-1 structureClick to view 3D structurePoly [ADP-ribose] polymerase tankyrase-1O95271HumansPredicted (SEA)
Prediction Confidence Score
0.482
Applicability Domain
0.585
Statistical Significance
6.10e-04
Supporting Reference Compounds
94
E-value
4.7488
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)
Prediction Confidence Score
0.465
Applicability Domain
0.703
Statistical Significance
0.0028
Supporting Reference Compounds
472
E-value
21.7199
Carbonic anhydrase 12 structureClick to view 3D structureCarbonic anhydrase 12O43570HumansPredicted (SEA)
Prediction Confidence Score
0.465
Applicability Domain
0.703
Statistical Significance
0.0019
Supporting Reference Compounds
332
E-value
14.48
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)
Prediction Confidence Score
0.465
Applicability Domain
0.703
Statistical Significance
0.0024
Supporting Reference Compounds
407
E-value
18.9952
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)
Prediction Confidence Score
0.444
Applicability Domain
0.587
Statistical Significance
0.005
Supporting Reference Compounds
793
E-value
38.8468
Cytochrome P450 1A1 structureClick to view 3D structureCytochrome P450 1A1P04798HumansPredicted (SEA)
Prediction Confidence Score
0.444
Applicability Domain
0.587
Statistical Significance
8.70e-04
Supporting Reference Compounds
77
E-value
6.77288
Vitamin K epoxide reductase complex subunit 1 structureClick to view 3D structureVitamin K epoxide reductase complex subunit 1Q9BQB6HumansPredicted (SEA)
Prediction Confidence Score
0.44
Applicability Domain
0.521
Statistical Significance
5.00e-05
Supporting Reference Compounds
2
E-value
0.389246
Amine oxidase [flavin-containing] A structureClick to view 3D structureAmine oxidase [flavin-containing] AP21397HumansPredicted (SEA)
Prediction Confidence Score
0.435
Applicability Domain
0.587
Statistical Significance
0.002
Supporting Reference Compounds
241
E-value
15.492
Carbonic anhydrase 9 structureClick to view 3D structureCarbonic anhydrase 9Q16790HumansPredicted (SEA)
Prediction Confidence Score
0.428
Applicability Domain
0.703
Statistical Significance
0.004
Supporting Reference Compounds
372
E-value
30.984
ATP-dependent translocase ABCB1 structureClick to view 3D structureATP-dependent translocase ABCB1P21447Mus musculusPredicted (SEA)
Prediction Confidence Score
0.412
Applicability Domain
0.587
Statistical Significance
1.20e-04
Supporting Reference Compounds
23
E-value
0.934191
Broad substrate specificity ATP-binding cassette transporter ABCG2 structureClick to view 3D structureBroad substrate specificity ATP-binding cassette transporter ABCG2Q9UNQ0HumansPredicted (SEA)
Prediction Confidence Score
0.409
Applicability Domain
0.585
Statistical Significance
0.0034
Supporting Reference Compounds
126
E-value
26.2352
Pyruvate kinase PKM structureClick to view 3D structurePyruvate kinase PKMP14618HumansPredicted (SEA)
Prediction Confidence Score
0.408
Applicability Domain
0.703
Statistical Significance
2.90e-04
Supporting Reference Compounds
29
E-value
2.25763
Click to view 3D structureInositol hexakisphosphate kinase 2Q9UHH9HumansPredicted (SEA)
Prediction Confidence Score
0.406
Applicability Domain
0.48
Statistical Significance
5.10e-04
Supporting Reference Compounds
13
E-value
3.97031
Xanthine dehydrogenase/oxidase structureClick to view 3D structureXanthine dehydrogenase/oxidaseP47989HumansPredicted (SEA)
Prediction Confidence Score
0.404
Applicability Domain
0.438
Statistical Significance
6.20e-04
Supporting Reference Compounds
37
E-value
4.82665
Protein deacetylase HDAC6 structureClick to view 3D structureProtein deacetylase HDAC6Q9UBN7HumansPredicted (SEA)
Prediction Confidence Score
0.404
Applicability Domain
0.44
Statistical Significance
0.0082
Supporting Reference Compounds
553
E-value
63.8364
Carbonic anhydrase 7 structureClick to view 3D structureCarbonic anhydrase 7P43166HumansPredicted (SEA)
Prediction Confidence Score
0.4
Applicability Domain
0.417
Statistical Significance
0.0034
Supporting Reference Compounds
242
E-value
26.6244
Carbonic anhydrase 4 structureClick to view 3D structureCarbonic anhydrase 4P22748HumansPredicted (SEA)
Prediction Confidence Score
0.4
Applicability Domain
0.417
Statistical Significance
0.0026
Supporting Reference Compounds
193
E-value
19.9294
Click to view 3D structureGag-Pol polyproteinQ7ZJM1Human immunodeficiency virus 1Predicted (SEA)
Prediction Confidence Score
0.393
Applicability Domain
0.438
Statistical Significance
0.0018
Supporting Reference Compounds
96
E-value
13.8572
Receptor-type tyrosine-protein kinase FLT3 structureClick to view 3D structureReceptor-type tyrosine-protein kinase FLT3P36888HumansPredicted (SEA)
Prediction Confidence Score
0.389
Applicability Domain
0.417
Statistical Significance
0.0339
Supporting Reference Compounds
1274
E-value
263.753
Acetylcholinesterase structureClick to view 3D structureAcetylcholinesteraseP22303HumansPredicted (SEA)
Prediction Confidence Score
0.386
Applicability Domain
0.438
Statistical Significance
0.0096
Supporting Reference Compounds
406
E-value
74.891
Cyclin-dependent kinase 2 structureClick to view 3D structureCyclin-dependent kinase 2P24941HumansPredicted (SEA)
Prediction Confidence Score
0.384
Applicability Domain
0.619
Statistical Significance
0.0234
Supporting Reference Compounds
1029
E-value
182.089
Multidrug resistance-associated protein 1 structureClick to view 3D structureMultidrug resistance-associated protein 1P33527HumansPredicted (SEA)
Prediction Confidence Score
0.38
Applicability Domain
0.426
Statistical Significance
6.60e-04
Supporting Reference Compounds
49
E-value
5.13805
Click to view 3D structure3-oxoacyl-acyl-carrier protein reductaseQ965D6Plasmodium falciparumPredicted (SEA)
Prediction Confidence Score
0.379
Applicability Domain
0.438
Statistical Significance
3.70e-04
Supporting Reference Compounds
12
E-value
2.88042
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available