(S)-Sibutramine (CED0055361)

Record Information

Version

1.0

Creation Date

2026-04-06 09:12:27 UTC

Update Date

2026-05-21 09:37:35 UTC

SynCED ID

CED0055361

Secondary Accession Numbers

CHEM121288

Identification

Common Name

(S)-Sibutramine

Class

Small Molecule

Description

(S)-Sibutramine is a compound associated with 13 recorded sources across multiple sectors. Within the healthcare, pharmaceuticals, and veterinary products sector, it is found in medical devices. In the energy, oil, and gas sector, as well as the industrial manufacturing and chemical processing sector, it is identified in lubricants. The compound is also present in food packaging within the food, food processing, and cookware sector. Further sources include textiles, leather, and furnishings, specifically synthetic textiles and carpets and rugs. It is also found in electrical and electronic equipment, including cell phones, capacitors, wires and cables, batteries, and printed circuit boards, among one other item. The compound is recorded in one additional sector. Exposure routes for (S)-Sibutramine include inhalation, oral, and touch.

Contaminant Type

PFAS

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

Not Available

Average Molecular Mass

Not Available

Monoisotopic Mass

Not Available

CAS Registry Number

153341-22-1

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3/t16-/m0/s1

InChI Key

UANXDKBXWMLN-INIZCTEOSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000007	Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.	Agriculture & land management	Not Available
CEDs000120	Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.	Electrical & Electronic Equipment	Not Available
CEDs000121	Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.	Electrical & Electronic Equipment	Not Available
CEDs000125	Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.	Electrical & Electronic Equipment	Not Available
CEDs000130	Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.	Electrical & Electronic Equipment	Not Available
CEDs000138	Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.	Energy, oil & gas	Not Available
CEDs000147	Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.	Food, food processing & cookware	Not Available
CEDs000174	Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.	Industrial manufacturing & chemical processing	Not Available
CEDs000234	Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000451	Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.	Textiles, leather & furnishings	Not Available
CEDs000454	Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.	Textiles, leather & furnishings	Not Available
CEDs000490		Personal care & cosmetics	Not Available
CEDs000492	Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.	Electrical & Electronic Equipment	Not Available
CEDs000493	Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.	Electrical & Electronic Equipment	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	Prediction Confidence Score 0.425 Applicability Domain 1.0 Statistical Significance 0.0033 Supporting Reference Compounds 451 E-value 25.9238
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	Prediction Confidence Score 0.423 Applicability Domain 1.0 Statistical Significance 0.0039 Supporting Reference Compounds 506 E-value 30.7504
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.423 Applicability Domain 1.0 Statistical Significance 0.0077 Supporting Reference Compounds 593 E-value 59.7882
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Predicted (SEA)	Prediction Confidence Score 0.384 Applicability Domain 1.0 Statistical Significance 0.0048 Supporting Reference Compounds 340 E-value 37.3676
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase 1	P50172	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.272 Applicability Domain 0.308 Statistical Significance 0.0018 Supporting Reference Compounds 41 E-value 14.0129
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.306 Statistical Significance 0.0585 Supporting Reference Compounds 297 E-value 455.262
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase type 2	P80365	Humans	Predicted (SEA)	Prediction Confidence Score 0.269 Applicability Domain 0.308 Statistical Significance 0.0017 Supporting Reference Compounds 32 E-value 13.3901
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.265 Applicability Domain 0.34 Statistical Significance 0.2988 Supporting Reference Compounds 1130 E-value 2325.9
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	Prediction Confidence Score 0.262 Applicability Domain 0.34 Statistical Significance 0.439 Supporting Reference Compounds 1538 E-value 3417.58
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.261 Applicability Domain 0.34 Statistical Significance 0.4324 Supporting Reference Compounds 1498 E-value 3365.97
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase 1	P28845	Humans	Predicted (SEA)	Prediction Confidence Score 0.258 Applicability Domain 0.308 Statistical Significance 0.007 Supporting Reference Compounds 76 E-value 54.8837
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.255 Applicability Domain 0.34 Statistical Significance 0.4561 Supporting Reference Compounds 1245 E-value 3550.94
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.254 Applicability Domain 0.27 Low confidence Statistical Significance 0.1892 Supporting Reference Compounds 562 E-value 1472.99
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase type 2	P51661	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.254 Applicability Domain 0.308 Statistical Significance 2.60e-04 Supporting Reference Compounds 10 E-value 2.02408
Click to view 3D structure	Alpha-1A adrenergic receptor	P43140	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.251 Applicability Domain 0.273 Low confidence Statistical Significance 0.0804 Supporting Reference Compounds 208 E-value 626.141
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	Prediction Confidence Score 0.251 Applicability Domain 0.27 Low confidence Statistical Significance 0.2978 Supporting Reference Compounds 1103 E-value 2318.66
Click to view 3D structure	Cytochrome P450 2C19	P33261	Humans	Predicted (SEA)	Prediction Confidence Score 0.249 Applicability Domain 0.34 Statistical Significance 0.3772 Supporting Reference Compounds 825 E-value 2936.32
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 2	O75469	Humans	Predicted (SEA)	Prediction Confidence Score 0.247 Applicability Domain 0.266 Low confidence Statistical Significance 0.032 Supporting Reference Compounds 146 E-value 248.884
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.246 Applicability Domain 0.27 Low confidence Statistical Significance 0.264 Supporting Reference Compounds 686 E-value 2055.45
Click to view 3D structure	D(4) dopamine receptor	P21917	Humans	Predicted (SEA)	Prediction Confidence Score 0.244 Applicability Domain 0.27 Low confidence Statistical Significance 0.2366 Supporting Reference Compounds 524 E-value 1842.07
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Predicted (SEA)	Prediction Confidence Score 0.244 Applicability Domain 0.27 Low confidence Statistical Significance 0.2431 Supporting Reference Compounds 527 E-value 1892.67
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.244 Applicability Domain 0.27 Low confidence Statistical Significance 0.3052 Supporting Reference Compounds 861 E-value 2375.72
Click to view 3D structure	Chemokine (C-C motif) receptor 1	Q2V0Q7	Canis lupus familiaris	Predicted (SEA)	Prediction Confidence Score 0.239 Applicability Domain 0.239 Low confidence Statistical Significance 0.002 Supporting Reference Compounds 1 E-value 15.6477
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q60492	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.239 Applicability Domain 0.25 Low confidence Statistical Significance 0.1546 Supporting Reference Compounds 229 E-value 1203.39
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.239 Applicability Domain 0.26 Low confidence Statistical Significance 0.3975 Supporting Reference Compounds 955 E-value 3094.82