4-Hydroxyretinol (CED0032390)

Record Information
Version1.0
Creation Date2026-04-06 09:16:03 UTC
Update Date2026-05-21 09:56:20 UTC
SynCED IDCED0032390
Secondary Accession Numbers
  • CHEM121361
Identification
Common Name4-Hydroxyretinol
ClassSmall Molecule
Description
4-Hydroxyretinol belongs to the retinoids, a subclass of prenol lipids within the organic compounds. This compound is categorized under the superclass of lipids and lipid-like molecules. It has been found in or released from 13 recorded sources across several sectors. Within the electrical and electronic equipment sector, it is associated with cell phones, capacitors, wires and cables, batteries, and printed circuit boards, among one other source. In the textiles, leather and furnishings sector, it is found in synthetic textiles as well as carpets and rugs. Its presence in the food, food processing and cookware sector is noted in food packaging, while in the healthcare, pharmaceuticals and veterinary products sector, it is linked to medical devices. Additionally, it is found in lubricants within both the energy, oil and gas sector and the industrial manufacturing and chemical processing sector, along with one further sector. Recorded exposure routes for 4-hydroxyretinol include inhalation, oral exposure, and touch.
Contaminant Type
  • PFAS
Chemical Structure
SynonymsNot Available
Chemical FormulaNot Available
Average Molecular MassNot Available
Monoisotopic MassNot Available
CAS Registry Number15353-44-3
IUPAC NameNot Available
Traditional NameNot Available
SMILESNot Available
InChI IdentifierInChI=1S/C20H30O2/c1-15(7-6-8-16(2)12-14-21)9-10-18-17(3)19(22)11-13-20(18,4)5/h6-10,12,19,21-22H,11,13-14H2,1-5H3/b8-6+,10-9+,15-7+,16-12+
InChI KeyIOELQUUUYMBPSA-RMWYGNQTSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted GC-MSPredicted GC-MS Spectrumsplash10-000i-1090000000-52b028e41df04dbf290bNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0f79-0392000000-bad1b05d757c759a9d6eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-00lb-3950000000-70d466d54e8e444d6f90Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0671-5920000000-bcdf95e8335f11c5f769Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0069000000-d10064c57a96187cd441Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0udi-0093000000-358f1093fbe884289b14Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4l-2390000000-9e411589205581a329b5Not AvailableView Spectrum
Toxicity Profile
Toxicity Values
Toxicity ValueOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalToxicity RatingReference
3501.0 Log mg/kg [2000:6200]RatLD50oralpredictedNot AvailableNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000007Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000120Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.Electrical & Electronic EquipmentNot Available
CEDs000121Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.Electrical & Electronic EquipmentNot Available
CEDs000125Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.Electrical & Electronic EquipmentNot Available
CEDs000130Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.Electrical & Electronic EquipmentNot Available
CEDs000138Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.Energy, oil & gasNot Available
CEDs000147Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.Food, food processing & cookwareNot Available
CEDs000174Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.Industrial manufacturing & chemical processingNot Available
CEDs000234Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000451Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.Textiles, leather & furnishingsNot Available
CEDs000454Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.Textiles, leather & furnishingsNot Available
CEDs000490Personal care & cosmeticsNot Available
CEDs000492Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.Electrical & Electronic EquipmentNot Available
CEDs000493Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.Electrical & Electronic EquipmentNot Available
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Beta-lactoglobulin structureClick to view 3D structureBeta-lactoglobulinP02754Bos taurusPredicted (SEA)
Prediction Confidence Score
0.436
Applicability Domain
0.646
Statistical Significance
2.00e-05
Supporting Reference Compounds
2
E-value
0.155698
Click to view 3D structureAldehyde dehydrogenase 1A1P27463Gallus gallusPredicted (SEA)
Prediction Confidence Score
0.4
Applicability Domain
0.4
Statistical Significance
5.00e-05
Supporting Reference Compounds
1
E-value
0.389246
Click to view 3D structureRetinoic acid receptor alphaP11416Mus musculusPredicted (SEA)
Prediction Confidence Score
0.392
Applicability Domain
0.436
Statistical Significance
1.40e-04
Supporting Reference Compounds
16
E-value
1.08989
Click to view 3D structureRetinoic acid receptor gammaP18911Mus musculusPredicted (SEA)
Prediction Confidence Score
0.387
Applicability Domain
0.436
Statistical Significance
1.40e-04
Supporting Reference Compounds
14
E-value
1.08989
Retinoic acid receptor beta structureClick to view 3D structureRetinoic acid receptor betaP22605Mus musculusPredicted (SEA)
Prediction Confidence Score
0.387
Applicability Domain
0.436
Statistical Significance
1.40e-04
Supporting Reference Compounds
14
E-value
1.08989
Retinoic acid receptor RXR-alpha structureClick to view 3D structureRetinoic acid receptor RXR-alphaP19793HumansPredicted (SEA)
Prediction Confidence Score
0.377
Applicability Domain
0.436
Statistical Significance
0.0015
Supporting Reference Compounds
82
E-value
11.5995
Retinoic acid receptor gamma structureClick to view 3D structureRetinoic acid receptor gammaP13631HumansPredicted (SEA)
Prediction Confidence Score
0.376
Applicability Domain
0.436
Statistical Significance
0.0012
Supporting Reference Compounds
52
E-value
9.10836
Amyloid-beta precursor protein structureClick to view 3D structureAmyloid-beta precursor proteinP05067HumansPredicted (SEA)
Prediction Confidence Score
0.36
Applicability Domain
0.646
Statistical Significance
0.0051
Supporting Reference Compounds
109
E-value
39.8588
Prosaposin structureClick to view 3D structureProsaposinP07602HumansPredicted (SEA)
Prediction Confidence Score
0.358
Applicability Domain
0.358
Statistical Significance
6.00e-05
Supporting Reference Compounds
1
E-value
0.467095
Alpha-synuclein structureClick to view 3D structureAlpha-synucleinP37840HumansPredicted (SEA)
Prediction Confidence Score
0.349
Applicability Domain
0.646
Statistical Significance
4.50e-04
Supporting Reference Compounds
38
E-value
3.50322
Retinoic acid receptor RXR-alpha structureClick to view 3D structureRetinoic acid receptor RXR-alphaP28700Mus musculusPredicted (SEA)
Prediction Confidence Score
0.346
Applicability Domain
0.436
Statistical Significance
3.20e-04
Supporting Reference Compounds
17
E-value
2.49118
Cellular retinoic acid-binding protein 1 structureClick to view 3D structureCellular retinoic acid-binding protein 1P62965Mus musculusPredicted (SEA)
Prediction Confidence Score
0.346
Applicability Domain
0.436
Statistical Significance
7.00e-05
Supporting Reference Compounds
7
E-value
0.544945
Click to view 3D structureCellular retinoic acid-binding protein 2P22935Mus musculusPredicted (SEA)
Prediction Confidence Score
0.346
Applicability Domain
0.436
Statistical Significance
7.00e-05
Supporting Reference Compounds
7
E-value
0.544945
Retinoic acid receptor beta structureClick to view 3D structureRetinoic acid receptor betaP10826HumansPredicted (SEA)
Prediction Confidence Score
0.342
Applicability Domain
0.436
Statistical Significance
7.70e-04
Supporting Reference Compounds
47
E-value
5.99439
Retinoic acid receptor alpha structureClick to view 3D structureRetinoic acid receptor alphaP10276HumansPredicted (SEA)
Prediction Confidence Score
0.342
Applicability Domain
0.436
Statistical Significance
0.0016
Supporting Reference Compounds
53
E-value
12.3002
Click to view 3D structureCellular retinoic acid-binding protein 1P40220Gallus gallusPredicted (SEA)
Prediction Confidence Score
0.337
Applicability Domain
0.436
Statistical Significance
6.00e-05
Supporting Reference Compounds
5
E-value
0.467095
Retinoic acid receptor RXR-gamma structureClick to view 3D structureRetinoic acid receptor RXR-gammaP48443HumansPredicted (SEA)
Prediction Confidence Score
0.326
Applicability Domain
0.436
Statistical Significance
5.90e-04
Supporting Reference Compounds
31
E-value
4.5931
Retinoic acid receptor RXR-beta structureClick to view 3D structureRetinoic acid receptor RXR-betaP28702HumansPredicted (SEA)
Prediction Confidence Score
0.317
Applicability Domain
0.436
Statistical Significance
6.90e-04
Supporting Reference Compounds
31
E-value
5.3716
Click to view 3D structureRetinoic acid receptor RXR-gammaP28705Mus musculusPredicted (SEA)
Prediction Confidence Score
0.281
Applicability Domain
0.436
Statistical Significance
8.20e-04
Supporting Reference Compounds
20
E-value
6.38364
Bile salt export pump structureClick to view 3D structureBile salt export pumpO95342HumansPredicted (SEA)
Prediction Confidence Score
0.277
Applicability Domain
0.49
Statistical Significance
0.0091
Supporting Reference Compounds
104
E-value
70.6871
Click to view 3D structureRetinoic acid receptor RXR-betaP28704Mus musculusPredicted (SEA)
Prediction Confidence Score
0.274
Applicability Domain
0.436
Statistical Significance
8.60e-04
Supporting Reference Compounds
19
E-value
6.69503
Adenosine receptor A3 structureClick to view 3D structureAdenosine receptor A3P0DMS8HumansPredicted (SEA)
Prediction Confidence Score
0.27
Applicability Domain
0.436
Statistical Significance
0.0606
Supporting Reference Compounds
391
E-value
471.611
5-hydroxytryptamine receptor 2B structureClick to view 3D structure5-hydroxytryptamine receptor 2BP41595HumansPredicted (SEA)
Prediction Confidence Score
0.27
Applicability Domain
0.436
Statistical Significance
0.1217
Supporting Reference Compounds
686
E-value
947.503
Click to view 3D structureSphingolipid delta(4)-desaturase DES1Q5XIF5Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.265
Applicability Domain
0.358
Statistical Significance
5.00e-05
Supporting Reference Compounds
3
E-value
0.389246
Retinol-binding protein 4 structureClick to view 3D structureRetinol-binding protein 4P02753HumansPredicted (SEA)
Prediction Confidence Score
0.255
Applicability Domain
0.646
Statistical Significance
0.0025
Supporting Reference Compounds
12
E-value
19.6959
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available