Pimobendan (CED0007396)

Record Information
Version1.0
Creation Date2026-04-06 09:17:27 UTC
Update Date2026-05-14 19:09:44 UTC
SynCED IDCED0007396
Secondary Accession Numbers
  • CHEM121391
Identification
Common NamePimobendan
ClassSmall Molecule
Description
Pimobendan is an organic compound with the chemical formula C19H18N4O2 and an average molecular weight of 334.38 g/mol. Pimobendan belongs to the phenylbenzimidazoles, a subclass of benzimidazoles within the organic compounds. It is further categorized as an organoheterocyclic compound. The substance is found in or released from 13 recorded sources across several sectors. In the healthcare, pharmaceuticals, and veterinary products sector, it is associated with medical devices. Within the energy, oil, and gas sector, as well as industrial manufacturing and chemical processing, it is found in lubricants. It is also present in food packaging within the food, food processing, and cookware sector. Additional sources include textiles, leather, and furnishings, specifically synthetic textiles and carpets and rugs. Furthermore, it is recorded in electrical and electronic equipment, including capacitors, batteries, wires and cables, printed circuit boards, and cell phones, among one other source. Recorded exposure routes for the compound include inhalation, oral, and touch.
Contaminant Type
  • PFAS
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC19H18N4O2
Average Molecular Mass334.379 g/mol
Monoisotopic Mass334.143 g/mol
CAS Registry Number74150-27-9
IUPAC NameNot Available
Traditional NameNot Available
SMILESCOC1=CC=C(C=C1)C1=NC2=CC(=CC=C2N1)C1=NNC(=O)CC1C
InChI IdentifierInChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)/t11-/m0/s1
InChI KeyGLBJJMFZWDBELO-NSHDSACASA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Toxicity ValuesNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000007Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000120Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.Electrical & Electronic EquipmentNot Available
CEDs000121Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.Electrical & Electronic EquipmentNot Available
CEDs000125Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.Electrical & Electronic EquipmentNot Available
CEDs000130Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.Electrical & Electronic EquipmentNot Available
CEDs000138Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.Energy, oil & gasNot Available
CEDs000147Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.Food, food processing & cookwareNot Available
CEDs000174Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.Industrial manufacturing & chemical processingNot Available
CEDs000234Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000451Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.Textiles, leather & furnishingsNot Available
CEDs000454Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.Textiles, leather & furnishingsNot Available
CEDs000490Personal care & cosmeticsNot Available
CEDs000492Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.Electrical & Electronic EquipmentNot Available
CEDs000493Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.Electrical & Electronic EquipmentNot Available
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Ribonuclease SLFN12 structureClick to view 3D structureRibonuclease SLFN12Q8IYM2HumansPredicted (SEA)
Prediction Confidence Score
0.431
Applicability Domain
0.431
Statistical Significance
2.00e-05
Supporting Reference Compounds
1
E-value
0.155698
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)
Prediction Confidence Score
0.329
Applicability Domain
0.349
Statistical Significance
0.0332
Supporting Reference Compounds
825
E-value
258.459
Cytochrome P450 1A2 structureClick to view 3D structureCytochrome P450 1A2P05177HumansPredicted (SEA)
Prediction Confidence Score
0.329
Applicability Domain
0.349
Statistical Significance
0.0345
Supporting Reference Compounds
793
E-value
268.736
Cytochrome P450 2C8 structureClick to view 3D structureCytochrome P450 2C8P10632HumansPredicted (SEA)
Prediction Confidence Score
0.321
Applicability Domain
0.333
Statistical Significance
0.0117
Supporting Reference Compounds
305
E-value
90.7722
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)
Prediction Confidence Score
0.32
Applicability Domain
0.333
Statistical Significance
0.1038
Supporting Reference Compounds
1538
E-value
808.075
Cytochrome P450 2C9 structureClick to view 3D structureCytochrome P450 2C9P11712HumansPredicted (SEA)
Prediction Confidence Score
0.314
Applicability Domain
0.333
Statistical Significance
0.0929
Supporting Reference Compounds
1245
E-value
723.609
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)
Prediction Confidence Score
0.312
Applicability Domain
0.333
Statistical Significance
0.0778
Supporting Reference Compounds
1130
E-value
605.667
Lysine--tRNA ligase structureClick to view 3D structureLysine--tRNA ligaseQ8IDJ8Plasmodium falciparum (isolate 3D7)Predicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0041
Supporting Reference Compounds
39
E-value
32.1517
Putative uncharacterized protein pk7 structureClick to view 3D structurePutative uncharacterized protein pk7O96214Plasmodium falciparumPredicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0042
Supporting Reference Compounds
40
E-value
32.3853
Calcium-dependent protein kinase 4 structureClick to view 3D structureCalcium-dependent protein kinase 4Q8IBS5Plasmodium falciparum (isolate 3D7)Predicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0059
Supporting Reference Compounds
52
E-value
46.0867
Click to view 3D structureMitogen-activated protein kinaseQ25917Plasmodium falciparumPredicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0041
Supporting Reference Compounds
38
E-value
32.1517
Proline--tRNA ligase structureClick to view 3D structureProline--tRNA ligaseQ8I5R7Plasmodium falciparum (isolate 3D7)Predicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0041
Supporting Reference Compounds
39
E-value
32.2296
Click to view 3D structureCdk-related protein kinase 6O77239Plasmodium falciparumPredicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.0073
Supporting Reference Compounds
43
E-value
56.6742
Click to view 3D structureCalcium-dependent protein kinase 1P62344Plasmodium falciparum (isolate 3D7)Predicted (SEA)
Prediction Confidence Score
0.3
Applicability Domain
0.362
Statistical Significance
0.025
Supporting Reference Compounds
123
E-value
194.312
Signal transducer and activator of transcription 1-alpha/beta structureClick to view 3D structureSignal transducer and activator of transcription 1-alpha/betaP42224HumansPredicted (SEA)
Prediction Confidence Score
0.298
Applicability Domain
0.509
Statistical Significance
3.50e-04
Supporting Reference Compounds
30
E-value
2.72472
Poly [ADP-ribose] polymerase 1 structureClick to view 3D structurePoly [ADP-ribose] polymerase 1P09874HumansPredicted (SEA)
Prediction Confidence Score
0.292
Applicability Domain
0.365
Statistical Significance
0.0126
Supporting Reference Compounds
146
E-value
98.4014
Serine/threonine-protein kinase TBK1 structureClick to view 3D structureSerine/threonine-protein kinase TBK1Q9UHD2HumansPredicted (SEA)
Prediction Confidence Score
0.291
Applicability Domain
0.325
Statistical Significance
0.0641
Supporting Reference Compounds
335
E-value
499.247
Aurora kinase B structureClick to view 3D structureAurora kinase BQ96GD4HumansPredicted (SEA)
Prediction Confidence Score
0.291
Applicability Domain
0.325
Statistical Significance
0.1393
Supporting Reference Compounds
1017
E-value
1084.36
Click to view 3D structureNeuropeptide Y receptor type 5O70342Mus musculusPredicted (SEA)
Prediction Confidence Score
0.291
Applicability Domain
0.333
Statistical Significance
0.001
Supporting Reference Compounds
13
E-value
7.86277
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A structureClick to view 3D structurecGMP-inhibited 3',5'-cyclic phosphodiesterase 3AQ14432HumansPredicted (SEA)
Prediction Confidence Score
0.29
Applicability Domain
0.431
Statistical Significance
0.0041
Supporting Reference Compounds
110
E-value
31.9182
Cytochrome P450 2B6 structureClick to view 3D structureCytochrome P450 2B6P20813HumansPredicted (SEA)
Prediction Confidence Score
0.288
Applicability Domain
0.333
Statistical Significance
0.0068
Supporting Reference Compounds
150
E-value
52.7818
Diacylglycerol O-acyltransferase 1 structureClick to view 3D structureDiacylglycerol O-acyltransferase 1O75907HumansPredicted (SEA)
Prediction Confidence Score
0.283
Applicability Domain
0.297 Low confidence
Statistical Significance
0.0036
Supporting Reference Compounds
44
E-value
27.7922
Plasminogen structureClick to view 3D structurePlasminogenP00747HumansPredicted (SEA)
Prediction Confidence Score
0.281
Applicability Domain
0.348
Statistical Significance
0.0461
Supporting Reference Compounds
195
E-value
358.963
Urokinase-type plasminogen activator structureClick to view 3D structureUrokinase-type plasminogen activatorP00749HumansPredicted (SEA)
Prediction Confidence Score
0.28
Applicability Domain
0.343
Statistical Significance
0.0289
Supporting Reference Compounds
151
E-value
224.984
Cytochrome P450 1B1 structureClick to view 3D structureCytochrome P450 1B1Q16678HumansPredicted (SEA)
Prediction Confidence Score
0.279
Applicability Domain
0.299 Low confidence
Statistical Significance
0.0126
Supporting Reference Compounds
88
E-value
97.9343
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available