(R)-Norfluoxetine (CED0027340)

Record Information
Version1.0
Creation Date2026-04-06 09:17:59 UTC
Update Date2026-05-21 10:00:01 UTC
SynCED IDCED0027340
Secondary Accession Numbers
  • CHEM121404
Identification
Common Name(R)-Norfluoxetine
ClassSmall Molecule
Description
(R)-Norfluoxetine belongs to the trifluoromethylbenzenes, a subclass of benzene and substituted derivatives within the organic compounds. This compound is associated with 13 recorded sources across multiple sectors. Within the healthcare, pharmaceuticals & veterinary products sector, it is found in medical devices. In the energy, oil & gas and industrial manufacturing & chemical processing sectors, it is present in lubricants. Sources related to electrical & electronic equipment include cell phones, capacitors, wires and cables, batteries, and printed circuit boards, among one other source. Additionally, it is found in food packaging within the food, food processing & cookware sector, and in synthetic textiles as well as carpets and rugs within the textiles, leather & furnishings sector. One additional sector is also recorded. Recorded exposure routes for (R)-Norfluoxetine include inhalation, oral, and touch.
Contaminant Type
  • PFAS
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaNot Available
Average Molecular MassNot Available
Monoisotopic MassNot Available
CAS Registry Number130194-43-3
IUPAC NameNot Available
Traditional NameNot Available
SMILESNot Available
InChI IdentifierInChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2/t15-/m1/s1
InChI KeyWIQRCHMSJFFONW-OAHLLOKOSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
SpectraNot Available
Toxicity Profile
Toxicity ValuesNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000007Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.Agriculture & land managementNot Available
CEDs000120Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.Electrical & Electronic EquipmentNot Available
CEDs000121Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.Electrical & Electronic EquipmentNot Available
CEDs000125Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.Electrical & Electronic EquipmentNot Available
CEDs000130Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.Electrical & Electronic EquipmentNot Available
CEDs000138Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.Energy, oil & gasNot Available
CEDs000147Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.Food, food processing & cookwareNot Available
CEDs000174Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.Industrial manufacturing & chemical processingNot Available
CEDs000234Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.Healthcare, pharmaceuticals & veterinary productsNot Available
CEDs000451Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.Textiles, leather & furnishingsNot Available
CEDs000454Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.Textiles, leather & furnishingsNot Available
CEDs000490Personal care & cosmeticsNot Available
CEDs000492Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.Electrical & Electronic EquipmentNot Available
CEDs000493Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.Electrical & Electronic EquipmentNot Available
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Click to view 3D structureVoltage-gated potassium channel KCNC1P25122Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
1.0
Applicability Domain
1.0
Statistical Significance
1.00e-05
Supporting Reference Compounds
1
E-value
0.0778492
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)
Prediction Confidence Score
0.538
Applicability Domain
1.0
Statistical Significance
0.0036
Supporting Reference Compounds
1498
E-value
27.7143
Sodium-dependent serotonin transporter structureClick to view 3D structureSodium-dependent serotonin transporterP31645HumansPredicted (SEA)
Prediction Confidence Score
0.496
Applicability Domain
0.683
Statistical Significance
0.0027
Supporting Reference Compounds
593
E-value
21.0971
Sodium-dependent noradrenaline transporter structureClick to view 3D structureSodium-dependent noradrenaline transporterP23975HumansPredicted (SEA)
Prediction Confidence Score
0.472
Applicability Domain
0.683
Statistical Significance
0.0015
Supporting Reference Compounds
451
E-value
11.8331
Click to view 3D structureSodium-dependent serotonin transporterP31652Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.465
Applicability Domain
0.683
Statistical Significance
0.0033
Supporting Reference Compounds
297
E-value
25.6902
Voltage-dependent L-type calcium channel subunit alpha-1C structureClick to view 3D structureVoltage-dependent L-type calcium channel subunit alpha-1CQ13936HumansPredicted (SEA)
Prediction Confidence Score
0.463
Applicability Domain
1.0
Statistical Significance
1.30e-04
Supporting Reference Compounds
71
E-value
1.01204
Click to view 3D structureTransporterQ63380Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.438
Applicability Domain
0.683
Statistical Significance
3.50e-04
Supporting Reference Compounds
54
E-value
2.72472
Click to view 3D structureSodium-dependent dopamine transporterP23977Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.428
Applicability Domain
0.683
Statistical Significance
0.0029
Supporting Reference Compounds
203
E-value
22.9655
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP08909RatPredicted (SEA)
Prediction Confidence Score
0.418
Applicability Domain
0.683
Statistical Significance
0.0035
Supporting Reference Compounds
185
E-value
27.3251
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansPredicted (SEA)
Prediction Confidence Score
0.41
Applicability Domain
0.683
Statistical Significance
0.0109
Supporting Reference Compounds
823
E-value
84.7
Cytochrome P450 2D6 structureClick to view 3D structureCytochrome P450 2D6P10635HumansPredicted (SEA)
Prediction Confidence Score
0.41
Applicability Domain
0.683
Statistical Significance
0.0112
Supporting Reference Compounds
1130
E-value
87.3468
Sodium-dependent dopamine transporter structureClick to view 3D structureSodium-dependent dopamine transporterQ01959HumansPredicted (SEA)
Prediction Confidence Score
0.38
Applicability Domain
0.683
Statistical Significance
0.0078
Supporting Reference Compounds
506
E-value
60.5667
Click to view 3D structureD(2) dopamine receptorP61169RatPredicted (SEA)
Prediction Confidence Score
0.37
Applicability Domain
0.683
Statistical Significance
0.0196
Supporting Reference Compounds
528
E-value
152.818
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP28223HumansPredicted (SEA)
Prediction Confidence Score
0.351
Applicability Domain
0.683
Statistical Significance
0.0337
Supporting Reference Compounds
955
E-value
262.585
Click to view 3D structureNorepinephrine transporterQ9WTR4Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.347
Applicability Domain
0.683
Statistical Significance
0.0047
Supporting Reference Compounds
112
E-value
36.2777
5-hydroxytryptamine receptor 2A structureClick to view 3D structure5-hydroxytryptamine receptor 2AP14842Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.344
Applicability Domain
0.549
Statistical Significance
0.0184
Supporting Reference Compounds
380
E-value
143.32
Potassium channel subfamily K member 2 structureClick to view 3D structurePotassium channel subfamily K member 2O95069HumansPredicted (SEA)
Prediction Confidence Score
0.344
Applicability Domain
1.0
Statistical Significance
1.20e-04
Supporting Reference Compounds
21
E-value
0.934191
Muscarinic acetylcholine receptor M5 structureClick to view 3D structureMuscarinic acetylcholine receptor M5P08912HumansPredicted (SEA)
Prediction Confidence Score
0.342
Applicability Domain
0.683
Statistical Significance
0.0057
Supporting Reference Compounds
266
E-value
44.2962
Sigma non-opioid intracellular receptor 1 structureClick to view 3D structureSigma non-opioid intracellular receptor 1Q99720HumansPredicted (SEA)
Prediction Confidence Score
0.34
Applicability Domain
0.683
Statistical Significance
0.0306
Supporting Reference Compounds
562
E-value
238.374
Histamine H3 receptor structureClick to view 3D structureHistamine H3 receptorQ9Y5N1HumansPredicted (SEA)
Prediction Confidence Score
0.332
Applicability Domain
0.683
Statistical Significance
0.0155
Supporting Reference Compounds
294
E-value
120.822
Cytochrome P450 3A4 structureClick to view 3D structureCytochrome P450 3A4P08684HumansPredicted (SEA)
Prediction Confidence Score
0.327
Applicability Domain
0.683
Statistical Significance
0.0885
Supporting Reference Compounds
1538
E-value
688.654
Alpha-2A adrenergic receptor structureClick to view 3D structureAlpha-2A adrenergic receptorP08913HumansPredicted (SEA)
Prediction Confidence Score
0.324
Applicability Domain
0.683
Statistical Significance
0.0234
Supporting Reference Compounds
487
E-value
182.245
Cytochrome P450 2C19 structureClick to view 3D structureCytochrome P450 2C19P33261HumansPredicted (SEA)
Prediction Confidence Score
0.322
Applicability Domain
0.683
Statistical Significance
0.0387
Supporting Reference Compounds
825
E-value
301.043
Click to view 3D structure5-hydroxytryptamine receptor 1AP19327Rattus norvegicusPredicted (SEA)
Prediction Confidence Score
0.318
Applicability Domain
0.549
Statistical Significance
0.0375
Supporting Reference Compounds
541
E-value
291.857
5-hydroxytryptamine receptor 6 structureClick to view 3D structure5-hydroxytryptamine receptor 6P50406HumansPredicted (SEA)
Prediction Confidence Score
0.316
Applicability Domain
0.683
Statistical Significance
0.0325
Supporting Reference Compounds
536
E-value
253.399
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available