Estradiol 2-O-glucuronide (CED0033481)

Record Information

Version

1.0

Creation Date

2026-04-06 09:25:19 UTC

Update Date

2026-05-21 10:13:57 UTC

SynCED ID

CED0033481

Secondary Accession Numbers

CHEM121567

Identification

Common Name

Estradiol 2-O-glucuronide

Class

Small Molecule

Description

Estradiol 2-O-glucuronide belongs to the steroidal glycosides, a subclass of steroids and steroid derivatives within the organic compounds. This compound is further classified under the superclass of lipids and lipid-like molecules. It has been identified in or released from 13 recorded sources across several diverse sectors. Within the energy, oil & gas and industrial manufacturing & chemical processing sectors, it is found in lubricants. In the healthcare, pharmaceuticals & veterinary products sector, it is associated with medical devices. The compound is also present in food packaging from the food, food processing & cookware sector. Additional sources include textiles, leather & furnishings, specifically synthetic textiles as well as carpets and rugs. Furthermore, it is found in electrical & electronic equipment, including cell phones, capacitors, wires and cables, batteries, and printed circuit boards, among one other item. One additional sector is also recorded as a source. Exposure to estradiol 2-O-glucuronide occurs through oral, inhalation, and touch routes.

Contaminant Type

PFAS

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

Not Available

Average Molecular Mass

Not Available

Monoisotopic Mass

Not Available

CAS Registry Number

Not Available

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C24H32O9/c1-24-7-6-11-12(14(24)4-5-17(24)26)3-2-10-8-15(25)16(9-13(10)11)32-23-20(29)18(27)19(28)21(33-23)22(30)31/h8-9,11-12,14,17-21,23,25-29H,2-7H2,1H3,(H,30,31)/t11-,12+,14-,17-,18-,19-,20+,21-,23+,24-/m0/s1

InChI Key

JWRIQYSRJXLEHG-OBRRSLBQSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
42.0 Log mg/kg [20:74]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000007	Pesticides?Pesticides are synthetic chemicals designed to prevent, destroy, or control pests that threaten crops and agricultural productivity.	Agriculture & land management	Not Available
CEDs000120	Wires and cables?Wires and cables are integral components in the transmission of electrical power and signals.	Electrical & Electronic Equipment	Not Available
CEDs000121	Printed circuit boards?Printed circuit boards (PCBs) are essential components in the manufacturing of electronic devices, serving as the backbone for electrical connections and circuit pathways.	Electrical & Electronic Equipment	Not Available
CEDs000125	Batteries?Batteries are devices that store and release electrical energy through electrochemical reactions.	Electrical & Electronic Equipment	Not Available
CEDs000130	Semiconductors?Semiconductors are materials that possess electrical conductivity between that of conductors and insulators, making them essential for various electronic applications, including transistors, diodes, and integrated circuits.	Electrical & Electronic Equipment	Not Available
CEDs000138	Lubricants?Lubricants are synthetic or petroleum-derived substances used to reduce friction between surfaces in machinery and equipment, enhancing operational efficiency and longevity.	Energy, oil & gas	Not Available
CEDs000147	Food packaging?Food packaging often utilizes synthetic chemicals, such as plastics and coatings, to enhance durability, moisture resistance, and shelf life.	Food, food processing & cookware	Not Available
CEDs000174	Lubricants?Lubricants are synthetic or petroleum-based substances used to reduce friction and wear between moving parts in machinery and equipment.	Industrial manufacturing & chemical processing	Not Available
CEDs000234	Medical devices?Medical devices often incorporate synthetic chemicals in their manufacturing processes, which can contribute to contamination in healthcare settings.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000451	Carpets and Rugs?Carpets and rugs are commonly manufactured using synthetic fibers such as nylon, polyester, and polypropylene, which can be derived from petrochemical sources.	Textiles, leather & furnishings	Not Available
CEDs000454	Synthetic textiles?Synthetic textiles are materials derived from man-made fibers, such as polyester, nylon, and acrylic, which are produced through chemical processes involving petrochemicals.	Textiles, leather & furnishings	Not Available
CEDs000490		Personal care & cosmetics	Not Available
CEDs000492	Cell phones?Cell phones contain a variety of synthetic chemicals and materials, including plastics, metals, and glass, which can contribute to environmental contamination.	Electrical & Electronic Equipment	Not Available
CEDs000493	Capacitors?Capacitors are electronic components that store and release electrical energy, often using dielectric materials that can include synthetic chemicals.	Electrical & Electronic Equipment	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Androgen receptor	P15207	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.477 Applicability Domain 0.59 Statistical Significance 6.30e-04 Supporting Reference Compounds 73 E-value 4.9045
Click to view 3D structure	Sex hormone-binding globulin	P04278	Humans	Predicted (SEA)	Prediction Confidence Score 0.468 Applicability Domain 0.635 Statistical Significance 4.80e-04 Supporting Reference Compounds 33 E-value 3.73676
Click to view 3D structure	Estrogen sulfotransferase	Q95MF8	Sus scrofa	Predicted (SEA)	Prediction Confidence Score 0.465 Applicability Domain 0.465 Statistical Significance 7.00e-05 Supporting Reference Compounds 1 E-value 0.544945
Click to view 3D structure	Solute carrier organic anion transporter family member 1A1	P46720	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.422 Applicability Domain 0.508 Statistical Significance 1.40e-04 Supporting Reference Compounds 10 E-value 1.08989
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	Prediction Confidence Score 0.416 Applicability Domain 0.508 Statistical Significance 0.0021 Supporting Reference Compounds 201 E-value 16.7376
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.403 Applicability Domain 0.508 Statistical Significance 0.0103 Supporting Reference Compounds 593 E-value 80.029
Click to view 3D structure	Progesterone receptor	Q690N0	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.399 Applicability Domain 0.508 Statistical Significance 5.80e-04 Supporting Reference Compounds 40 E-value 4.51525
Click to view 3D structure	Corticosteroid-binding globulin	P08185	Humans	Predicted (SEA)	Prediction Confidence Score 0.378 Applicability Domain 0.508 Statistical Significance 0.0011 Supporting Reference Compounds 21 E-value 8.87481
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Predicted (SEA)	Prediction Confidence Score 0.372 Applicability Domain 0.508 Statistical Significance 0.0026 Supporting Reference Compounds 174 E-value 20.63
Click to view 3D structure	Steryl-sulfatase	P08842	Humans	Predicted (SEA)	Prediction Confidence Score 0.366 Applicability Domain 0.41 Statistical Significance 3.60e-04 Supporting Reference Compounds 14 E-value 2.80257
Click to view 3D structure	Carbonic anhydrase 2	P00918	Humans	Predicted (SEA)	Prediction Confidence Score 0.363 Applicability Domain 0.41 Statistical Significance 0.0136 Supporting Reference Compounds 472 E-value 105.719
Click to view 3D structure	17-beta-hydroxysteroid dehydrogenase type 1	P14061	Humans	Predicted (SEA)	Prediction Confidence Score 0.36 Applicability Domain 0.403 Statistical Significance 0.001 Supporting Reference Compounds 42 E-value 8.17417
Click to view 3D structure	Androgen receptor	P10275	Humans	Predicted (SEA)	Prediction Confidence Score 0.338 Applicability Domain 0.508 Statistical Significance 0.0051 Supporting Reference Compounds 146 E-value 39.781
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Predicted (SEA)	Prediction Confidence Score 0.336 Applicability Domain 0.48 Statistical Significance 0.0044 Supporting Reference Compounds 154 E-value 34.098
Click to view 3D structure	Solute carrier family 22 member 3	O88446	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.334 Applicability Domain 0.508 Statistical Significance 3.50e-04 Supporting Reference Compounds 3 E-value 2.72472
Click to view 3D structure	Carbonic anhydrase 9	Q16790	Humans	Predicted (SEA)	Prediction Confidence Score 0.319 Applicability Domain 0.41 Statistical Significance 0.0232 Supporting Reference Compounds 372 E-value 180.922
Click to view 3D structure	Aromatase	P11511	Humans	Predicted (SEA)	Prediction Confidence Score 0.315 Applicability Domain 0.403 Statistical Significance 0.0066 Supporting Reference Compounds 127 E-value 51.1469
Click to view 3D structure	Aldo-keto reductase family 1 member B10	O60218	Humans	Predicted (SEA)	Prediction Confidence Score 0.302 Applicability Domain 0.508 Statistical Significance 0.0044 Supporting Reference Compounds 49 E-value 34.1758
Click to view 3D structure	Solute carrier organic anion transporter family member 1B2	Q9QZX8	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.284 Applicability Domain 0.284 Low confidence Statistical Significance 3.30e-04 Supporting Reference Compounds 1 E-value 2.56902
Click to view 3D structure	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	P54751	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.282 Applicability Domain 0.282 Low confidence Statistical Significance 4.30e-04 Supporting Reference Compounds 1 E-value 3.34752
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.278 Applicability Domain 0.408 Statistical Significance 0.0644 Supporting Reference Compounds 407 E-value 501.349
Click to view 3D structure	Polyunsaturated fatty acid lipoxygenase ALOX15	P12530	Oryctolagus cuniculus	Predicted (SEA)	Prediction Confidence Score 0.277 Applicability Domain 0.375 Statistical Significance 0.0028 Supporting Reference Compounds 47 E-value 21.7199
Click to view 3D structure	Sulfotransferase 1E1	P19217	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.277 Applicability Domain 0.277 Low confidence Statistical Significance 7.70e-04 Supporting Reference Compounds 1 E-value 5.99439
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.276 Applicability Domain 0.48 Statistical Significance 0.1025 Supporting Reference Compounds 686 E-value 797.721
Click to view 3D structure	Solute carrier family 22 member 1	O15245	Humans	Predicted (SEA)	Prediction Confidence Score 0.271 Applicability Domain 0.508 Statistical Significance 0.0013 Supporting Reference Compounds 30 E-value 9.809