Velcalcetide (CED0018737)

Record Information
Version1.0
Creation Date2026-04-06 14:10:01 UTC
Update Date2026-08-31 22:49:50 UTC
Accession NumberCHEM126352
Identification
Common NameVelcalcetide
ClassSmall Molecule
Description
Velcalcetide is an organic compound with the formula C38H73N21O10S2. Velcalcetide belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 1,048 g/mol, Velcalcetide is a heavy molecule. It acts as an agonist of the extracellular calcium-sensing receptor (CASR). In terms of application, it is found in healthcare, pharmaceuticals, and veterinary products as an anti-parathyroid agent. The recorded route of exposure for this compound is intravenous.
Contaminant TypeNot Available
Chemical Structure
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC38H73N21O10S2
Average Molecular Mass1048.260 g/mol
Monoisotopic Mass1047.529 g/mol
CAS Registry Number1262780-97-1
IUPAC NameNot Available
Traditional NameNot Available
SMILESC[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](N)C(O)=O)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(N)=O
InChI IdentifierInChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
InChI KeyANIAZGVDEUQPRI-ZJQCGQFWSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0ac0-9322010211-54166bcfdae8dd1b8cadNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0abj-8967020221-fc272c15b9c8df506b2fNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-08mr-8966220015-0a463b18841f8fd554aeNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0w2i-7100000019-785d3b851c50e65a87b3Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-03dr-5300000039-37795563659ab3c4841dNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0a4l-9001012310-381ac5fa5670caf9c657Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityNot Available
Carcinogenicity (IARC Classification)Not Available
Minimum Risk LevelNot Available
SymptomsNot Available
TreatmentNot Available
Toxicity ValuesNot Available
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
337Anti-parathyroid agentsHealthcare, pharmaceuticals & veterinary productsNot Available
Pathways
1 pathway
Etelcalcetide Drug Metabolism Action Pathway
Etelcalcetide Drug Metabolism Action Pathway
Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Complement C2 structureClick to view 3D structureComplement C2P06681HumansPredicted (SEA)0.934191
Suppressor of tumorigenicity 14 protein structureClick to view 3D structureSuppressor of tumorigenicity 14 proteinQ9Y5Y6HumansPredicted (SEA)25.6902
Click to view 3D structureMelanocortin receptor 3P33033Mus musculusPredicted (SEA)60.8002
Click to view 3D structureMelanocyte-stimulating hormone receptorQ01727Mus musculusPredicted (SEA)74.5796
Click to view 3D structureSuppressor of tumorigenicity 14 protein homologP56677Mus musculusPredicted (SEA)7.70707
Click to view 3D structureNeuropeptide FF receptor 2Q9Y5X5HumansPredicted (SEA)76.3701
Click to view 3D structureNeuropeptide FF receptor 1Q9GZQ6HumansPredicted (SEA)66.7168
Serine protease hepsin structureClick to view 3D structureSerine protease hepsinP05981HumansPredicted (SEA)8.01847
Neuropeptide Y receptor type 4 structureClick to view 3D structureNeuropeptide Y receptor type 4P50391HumansPredicted (SEA)52.3147
Click to view 3D structureMonofunctional C1-tetrahydrofolate synthase, mitochondrialQ6UB35HumansPredicted (SEA)55.74
Furin structureClick to view 3D structureFurinP09958HumansPredicted (SEA)22.4206
Click to view 3D structureProprotein convertase subtilisin/kexin type 4Q6UW60HumansPredicted (SEA)24.3668
Click to view 3D structureProprotein convertase subtilisin/kexin type 6Q63415Rattus norvegicusPredicted (SEA)24.3668
Nociceptin receptor structureClick to view 3D structureNociceptin receptorP41146HumansPredicted (SEA)74.7353
Neuropeptide Y receptor type 2 structureClick to view 3D structureNeuropeptide Y receptor type 2P49146HumansPredicted (SEA)93.4969
Click to view 3D structureProprotein convertase subtilisin/kexin type 6P29122HumansPredicted (SEA)19.1509
Thrombospondin-1 structureClick to view 3D structureThrombospondin-1P07996HumansPredicted (SEA)10.2761
Click to view 3D structureC5a anaphylatoxin chemotactic receptor 1P30993Mus musculusPredicted (SEA)59.7104
Click to view 3D structureMelanocortin receptor 5P41149Mus musculusPredicted (SEA)100.27
Click to view 3D structureDeoxyribonuclease-2-alphaO00115HumansPredicted (SEA)56.0514
Neuropeptide Y receptor type 1 structureClick to view 3D structureNeuropeptide Y receptor type 1P25929HumansPredicted (SEA)93.4191
Delta-type opioid receptor structureClick to view 3D structureDelta-type opioid receptorP41143HumansPredicted (SEA)220.391
Click to view 3D structureNeuroendocrine convertase 2P16519HumansPredicted (SEA)18.061
Click to view 3D structureNeuropeptide FF receptor 2Q924H0Mus musculusPredicted (SEA)10.5875
Click to view 3D structureNeuropeptide Y receptor type 5Q15761HumansPredicted (SEA)73.4897
Concentrations
Not Available
External Links
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available