Levomilnacipran (CED0009932)

Record Information

Version

1.0

Creation Date

2026-04-14 17:34:24 UTC

Update Date

2026-05-14 19:00:47 UTC

SynCED ID

CED0009932

Secondary Accession Numbers

CHEM130298

Identification

Common Name

Levomilnacipran

Class

Small Molecule

Description

Levomilnacipran is an organic compound with the formula C15H22N2O and an average molecular weight of 246.35 g/mol. Levomilnacipran belongs to the phenylacetamides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as an inhibitor of the sodium-dependent noradrenaline transporter (SLC6A2) and the sodium-dependent serotonin transporter (SLC6A4). It is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically as an antidepressant. The recorded route of exposure for this substance is oral.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₁₅H₂₂N₂O

Average Molecular Mass

246.348 g/mol

Monoisotopic Mass

246.173 g/mol

CAS Registry Number

96847-54-0

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CCN(CC)C(=O)[C@]1(C[C@H]1CN)C1=CC=CC=C1

InChI Identifier

InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1

InChI Key

GJJFMKBJSRMPLA-DZGCQCFKSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0002-5910000000-6041b8fa3fe52b885b2c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000t-0190000000-ac9945cd8c8043e9e92f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-008a-1980000000-989c19c8db76f07da08b	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-5900000000-10e08ed18b692dc26d79	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-0090000000-a43b5ce382df221bf86d	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-4490000000-60028333af69e8af02bd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00dl-9400000000-4f89e1fb8d13d48f3511	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
220.0 Log mg/kg [120:390]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000377	Antidepressants?Antidepressants, a class of synthetic chemicals designed to alleviate symptoms of depression and anxiety, can enter the environment through various pathways, leading to contamination of water systems.	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.741 Applicability Domain 1.0 Statistical Significance 4.00e-05 Supporting Reference Compounds 297 E-value 0.311397
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.704 Applicability Domain 1.0 Statistical Significance 1.30e-04 Supporting Reference Compounds 593 E-value 1.01204
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	Prediction Confidence Score 0.704 Applicability Domain 1.0 Statistical Significance 1.30e-04 Supporting Reference Compounds 506 E-value 1.01204
Click to view 3D structure	Transporter	Q63380	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.704 Applicability Domain 1.0 Statistical Significance 2.00e-05 Supporting Reference Compounds 54 E-value 0.155698
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	Prediction Confidence Score 0.704 Applicability Domain 1.0 Statistical Significance 8.00e-05 Supporting Reference Compounds 451 E-value 0.622794
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.508 Applicability Domain 1.0 Statistical Significance 0.0055 Supporting Reference Compounds 1498 E-value 42.7392
Click to view 3D structure	Sodium-dependent dopamine transporter	P23977	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.411 Applicability Domain 0.538 Statistical Significance 0.0035 Supporting Reference Compounds 203 E-value 27.4808
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.35 Applicability Domain 0.528 Statistical Significance 0.0335 Supporting Reference Compounds 1130 E-value 260.717
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.304 Applicability Domain 0.333 Statistical Significance 0.0579 Supporting Reference Compounds 562 E-value 450.436
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q60492	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.3 Applicability Domain 0.344 Statistical Significance 0.0355 Supporting Reference Compounds 229 E-value 276.131
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.296 Applicability Domain 0.309 Statistical Significance 0.0693 Supporting Reference Compounds 532 E-value 539.339
Click to view 3D structure	D(2) dopamine receptor	P61169	Rat	Predicted (SEA)	Prediction Confidence Score 0.296 Applicability Domain 0.344 Statistical Significance 0.0584 Supporting Reference Compounds 528 E-value 454.328
Click to view 3D structure	D(1A) dopamine receptor	P18901	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.293 Applicability Domain 0.344 Statistical Significance 0.0259 Supporting Reference Compounds 206 E-value 201.318
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	Prediction Confidence Score 0.29 Applicability Domain 0.31 Statistical Significance 0.0405 Supporting Reference Compounds 385 E-value 315.601
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	Prediction Confidence Score 0.29 Applicability Domain 0.31 Statistical Significance 0.037 Supporting Reference Compounds 373 E-value 287.731
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Predicted (SEA)	Prediction Confidence Score 0.29 Applicability Domain 0.302 Statistical Significance 0.0848 Supporting Reference Compounds 527 E-value 659.85
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Predicted (SEA)	Prediction Confidence Score 0.289 Applicability Domain 0.302 Statistical Significance 0.0698 Supporting Reference Compounds 427 E-value 543.076
Click to view 3D structure	Glutamate receptor ionotropic, NMDA 2C	Q00961	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.276 Applicability Domain 0.636 Statistical Significance 0.0069 Supporting Reference Compounds 35 E-value 53.8717
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q9R0C9	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.31 Statistical Significance 0.0474 Supporting Reference Compounds 207 E-value 368.772
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.267 Applicability Domain 0.344 Statistical Significance 0.1629 Supporting Reference Compounds 823 E-value 1268.01
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Predicted (SEA)	Prediction Confidence Score 0.267 Applicability Domain 0.294 Low confidence Statistical Significance 0.0634 Supporting Reference Compounds 310 E-value 493.331
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Predicted (SEA)	Prediction Confidence Score 0.267 Applicability Domain 0.294 Low confidence Statistical Significance 0.0608 Supporting Reference Compounds 297 E-value 473.401
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P10980	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.265 Applicability Domain 0.333 Statistical Significance 0.0129 Supporting Reference Compounds 98 E-value 100.581
Click to view 3D structure	Mu-type opioid receptor	P33535	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.265 Applicability Domain 0.27 Low confidence Statistical Significance 0.0676 Supporting Reference Compounds 229 E-value 525.949
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P14842	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.261 Applicability Domain 0.344 Statistical Significance 0.1019 Supporting Reference Compounds 380 E-value 793.595