Capmatinib (CED0006172)

Record Information

Version

1.0

Creation Date

2026-04-14 18:23:26 UTC

Update Date

2026-08-21 23:33:19 UTC

Accession Number

CHEM131344

Identification

Common Name

Capmatinib

Class

Small Molecule

Description

Capmatinib is an organic compound with the formula C23H17FN6O and an average molecular weight of 412.43 g/mol. Capmatinib belongs to the quinolines and derivatives, a class of organoheterocyclic compounds within the organic compounds. It functions as an inhibitor of the Hepatocyte growth factor receptor (MET). This compound is found in healthcare, pharmaceuticals, and veterinary products as an antineoplastic agent and is administered via the oral exposure route.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₃H₁₇FN₆O

Average Molecular Mass

412.428 g/mol

Monoisotopic Mass

412.145 g/mol

CAS Registry Number

1029712-80-8

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

CNC(=O)C1=C(F)C=C(C=C1)C1=NN2C(CC3=CC4=C(C=C3)N=CC=C4)=CN=C2N=C1

InChI Identifier

InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

InChI Key

LIOLIMKSCNQPLV-UHFFFAOYSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-001i-1809000000-d62f7a3b9d4a5fbb45b1	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0001900000-0cc6d4d4bc96a5d46f54	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0107900000-425c737fbedbcd8bc5ad	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-1912000000-79e16910c22603b36cce	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0001900000-8ac0b88435e7f5e1f167	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-2056900000-1b386b29b4bf02fd6ab3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0pdi-7469000000-82eb0ed7ecfee504acfa	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0003900000-d9aa53ade067433bbf93	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0009200000-b9682800f486c3b7c4b5	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0pvl-0739000000-bf6e990134c6a304b897	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0004900000-0c20e40b9710bc4c99be	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0gvx-0009200000-e3076d5dd4287363d8c5	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0ufr-0951000000-d57ae80d4509ee03e237	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
358	Antineoplastic agents	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

2 pathways

Capmatinib Drug Metabolism

Capmatinib Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Hepatocyte growth factor receptor	P08581	Humans	Predicted (SEA)	65.0041
Click to view 3D structure	Cyclin-dependent kinase-like 5	O76039	Humans	Predicted (SEA)	12.5337
Click to view 3D structure	Regulator of chromosome condensation	P18754	Humans	Predicted (SEA)	7.31783
Click to view 3D structure	High affinity nerve growth factor receptor	P04629	Humans	Predicted (SEA)	585.815
Click to view 3D structure	BDNF/NT-3 growth factors receptor	Q16620	Humans	Predicted (SEA)	490.372
Click to view 3D structure	Tyrosine-protein kinase receptor UFO	P30530	Humans	Predicted (SEA)	344.561
Click to view 3D structure	NT-3 growth factor receptor	Q16288	Humans	Predicted (SEA)	406.295
Click to view 3D structure	Fibroblast growth factor receptor 1	P11362	Humans	Predicted (SEA)	624.74
Click to view 3D structure	Insulin-like growth factor 1 receptor	P08069	Humans	Predicted (SEA)	557.011
Click to view 3D structure	Tyrosine-protein kinase JAK2	O60674	Humans	Predicted (SEA)	706.404
Click to view 3D structure	Vascular endothelial growth factor receptor 2	P35968	Humans	Predicted (SEA)	910.135
Click to view 3D structure	Platelet-derived growth factor receptor alpha	P16234	Humans	Predicted (SEA)	423.111
Click to view 3D structure	Epidermal growth factor receptor	P00533	Humans	Predicted (SEA)	830.262
Click to view 3D structure	Vascular endothelial growth factor receptor 3	P35916	Humans	Predicted (SEA)	497.223
Click to view 3D structure	Receptor-type tyrosine-protein kinase FLT3	P36888	Humans	Predicted (SEA)	883.044
Click to view 3D structure	Macrophage colony-stimulating factor 1 receptor	P07333	Humans	Predicted (SEA)	672.929
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	Humans	Predicted (SEA)	657.592
Click to view 3D structure	Aurora kinase A	O14965	Humans	Predicted (SEA)	764.635
Click to view 3D structure	Tyrosine-protein kinase Lck	P06239	Humans	Predicted (SEA)	882.966
Click to view 3D structure	Serine/threonine-protein kinase Chk1	O14757	Humans	Predicted (SEA)	617.967
Click to view 3D structure	Insulin receptor	P06213	Humans	Predicted (SEA)	612.907
Click to view 3D structure	Aurora kinase B	Q96GD4	Humans	Predicted (SEA)	771.408
Click to view 3D structure	Vascular endothelial growth factor receptor 1	P17948	Humans	Predicted (SEA)	603.254
Click to view 3D structure	Tyrosine-protein kinase receptor TYRO3	Q06418	Humans	Predicted (SEA)	520.5
Click to view 3D structure	Cyclin-dependent kinase 2	P24941	Humans	Predicted (SEA)	765.024