Lefamulin (CED0010609)

Record Information

Version

1.0

Creation Date

2026-04-14 19:06:04 UTC

Update Date

2026-08-22 08:39:42 UTC

Accession Number

CHEM131732

Identification

Common Name

Lefamulin

Class

Small Molecule

Description

Lefamulin is an organic compound with the formula C28H45NO5S. Lefamulin belongs to the diterpenoids, a subclass of prenol lipids within the organic compounds. With an average molecular weight of 507.73 g/mol, Lefamulin is a heavy molecule. It is found in healthcare, pharmaceuticals, and veterinary products as an antibacterial agent, with recorded exposure routes including oral and intravenous administration. Regarding its mechanism of action, it acts as a binder and inhibitor of the large ribosomal subunit protein uL22 (rplV).

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₈H₄₅NO₅S

Average Molecular Mass

507.730 g/mol

Monoisotopic Mass

507.302 g/mol

CAS Registry Number

1061337-51-6

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

[H][C@@]12C(=O)CC[C@]11CCC(C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O

InChI Identifier

InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16?,17-,18+,20+,21+,22+,24-,25-,26+,27-,28-/m0/s1

InChI Key

KPVIXBKIJXZQJX-CSOZIWFHSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
1605.0	Log mg/kg	[900:2900]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference

Exposure Sources

Source ID	Source	Sector	Reference
347	Antibacterials	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

1 pathway

Lefamulin Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Adenylate cyclase type 1	P19754	Bos taurus	Predicted (SEA)	3.42537
Click to view 3D structure	Transient receptor potential cation channel subfamily M member 2	E9PTA2	Rattus norvegicus	Predicted (SEA)	11.2881
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 2	Q9R1A7	Rattus norvegicus	Predicted (SEA)	15.492
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Predicted (SEA)	3611.81
Click to view 3D structure	DNA topoisomerase 2-alpha	P11388	Humans	Predicted (SEA)	754.67
Click to view 3D structure	Mineralocorticoid receptor	P08235	Humans	Predicted (SEA)	2762.71
Click to view 3D structure	Androgen receptor	P10275	Humans	Predicted (SEA)	4472.83
Click to view 3D structure	Glucocorticoid receptor	P06536	Rattus norvegicus	Predicted (SEA)	334.362
Click to view 3D structure	Tubulin--tyrosine ligase	Q8NG68	Humans	Predicted (SEA)	7.16213
Click to view 3D structure	Androgen receptor	P15207	Rattus norvegicus	Predicted (SEA)	1191.95
Click to view 3D structure	Tyrosine-protein phosphatase non-receptor type 1	P18031	Humans	Predicted (SEA)	4054.31
Click to view 3D structure	Phospholipase A2, membrane associated	P14555	Humans	Predicted (SEA)	2460.04
Click to view 3D structure	Glycogen [starch] synthase, liver	P54840	Humans	Predicted (SEA)	35.5771
Click to view 3D structure	Glucose-6-phosphatase catalytic subunit 1	P43428	Rattus norvegicus	Predicted (SEA)	35.5771
Click to view 3D structure	Progesterone receptor	Q690N0	Bos taurus	Predicted (SEA)	266.789
Click to view 3D structure	Progesterone receptor	P06401	Humans	Predicted (SEA)	4859.5
Click to view 3D structure	Corticosteroid-binding globulin	P08185	Humans	Predicted (SEA)	76.2922
Click to view 3D structure	Sex hormone-binding globulin	P04278	Humans	Predicted (SEA)	151.417
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase type 2	P80365	Humans	Predicted (SEA)	1011.34
Click to view 3D structure	Solute carrier family 2, facilitated glucose transporter member 1	P11166	Humans	Predicted (SEA)	5176.35
Click to view 3D structure	11-beta-hydroxysteroid dehydrogenase 1	P28845	Humans	Predicted (SEA)	3900.56
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	7350.45
Click to view 3D structure	Protein deacetylase HDAC6	Q9UBN7	Humans	Predicted (SEA)	7458.5
Click to view 3D structure	Glucocorticoid receptor	P06537	Mus musculus	Predicted (SEA)	115.528
Click to view 3D structure	Tyrosine aminotransferase	P04694	Rattus norvegicus	Predicted (SEA)	19.6959