Oliceridine (CED0010294)

Record Information

Version

1.0

Creation Date

2026-04-14 19:59:03 UTC

Update Date

2026-08-21 22:54:44 UTC

SynCED ID

CED0010294

Secondary Accession Numbers

CHEM132606

Identification

Common Name

Oliceridine

Class

Small Molecule

Description

Oliceridine is an organic compound with the formula C22H30N2O2S and an average molecular weight of 386.55 g/mol. Oliceridine belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. It acts as an agonist of the Mu-type opioid receptor (OPRM1). This compound is found in healthcare, pharmaceuticals, and veterinary products used as analgesics, with a recorded exposure route of intravenous administration.

Contaminant Type

Not Available

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂₂H₃₀N₂O₂S

Average Molecular Mass

386.550 g/mol

Monoisotopic Mass

386.203 g/mol

CAS Registry Number

1401028-24-7

IUPAC Name

Not Available

Traditional Name

Not Available

SMILES

COC1=C(CNCC[C@]2(CCOC3(CCCC3)C2)C2=NC=CC=C2)SC=C1

InChI Identifier

InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3/t21-/m1/s1

InChI Key

DMNOVGJWPASQDL-OAQYLSRUSA-N

Chemical Taxonomy

Classification

Not classified

Biological Properties

Status

Detected and Not Quantified

Origin

Not Available

Cellular Locations

Not Available

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

agonist (PMC7060366 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Not Available

Appearance

Not Available

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Not Available

Spectra

Not Available

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
1000.0 Log mg/kg [560:1800]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Not Available

Carcinogenicity (IARC Classification)

Not Available

Minimum Risk Level

Not Available

Symptoms

Not Available

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference
pain	Has Therapeutic Effect On	Not Available	A disorder characterized by the sensation of marked discomfort, distress or agony. (NCI CTCAE)	PMC7383964
pain agnosia	Has Therapeutic Effect On	Not Available	Not Available	PMC7060366
acute pain	Not Available	Not Available	Not Available	PMC7865374

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000370	Analgesics?Analgesics are a class of synthetic chemicals designed to alleviate pain.	Healthcare, pharmaceuticals & veterinary products	Not Available

Pathways

3 pathwaysPathway Source: PathBank

Oliceridine Opioid Agonist Action Pathway

Oliceridine Drug Metabolism Action Pathway

Oliceridine Predicted Metabolism Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Predicted (SEA)	Prediction Confidence Score 0.514 Applicability Domain 1.0 Statistical Significance 0.0082 Supporting Reference Compounds 527 E-value 64.1478
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.474 Applicability Domain 1.0 Statistical Significance 0.0118 Supporting Reference Compounds 532 E-value 92.0956
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.461 Applicability Domain 1.0 Statistical Significance 0.0111 Supporting Reference Compounds 1498 E-value 86.5683
Click to view 3D structure	Sodium channel protein type 5 subunit alpha	Q14524	Humans	Predicted (SEA)	Prediction Confidence Score 0.461 Applicability Domain 1.0 Statistical Significance 0.0031 Supporting Reference Compounds 139 E-value 23.9776
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Predicted (SEA)	Prediction Confidence Score 0.46 Applicability Domain 1.0 Statistical Significance 0.0144 Supporting Reference Compounds 427 E-value 112.025
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.399 Applicability Domain 1.0 Statistical Significance 0.0157 Supporting Reference Compounds 861 E-value 121.99
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.391 Applicability Domain 1.0 Statistical Significance 0.0157 Supporting Reference Compounds 1130 E-value 122.145
Click to view 3D structure	Mu-type opioid receptor	P42866	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.331 Applicability Domain 1.0 Statistical Significance 0.0183 Supporting Reference Compounds 107 E-value 142.775
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	Prediction Confidence Score 0.247 Applicability Domain 0.254 Low confidence Statistical Significance 0.1585 Supporting Reference Compounds 373 E-value 1234.22
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Predicted (SEA)	Prediction Confidence Score 0.243 Applicability Domain 0.254 Low confidence Statistical Significance 0.2127 Supporting Reference Compounds 406 E-value 1655.93
Click to view 3D structure	Cholinesterase	P06276	Humans	Predicted (SEA)	Prediction Confidence Score 0.239 Applicability Domain 0.254 Low confidence Statistical Significance 0.1545 Supporting Reference Compounds 234 E-value 1202.54
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	Prediction Confidence Score 0.237 Applicability Domain 0.25 Low confidence Statistical Significance 0.385 Supporting Reference Compounds 953 E-value 2997.04
Click to view 3D structure	Alpha-1A adrenergic receptor	P35348	Humans	Predicted (SEA)	Prediction Confidence Score 0.236 Applicability Domain 0.25 Low confidence Statistical Significance 0.2221 Supporting Reference Compounds 376 E-value 1729.42
Click to view 3D structure	Muscarinic acetylcholine receptor M3	Q8VH26	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.232 Applicability Domain 0.254 Low confidence Statistical Significance 0.0182 Supporting Reference Compounds 52 E-value 141.608
Click to view 3D structure	Alpha-1D adrenergic receptor	P25100	Humans	Predicted (SEA)	Prediction Confidence Score 0.23 Applicability Domain 0.25 Low confidence Statistical Significance 0.182 Supporting Reference Compounds 258 E-value 1416.62
Click to view 3D structure	Alpha-1B adrenergic receptor	P35368	Humans	Predicted (SEA)	Prediction Confidence Score 0.23 Applicability Domain 0.25 Low confidence Statistical Significance 0.2248 Supporting Reference Compounds 298 E-value 1750.36
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P19327	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.224 Applicability Domain 0.241 Low confidence Statistical Significance 0.3802 Supporting Reference Compounds 541 E-value 2959.59
Click to view 3D structure	D(4) dopamine receptor	P21917	Humans	Predicted (SEA)	Prediction Confidence Score 0.22 Applicability Domain 0.244 Low confidence Statistical Significance 0.4611 Supporting Reference Compounds 524 E-value 3589.86
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P14842	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.219 Applicability Domain 0.241 Low confidence Statistical Significance 0.3538 Supporting Reference Compounds 380 E-value 2753.99
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	Prediction Confidence Score 0.218 Applicability Domain 0.254 Low confidence Statistical Significance 0.4432 Supporting Reference Compounds 385 E-value 3450.28
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Predicted (SEA)	Prediction Confidence Score 0.218 Applicability Domain 0.254 Low confidence Statistical Significance 0.3297 Supporting Reference Compounds 266 E-value 2566.92
Click to view 3D structure	D(2) dopamine receptor	P61169	Rat	Predicted (SEA)	Prediction Confidence Score 0.217 Applicability Domain 0.227 Low confidence Statistical Significance 0.4165 Supporting Reference Compounds 528 E-value 3242.73
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	Prediction Confidence Score 0.216 Applicability Domain 0.244 Low confidence Statistical Significance 0.6659 Supporting Reference Compounds 1103 E-value 5184.37
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.215 Applicability Domain 0.233 Low confidence Statistical Significance 0.6467 Supporting Reference Compounds 823 E-value 5034.2
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.213 Applicability Domain 0.227 Low confidence Statistical Significance 0.6571 Supporting Reference Compounds 686 E-value 5115.78